Searching for up to 100 curated homologs for 15023 FitnessBrowser__Keio:15023 (476 a.a.)

Found high-coverage hits (≥70%) to 10 curated proteins.

Removed hits that are identical to the query, leaving 9

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ACAP_LACLM / A2RL65 Aspartate/glutamate permease AcaP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    58% identity, 99% coverage of query (553 bits)

TC 2.A.3.7.6 / F2HJG8 Aspartate/Glutamate transporter of 488 aas and 12 TMSs, AcaP from Lactococcus lactis subsp. lactis (strain CV56)
    58% identity, 99% coverage of query (551 bits)

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Build an alignment for 15023 and 2 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

YgjI / b3078 putative transporter YgjI from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    23% identity, 82% coverage of query (114 bits)

YjeM / b4156 putative transporter YjeM from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    22% identity, 91% coverage of query (109 bits)

GadC / b1492 L-glutamate:4-aminobutyrate antiporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gadC / P63235 L-glutamate:4-aminobutyrate antiporter from Escherichia coli (strain K12) (see 14 papers)
GADC_ECOLI / P63235 Glutamate/gamma-aminobutyrate antiporter; Glu/GABA antiporter; Extreme acid sensitivity protein from Escherichia coli (strain K12) (see 12 papers)
GADC_SHIFL / P63236 Glutamate/gamma-aminobutyrate antiporter; Glu/GABA antiporter from Shigella flexneri (see paper)
TC 2.A.3.7.3 / C8U8G2 Glutamate:GABA antiporter, GadC (YcaM). GadC, transports GABA/Glu only under acidic conditions, with no detectable activity at pH  values higher than 6.5 (Ma et al., 2012). Ma et al. (2012) determined the crystal structure of GadC at 3.1 Å resolution under basic conditions. GadC, comprising 12 TMSs, exists in a closed state, with its carboxy-terminal domain serving as a plug to block an otherwise inward-open conformation. Structural and biochemical analyses revealed the essential transport residues, identified the transport path and suggested a transport mechanism involving the rigid-body rotation of a helical bundle for GadC and other amino acid antiporters from Escherichia coli O103:H2 (strain 12009 / EHEC) (see paper)
gadC extreme acid sensitivity protein XasA from Escherichia coli K12 (see 12 papers)
    24% identity, 82% coverage of query (69.7 bits)

GADC_ECO57 / P58229 Glutamate/gamma-aminobutyrate antiporter; Glu/GABA antiporter from Escherichia coli O157:H7 (see paper)
    24% identity, 82% coverage of query (69.7 bits)

TC 2.A.3.7.7 / F2HL33 Putriscine/agmatine transporter of 466 aas and 12 TMSs, AguD or YrfD from Lactococcus lactis subsp. lactis (strain CV56)
    22% identity, 76% coverage of query (54.7 bits)

AGUD_LACLA / Q9CEY5 Probable agmatine/putrescine antiporter AguD from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
    22% identity, 76% coverage of query (52.0 bits)

GADC_LACLM / O30417 Glutamate/gamma-aminobutyrate antiporter; Glu/GABA antiporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
TC 2.A.3.7.1 / O30417 Glutamate:γ-aminobutyrate antiporter of 477 aas and 12 TMSs, GadC from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (see 3 papers)
    20% identity, 74% coverage of query (50.8 bits)

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