Searching for up to 100 curated homologs for 15027 FitnessBrowser__Keio:15027 (760 a.a.)

Found high-coverage hits (≥70%) to 22 curated proteins.

Removed hits that are identical to the query, leaving 20

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1cm5A / P09373 Crystal structure of c418a,c419a mutant of pfl from e.Coli (see paper)
    100% identity, 100% coverage of query (1579 bits)

TDCE_ECOLI / P42632 PFL-like enzyme TdcE; Keto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; Pyruvate formate-lyase; PFL; EC 2.3.1.-; EC 2.3.1.54 from Escherichia coli (strain K12) (see paper)
tdcE / EW|b3114 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase from Escherichia coli K12 (see paper)
    80% identity, 99% coverage of query (1292 bits)

PFLB_STAAC / Q5HJF4 Formate acetyltransferase; Pyruvate formate-lyase; EC 2.3.1.54 from Staphylococcus aureus (strain COL) (see paper)
    66% identity, 100% coverage of query (1073 bits)

pfl / Q46266 pyruvate formate-lyase subunit (EC 2.3.1.54) from Clostridium pasteurianum (see 6 papers)
Q46266 formate C-acetyltransferase (EC 2.3.1.54) from Clostridium pasteurianum (see paper)
    62% identity, 99% coverage of query (951 bits)

PFL1 / Q1RS83 pyruvate formate lyase (EC 2.3.1.54) from Chlamydomonas reinhardtii (see 6 papers)
Q1RS83 formate C-acetyltransferase (EC 2.3.1.54) from Chlamydomonas reinhardtii (see paper)
    58% identity, 97% coverage of query (881 bits)

pfl / Q59934 pyruvate formate-lyase subunit (EC 2.3.1.54) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 2 papers)
    45% identity, 99% coverage of query (630 bits)

O66391 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus equinus (see paper)
    44% identity, 99% coverage of query (625 bits)

Q5M2Y4 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus thermophilus (see paper)
    44% identity, 99% coverage of query (621 bits)

A0A0H2ZQE4 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus pneumoniae (see paper)
    44% identity, 99% coverage of query (620 bits)

pfl / CAA03991.1 pyruvate formate-lyase from Lactococcus lactis (see paper)
    43% identity, 99% coverage of query (601 bits)

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Build an alignment for 15027 and 10 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q8GEZ8 glycerol dehydratase (EC 4.2.1.30) from Clostridium butyricum (see 2 papers)
    28% identity, 77% coverage of query (192 bits)

1r9dA / Q8GEZ8 Glycerol bound form of the b12-independent glycerol dehydratase from clostridium butyricum (see paper)
    28% identity, 77% coverage of query (192 bits)

2f3oA / O28823 Crystal structure of a glycyl radical enzyme from archaeoglobus fulgidus (see paper)
    23% identity, 87% coverage of query (140 bits)

O28823 formate C-acetyltransferase (EC 2.3.1.54) from Archaeoglobus fulgidus (see paper)
    23% identity, 87% coverage of query (140 bits)

t4LhypD / Q180C6 trans-4-hydroxy-L-proline dehydratase (EC 4.2.1.172) from Clostridioides difficile (strain 630) (see paper)
    24% identity, 83% coverage of query (135 bits)

HYPD_CLODI / A0A031WDE4 Trans-4-hydroxy-L-proline dehydratase; Glycyl radical enzyme; Hyp dehydratase; EC 4.2.1.172 from Clostridioides difficile (Peptoclostridium difficile) (see paper)
6vxeA / A0A031WDE4 Crystal structure of hydroxyproline dehydratase (hypd) from clostridioides difficile with substrate trans-4-hydroxy-l-proline bound (see paper)
    24% identity, 83% coverage of query (134 bits)

ISLA_DESDA / B8J0R1 Isethionate sulfite-lyase; Glycyl radical enzyme IslA; GRE IslA; EC 4.4.1.38 from Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB) (see paper)
B8J0R1 isethionate sulfite-lyase (EC 4.4.1.38) from Desulfovibrio desulfuricans (see paper)
    23% identity, 76% coverage of query (114 bits)

IAD_TRASO / A0A100YXA1 Indoleacetate decarboxylase; IAD; OsIAD; EC 4.1.1.115 from Tractidigestivibacter scatoligenes (Olsenella scatoligenes) (see paper)
A0A100YXA1 indoleacetate decarboxylase (EC 4.1.1.115) from Tractidigestivibacter scatoligenes (see paper)
    24% identity, 71% coverage of query (109 bits)

hpfG / A0A318FL05 (2S)-3-sulfopropanediol dehydratase (EC 4.2.1.177) from Klebsiella oxytoca (see paper)
HPFG_KLEOX / A0A318FL05 (2S)-3-sulfopropanediol dehydratase; (S)-DHPS dehydratase; EC 4.2.1.177 from Klebsiella oxytoca (see paper)
A0A318FL05 (2S)-3-sulfopropanediol dehydratase (EC 4.2.1.177) from Klebsiella oxytoca (see paper)
    24% identity, 78% coverage of query (108 bits)

masD / CAO03074.1 1-methyl alkyl succinate synthase subunit MasD from Azoarcus sp. HxN1 (see paper)
    22% identity, 74% coverage of query (104 bits)

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