Searching for up to 100 curated homologs for 15302 b1180 predicted isomerase/hydrolase (NCBI) (219 a.a.)
Found high-coverage hits (≥70%) to 53 curated proteins.
Removed hits that are identical to the query, leaving 52
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1nr9B / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
96% identity, 100% coverage of query (429 bits)
1nr9D / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
96% identity, 100% coverage of query (428 bits)
1nr9A / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
95% identity, 100% coverage of query (426 bits)
1nr9C / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
95% identity, 100% coverage of query (426 bits)
3v77A / D2YW46 Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
50% identity, 94% coverage of query (209 bits)
FAHD1_MOUSE / Q8R0F8 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; EC 3.7.1.5; EC 4.1.1.112 from Mus musculus (Mouse) (see 2 papers)
49% identity, 88% coverage of query (190 bits)
6sbiA / Q8R0F8 X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
49% identity, 88% coverage of query (189 bits)
FAHD1_HUMAN / Q6P587 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; YisK-like protein; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 3 papers)
Q6P587 acylpyruvate hydrolase (EC 3.7.1.5); oxaloacetate decarboxylase (EC 4.1.1.112) from Homo sapiens (see 3 papers)
47% identity, 91% coverage of query (188 bits)
6fogA / Q6P587 X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
47% identity, 91% coverage of query (188 bits)
FAHD1_ARATH / Q93ZE5 Probable acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
48% identity, 90% coverage of query (187 bits)
A0A0D5YDA5 fumarylacetoacetase (EC 3.7.1.2) from Acinetobacter baumannii (see paper)
43% identity, 90% coverage of query (174 bits)
FAHD2_ARATH / Q9LUR3 Probable acylpyruvase FAHD2, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2; FAH domain-containing protein 2; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
44% identity, 90% coverage of query (165 bits)
6j5yA / Q9I111 Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
40% identity, 94% coverage of query (162 bits)
A0A080VH08 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Pseudomonas aeruginosa (see paper)
40% identity, 94% coverage of query (162 bits)
Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
41% identity, 89% coverage of query (152 bits)
A0A0M3SVN7 fumarylacetoacetase (EC 3.7.1.2) from Cupriavidus gilardii (see paper)
41% identity, 90% coverage of query (149 bits)
A0A1B0ZSC0 fumarylacetoacetase (EC 3.7.1.2) from Phaeobacter gallaeciensis (see paper)
38% identity, 91% coverage of query (144 bits)
YOS9_SCHPO / Q9P7L4 Uncharacterized hydrolase C21C3.09c; EC 3.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
39% identity, 86% coverage of query (141 bits)
FMP41_YEAST / P53889 Uncharacterized mitochondrial hydrolase FMP41; EC 3.-.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
35% identity, 86% coverage of query (140 bits)
1nkqA / P53889 Crystal structure of yeast ynq8, a fumarylacetoacetate hydrolase family protein
36% identity, 86% coverage of query (133 bits)
3qdfA / B2HIH3 Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
37% identity, 89% coverage of query (131 bits)
naaD / F8QQ75 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Bradyrhizobium sp. JS329 (see paper)
36% identity, 88% coverage of query (129 bits)
UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) (see paper)
39% identity, 83% coverage of query (129 bits)
HPCE_ECOLX / P37352 Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase; EC 5.3.3.10; EC 4.1.1.68 from Escherichia coli (see 2 papers)
39% identity, 85% coverage of query (128 bits)
hpaG / Q46978 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (EC 4.1.1.68) from Escherichia coli (see 2 papers)
39% identity, 85% coverage of query (128 bits)
8gsrA / Q1NEI7 Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
37% identity, 83% coverage of query (127 bits)
BMULJ_04921 / A0A0H3KT28 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Burkholderia multivorans (strain ATCC 17616 / 249) (see 2 papers)
37% identity, 89% coverage of query (127 bits)
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form)
37% identity, 83% coverage of query (127 bits)
lra6 / Q1NEI7 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
36% identity, 83% coverage of query (126 bits)
SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
34% identity, 89% coverage of query (125 bits)
BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
37% identity, 83% coverage of query (124 bits)
1gttA / P37352 Crystal structure of hpce (see paper)
38% identity, 84% coverage of query (121 bits)
6iymA / K0A9N9 Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
37% identity, 90% coverage of query (121 bits)
G2IPX5 maleylpyruvate hydrolase (EC 3.7.1.23) from Sphingobium sp. SYK-6 (see paper)
34% identity, 93% coverage of query (120 bits)
K0A9N9 fumarylacetoacetase (EC 3.7.1.2) from Exiguobacterium antarcticum (see paper)
37% identity, 90% coverage of query (120 bits)
HSERO_RS06355 2,4-diketo-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Herbaspirillum seropedicae SmR1
33% identity, 89% coverage of query (119 bits)
8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
34% identity, 89% coverage of query (118 bits)
YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
34% identity, 89% coverage of query (118 bits)
C785_RS20550 / A0A2E7P912 5-hydroxy-2,4-dioxopentanoate hydrolase (EC 3.7.1.26) from Herbaspirillum sp. (see paper)
33% identity, 89% coverage of query (118 bits)
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
34% identity, 89% coverage of query (118 bits)
6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
33% identity, 93% coverage of query (115 bits)
A0A1R4GQY2 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Corynebacterium glutamicum (see paper)
37% identity, 82% coverage of query (109 bits)
6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
37% identity, 82% coverage of query (109 bits)
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
37% identity, 82% coverage of query (109 bits)
hbzF / Q0QFQ3 maleylpyruvate hydrolase monomer (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
HBZF_PSEAC / Q0QFQ3 Maleylpyruvate hydrolase; MPH11; EC 3.7.1.23 from Pseudomonas alcaligenes (see 3 papers)
Q0QFQ3 maleylpyruvate hydrolase (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
32% identity, 93% coverage of query (102 bits)
6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
34% identity, 89% coverage of query (98.6 bits)
4dbhA / Q8NQY2 Crystal structure of cg1458 with inhibitor (see paper)
32% identity, 89% coverage of query (95.1 bits)
Build an alignment for 15302 and 47 homologs with ≥ 30% identity
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nagK / O86042 fumarylpyruvate hydrolase (EC 3.7.1.20) from Ralstonia sp. (see paper)
NAGK_RALSP / O86042 Fumarylpyruvate hydrolase; Naphthalene degradation protein K; EC 3.7.1.20 from Ralstonia sp. (see paper)
O86042 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Ralstonia sp. (see paper)
29% identity, 79% coverage of query (94.4 bits)
dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
29% identity, 90% coverage of query (91.7 bits)
3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
30% identity, 82% coverage of query (87.0 bits)
A0A076VF18 fumarylacetoacetase (EC 3.7.1.2) from Rhodotorula diobovata (see paper)
33% identity, 77% coverage of query (83.2 bits)
CPH_NEONM / A0A3G9JYJ6 Caffeoylpyruvate hydrolase; CPH; Fungal bioluminescence cycle protein cph; EC 3.7.-.- from Neonothopanus nambi (Agaricus nambi) (see 2 papers)
29% identity, 92% coverage of query (77.4 bits)
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Lawrence Berkeley National Laboratory