Searching for up to 100 curated homologs for 15364 FitnessBrowser__Keio:15364 (306 a.a.)
Found high-coverage hits (≥70%) to 34 curated proteins.
Removed hits that are identical to the query, leaving 33
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.5.1 / P08005 OppB aka STM1745, component of Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA from Salmonella typhimurium (see 3 papers)
96% identity, 100% coverage of query (594 bits)
Q5V9S1 ABC-type oligopeptide transporter (EC 7.4.2.6) from Vibrio fluvialis (see paper)
TC 3.A.1.5.22 / Q5V9S1 OppB, component of The peptide transporter OppA,B,C,D,F (influences biofilm formation; Lee et al., 2004). Similar to 3.A.1.5.1, OppA is similar to the Vibrio furnissii OppA that provides several functions: hemolysis, antibiotic resistance, and virulence from Vibrio fluvialis (see paper)
68% identity, 100% coverage of query (432 bits)
OPPB_BACSU / P24138 Oligopeptide transport system permease protein OppB; Stage 0 sporulation protein KB from Bacillus subtilis (strain 168) (see 2 papers)
51% identity, 100% coverage of query (293 bits)
TC 3.A.1.5.19 / Q2FZR7 OppB, component of The major oligopeptide uptake porter, Opp-3 (of four paralogues, this is the only one that mediates nitrogen nutrition from Staphylococcus aureus (strain NCTC 8325)
45% identity, 100% coverage of query (257 bits)
TC 3.A.1.5.18 / O31307 OppB1, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see 2 papers)
42% identity, 99% coverage of query (255 bits)
TC 3.A.1.5.2 / P26903 DppB aka DCIAB, component of Dipeptide porter. Also transports δ-aminolevulinic acid (ALA) and heme from Bacillus subtilis (see 2 papers)
43% identity, 100% coverage of query (255 bits)
TC 3.A.1.5.15 / Q9X269 TM1747, component of Probable mannose/mannoside porter. Induced by beta-mannan (Conners et al., 2005). Regulated by mannose-responsive regulator manR (see paper)
40% identity, 95% coverage of query (238 bits)
TC 3.A.1.5.20 / P42062 AppB, component of 5-6 amino acyl oligopeptide transporter AppA-F from Bacillus subtilis (see 3 papers)
36% identity, 100% coverage of query (211 bits)
appB / GB|CAB12996.1 oligopeptide ABC transporter, permease protein AppB from Bacillus subtilis (see 2 papers)
36% identity, 100% coverage of query (201 bits)
DPPB_LACLM / A2RI75 Dipeptide transport system permease protein DppB from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
36% identity, 92% coverage of query (199 bits)
TC 3.A.1.5.25 / Q9CIL1 Oligopeptide ABC trasporter permease protein, component of The ABC peptide/signalling peptide transporter. OptA binds peptides of 3-6 aas; OptS binds dipeptides. OptB,C,D are most similar to 3.A.1.5.19 from Lactococcus lactis subsp. lactis (see paper)
36% identity, 92% coverage of query (198 bits)
DPPB_PSEAB / A0A0H2ZGW7 Di/tripeptide transport system permease protein DppB from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
TC 3.A.1.5.39 / W0WN20 Dipeptide transport system permease protein dppB, component of Di- and tri-peptide transporter, DppBCDF with periplasmic substrate binding receptors, A1, A3, A5, A7 and A9, each with differing specificities for peptides from Pseudomonas aeruginosa MH38
35% identity, 100% coverage of query (197 bits)
DppB / b3543 dipeptide ABC transporter membrane subunit DppB (EC 7.4.2.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
dppB / P0AEF8 dipeptide ABC transporter membrane subunit DppB (EC 7.4.2.9) from Escherichia coli (strain K12) (see paper)
DPPB_ECOLI / P0AEF8 Dipeptide transport system permease protein DppB from Escherichia coli (strain K12) (see 4 papers)
dppB / GB|AAC76568.1 dipeptide ABC transporter, permease protein DppB from Escherichia coli (see 7 papers)
35% identity, 100% coverage of query (194 bits)
GsiC / b0831 glutathione ABC transporter membrane subunit GsiC (EC 7.4.2.10) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
gsiC / P75798 glutathione ABC transporter membrane subunit GsiC (EC 7.4.2.10) from Escherichia coli (strain K12) (see paper)
GSIC_ECOLI / P75798 Glutathione transport system permease protein GsiC from Escherichia coli (strain K12) (see 2 papers)
P75798 ABC-type glutathione transporter (EC 7.4.2.10) from Escherichia coli (see paper)
TC 3.A.1.5.11 / P75798 Inner membrane ABC transporter permease protein yliC, component of Glutathione porter, YliABCD or GsiABCD from Escherichia coli (see 5 papers)
gsiC / GB|ABE06320.1 glutathione ABC transporter, permease protein GsiC from Escherichia coli K12 (see paper)
36% identity, 100% coverage of query (193 bits)
TC 3.A.1.5.27 / P45096 Dipeptide transport system permease protein dppB, component of The glutathione uptake porter, DppBCDF with the glutathione binding protein, DppA (GbpA; HbpA). Takes up reduced (GSH) and oxidized (GSSG) but not bulky glutathione S conjugates or glutathione derivatives with C-terminal modifications from Haemophilus influenzae (see 2 papers)
33% identity, 100% coverage of query (186 bits)
NikB / b3477 Ni(2+) ABC transporter membrane subunit NikB from Escherichia coli K-12 substr. MG1655 (see 3 papers)
nikB / P33591 nickel ABC transporter membrane subunit NikB from Escherichia coli (strain K12) (see paper)
TC 3.A.1.5.3 / P33591 NikB aka B3477, component of Nickel porter from Escherichia coli (see 5 papers)
35% identity, 100% coverage of query (176 bits)
TC 3.A.1.5.4 / O30543 AccD, component of Agrocinopine (an opine)/Agrocin 84 (an antibiotic) porter from Agrobacterium radiobacter (see 3 papers)
34% identity, 100% coverage of query (167 bits)
TC 3.A.1.5.32 / F0TFS8 Oligopeptide transport protein, component of ABC α-galactoside uptake porter from Lactobacillus acidophilus (strain 30SC)
32% identity, 100% coverage of query (166 bits)
TC 3.A.1.5.37 / B1W1M1 Putative peptide ABC transporter permease protein, component of The ABC BldKA-E (SGR_2418-2414) oligopeptide transport system. It controls aerial mycelium formation on glucose media. Probably involved in extracellular peptide signalling (Akanuma et al. 2011). Probably orthologous to 3.A.1.5.35 from Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
31% identity, 100% coverage of query (162 bits)
Build an alignment for 15364 and 19 homologs with ≥ 30% identity
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TC 3.A.1.5.36 / Q93IU1 BldKC, putative ABC transport system integral membrane protein, component of Peptide transporter encoded adjacent to the putative transport system with TC#3.A.1.5.35 (Akanuma et al. 2011). Induced by exogenous S-adenosylmethionine (SAM) at a concentration of 2muM which also enhanced antibiotic production and inhibited morphological development (Park et al. 2005). SAM can be imported into cells. Mutants in the bldK genes confer resistance to the toxic tripeptide, bialaphos from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
28% identity, 100% coverage of query (150 bits)
NIKB_STAA8 / Q2FYQ5 Nickel import system permease protein NikB from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see paper)
27% identity, 100% coverage of query (149 bits)
TC 3.A.1.5.33 / I0C488 NikB, component of The Nickel (Ni2+) uptake porter, NikABCDE from Staphylococcus aureus subsp. aureus 71193
27% identity, 100% coverage of query (145 bits)
TC 3.A.1.5.10 / P0A4N7 OppB, component of Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see 2 papers)
32% identity, 100% coverage of query (144 bits)
TC 3.A.1.5.26 / P66966 Putative peptide transport permease protein Rv1283c/MT1320, component of The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis from Mycobacterium tuberculosis (see 2 papers)
33% identity, 86% coverage of query (143 bits)
TC 3.A.1.5.23 / Q9F9T6 EppB, component of The Ethylene diamine tetraacetate (EDTA) uptake porter, EppABCD (see 2 papers)
32% identity, 96% coverage of query (142 bits)
TC 3.A.1.5.40 / Q7VJ34 Nickel transport system permease protein NikB, component of Nickel uptake porter, NikAB(CD)E from Helicobacter hepaticus (strain ATCC 51449 / 3B1)
32% identity, 86% coverage of query (142 bits)
TC 3.A.1.5.24 / Q7CQ74 YejB, component of The antimicrobial peptide (protamine, melittin, polymyxin B, human defensin (HBD)-1 and HBD-2 exporter, YejABEF (Eswarappa et al., 2008). Prefers N-formyl methionine peptides, such as Microcin C (of prokaryotic origin) to non formylated peptides (of eukaryotic origin) from Salmonella typhimurium (see paper)
26% identity, 100% coverage of query (136 bits)
YejB / b2178 putative oligopeptide ABC transporter membrane subunit YejB (EC 7.4.2.6) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
YejB / P0AFU0 putative oligopeptide ABC transporter membrane subunit YejB (EC 7.4.2.6) from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.5.21 / P0AFU1 YejB, component of The Microcin C/peptide uptake porter, YejABEF from Escherichia coli O157:H7 (see 2 papers)
yejB / RF|NP_416683 inner membrane ABC transporter permease protein yejB from Escherichia coli K12 (see 5 papers)
27% identity, 100% coverage of query (135 bits)
CNTB_STAA8 / Q2FVE8 Metal-staphylopine import system permease protein CntB from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
TC 3.A.1.5.43 / Q2FVE8 Peptide ABC transporter, permease protein, putative, component of The metal-staphylopine (nicotianamine-like metalophore) complex uptake system, CntABCDF from Staphylococcus aureus (strain NCTC 8325)
28% identity, 100% coverage of query (135 bits)
CNTB_STAAM / A0A0H3K104 Metal-staphylopine import system permease protein CntB from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
28% identity, 100% coverage of query (133 bits)
DdpB / b1486 putative D,D-dipeptide ABC transporter membrane subunit DdpB from Escherichia coli K-12 substr. MG1655 (see 3 papers)
DDPB_ECOLI / P77308 Probable D,D-dipeptide transport system permease protein DdpB from Escherichia coli (strain K12) (see paper)
30% identity, 97% coverage of query (128 bits)
TC 3.A.1.5.12 / Q9X0F6 TM1066, component of Probable rhamnose oligosaccharide porter. Induced by rhamnose (see paper)
28% identity, 100% coverage of query (126 bits)
Q9ZAS5 ABC-type dipeptide transporter (EC 7.4.2.9) from Streptococcus pyogenes (see paper)
27% identity, 97% coverage of query (126 bits)
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Lawrence Berkeley National Laboratory