Searching for up to 100 curated homologs for 15365 FitnessBrowser__Keio:15365 (302 a.a.)
Found high-coverage hits (≥70%) to 35 curated proteins.
Removed hits that are identical to the query, leaving 34
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.5.1 / P08006 OppC aka STM1744, component of Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA from Salmonella typhimurium (see 3 papers)
oppC / GB|AAV77094.1 oligopeptide ABC transporter, permease protein OppC from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
96% identity, 100% coverage of query (558 bits)
Q5V9S0 ABC-type oligopeptide transporter (EC 7.4.2.6) from Vibrio fluvialis (see paper)
TC 3.A.1.5.22 / Q5V9S0 OppC, component of The peptide transporter OppA,B,C,D,F (influences biofilm formation; Lee et al., 2004). Similar to 3.A.1.5.1, OppA is similar to the Vibrio furnissii OppA that provides several functions: hemolysis, antibiotic resistance, and virulence from Vibrio fluvialis (see paper)
69% identity, 100% coverage of query (439 bits)
OPPC_BACSU / P24139 Oligopeptide transport system permease protein OppC; Stage 0 sporulation protein KC from Bacillus subtilis (strain 168) (see paper)
oppC / GB|CAB13002.1 oligopeptide ABC transporter, permease protein OppC from Bacillus subtilis (see paper)
46% identity, 95% coverage of query (267 bits)
TC 3.A.1.5.20 / P42063 AppC, component of 5-6 amino acyl oligopeptide transporter AppA-F from Bacillus subtilis (see 2 papers)
appC / GB|CAB12997.1 oligopeptide ABC transporter, permease protein AppC from Bacillus subtilis (see paper)
40% identity, 96% coverage of query (228 bits)
TC 3.A.1.5.2 / P26904 DppC aka DCIAC, component of Dipeptide porter. Also transports δ-aminolevulinic acid (ALA) and heme from Bacillus subtilis (see 3 papers)
41% identity, 99% coverage of query (226 bits)
TC 3.A.1.5.19 / Q2FZR6 OppC, component of The major oligopeptide uptake porter, Opp-3 (of four paralogues, this is the only one that mediates nitrogen nutrition from Staphylococcus aureus (strain NCTC 8325)
36% identity, 96% coverage of query (222 bits)
TC 3.A.1.5.18 / O51310 OppC1, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see paper)
43% identity, 73% coverage of query (209 bits)
TC 3.A.1.5.15 / Q9X270 TM1748, component of Probable mannose/mannoside porter. Induced by beta-mannan (Conners et al., 2005). Regulated by mannose-responsive regulator manR (see paper)
36% identity, 95% coverage of query (199 bits)
GsiD / b0832 glutathione ABC transporter membrane subunit GsiD (EC 7.4.2.10) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
gsiD / P75799 glutathione ABC transporter membrane subunit GsiD (EC 7.4.2.10) from Escherichia coli (strain K12) (see paper)
GSID_ECOLI / P75799 Glutathione transport system permease protein GsiD from Escherichia coli (strain K12) (see paper)
P75799 ABC-type glutathione transporter (EC 7.4.2.10) from Escherichia coli (see paper)
TC 3.A.1.5.11 / P75799 Hypothetical ABC transporter permease protein yliD, component of Glutathione porter, YliABCD or GsiABCD from Escherichia coli (see 4 papers)
37% identity, 92% coverage of query (194 bits)
TC 3.A.1.5.26 / P66964 Putative peptide transport permease protein Rv1282c/MT1319, component of The glutathione transporter, OppA (Dasgupta et al., 2010). OppA binds glutathione and the nanopeptide, bradykinin. Also regulates cytokine release, apoptosis and the innate immune response of macrophages infected with M. tuberculosis from Mycobacterium tuberculosis (see 2 papers)
41% identity, 90% coverage of query (186 bits)
TC 3.A.1.5.23 / Q9F9T5 EppC, component of The Ethylene diamine tetraacetate (EDTA) uptake porter, EppABCD (see 2 papers)
37% identity, 92% coverage of query (185 bits)
SM_b21645 ABC transporter for D-Raffinose, permease component 1 from Sinorhizobium meliloti 1021
43% identity, 72% coverage of query (180 bits)
DPPC_LACLM / A2RI76 Dipeptide transport system permease protein DppC from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
39% identity, 95% coverage of query (180 bits)
TC 3.A.1.5.25 / Q9CIL0 Oligopeptide ABC trasporter permease protein, component of The ABC peptide/signalling peptide transporter. OptA binds peptides of 3-6 aas; OptS binds dipeptides. OptB,C,D are most similar to 3.A.1.5.19 from Lactococcus lactis subsp. lactis (see paper)
37% identity, 95% coverage of query (179 bits)
TC 3.A.1.5.12 / Q9X0F5 TM1065, component of Probable rhamnose oligosaccharide porter. Induced by rhamnose (see paper)
41% identity, 74% coverage of query (178 bits)
TC 3.A.1.5.36 / Q93IU3 BldKA, putative ABC transport system integral membrane protein, component of Peptide transporter encoded adjacent to the putative transport system with TC#3.A.1.5.35 (Akanuma et al. 2011). Induced by exogenous S-adenosylmethionine (SAM) at a concentration of 2muM which also enhanced antibiotic production and inhibited morphological development (Park et al. 2005). SAM can be imported into cells. Mutants in the bldK genes confer resistance to the toxic tripeptide, bialaphos from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
33% identity, 98% coverage of query (169 bits)
DdpC / b1485 putative D,D-dipeptide ABC transporter membrane subunit DdpC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
DDPC_ECOLI / P77463 Probable D,D-dipeptide transport system permease protein DdpC from Escherichia coli (strain K12) (see paper)
35% identity, 86% coverage of query (168 bits)
TC 3.A.1.5.37 / B1W1M0 Putative peptide ABC transporter permease protein, component of The ABC BldKA-E (SGR_2418-2414) oligopeptide transport system. It controls aerial mycelium formation on glucose media. Probably involved in extracellular peptide signalling (Akanuma et al. 2011). Probably orthologous to 3.A.1.5.35 from Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
31% identity, 93% coverage of query (167 bits)
TC 3.A.1.5.4 / O30544 AccE, component of Agrocinopine (an opine)/Agrocin 84 (an antibiotic) porter from Agrobacterium radiobacter (see 3 papers)
34% identity, 90% coverage of query (164 bits)
TC 3.A.1.5.27 / P51000 Dipeptide transport system permease protein dppC, component of The glutathione uptake porter, DppBCDF with the glutathione binding protein, DppA (GbpA; HbpA). Takes up reduced (GSH) and oxidized (GSSG) but not bulky glutathione S conjugates or glutathione derivatives with C-terminal modifications from Haemophilus influenzae (see 2 papers)
31% identity, 97% coverage of query (152 bits)
TC 3.A.1.5.29 / Q9WXR5 ABC-type transporter, integral membrane subunit, component of Probable xylan oligosaccharide porter (Conners et al. 2005). Induced by cylan and xylose. Regulated by xylose-responsive regulator XylR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
41% identity, 72% coverage of query (151 bits)
NIKC_STAA8 / Q2FYQ6 Nickel import system permease protein NikC from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
35% identity, 72% coverage of query (147 bits)
TC 3.A.1.5.33 / I0C487 NikC, component of The Nickel (Ni2+) uptake porter, NikABCDE from Staphylococcus aureus subsp. aureus 71193
35% identity, 72% coverage of query (145 bits)
Build an alignment for 15365 and 23 homologs with ≥ 30% identity
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DPPC_PSEAB / A0A0H2ZFV0 Di/tripeptide transport system permease protein DppC from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
29% identity, 92% coverage of query (144 bits)
TC 3.A.1.5.39 / W0WMS8 Dipeptide transport system permease protein dppC, component of Di- and tri-peptide transporter, DppBCDF with periplasmic substrate binding receptors, A1, A3, A5, A7 and A9, each with differing specificities for peptides from Pseudomonas aeruginosa MH38
29% identity, 92% coverage of query (144 bits)
TC 3.A.1.5.10 / P0A4N9 OppC, component of Oligopeptide porter (transports peptides of 4-35) amino acyl residues; di- and tripeptides are not transported; hydrophobic basic peptides are preferred). OppA determines the specificity of the system (Doeven et al., 2004). A large cavity in OppA binds proline-rich peptides preferentially (Berntsson et al., 2009). Two crystal structures of OppA with different nonapeptides show binding in different registers from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see 2 papers)
29% identity, 95% coverage of query (134 bits)
TC 3.A.1.5.24 / Q8ZNJ9 YejE, component of The antimicrobial peptide (protamine, melittin, polymyxin B, human defensin (HBD)-1 and HBD-2 exporter, YejABEF (Eswarappa et al., 2008). Prefers N-formyl methionine peptides, such as Microcin C (of prokaryotic origin) to non formylated peptides (of eukaryotic origin) from Salmonella typhimurium (see paper)
33% identity, 82% coverage of query (133 bits)
CNTC_STAA8 / Q2FVE9 Metal-staphylopine import system permease protein CntC from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 2 papers)
TC 3.A.1.5.43 / Q2FVE9 Nickel ABC transporter, permease protein, putative, component of The metal-staphylopine (nicotianamine-like metalophore) complex uptake system, CntABCDF from Staphylococcus aureus (strain NCTC 8325)
30% identity, 89% coverage of query (132 bits)
NikC / b3478 Ni(2+) ABC transporter membrane subunit NikC from Escherichia coli K-12 substr. MG1655 (see 3 papers)
nikC / P0AFA9 nickel ABC transporter membrane subunit NikC from Escherichia coli (strain K12) (see paper)
TC 3.A.1.5.3 / P0AFA9 Nickel transport system permease protein NikC aka B3478, component of Nickel porter from Escherichia coli (see 5 papers)
31% identity, 75% coverage of query (131 bits)
CNTC_STAAM / A0A0H3JU73 Metal-staphylopine import system permease protein CntC from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
30% identity, 89% coverage of query (130 bits)
YejE / b2179 putative oligopeptide ABC transporter membrane subunit YejE (EC 7.4.2.6) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
YejE / P33915 putative oligopeptide ABC transporter membrane subunit YejE (EC 7.4.2.6) from Escherichia coli (strain K12) (see 3 papers)
TC 3.A.1.5.21 / P33915 YejE, component of The Microcin C/peptide uptake porter, YejABEF from Escherichia coli (strain K12) (see 4 papers)
32% identity, 83% coverage of query (130 bits)
DppC / b3542 dipeptide ABC transporter membrane subunit DppC (EC 7.4.2.9) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
dppC / P0AEG1 dipeptide ABC transporter membrane subunit DppC (EC 7.4.2.9) from Escherichia coli (strain K12) (see 2 papers)
DPPC_ECOLI / P0AEG1 Dipeptide transport system permease protein DppC from Escherichia coli (strain K12) (see 4 papers)
dppC / GB|AAC76567.1 dipeptide ABC transporter, permease protein DppC from Escherichia coli (see 7 papers)
32% identity, 91% coverage of query (129 bits)
Q73NS8 ABC-type dipeptide transporter (EC 7.4.2.9) from Treponema denticola (see paper)
35% identity, 72% coverage of query (126 bits)
TC 3.A.1.5.32 / F0TFS7 Oligopeptide ABC transporter, permease protein, component of ABC α-galactoside uptake porter from Lactobacillus acidophilus (strain 30SC)
32% identity, 74% coverage of query (125 bits)
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Lawrence Berkeley National Laboratory