Searching for up to 100 curated homologs for 15380 FitnessBrowser__Keio:15380 (268 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
Removed hits that are identical to the query, leaving 49
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
P00929 tryptophan synthase (EC 4.2.1.20) from Salmonella enterica subsp. enterica serovar Typhimurium (see 5 papers)
trpA / PDB|1QOQ_A tryptophan synthase alpha chain; EC 4.2.1.20 from Salmonella enterica subsp. enterica serovar Typhimurium (see 10 papers)
85% identity, 100% coverage of query (459 bits)
8b08A / P00929 Tryptophan synthase - cryo-trapping by the spitrobot crystal plunger after 30 sec (see paper)
85% identity, 100% coverage of query (459 bits)
1tjpA Crystal structure of wild-type tryptophan synthase complexed with 1- [(2-hydroxylphenyl)amino]3-glycerolphosphate
85% identity, 100% coverage of query (459 bits)
1k3uA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]aspartic acid
85% identity, 100% coverage of query (459 bits)
2clkA Tryptophan synthase in complex with d-glyceraldehyde 3- phosphate (g3p)
85% identity, 100% coverage of query (458 bits)
7jllA The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with inhibitor 2- ({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (f9f) at the alpha-site, cesium ion at the metal coordination site and l-tryptophan at the enzyme beta-site
85% identity, 100% coverage of query (457 bits)
6xncA Salmonella typhimurium tryptophan synthase complexed with l-tryptophan and d-glycerol-3-phosphate
85% identity, 100% coverage of query (457 bits)
3cepA Structure of a tryptophan synthase quinonoid intermediate
85% identity, 99% coverage of query (455 bits)
1cx9A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-aminophenylthio)- butylphosphonic acid
85% identity, 99% coverage of query (448 bits)
1cw2A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylsulfinyl)- butylphosphonic acid
85% identity, 99% coverage of query (448 bits)
1c9dA Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxy-4- fluorophenylthio)-butylphosphonic acid
85% identity, 99% coverage of query (448 bits)
1c29A Crystal structure of the complex of bacterial tryptophan synthase with the transition state analogue inhibitor 4-(2-hydroxyphenylthio)-1- butenylphosphonic acid
85% identity, 99% coverage of query (448 bits)
2trsA Crystal structures of mutant (betak87t) tryptophan synthase alpha2 beta2 complex with ligands bound to the active sites of the alpha and beta subunits reveal ligand-induced conformational changes
83% identity, 100% coverage of query (444 bits)
1xc4A / P0A877 Crystal structure of wild-type tryptophan synthase alpha-subunits from escherichia coli (see paper)
89% identity, 100% coverage of query (441 bits)
1k7eA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]glycine acid
83% identity, 100% coverage of query (441 bits)
1a50A Crystal structure of wild-type tryptophan synthase complexed with 5- fluoroindole propanol phosphate
83% identity, 99% coverage of query (441 bits)
2clhA Tryptophan synthase in complex with (naphthalene-2'-sulfonyl)-2-amino- 1-ethylphosphate (f19)
82% identity, 100% coverage of query (436 bits)
2cliA Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (f9)
82% identity, 100% coverage of query (436 bits)
6xinA The crystal structure of tryptophan synthase from salmonella enterica serovar typhimurium in complex with (2s)-3-amino-3-imino-2- phenyldiazenylpropanamide at the enzyme alpha-site.
82% identity, 100% coverage of query (434 bits)
1k7fA Crystal structure of wild-type tryptophan synthase complexed with n- [1h-indol-3-yl-acetyl]valine acid
81% identity, 100% coverage of query (425 bits)
7jqwA The external aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-s377a in complex with cesium ion at the metal coordination site. The single beta-q114 rotamer conformation allows a hydrogen bond to form with the plp oxygen at the position 3 in the ring
80% identity, 100% coverage of query (423 bits)
6x0cA Tryptophan synthase mutant beta-q114a in complex with cesium ion at the metal coordination site and aminoacrylate and benzimidazole at the enzyme beta site
80% identity, 100% coverage of query (423 bits)
6vfdA Tryptophan synthase mutant q114a in complex with cesium ion at the metal coordination site and 2-aminophenol quinonoid at the enzyme beta site
80% identity, 100% coverage of query (423 bits)
2cleA Tryptophan synthase in complex with n-(4'- trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (f6) - lowf6 complex
80% identity, 99% coverage of query (421 bits)
1a5bA Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alpha d60n) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alpha glu 49
79% identity, 100% coverage of query (413 bits)
5ey5A Lbcats
41% identity, 100% coverage of query (202 bits)
TRPA1_ARATH / O22765 Tryptophan synthase alpha chain; Indole synthase; Indole-3-glycerol-phosphate lyase; EC 4.2.1.20; EC 4.1.2.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O22765 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Arabidopsis thaliana (see paper)
35% identity, 96% coverage of query (171 bits)
B2Y0K4 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Zea mays (see paper)
34% identity, 96% coverage of query (168 bits)
TRPA2_ARATH / Q42529 Tryptophan synthase alpha chain, chloroplastic; Indole-3-glycerol-phosphate lyase, chloroplastic; Protein TRYPTOPHAN-REQUIRING 3; EC 4.2.1.20; EC 4.1.2.8 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
TSA1 / AAC49117.1 tryptophan synthase alpha chain from Arabidopsis thaliana (see 2 papers)
35% identity, 93% coverage of query (160 bits)
trpA / Q9YGA9 tryptophan synthase subunit α (EC 4.1.2.8) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
Q9YGA9 tryptophan synthase (subunit 1/2) (EC 4.2.1.20) from Thermococcus kodakarensis (see paper)
35% identity, 88% coverage of query (158 bits)
Q659I8 tryptophan synthase (EC 4.2.1.20) from Isatis tinctoria (see paper)
34% identity, 96% coverage of query (157 bits)
TRPA_HALVD / P18284 Tryptophan synthase alpha chain; EC 4.2.1.20 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
37% identity, 85% coverage of query (155 bits)
Q8U094 tryptophan synthase (subunit 1/2) (EC 4.2.1.20) from Pyrococcus furiosus (see paper)
35% identity, 89% coverage of query (150 bits)
Q7Y1I9 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Oryza sativa (see paper)
32% identity, 96% coverage of query (148 bits)
Igl / Q9FQ77 indole-3-glycerol phosphate lyase (EC 4.1.2.8) from Zea mays (see 2 papers)
Q9FQ77 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Zea mays (see paper)
33% identity, 96% coverage of query (148 bits)
A0A1C9CXC5 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Persicaria tinctoria (see paper)
35% identity, 87% coverage of query (148 bits)
trpB bifunctional tryptophan synthase TRPB from Emericella nidulans (see 2 papers)
32% identity, 90% coverage of query (144 bits)
TRP_YEAST / P00931 Tryptophan synthase; EC 4.2.1.20 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 89% coverage of query (143 bits)
TRP5 likely tryptophan synthetase alpha chain from Candida albicans (see paper)
32% identity, 87% coverage of query (140 bits)
Bx1 / P42390 indole-3-glycerol phosphate lyase (EC 4.1.2.8) from Zea mays (see 2 papers)
TRPA_MAIZE / P42390 Indole-3-glycerol phosphate lyase, chloroplastic; Benzoxazineless 1; Indole synthase; Tryptophan synthase alpha chain; EC 4.1.2.8; EC 4.2.1.20 from Zea mays (Maize) (see paper)
P42390 indole-3-glycerol-phosphate lyase (EC 4.1.2.8) from Zea mays (see 2 papers)
32% identity, 96% coverage of query (131 bits)
trpA / P50908 α subunit of tryptophan synthase (EC 4.1.2.8) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 2 papers)
34% identity, 89% coverage of query (120 bits)
Build an alignment for 15380 and 41 homologs with ≥ 30% identity
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A0A2U8JPY3 tryptophan synthase (indole-salvaging) (EC 4.2.1.122); tryptophan synthase (EC 4.2.1.20) from Psilocybe cubensis (see paper)
28% identity, 91% coverage of query (118 bits)
6u6cE Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form
26% identity, 91% coverage of query (75.9 bits)
6usaA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk1-bound form
27% identity, 91% coverage of query (75.1 bits)
6u6cA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and gsk2-bound form
27% identity, 91% coverage of query (75.1 bits)
6dweA Crystal structure of tryptophan synthase from m. Tuberculosis - aminoacrylate- and brd0059-bound form
27% identity, 91% coverage of query (75.1 bits)
5tciA Crystal structure of tryptophan synthase from m. Tuberculosis - brd4592-bound form
27% identity, 91% coverage of query (75.1 bits)
6uapC / P9WFY1 Crystal structure of tryptophan synthase from m. Tuberculosis - open form with brd6309 bound
26% identity, 91% coverage of query (74.3 bits)
6hulA / P50382 Sulfolobus solfataricus tryptophan synthase ab complex (see paper)
23% identity, 84% coverage of query (55.5 bits)
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Lawrence Berkeley National Laboratory