Searching for up to 100 curated homologs for 15509 b1387 fused aldehyde dehydrogenase/enoyl-CoA hydratase (NCBI) (681 a.a.)
Found high-coverage hits (≥70%) to 78 curated proteins.
Removed hits that are identical to the query, leaving 74
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
N0DT23 4-trimethylammoniobutyraldehyde dehydrogenase (EC 1.2.1.47) from Pseudomonas sp. (see paper)
28% identity, 71% coverage of query (128 bits)
Q9L4P8 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Staphylococcus aureus (see paper)
25% identity, 74% coverage of query (118 bits)
4neaA / A0A0H2X0S3 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
25% identity, 74% coverage of query (118 bits)
cnbD / Q38M39 2-aminomuconate semialdehyde dehydrogenase (EC 1.2.1.32) from Comamonas testosteroni CNB-1 (see paper)
26% identity, 73% coverage of query (103 bits)
Q155V4 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Suaeda salsa (see paper)
Q8W5A1 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Suaeda liaotungensis (see 2 papers)
24% identity, 72% coverage of query (101 bits)
AL7B4_ARATH / Q9SYG7 Aldehyde dehydrogenase family 7 member B4; Antiquitin-1; Turgor-responsive ALDH; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SYG7 glycolaldehyde dehydrogenase (EC 1.2.1.21); aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) from Arabidopsis thaliana (see 2 papers)
aldh7B4 / CAE48164.1 putative aldehyde dehydrogenase from Arabidopsis thaliana (see paper)
23% identity, 73% coverage of query (100 bits)
P42757 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Atriplex hortensis (see paper)
24% identity, 72% coverage of query (99.8 bits)
S4S7H4 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Atriplex canescens (see paper)
23% identity, 72% coverage of query (97.4 bits)
desV / G2IKV5 aromatic aldehyde dehydrogenase monomer (EC 1.2.1.67; EC 1.2.1.29) from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
G2IKV5 vanillin dehydrogenase (EC 1.2.1.67) from Sphingobium sp. SYK-6 (see paper)
25% identity, 72% coverage of query (94.0 bits)
doeC / E1V7V8 aspartate-semialdehyde dehydrogenase (non-phosphorylating) from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) (see paper)
DOEC_HALED / E1V7V8 Aspartate-semialdehyde dehydrogenase (Non-phosphorylating); EC 1.2.1.- from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9) (see paper)
24% identity, 72% coverage of query (93.2 bits)
BADH_SPIOL / P17202 Aminoaldehyde dehydrogenase BADH; 4-trimethylammoniobutyraldehyde dehydrogenase BADH; Aminobutyraldehyde dehydrogenase BADH; Betaine aldehyde dehydrogenase; SoBADH; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8 from Spinacia oleracea (Spinach) (see 5 papers)
P17202 betaine-aldehyde dehydrogenase (EC 1.2.1.8) from Spinacia oleracea (see 3 papers)
24% identity, 72% coverage of query (92.4 bits)
5x5uA Crystal structure of alpha-ketoglutarate-semialdehyde dehydrogenase (kgsadh) complexed with NAD
24% identity, 72% coverage of query (90.9 bits)
5x5tA / Q1JUP4 Crystal structure of alpha-ketoglutarate semialdehyde dehydrogenase (kgsadh) from azospirillum brasilense (see paper)
24% identity, 72% coverage of query (90.9 bits)
AADH1_SOLLC / Q56R04 Aminoaldehyde dehydrogenase 1; SlAMADH1; 4-trimethylammoniobutyraldehyde dehydrogenase AMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Betaine aldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.47; EC 1.2.1.19; EC 1.2.1.8; EC 1.2.1.54 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
25% identity, 70% coverage of query (90.9 bits)
4i9bA / Q56R04 Structure of aminoaldehyde dehydrogenase 1 from solanum lycopersium (slamadh1) with a thiohemiacetal intermediate (see paper)
25% identity, 72% coverage of query (90.5 bits)
7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28
25% identity, 71% coverage of query (88.6 bits)
7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28
25% identity, 71% coverage of query (88.6 bits)
7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28
25% identity, 71% coverage of query (88.6 bits)
7jwtA Crystal structure of human aldh1a1 bound to compound (r)-28
25% identity, 71% coverage of query (88.6 bits)
7jwsA Crystal structure of human aldh1a1 bound to compound (r)-28
25% identity, 71% coverage of query (88.6 bits)
6dumA Aldh1a1 n121s in complex with 6-{[(3-fluorophenyl)methyl]sulfanyl}-2- (oxetan-3-yl)-5-phenyl-2,5-dihydro-4h-pyrazolo[3,4-d]pyrimidin-4-one (compound 13g)
25% identity, 71% coverage of query (88.6 bits)
4wp7A Structure of human aldh1a1 with inhibitor cm026
25% identity, 71% coverage of query (88.6 bits)
4wb9A Human aldh1a1 complexed with nadh
25% identity, 71% coverage of query (88.6 bits)
5teiA Structure of human aldh1a1 with inhibitor cm039
25% identity, 71% coverage of query (88.6 bits)
4x4lA Structure of human aldh1a1 with inhibitor cm037
25% identity, 71% coverage of query (88.6 bits)
ALDH1A1 / P00352 retinal dehydrogenase 1 (EC 1.2.1.36) from Homo sapiens (see 10 papers)
AL1A1_HUMAN / P00352 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Homo sapiens (Human) (see 7 papers)
P00352 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
25% identity, 71% coverage of query (88.2 bits)
4v37A / P17202 Crystal structure of betaine aldehyde dehydrogenase from spinach showing a thiohemiacetal with 3-aminopropionaldehyde
24% identity, 72% coverage of query (88.2 bits)
7um9A Human aldh1a1 with bound compound cm38
25% identity, 71% coverage of query (88.2 bits)
5l2oA Crystal structure of aldh1a1 in complex with buc22
25% identity, 71% coverage of query (88.2 bits)
5l2nA Structure of aldh1a1 in complex with buc25
25% identity, 71% coverage of query (88.2 bits)
5l2mA Structure of aldh1a1 in complex with buc11
25% identity, 71% coverage of query (88.2 bits)
4wpnA Structure of human aldh1a1 with inhibitor cm053
25% identity, 71% coverage of query (88.2 bits)
5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog
25% identity, 70% coverage of query (86.7 bits)
5abmA / P51977 Sheep aldehyde dehydrogenase 1a1 (see paper)
25% identity, 70% coverage of query (86.7 bits)
1bxsA Sheep liver class 1 aldehyde dehydrogenase with NAD bound
25% identity, 70% coverage of query (86.7 bits)
AL1A1_SHEEP / P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
25% identity, 70% coverage of query (86.7 bits)
AL1A2_RAT / Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
Q63639 retinal dehydrogenase (EC 1.2.1.36) from Rattus norvegicus (see 4 papers)
23% identity, 71% coverage of query (85.1 bits)
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121)
24% identity, 71% coverage of query (84.7 bits)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118)
24% identity, 71% coverage of query (84.7 bits)
6aljA / O94788 Aldh1a2 liganded with NAD and compound win18,446 (see paper)
24% identity, 71% coverage of query (84.7 bits)
ALDH1A2 / O94788 retinal dehydrogenase 2 (EC 1.2.1.36) from Homo sapiens (see 4 papers)
AL1A2_HUMAN / O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 3 papers)
O94788 retinal dehydrogenase (EC 1.2.1.36) from Homo sapiens (see 6 papers)
24% identity, 71% coverage of query (84.7 bits)
3iwkH / Q8VWZ1 Crystal structure of aminoaldehyde dehydrogenase 1 from pisum sativum (psamadh1) (see paper)
25% identity, 70% coverage of query (84.0 bits)
AADH1_PEA / Q8VWZ1 Aminoaldehyde dehydrogenase 1, peroxisomal; PsAMADH1; Aminobutyraldehyde dehydrogenase AMADH1; Gamma-guanidinobutyraldehyde dehydrogenase AMADH1; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
Q8VWZ1 aminobutyraldehyde dehydrogenase (EC 1.2.1.19) from Pisum sativum (see 3 papers)
25% identity, 70% coverage of query (84.0 bits)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
25% identity, 73% coverage of query (84.0 bits)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
25% identity, 73% coverage of query (84.0 bits)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound
23% identity, 70% coverage of query (83.2 bits)
7a6qA / P47895 Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
23% identity, 70% coverage of query (83.2 bits)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid
23% identity, 70% coverage of query (83.2 bits)
7qk9A Crystal structure of the aldh1a3-atp complex
23% identity, 70% coverage of query (83.2 bits)
6tgwA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with a selective inhibitor
23% identity, 70% coverage of query (83.2 bits)
ALDH1A3 / P47895 retinal dehydrogenase 3 (EC 1.2.1.36) from Homo sapiens (see 3 papers)
AL1A3_HUMAN / P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 9 papers)
P47895 retinal dehydrogenase (EC 1.2.1.36); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) from Homo sapiens (see 6 papers)
23% identity, 70% coverage of query (82.8 bits)
AL1A1_HORSE / P15437 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Equus caballus (Horse) (see paper)
25% identity, 71% coverage of query (82.4 bits)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin
25% identity, 71% coverage of query (79.7 bits)
4fr8C / P05091 Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
25% identity, 71% coverage of query (79.3 bits)
6tryA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with mf13 inhibitor compound
23% identity, 70% coverage of query (79.3 bits)
6te5B Crystal structure of human aldehyde dehydrogenase 1a3 in complex with lq43 inhibitor compound
23% identity, 70% coverage of query (79.3 bits)
AADH2_PEA / Q93YB2 Aminoaldehyde dehydrogenase 2, peroxisomal; PsAMADH2; Aminobutyraldehyde dehydrogenase AMADH2; Gamma-guanidinobutyraldehyde dehydrogenase AMADH2; EC 1.2.1.-; EC 1.2.1.19; EC 1.2.1.54 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
Q93YB2 aminobutyraldehyde dehydrogenase (EC 1.2.1.19) from Pisum sativum (see 2 papers)
25% identity, 70% coverage of query (78.2 bits)
3iwjA / Q93YB2 Crystal structure of aminoaldehyde dehydrogenase 2 from pisum sativum (psamadh2) (see paper)
25% identity, 70% coverage of query (77.8 bits)
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+
25% identity, 71% coverage of query (77.8 bits)
5l13A Structure of aldh2 in complex with 2p3
25% identity, 71% coverage of query (77.8 bits)
4kwgA Crystal structure analysis of aldh2+aldib13
25% identity, 71% coverage of query (77.8 bits)
4kwfA Crystal structure analysis of aldh2+aldib33
25% identity, 71% coverage of query (77.8 bits)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one
25% identity, 71% coverage of query (77.8 bits)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1
25% identity, 71% coverage of query (77.8 bits)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase
25% identity, 71% coverage of query (77.8 bits)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+
25% identity, 71% coverage of query (77.8 bits)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+
25% identity, 71% coverage of query (77.8 bits)
7w5nA / Q47943 The crystal structure of the reduced form of gluconobacter oxydans wsh-004 sndh (see paper)
25% identity, 73% coverage of query (77.8 bits)
7radA Crystal structure analysis of aldh1b1
25% identity, 71% coverage of query (75.1 bits)
7mjdA Crystal structure analysis of aldh1b1
25% identity, 71% coverage of query (75.1 bits)
7mjcA / P30837 Crystal structure analysis of aldh1b1
25% identity, 71% coverage of query (75.1 bits)
7w5kA The c296a mutant of l-sorbosone dehydrogenase (sndh) from gluconobacter oxydans wsh-004
25% identity, 73% coverage of query (73.6 bits)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+
25% identity, 71% coverage of query (73.6 bits)
6s6wA Crystal structure of human aldh1a3 in complex with 2,6- diphenylimidazo[1,2-a]pyridine (compound ga11) and NAD+
23% identity, 70% coverage of query (71.6 bits)
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Lawrence Berkeley National Laboratory