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Searching for up to 100 curated homologs for 15726 FitnessBrowser__Keio:15726 (460 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

Removed hits that are identical to the query, leaving 19

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AAXC_CHLPN / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (Chlamydophila pneumoniae) (see paper)
TC 2.A.3.2.7 / Q9Z6M8 Arginine/agmatine antiporter from Chlamydia pneumoniae (see 4 papers)
    41% identity, 98% coverage of query (346 bits)

ARCD_PSEAE / P18275 Arginine/ornithine antiporter; Arginine-ornithine exchanger from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
TC 2.A.3.2.3 / P18275 Arginine:ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
arcD / GB|AAG08555.1 arginine/ornithine antiporter from Pseudomonas aeruginosa (see 3 papers)
    47% identity, 93% coverage of query (338 bits)

arcD / CAA04686.1 arginine /ornithine antiporter from Lactobacillus sakei (see 2 papers)
    37% identity, 99% coverage of query (296 bits)

TC 2.A.3.2.4 / P35865 Lysine permease from Corynebacterium glutamicum (Brevibacterium flavum) (see 2 papers)
lysI / RF|YP_225261.1 L-lysine transport protein from Corynebacterium glutamicum (see paper)
    36% identity, 96% coverage of query (270 bits)

TC 2.A.3.2.11 / F2HL56 Arginine/Ornithine antiporter of 526 aas and 14 TMSs from Lactococcus lactis subsp. lactis (strain CV56)
    33% identity, 99% coverage of query (265 bits)

ARCD1_LACLM / A2RNI5 Arginine/ornithine antiporter ArcD1; Arginine/ornithine exchanger from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
    33% identity, 99% coverage of query (265 bits)

TC 2.A.3.2.10 / F2HL52 Arginine/Ornithine antiporter of 497 aas and 13 TMSs, ArcD2 from Lactococcus lactis subsp. lactis (strain CV56)
    34% identity, 89% coverage of query (238 bits)

ARCD2_LACLM / A2RNI1 Arginine/ornithine antiporter ArcD2; Arginine/ornithine exchanger from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
    32% identity, 93% coverage of query (233 bits)

Build an alignment

Build an alignment for 15726 and 8 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

ADIC_SALTY / P60066 Arginine/agmatine antiporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
    29% identity, 90% coverage of query (127 bits)

3l1lA Structure of arg-bound escherichia coli adic
    29% identity, 90% coverage of query (127 bits)

5j4nA / P60061 Crystal structure of the l-arginine/agmatine antiporter adic in complex with agmatine at 2.6 angstroem resolution (see paper)
    29% identity, 90% coverage of query (126 bits)

YjdD / b4115 arginine:agmatine antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
adiC / P60061 arginine:agmatine antiporter from Escherichia coli (strain K12) (see 2 papers)
ADIC_ECOLI / P60061 Arginine/agmatine antiporter from Escherichia coli (strain K12) (see 6 papers)
ADIC_ECO57 / P60063 Arginine/agmatine antiporter from Escherichia coli O157:H7 (see 3 papers)
TC 2.A.3.2.5 / P60061 Homodimeric electrogenic arginine (Km=80μM):agmatine antiporter, AdiC, involved in extreme acid resistance (Fang et al., 2007; Gong et al., 2003; Iyer et al., 2003). A projection structure at 6.5 Å resolution has been published (Casagrande et al., 2008), and the 3.2 Å resolution X-ray structure was determined by Fang et al., 2009 and Gao et al., 2009 from Escherichia coli (see 6 papers)
adiC / GB|AAN45533.1 arginine/agmatine antiporter from Shigella flexneri (see 6 papers)
    29% identity, 90% coverage of query (125 bits)

PotE / b0692 putrescine transporter PotE from Escherichia coli K-12 substr. MG1655 (see 13 papers)
potE / P0AAF1 putrescine transporter PotE from Escherichia coli (strain K12) (see 14 papers)
POTE_ECOLI / P0AAF1 Putrescine transporter PotE; Putrescine-proton symporter / putrescine-ornithine antiporter from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.3.2.1 / P0AAF1 Putrescine:ornithine antiporter for putrescine export; putrescine:H+ symporter for uptake from Escherichia coli (see 5 papers)
    27% identity, 89% coverage of query (107 bits)

6f2wA / A8UCQ5 Bacterial asc transporter crystal structure in open to in conformation (see paper)
    23% identity, 93% coverage of query (80.9 bits)

CadB / b4132 lysine:cadaverine antiporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
CadB / P0AAE8 lysine:cadaverine antiporter from Escherichia coli (strain K12) (see 12 papers)
CADB_ECOLI / P0AAE8 Cadaverine/lysine antiporter from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.2.2 / P0AAE8 Cadaverine:lysine antiporter [Catalyzes cadaverine uptake via H+ symport (Km=21μM) and cadaverine export (Km=300 μM) via cadaverine:lysine antiport.] (Soksawatmaekhin et al., 2004). Modeling tools have been used to gain information about the structures and functions of CadB and PotE in E. coli from Escherichia coli (see 6 papers)
    23% identity, 94% coverage of query (76.6 bits)

STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
    23% identity, 85% coverage of query (71.6 bits)

BPHYT_RS17540 L-aspartate/L-glutamate/L-glutamine:H+ symporter from Burkholderia phytofirmans PsJN
    26% identity, 84% coverage of query (62.0 bits)

AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
    25% identity, 70% coverage of query (58.5 bits)

S7A12_MOUSE / Q8VIE6 Solute carrier family 7 member 12; Asc-type amino acid transporter 2; Asc-2; X-amino acid transporter 1; XAT-1 from Mus musculus (Mouse) (see 2 papers)
TC 2.A.3.8.14 / Q8VIE6 The Asc-type small neutral L-amino acid:H+ symport transporter-2 (Asc-2). Does not associate with 4F2hc or rBAT, but probably associates with some comparable heavy chain. Doesn't transport some substrates of Asc-1 such as α-aminoisobutyric acid and β-alanine from Mus musculus (Mouse) (see 2 papers)
Slc7a12 / RF|NP_543128.1 Asc-type amino acid transporter 2 from Mus musculus (see paper)
    23% identity, 72% coverage of query (47.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory