Searching for up to 100 curated homologs for 15727 FitnessBrowser__Keio:15727 (240 a.a.)
Found high-coverage hits (≥70%) to 84 curated proteins.
Removed hits that are identical to the query, leaving 83
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
29% identity, 97% coverage of query (91.3 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
25% identity, 98% coverage of query (85.1 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
28% identity, 95% coverage of query (73.9 bits)
5ha5D Crystal structure of an NAD-bound oxidoreductase from brucella ovis
27% identity, 95% coverage of query (70.5 bits)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
27% identity, 95% coverage of query (63.2 bits)
YqfD / b2902 putative oxidoreductase YgfF from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ygfF / RF|NP_417378 uncharacterized oxidoreductase ygfF from Escherichia coli K12 (see paper)
26% identity, 95% coverage of query (62.0 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
26% identity, 98% coverage of query (59.7 bits)
4fc6B / Q9NUI1 Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr (see paper)
27% identity, 96% coverage of query (59.7 bits)
DECR2_HUMAN / Q9NUI1 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; pDCR; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1; EC 1.3.1.124 from Homo sapiens (Human) (see 2 papers)
Q9NUI1 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) from Homo sapiens (see paper)
27% identity, 96% coverage of query (59.7 bits)
4fc7A Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr
27% identity, 96% coverage of query (59.7 bits)
Q5SLC4 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermus thermophilus (see paper)
26% identity, 95% coverage of query (58.9 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
24% identity, 96% coverage of query (58.5 bits)
4bo8A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7a resolution
25% identity, 96% coverage of query (57.4 bits)
4bo0A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4a resolution
25% identity, 96% coverage of query (57.4 bits)
4bo2A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9a resolution
25% identity, 96% coverage of query (57.0 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
24% identity, 96% coverage of query (57.0 bits)
ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
32% identity, 76% coverage of query (56.2 bits)
BN592_00769 / R7B6R4 3α-hydroxysteroid dehydrogenase (EC 1.1.1.52) from Eggerthella sp. CAG:298 (see paper)
R7B6R4 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) (EC 1.1.1.213) from Eggerthella sp. CAG:298 (see paper)
24% identity, 98% coverage of query (55.8 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
27% identity, 96% coverage of query (55.8 bits)
GOLD_LISIN / Q92EU6 NAD-dependent glycerol dehydrogenase; Dha-forming NAD-dependent glycerol dehydrogenase; EC 1.1.1.6 from Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262) (see paper)
23% identity, 96% coverage of query (55.5 bits)
1mxhA / Q8I814 Crystal structure of substrate complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi (see paper)
24% identity, 95% coverage of query (54.7 bits)
NR_NARAP / A0A1C9II22 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus aff. pseudonarcissus MK-2014 (Daffodil) (see paper)
NR_NARPS / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see 2 papers)
5ff9B / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
22% identity, 96% coverage of query (54.7 bits)
4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
23% identity, 96% coverage of query (54.7 bits)
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal
22% identity, 96% coverage of query (54.7 bits)
4bo9A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9a resolution
25% identity, 96% coverage of query (54.7 bits)
4bo6A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8a resolution
25% identity, 96% coverage of query (54.3 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
21% identity, 96% coverage of query (53.9 bits)
chcA / P95727 cyclohexane-1-carbonyl-CoA dehydrogenase monomer (EC 1.3.1.120) from Streptomyces collinus (see 2 papers)
CHCA_STRCU / P95727 1-cyclohexenylcarbonyl-CoA reductase; Cyclohexane-1-carbonyl-CoA reductase (NADP(+)); EC 1.3.1.120 from Streptomyces collinus (see 3 papers)
P95727 cyclohexane-1-carbonyl-CoA reductase (NADP+) (EC 1.3.1.120) from Streptomyces collinus (see 3 papers)
25% identity, 95% coverage of query (53.9 bits)
5t2uA / A0R723 Short chain dehydrogenase/reductase family protein (see paper)
28% identity, 98% coverage of query (53.9 bits)
A0R723 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); acetoacetyl-CoA reductase (EC 1.1.1.36) from Mycolicibacterium smegmatis (see paper)
28% identity, 98% coverage of query (53.9 bits)
Q4AE87 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas sp. (see paper)
fabG / BAE19680.1 3-oxoacyl-(acyl-carrier-protein) reductase from Pseudomonas sp. 61-3 (see paper)
26% identity, 96% coverage of query (53.5 bits)
rhlG / Q9RPT1 NADPH-dependent β-ketoacyl reductase subunit (EC 1.1.1.100) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
2b4qA / Q9RPT1 Pseudomonas aeruginosa rhlg/NADP active-site complex (see paper)
27% identity, 96% coverage of query (53.5 bits)
7nm8AAA 7nm8AAA (see paper)
24% identity, 96% coverage of query (53.1 bits)
5t5qC / Q2YL80 Crystal structure of short-chain dehydrogenase/reductase sdr:glucose/ribitol dehydrogenase from brucella melitensis
27% identity, 77% coverage of query (52.8 bits)
4jroC / Q8Y690 Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
22% identity, 95% coverage of query (52.4 bits)
8bcjB / Q9HZ96 Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
27% identity, 73% coverage of query (52.0 bits)
GALD_RHIME / Q92RN6 Probable galactose dehydrogenase GalD; EC 1.1.1.- from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
23% identity, 95% coverage of query (52.0 bits)
S5U393 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Comamonas testosteroni (see paper)
24% identity, 95% coverage of query (51.6 bits)
DCXR / Q91XV4 L-xylulose reductase subunit (EC 1.1.1.10) from Mesocricetus auratus (see paper)
DCXR_MESAU / Q91XV4 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; Sperm antigen P26h; EC 1.1.1.10 from Mesocricetus auratus (Golden hamster) (see 3 papers)
Q91XV4 L-xylulose reductase (EC 1.1.1.10) from Mesocricetus auratus (see paper)
23% identity, 95% coverage of query (51.6 bits)
7xqmB / Q72LQ6 Indel-mutant short chain dehydrogenase bound to sah (see paper)
26% identity, 95% coverage of query (51.6 bits)
antM / M1TCK3 antimycin intermediate C8-ketoreductase monomer from Streptomyces sp. NRRL 2288 (see paper)
24% identity, 96% coverage of query (51.2 bits)
DCXR_MOUSE / Q91X52 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; EC 1.1.1.10 from Mus musculus (Mouse) (see paper)
Q91X52 L-xylulose reductase (EC 1.1.1.10) from Mus musculus (see paper)
21% identity, 95% coverage of query (50.8 bits)
4bntB Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1h- benzimidazole at 2.3a resolution
26% identity, 96% coverage of query (50.8 bits)
DCXR_RAT / Q920P0 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; EC 1.1.1.10 from Rattus norvegicus (Rat) (see 3 papers)
Q920P0 L-xylulose reductase (EC 1.1.1.10) from Rattus norvegicus (see paper)
22% identity, 95% coverage of query (50.4 bits)
A0A6B7HCZ2 tropinone reductase I (EC 1.1.1.206) from Przewalskia tangutica (see paper)
23% identity, 95% coverage of query (49.7 bits)
AACUN_ASPA1 / A0A1L9WLH9 Short chain dehydrogenase/reductase AacuN; SDR AacuN; Secalonic acid biosynthesis cluster protein N; EC 1.3.1.- from Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094) (see 6 papers)
25% identity, 95% coverage of query (49.3 bits)
8jfgA / G2M827 Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori (see paper)
23% identity, 96% coverage of query (49.3 bits)
YjgU / b4266 5-keto-D-gluconate 5-reductase (EC 1.1.1.69) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
idnO / P0A9P9 5-keto-D-gluconate 5-reductase (EC 1.1.1.69) from Escherichia coli (strain K12) (see 4 papers)
IDNO_ECOLI / P0A9P9 5-keto-D-gluconate 5-reductase; EC 1.1.1.69 from Escherichia coli (strain K12) (see paper)
27% identity, 95% coverage of query (48.9 bits)
FABG_SYNY3 / P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
26% identity, 95% coverage of query (48.9 bits)
5u2wA / B4E730 Crystal structure of a short chain dehydrogenase from burkholderia cenocepacia j2315 in complex with NADP
26% identity, 98% coverage of query (48.9 bits)
6j7uA / D6NKF4 Crystal structure of blue fluorescent protein from metagenomic library in complex with NADPH (see paper)
26% identity, 95% coverage of query (48.5 bits)
BdcA / b4249 c-di-GMP-binding biofilm dispersal mediator protein from Escherichia coli K-12 substr. MG1655 (see 3 papers)
BDCA_ECOLI / P39333 Cyclic-di-GMP-binding biofilm dispersal mediator protein from Escherichia coli (strain K12) (see paper)
yjgI / RF|NP_418670 uncharacterized oxidoreductase yjgI from Escherichia coli K12 (see paper)
27% identity, 98% coverage of query (48.5 bits)
A0A1B3EB36 (+)-borneol dehydrogenase (EC 1.1.1.198); (-)-borneol dehydrogenase (EC 1.1.1.227) from Pseudomonas sp. TCU-HL1 (see 2 papers)
24% identity, 95% coverage of query (48.5 bits)
3wyeA / Q48436,Q9ZNN8 Crystal structure of chimeric engineered (2s,3s)-butanediol dehydrogenase complexed with NAD+
26% identity, 95% coverage of query (48.1 bits)
5z2lK / P39333 Crystal structure of bdca in complex with NADPH (see paper)
27% identity, 98% coverage of query (48.1 bits)
8jfhD Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori in an inactive form that priors the acyl substrate delivery
23% identity, 96% coverage of query (48.1 bits)
fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
23% identity, 95% coverage of query (47.8 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
25% identity, 96% coverage of query (47.8 bits)
7pxxC The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
24% identity, 96% coverage of query (47.4 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
24% identity, 96% coverage of query (47.4 bits)
5l4nA Leishmania major pteridine reductase 1 (ptr1) in complex with compound 1
24% identity, 96% coverage of query (47.4 bits)
6yq3AAA Monooxygenase
25% identity, 96% coverage of query (47.0 bits)
8jfiC Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-hexanoyl-acp from helicobacter pylori
22% identity, 96% coverage of query (47.0 bits)
6vspA Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a
25% identity, 98% coverage of query (46.6 bits)
6xewA Structure of serratia marcescens 2,3-butanediol dehydrogenase
25% identity, 98% coverage of query (46.6 bits)
budC / H9XP47 meso-butanediol dehydrogenase [(R)-acetoin-forming] (EC 1.1.1.304; EC 1.1.1.76) from Serratia marcescens (see paper)
MBDH_SERMA / H9XP47 Meso-2,3-butanediol dehydrogenase; BDH; meso-2,3-BDH; (R,S)-butane-2,3-diol dehydrogenase; NAD(H)-dependent meso-2,3-BDH; SmBdh; EC 1.1.1.- from Serratia marcescens (see 3 papers)
26% identity, 95% coverage of query (46.6 bits)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
25% identity, 95% coverage of query (46.6 bits)
3ndrA / Q988B7 Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
25% identity, 95% coverage of query (46.6 bits)
6vspB / H9XP47 Structure of serratia marcescens 2,3-butanediol dehydrogenase mutant q247a (see paper)
25% identity, 98% coverage of query (46.6 bits)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
22% identity, 96% coverage of query (46.6 bits)
5gwrA 4-hydroxyisoleucine dehydrogenase complexed with nadh (see paper)
23% identity, 95% coverage of query (45.1 bits)
3gegA / A3DFK9 Fingerprint and structural analysis of a scor enzyme with its bound cofactor from clostridium thermocellum (see paper)
22% identity, 97% coverage of query (45.1 bits)
6yq0AAA / A0A2S6PN47 6yq0AAA (see paper)
25% identity, 96% coverage of query (44.7 bits)
6ypzAAA Monooxygenase
25% identity, 96% coverage of query (44.7 bits)
6pejA / Q92N06 Structure of sorbitol dehydrogenase from sinorhizobium meliloti 1021 bound to sorbitol
23% identity, 100% coverage of query (43.9 bits)
3ijrF / A0A6L8PL20 2.05 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD+
24% identity, 95% coverage of query (43.9 bits)
3i3oA 2.06 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD-acetone
24% identity, 95% coverage of query (43.9 bits)
1zemA / Q8GR61 Crystal structure of NAD+-bound xylitol dehydrogenase (see paper)
22% identity, 95% coverage of query (43.5 bits)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
22% identity, 76% coverage of query (43.1 bits)
TR2 / P50163 tropinone reductase (EC 1.1.1.236) from Datura stramonium (see paper)
TRN2_DATST / P50163 Tropinone reductase 2; Tropinone reductase II; TR-II; EC 1.1.1.236 from Datura stramonium (Jimsonweed) (Common thornapple) (see paper)
P50163 tropinone reductase II (EC 1.1.1.236) from Datura stramonium (see 3 papers)
20% identity, 95% coverage of query (42.4 bits)
2ae2A / P50163 Tropinone reductase-ii complexed with NADP+ and pseudotropine (see paper)
20% identity, 95% coverage of query (42.4 bits)
1ipfA Tropinone reductase-ii complexed with NADPH and tropinone
20% identity, 95% coverage of query (42.4 bits)
1ipeA Tropinone reductase-ii complexed with NADPH
20% identity, 95% coverage of query (42.4 bits)
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Lawrence Berkeley National Laboratory