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Searching for up to 100 curated homologs for 15743 FitnessBrowser__Keio:15743 (390 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

Removed hits that are identical to the query, leaving 67

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A0A223K4L6 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); amino-acid racemase (EC 5.1.1.10) from Latilactobacillus sakei (see paper)
    42% identity, 100% coverage of query (315 bits)

4dq6A / Q183G9 Crystal structure of plp-bound putative aminotransferase from clostridium difficile 630
    32% identity, 99% coverage of query (259 bits)

CBL_BACSU / Q08432 Cystathionine beta-lyase PatB; CBL; Beta-cystathionase PatB; Cysteine lyase PatB; Cysteine-S-conjugate beta-lyase PatB; EC 4.4.1.13 from Bacillus subtilis (strain 168) (see paper)
6qp3A / Q08432 Crystal structure of the plp-bound c-s lyase from bacillus subtilis (strain 168) (see paper)
    34% identity, 97% coverage of query (254 bits)

B9X1L2 L-cysteine desulfidase (EC 4.4.1.28) from Prevotella intermedia (see paper)
    32% identity, 99% coverage of query (219 bits)

3b1cA / A6BMJ3 Crystal structure of betac-s lyase from streptococcus anginosus: internal aldimine form (see paper)
    33% identity, 89% coverage of query (207 bits)

lcd / Q8L0M8 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Streptococcus anginosus (see paper)
    32% identity, 92% coverage of query (207 bits)

3b1eA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: alpha-aminoacrylate form
    33% identity, 89% coverage of query (207 bits)

3b1dA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: external aldimine form
    33% identity, 89% coverage of query (207 bits)

A0A0U5KG73 L-cysteine desulfidase (EC 4.4.1.28) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
    32% identity, 98% coverage of query (199 bits)

3l8aB / Q8DST5 Crystal structure of metc from streptococcus mutans
    30% identity, 98% coverage of query (198 bits)

5z0qC / B2VJB8 Crystal structure of ovob (see paper)
    34% identity, 99% coverage of query (196 bits)

Build an alignment

Build an alignment for 15743 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

1c7nA / Q56257 Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate cofactor (see paper)
    27% identity, 100% coverage of query (191 bits)

1c7oA Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate-l-aminoethoxyvinylglycine complex
    27% identity, 100% coverage of query (191 bits)

hly hemolysin from Treponema denticola (see paper)
hly / AAA85439.1 hemolysin from Treponema denticola (see paper)
    27% identity, 100% coverage of query (190 bits)

7qugA Crystal structure of carbon-sulfur lyase fnapatb1 from fusobacterium nucleatum subspecies animalis in complex with allyl-cysteine (see paper)
    28% identity, 99% coverage of query (186 bits)

A6YH85 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei (see paper)
    33% identity, 84% coverage of query (181 bits)

6qp1B Crystal structure of the plp-bound c-s lyase in the external aldimine form from staphylococcus hominis complexed with an inhibitor, l- cycloserine. (see paper)
    27% identity, 99% coverage of query (171 bits)

6qp2A Crystal structure of the plp-bound c-s lyase from staphylococcus hominis
    27% identity, 99% coverage of query (170 bits)

CBL_THET8 / Q5SHW0 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    28% identity, 92% coverage of query (143 bits)

CBL_CORGT / Q93QC6 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Corynebacterium glutamicum (Brevibacterium saccharolyticum) (see paper)
    29% identity, 90% coverage of query (121 bits)

metC / Q64HC5 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Corynebacterium striatum (see paper)
CBL_CORST / Q64HC5 Cysteine-S-conjugate beta-lyase; C-S lyase; Cystathionine beta-lyase; CBL; EC 4.4.1.13 from Corynebacterium striatum (see 2 papers)
    25% identity, 93% coverage of query (114 bits)

Q46061 L-cysteine desulfidase (EC 4.4.1.28) from Corynebacterium glutamicum (see paper)
    28% identity, 83% coverage of query (103 bits)

Q9RAT0 aromatic-amino-acid transaminase (EC 2.6.1.57) from Lactococcus lactis (see paper)
    27% identity, 93% coverage of query (89.0 bits)

Q8YMS6 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    23% identity, 92% coverage of query (84.3 bits)

aruH / Q9HUI9 L-arginine:pyruvate transaminase subunit (EC 2.6.1.84) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
ARUH_PSEAE / Q9HUI9 Arginine--pyruvate transaminase AruH; EC 2.6.1.84 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HUI9 arginine-pyruvate transaminase (EC 2.6.1.84) from Pseudomonas aeruginosa (see paper)
    24% identity, 94% coverage of query (84.0 bits)

patA / P16524 N-acetyl-L,L-diaminopimelate aminotransferase from Bacillus subtilis (strain 168) (see 3 papers)
DAPX_BACSU / P16524 Probable N-acetyl-LL-diaminopimelate aminotransferase; Putative aminotransferase A; EC 2.6.1.- from Bacillus subtilis (strain 168) (see paper)
    24% identity, 90% coverage of query (75.1 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    22% identity, 91% coverage of query (74.3 bits)

O59096 aromatic-amino-acid transaminase (EC 2.6.1.57) from Pyrococcus horikoshii (see paper)
    22% identity, 91% coverage of query (74.3 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    22% identity, 91% coverage of query (74.3 bits)

aspB / GB|CAB14153.1 aspartate transaminase; EC 2.6.1.1 from Bacillus subtilis (see paper)
aspB / AAB38454.1 aspartate aminotransferase from Bacillus subtilis (see paper)
    23% identity, 90% coverage of query (72.8 bits)

orf19.7522 putative uncharacterized protein from Candida albicans (see paper)
    21% identity, 86% coverage of query (72.4 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    23% identity, 87% coverage of query (71.6 bits)

bacF / P39643 3-[(2S,5R)-5-hydroxy-7-oxabicyclo[4.1.0]heptan-2-yl]-2-oxopropanoate aminotransferase (EC 2.6.1.57) from Bacillus subtilis (strain 168) (see 2 papers)
BACF_BACSU / P39643 Transaminase BacF; Transaminase A; EC 2.6.1.- from Bacillus subtilis (strain 168) (see 3 papers)
    23% identity, 87% coverage of query (71.6 bits)

6l1nA Substrate bound bacf structure from bacillus subtillis
    23% identity, 87% coverage of query (71.6 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    23% identity, 87% coverage of query (71.6 bits)

1j32A / Q8RR70 Aspartate aminotransferase from phormidium lapideum
aspC / BAB86290.1 aspartate aminotransferase from Phormidium lapideum (see paper)
    22% identity, 91% coverage of query (69.7 bits)

AAT_MUSP7 / C6C2Z3 Aspartate aminotransferase; AAT; AspAT; EC 2.6.1.1 from Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya dadantii) (see paper)
    23% identity, 84% coverage of query (68.2 bits)

AAT_SYNY3 / Q55128 Aspartate aminotransferase; AAT; AspAT; EC 2.6.1.1 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    21% identity, 91% coverage of query (66.6 bits)

Q8YY14 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    24% identity, 80% coverage of query (66.6 bits)

1v2eA / Q75WK2 Crystal structure of t.Th hb8 glutamine aminotransferase complex with a-keto-g-methylthiobutyrate (see paper)
    24% identity, 70% coverage of query (65.5 bits)

1v2fA Crystal structure of t.Th hb8 glutamine aminotransferase complex with 3-phenylpropionate
    24% identity, 70% coverage of query (65.5 bits)

BAD06364.1 aminotransferase from Thermus thermophilus (see paper)
    24% identity, 70% coverage of query (65.1 bits)

aspB-2 / P14909 aspartate aminotransferase subunit (EC 2.6.1.1) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
P14909 aspartate transaminase (EC 2.6.1.1) from Saccharolobus solfataricus (see 5 papers)
    19% identity, 91% coverage of query (64.3 bits)

P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    19% identity, 91% coverage of query (64.3 bits)

GLII_ASPFU / Q4WMJ9 Probable aminotransferase gliI; Gliotoxin biosynthesis protein I; EC 2.6.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 12 papers)
    24% identity, 80% coverage of query (63.5 bits)

YfdZ / b2379 glutamate—pyruvate aminotransferase AlaC (EC 2.6.1.2) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
alaC / P77434 glutamate—pyruvate aminotransferase AlaC (EC 2.6.1.2) from Escherichia coli (strain K12) (see 4 papers)
ALAC_ECOLI / P77434 Glutamate-pyruvate aminotransferase AlaC; EC 2.6.1.2 from Escherichia coli (strain K12) (see 3 papers)
    24% identity, 94% coverage of query (63.5 bits)

2x5dD / Q9HV83 Crystal structure of a probable aminotransferase from pseudomonas aeruginosa (see paper)
    24% identity, 94% coverage of query (62.0 bits)

Q8TQ40 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Methanosarcina acetivorans (see paper)
    21% identity, 90% coverage of query (62.0 bits)

PAT_PETHY / E9L7A5 Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; PhPPA-AT; EC 2.6.1.1; EC 2.6.1.78; EC 2.6.1.79 from Petunia hybrida (Petunia) (see 2 papers)
    22% identity, 90% coverage of query (61.6 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    22% identity, 90% coverage of query (60.8 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    22% identity, 90% coverage of query (60.8 bits)

ARAT2_THELN / H3ZPU1 Aromatic-amino-acid aminotransferase 2; ARAT-II; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    22% identity, 91% coverage of query (60.5 bits)

A0A2K9VP07 tyrosine transaminase (EC 2.6.1.5) from Malus domestica (see paper)
    22% identity, 79% coverage of query (60.5 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    22% identity, 90% coverage of query (58.9 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    22% identity, 90% coverage of query (58.9 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    22% identity, 90% coverage of query (58.9 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    22% identity, 90% coverage of query (58.5 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    22% identity, 89% coverage of query (57.4 bits)

5wmiA Arabidopsis thaliana prephenate aminotransferase mutant- t84v
    24% identity, 72% coverage of query (53.1 bits)

4cvqA / P0A959 Crystal structure of an aminotransferase from escherichia coli at 2. 11 angstroem resolution (see paper)
    18% identity, 71% coverage of query (53.1 bits)

YfbQ / b2290 glutamate—pyruvate aminotransferase AlaA (EC 2.6.1.2) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
alaA / P0A959 glutamate—pyruvate aminotransferase AlaA (EC 2.6.1.2) from Escherichia coli (strain K12) (see 6 papers)
ALAA_ECOLI / P0A959 Glutamate-pyruvate aminotransferase AlaA; EC 2.6.1.2 from Escherichia coli (strain K12) (see 2 papers)
D2AFZ3 valine-3-methyl-2-oxovalerate transaminase (EC 2.6.1.32) from Escherichia coli (see paper)
P0A959 alanine transaminase (EC 2.6.1.2) from Escherichia coli (see paper)
yfbQ / RF|NP_416793 uncharacterized aminotransferase yfbQ from Escherichia coli K12 (see paper)
    18% identity, 71% coverage of query (53.1 bits)

5yhvB Crystal structure of an aminotransferase from mycobacterium tuberculosis
    23% identity, 80% coverage of query (53.1 bits)

5yhvA / P96847 Crystal structure of an aminotransferase from mycobacterium tuberculosis
    23% identity, 80% coverage of query (53.1 bits)

AVTA_MYCTU / P96847 Valine--pyruvate aminotransferase; Alanine--valine transaminase; EC 2.6.1.66 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    23% identity, 80% coverage of query (53.1 bits)

5wmlA / Q9SIE1 Arabidopsis thaliana prephenate aminotransferase mutant- k306a (see paper)
    23% identity, 72% coverage of query (51.2 bits)

ISS1 / Q9C969 aromatic aminotransferase ISS1 (EC 2.6.1.27) from Arabidopsis thaliana (see paper)
ISS1_ARATH / Q9C969 Aromatic aminotransferase ISS1; Methionine aminotransferase ISS1; Phenylalanine aminotransferase ISS1; Protein INDOLE SEVERE SENSITIVE 1; Protein REVERSAL OF SAV3 PHENOTYPE 1; Tryptophan aminotransferase ISS1; Tyrosine aminotransferase ISS1; EC 2.6.1.27; EC 2.6.1.5; EC 2.6.1.88 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9C969 aromatic-amino-acid transaminase (EC 2.6.1.57) from Arabidopsis thaliana (see paper)
    22% identity, 72% coverage of query (46.2 bits)

ATTY_CAEEL / Q93703 Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase; EC 2.6.1.5 from Caenorhabditis elegans (see 3 papers)
    21% identity, 74% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory