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Searching for up to 100 curated homologs for 15854 FitnessBrowser__Keio:15854 (116 a.a.)

Found high-coverage hits (≥70%) to 16 curated proteins.

Removed hits that are identical to the query, leaving 15

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 4.A.3.2.7 / C4X746 PEP-dependent phosphotransferase enzyme III, component of N,N'-diacetylchitobiose (cellobiose) PTS permease, CelABC (IIABC) from Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
    82% identity, 99% coverage of query (186 bits)

TC 4.A.3.2.6 / Q9KSH3 VC_1283 aka IIA, component of Glucosamine β(1→4) glucosamine (GlcN)2 (glucosamine dimer) transporter, VC1281-1283 (IIB; IIC; IIA, respectively) from Vibrio cholerae (see paper)
    53% identity, 85% coverage of query (108 bits)

TC 4.A.3.2.9 / U5MLJ3 PTS lactose transporter subunit IIA, component of PTS-type lactose transporter, IIC-IIB-IIA from Klebsiella pneumoniae CG43
    48% identity, 87% coverage of query (99.0 bits)

Q45402 protein-Npi-phosphohistidine-cellobiose phosphotransferase (EC 2.7.1.205) from Geobacillus stearothermophilus (see paper)
    43% identity, 84% coverage of query (84.3 bits)

TC 4.A.3.2.8 / Q72XQ1 PTS system, cellobiose-specific IIA component, component of N-, N'-diacetylchitobiose PTS permease, IIABCChb from Bacillus cereus (strain ATCC 10987)
    43% identity, 84% coverage of query (83.2 bits)

TC 4.A.3.2.2 / P46319 PTCA aka LicA aka CELC, component of Lichenan oligosaccharide (Lic) porter from Bacillus subtilis (see 3 papers)
    40% identity, 86% coverage of query (80.5 bits)

PTCA_LACLA / Q9CIE9 PTS system cellobiose-specific EIIA component from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see 2 papers)
TC 4.A.3.2.4 / Q9CIE9 PtcA, component of The cellobiose-specific (PtcA-PtcB-CelB) porter (Kowalczyk et al., 2008 ) from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see paper)
    41% identity, 84% coverage of query (77.8 bits)

PTCA_LACLM / A2RIE7 PTS system galactose-specific EIIA component from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
    41% identity, 84% coverage of query (76.6 bits)

PTLA_LACCA / P11502 PTS system lactose-specific EIIA component; EIIA-Lac; EIII-Lac; FIII-Lac; Lactose-specific phosphotransferase enzyme IIA component from Lacticaseibacillus casei (Lactobacillus casei) (see paper)
    37% identity, 87% coverage of query (69.7 bits)

TC 4.A.3.1.3 / Q045H4 Cellobiose-specific PTS system IIA component, component of Lactose PTS group translocator #2, IIA/IICB from Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
    34% identity, 90% coverage of query (67.0 bits)

PTLA_STAAU / P0A0D6 PTS system lactose-specific EIIA component; EIIA-Lac; EIII-Lac; Lactose-specific phosphotransferase enzyme IIA component from Staphylococcus aureus (see 8 papers)
TC 4.A.3.1.1 / P0A0D6 PtlA aka LACF, component of Lactose (Lac) porter, LacEF from Staphylococcus aureus (see 5 papers)
    34% identity, 85% coverage of query (65.5 bits)

PTLA_LACLL / P23532 PTS system lactose-specific EIIA component; EIIA-Lac; EIII-Lac; Lactose-specific phosphotransferase enzyme IIA component from Lactococcus lactis subsp. lactis (Streptococcus lactis) (see 2 papers)
    35% identity, 85% coverage of query (65.1 bits)

PTEA_BACSU / O05506 PTS system oligo-beta-mannoside-specific EIIA component; Glucomannan utilization protein A; Oligo-beta-mannoside-specific phosphotransferase enzyme IIA component from Bacillus subtilis (strain 168) (see paper)
    33% identity, 80% coverage of query (60.8 bits)

TC 4.A.3.1.2 / Q045X4 PTS system lactose-specific IIA component, Lac family, component of Lactose PTS group translocator #1, IIA/IICB from Lactobacillus gasseri (strain ATCC 33323 / DSM 20243)
    31% identity, 85% coverage of query (59.7 bits)

Build an alignment

Build an alignment for 15854 and 14 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

TC 4.A.3.2.3 / O50981 ChbA, component of N,N'-diacetylchitobiose porter, ChbABC from Borrelia burgdorferi (Lyme disease spirochete) (see paper)
    27% identity, 83% coverage of query (52.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory