Searching for up to 100 curated homologs for 15889 FitnessBrowser__Keio:15889 (326 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 99
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1pz1A / P80874 Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
39% identity, 91% coverage of query (188 bits)
GS69_BACSU / P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
39% identity, 91% coverage of query (187 bits)
F2YCN5 D-xylose reductase (EC 1.1.1.307) from Zymomonas mobilis subsp. mobilis (see paper)
36% identity, 95% coverage of query (183 bits)
IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
32% identity, 98% coverage of query (180 bits)
1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
31% identity, 98% coverage of query (177 bits)
AKR1_SOYBN / C6TBN2 Probable aldo-keto reductase 1; GmAKR1; EC 1.1.1.- from Glycine max (Soybean) (Glycine hispida) (see paper)
34% identity, 99% coverage of query (169 bits)
Q5FQJ0 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans (see paper)
37% identity, 89% coverage of query (166 bits)
PR / Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 2 papers)
PERR_RAUSE / Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see 2 papers)
Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 3 papers)
32% identity, 99% coverage of query (165 bits)
3v0sA / Q3L181 Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
31% identity, 99% coverage of query (147 bits)
YajO / b0419 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli K-12 substr. MG1655 (see 7 papers)
yajO / P77735 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli (strain K12) (see 6 papers)
YAJO_ECOLI / P77735 1-deoxyxylulose-5-phosphate synthase YajO; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
P77735 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (see paper)
34% identity, 95% coverage of query (138 bits)
ALKR4_ARATH / Q93ZN2 Probable aldo-keto reductase 4; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 99% coverage of query (131 bits)
1ynpB / Q9KE47 Aldo-keto reductase akr11c1 from bacillus halodurans (apo form) (see paper)
33% identity, 94% coverage of query (128 bits)
1ynqB Aldo-keto reductase akr11c1 from bacillus halodurans (holo form)
33% identity, 94% coverage of query (128 bits)
C0LVA5 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Actinidia eriantha (see paper)
32% identity, 98% coverage of query (127 bits)
STR7_STRTC / A0A3B1EFQ1 Aldo-keto reductase str7; Strobilurin A biosynthesis cluster protein r7; EC 1.1.1.- from Strobilurus tenacellus (see 3 papers)
30% identity, 99% coverage of query (124 bits)
Build an alignment for 15889 and 15 homologs with ≥ 30% identity
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FDB38_GIBM7 / W7N2Q9 Aldo-keto reductase FVEG_12638; Fusarium detoxification of benzoxazolinone cluster 2 protein FVEG_12638; FDB2 cluster protein FVEG_12638; EC 1.1.1.- from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 4 papers)
29% identity, 97% coverage of query (122 bits)
1ynpA Aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
32% identity, 94% coverage of query (122 bits)
YAKC_SCHPO / Q09923 Aldo-keto reductase yakc [NADP(+)]; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
yak3 aldose reductase YakC from Schizosaccharomyces pombe (see 3 papers)
30% identity, 87% coverage of query (120 bits)
KCAB1_MOUSE / P63143 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mus musculus (Mouse) (see 5 papers)
30% identity, 94% coverage of query (120 bits)
KCAB1_RAT / P63144 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Rattus norvegicus (Rat) (see 9 papers)
30% identity, 94% coverage of query (120 bits)
6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
29% identity, 96% coverage of query (119 bits)
Q9X265 carbonyl reductase (NADPH) (EC 1.1.1.184) from Thermotoga maritima (see 2 papers)
29% identity, 96% coverage of query (119 bits)
KCAB1_HUMAN / Q14722 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Homo sapiens (Human) (see 13 papers)
30% identity, 93% coverage of query (119 bits)
KCAB1_RABIT / Q9XT31 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Oryctolagus cuniculus (Rabbit) (see paper)
30% identity, 93% coverage of query (119 bits)
6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
29% identity, 96% coverage of query (119 bits)
5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
29% identity, 96% coverage of query (119 bits)
KCAB_SCHPO / O59826 Putative voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
31% identity, 94% coverage of query (118 bits)
KCAB1_MUSPU / Q28528 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mustela putorius (European polecat) (see paper)
30% identity, 93% coverage of query (117 bits)
6ow0A / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
32% identity, 85% coverage of query (117 bits)
8hw0A / A0A6B8QIS5 The structure of akr6d1
30% identity, 92% coverage of query (116 bits)
KCAB_ARATH / O23016 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; Potassium voltage beta 1; KV-beta1; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 94% coverage of query (115 bits)
LGALDH / O81884 L-galactose dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
GALDH_ARATH / O81884 L-galactose dehydrogenase; At-GalDH; L-GalDH; EC 1.1.1.316 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O81884 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
L-GalDH / CAD10386.1 L-galactose dehydrogenase from Arabidopsis thaliana (see paper)
31% identity, 92% coverage of query (115 bits)
5c7hA / Q92NR7 Crystal structure of aldo-keto reductase from sinorhizobium meliloti 1021 in complex with NADPH
32% identity, 90% coverage of query (115 bits)
4pmjA Crystal structure of a putative oxidoreductase from sinorhizobium meliloti 1021 in complex with NADP
32% identity, 90% coverage of query (115 bits)
7eziA / Q2QQV2 Rice l-galactose dehydrogenase (apo form)
31% identity, 98% coverage of query (114 bits)
FDB25_FUSPC / K3VD70 Aldo-keto reductase FPSE_08125; Fusarium detoxification of benzoxazolinone cluster protein FPSE_08125; FDB cluster protein FPSE_08125; EC 1.1.1.- from Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot fungus) (see 3 papers)
27% identity, 100% coverage of query (114 bits)
7ezlA Rice l-galactose dehydrogenase (holo form)
31% identity, 98% coverage of query (114 bits)
KCAB_ORYSJ / Q40648 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Oryza sativa subsp. japonica (Rice) (see paper)
29% identity, 94% coverage of query (113 bits)
Q84L20 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Malus domestica (see paper)
31% identity, 92% coverage of query (113 bits)
KCAB2_XENLA / Q9PTM5 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
29% identity, 97% coverage of query (112 bits)
KCAB2_MOUSE / P62482 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5; EC 1.1.1.- from Mus musculus (Mouse) (see 8 papers)
KCAB2_RAT / P62483 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Rattus norvegicus (Rat) (see 19 papers)
29% identity, 97% coverage of query (112 bits)
KCAB2_BOVIN / Q27955 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Bos taurus (Bovine) (see paper)
28% identity, 97% coverage of query (112 bits)
3eauA Voltage-dependent k+ channel beta subunit in complex with cortisone
29% identity, 97% coverage of query (112 bits)
1exbA Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels
29% identity, 97% coverage of query (112 bits)
6ow0B / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
31% identity, 84% coverage of query (111 bits)
mtmW / Q194Q1 mithramycin dehydrogenase from Streptomyces argillaceus (see 2 papers)
31% identity, 85% coverage of query (110 bits)
KCAB2_HUMAN / Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 4 papers)
28% identity, 98% coverage of query (108 bits)
7wf3C / Q13303 Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
28% identity, 97% coverage of query (108 bits)
E9M5S4 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Citrus unshiu (see paper)
30% identity, 92% coverage of query (108 bits)
KCAB3_XENLA / Q9PTM4 Voltage-gated potassium channel subunit beta-3; K(+) channel subunit beta-3; Kv-beta-3; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
30% identity, 94% coverage of query (108 bits)
Q6BDJ2 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Spinacia oleracea (see paper)
GDH / BAD32687.1 L-galactose dehydrogenase from Spinacia oleracea (see paper)
27% identity, 100% coverage of query (107 bits)
7svqA / Q6BDJ2 Crystal structure of l-galactose dehydrogenase from spinacia oleracea in complex with NAD+ (see paper)
27% identity, 100% coverage of query (107 bits)
Y1669_ARATH / Q94A68 Uncharacterized oxidoreductase At1g06690, chloroplastic; EC 1.-.-.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 99% coverage of query (105 bits)
YH5B_SCHPO / O94315 Uncharacterized oxidoreductase C215.11c; EC 1.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
27% identity, 92% coverage of query (104 bits)
FCDH_PSESP / Q52472 D-threo-aldose 1-dehydrogenase; L-fucose dehydrogenase; EC 1.1.1.122 from Pseudomonas sp.
Q52472 D-threo-aldose 1-dehydrogenase (EC 1.1.1.122) from Pseudomonas sp. (see paper)
29% identity, 92% coverage of query (103 bits)
Q8TZM9 alcohol dehydrogenase (EC 1.1.1.1) from Pyrococcus furiosus (see 2 papers)
30% identity, 96% coverage of query (103 bits)
YgdS / b2834 putative NADP(H)-dependent aldo-keto reductase Tas from Escherichia coli K-12 substr. MG1655 (see 6 papers)
1lqaA / P0A9T4 Tas protein from escherichia coli in complex with NADPH (see paper)
tas protein Tas from Escherichia coli str. K12 substr. MG1655 (see paper)
29% identity, 95% coverage of query (103 bits)
P0A9T4 Protein tas from Escherichia coli (strain K12)
29% identity, 95% coverage of query (103 bits)
VRDA_ASPPA / B9WYE6 Versiconal hemiacetal acetate reductase; VHA reductase; EC 1.1.1.353 from Aspergillus parasiticus (see paper)
B9WYE6 versiconal hemiacetal acetate reductase (EC 1.1.1.353) from Aspergillus parasiticus (see paper)
28% identity, 98% coverage of query (102 bits)
YI7E_SCHPO / Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 96% coverage of query (102 bits)
PLD_MICLT / Q76KC2 Pyridoxal 4-dehydrogenase; EC 1.1.1.107 from Microbacterium luteolum (Aureobacterium luteolum) (see paper)
26% identity, 97% coverage of query (102 bits)
AFTS1_ALTAL / Q75ZG3 Aldo-keto reductase AFTS1; AF-toxin biosynthesis protein S1; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
29% identity, 94% coverage of query (102 bits)
6ciaA / A6T7Q7 Crystal structure of aldo-keto reductase from klebsiella pneumoniae in complex with NADPH.
28% identity, 90% coverage of query (101 bits)
8hnqA / A0A6B8QJ47 The structure of a alcohol dehydrogenase akr13b2 with NADP
27% identity, 93% coverage of query (100 bits)
YeaE / b1781 methylglyoxal reductase YeaE from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yeaE / P76234 methylglyoxal reductase YeaE (EC 1.1.1.21) from Escherichia coli (strain K12) (see 3 papers)
27% identity, 95% coverage of query (100 bits)
4wghA Crystal structure of aldo/keto reductase from klebsiella pneumoniae in complex with NADP and acetate at 1.8 a resolution
28% identity, 90% coverage of query (100 bits)
NORB_DOTSN / M2YJQ2 Norsolorinic acid reductase B; Dothistromin biosynthesis protein norB; EC 1.1.1.- from Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini) (see 3 papers)
28% identity, 93% coverage of query (98.2 bits)
BPHYT_RS34225 L-fucose dehydrogenase (EC 1.1.1.122) from Burkholderia phytofirmans PsJN
25% identity, 96% coverage of query (98.2 bits)
SAN2_FUSV7 / C7ZBE5 Aldo-keto reductase NECHADRAFT_45914; Sansalvamide biosynthesis cluster protein NECHADRAFT_45914; EC 1.1.1.- from Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi) (see paper)
26% identity, 97% coverage of query (97.4 bits)
6hg6A / A0A1S8QGT2 Clostridium beijerinckii aldo-keto reductase cbei_3974 with NADPH (see paper)
26% identity, 98% coverage of query (93.2 bits)
3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium
28% identity, 92% coverage of query (91.7 bits)
5t79A / Q8ZNA1 X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
28% identity, 92% coverage of query (91.3 bits)
4aubB / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
26% identity, 92% coverage of query (86.7 bits)
2bp1A Structure of the aflatoxin aldehyde reductase in complex with NADPH
26% identity, 79% coverage of query (81.6 bits)
AKR7A2 / O43488 aflatoxin B1 aldehyde reductase member 2 from Homo sapiens (see 4 papers)
ARK72_HUMAN / O43488 Aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; EC 1.1.1.n11 from Homo sapiens (Human) (see 3 papers)
26% identity, 79% coverage of query (80.9 bits)
3n6qD Crystal structure of yghz from e. Coli
27% identity, 92% coverage of query (80.1 bits)
2clpG Crystal structure of human aflatoxin b1 aldehyde reductase member 3
26% identity, 79% coverage of query (79.3 bits)
2clpA / O95154 Crystal structure of human aflatoxin b1 aldehyde reductase member 3
26% identity, 79% coverage of query (79.3 bits)
ARK73_HUMAN / O95154 Aflatoxin B1 aldehyde reductase member 3; AFB1 aldehyde reductase 2; AFB1-AR 2; EC 1.-.-.- from Homo sapiens (Human) (see 2 papers)
26% identity, 79% coverage of query (79.0 bits)
4aubE The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate
25% identity, 95% coverage of query (76.6 bits)
1gveA / P38918 Aflatoxin aldehyde reductase (akr7a1) from rat liver (see paper)
25% identity, 78% coverage of query (73.2 bits)
ARK73_RAT / P38918 Aflatoxin B1 aldehyde reductase member 3; AFB1-AR; Aflatoxin B1 aldehyde reductase member 1; rAFAR1; EC 1.-.-.- from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 78% coverage of query (73.2 bits)
3krbA / A8BGX6 Structure of aldose reductase from giardia lamblia at 1.75a resolution (see paper)
24% identity, 92% coverage of query (71.2 bits)
4aubF / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
25% identity, 92% coverage of query (67.0 bits)
4g5dA / P22045 X-ray crystal structure of prostaglandin f synthase from leishmania major friedlin bound to NADPH (see paper)
26% identity, 72% coverage of query (65.1 bits)
1vp5A / Q9X0A2 Crystal structure of 2,5-diketo-d-gluconic acid reductase (tm1009) from thermotoga maritima at 2.40 a resolution
22% identity, 84% coverage of query (57.0 bits)
5az1A Crystal structure of aldo-keto reductase (akr2e5) complexed with nadph (see paper)
25% identity, 94% coverage of query (53.1 bits)
7s5fB / A0A1U9WT24 Crystal structure of mannose-6-phosphate reductase from celery (apium graveolens) leaves with NADP+ and mannonic acid bound (see paper)
20% identity, 94% coverage of query (52.8 bits)
3ufyA Akr1c3 complex with r-naproxen
23% identity, 91% coverage of query (50.8 bits)
3r94A Akr1c3 complex with flurbiprofen
23% identity, 91% coverage of query (50.8 bits)
3r8hA Akr1c3 complex with zomepirac
23% identity, 91% coverage of query (50.8 bits)
3r8gA Akr1c3 complex with ibuprofen
23% identity, 91% coverage of query (50.8 bits)
3r7mA Akr1c3 complex with sulindac
23% identity, 91% coverage of query (50.8 bits)
3r6iA Akr1c3 complex with meclofenamic acid
23% identity, 91% coverage of query (50.8 bits)
3r58A Akr1c3 complex with naproxen
23% identity, 91% coverage of query (50.8 bits)
4falA Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1h)-yl)sulfonyl)-n- methylbenzamide (80)
23% identity, 91% coverage of query (50.4 bits)
E3W861 carbonyl reductase (NADPH) (EC 1.1.1.184) from Bacillus sp. (in: Bacteria) (see paper)
3b3dA / O34678 B.Subtilis ytbe (see paper)
24% identity, 85% coverage of query (50.4 bits)
4wdxA 17beta-hsd5 in complex with [4-(2-hydroxyethyl)piperidin-1-yl](5- methyl-1h-indol-2-yl)methanone
22% identity, 91% coverage of query (49.7 bits)
7x3oA Crystal structure of aldo-keto reductase 1c3 complexed with compound s07054
23% identity, 91% coverage of query (48.9 bits)
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Lawrence Berkeley National Laboratory