Searching for up to 100 curated homologs for 16329 b2221 acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (NCBI) (220 a.a.)
Found high-coverage hits (≥70%) to 39 curated proteins.
Removed hits that are identical to the query, leaving 37
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
CTFA_CLOAB / P33752 Acetoacetyl-CoA:acetate/butyrate CoA transferase alpha subunit; Butyrate--acetoacetate CoA-transferase subunit A; Coat A; EC 2.8.3.9 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 3 papers)
47% identity, 97% coverage of query (231 bits)
scoA / P56006 succinyl-CoA-transferase subunit A (EC 2.8.3.5) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
SCOA_HELPY / P56006 Succinyl-CoA:3-ketoacid coenzyme A transferase subunit A; Succinyl-CoA:3-oxoacid CoA-transferase; OXCT A; EC 2.8.3.5 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
43% identity, 97% coverage of query (196 bits)
RR42_RS06555 3-oxoacid CoA-transferase (EC 2.8.3.5), subunit A from Cupriavidus basilensis FW507-4G11
43% identity, 93% coverage of query (194 bits)
Q63TL3 3-oxoacid CoA-transferase (EC 2.8.3.5) from Burkholderia pseudomallei (see paper)
45% identity, 93% coverage of query (190 bits)
Sama_1357 3-oxoacid CoA-transferase (EC 2.8.3.5), subunit A from Shewanella amazonensis SB2B
51% identity, 90% coverage of query (188 bits)
pcaI / Q01103 α subunit of β-ketoadipate succinyl-CoA transferase (EC 2.8.3.6) from Pseudomonas putida (see 3 papers)
Q01103 3-oxoadipate CoA-transferase (subunit 2/2) (EC 2.8.3.6) from Pseudomonas putida (see paper)
pcaI / GB|AAA25922.1 3-oxoadipate CoA-transferase subunit A; EC 2.8.3.6 from Pseudomonas putida (see paper)
45% identity, 88% coverage of query (186 bits)
pcaI / Q0K4S5 adipate CoA-transferase α subunit (EC 6.2.1.5) from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (see paper)
43% identity, 97% coverage of query (184 bits)
catI / AAC46432.1 beta-ketoadipate succinyl-CoA transferase alpha-subunit from Acinetobacter baylyi (see 8 papers)
41% identity, 97% coverage of query (181 bits)
lpsI / AAK53462.1 alpha subunit of putative 3-oxoacid CoA-transferase from Xanthomonas campestris pv. campestris (see 4 papers)
42% identity, 93% coverage of query (176 bits)
Psest_1078 acetyl-CoA:acetoacetate CoA transferase, A subunit (EC 2.8.3.8) from Pseudomonas stutzeri RCH2
46% identity, 92% coverage of query (174 bits)
Pf6N2E2_2111 Dehydrocarnitine CoA-transferase and acetoacetate CoA-transferase, subunit A from Pseudomonas fluorescens FW300-N2E2
41% identity, 99% coverage of query (174 bits)
SCOT_DROME / Q9W058 Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial; 3-oxoacid CoA-transferase; EC 2.8.3.5 from Drosophila melanogaster (Fruit fly) (see paper)
Q9W058 3-oxoacid CoA-transferase (EC 2.8.3.5) from Drosophila melanogaster (see paper)
40% identity, 93% coverage of query (171 bits)
1o9lA / Q29551 Succinate:coenzyme-a transferase (pig heart)
36% identity, 98% coverage of query (162 bits)
SCOT1_PIG / Q29551 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinate-coenzyme A transferase; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Sus scrofa (Pig) (see 6 papers)
Q29551 3-oxoacid CoA-transferase (EC 2.8.3.5) from Sus scrofa (see 3 papers)
36% identity, 92% coverage of query (162 bits)
OXCT1 / P55809 succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) from Homo sapiens (see 4 papers)
SCOT1_HUMAN / P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Homo sapiens (Human) (see 7 papers)
P55809 3-oxoacid CoA-transferase (EC 2.8.3.5) from Homo sapiens (see 3 papers)
37% identity, 92% coverage of query (161 bits)
2nrbA / Q29551 C28s mutant of succinyl-coa:3-ketoacid coa transferase from pig heart (see paper)
36% identity, 98% coverage of query (161 bits)
3oxoE Succinyl-coa:3-ketoacid coa transferase from pig heart covalently bound to coa
36% identity, 98% coverage of query (161 bits)
3k6mC Dynamic domains of succinyl-coa:3-ketoacid-coenzyme a transferase from pig heart.
36% identity, 98% coverage of query (161 bits)
Q9D0K2 3-oxoacid CoA-transferase (EC 2.8.3.5) from Mus musculus (see paper)
37% identity, 92% coverage of query (157 bits)
SCOT1_RAT / B2GV06 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; SCOT; 3-oxoacid CoA-transferase 1; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; SCOT-s; Succinyl-CoA:3-oxoacid CoA transferase; EC 2.8.3.5 from Rattus norvegicus (Rat) (see paper)
B2GV06 3-oxoacid CoA-transferase (EC 2.8.3.5) from Rattus norvegicus (see 2 papers)
37% identity, 92% coverage of query (156 bits)
SCOT2_HUMAN / Q9BYC2 Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase; SCOT-t; EC 2.8.3.5 from Homo sapiens (Human) (see paper)
Q9BYC2 3-oxoacid CoA-transferase (EC 2.8.3.5) from Homo sapiens (see paper)
38% identity, 93% coverage of query (155 bits)
Q9JJN4 3-oxoacid CoA-transferase (EC 2.8.3.5) from Mus musculus (see paper)
38% identity, 90% coverage of query (149 bits)
8i3yD / Q386P1 Crystal structure of asct from trypanosoma brucei in complex with succinyl-coa.
34% identity, 99% coverage of query (148 bits)
8i3yA Crystal structure of asct from trypanosoma brucei in complex with succinyl-coa.
34% identity, 99% coverage of query (148 bits)
8i40A Crystal structure of asct from trypanosoma brucei in complex with coa.
34% identity, 99% coverage of query (148 bits)
SCO2B_MOUSE / Q9ESL0 Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; 3-oxoacid CoA-transferase 2B; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 2; SCOT-t2; EC 2.8.3.5 from Mus musculus (Mouse) (see paper)
37% identity, 90% coverage of query (146 bits)
SCO2A_RAT / Q5XIJ9 Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; 3-oxoacid CoA-transferase 2A; Testis-specific succinyl-CoA:3-oxoacid CoA-transferase 1; SCOT-t1; EC 2.8.3.5 from Rattus norvegicus (Rat) (see paper)
37% identity, 90% coverage of query (144 bits)
Build an alignment for 16329 and 27 homologs with ≥ 30% identity
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YdiF / b1694 putative acetate-CoA transferase YdiF (EC 2.8.3.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
24% identity, 99% coverage of query (75.1 bits)
YDIF_ECO57 / Q8X5X6 Acetate CoA-transferase YdiF; Short-chain acyl-CoA:acetate CoA-transferase; EC 2.8.3.8 from Escherichia coli O157:H7 (see paper)
24% identity, 99% coverage of query (74.7 bits)
2ahvA / Q8X5X6 Crystal structure of acyl-coa transferase from e. Coli o157:h7 (ydif)- thioester complex with coa- 1 (see paper)
24% identity, 99% coverage of query (74.3 bits)
BWI76_RS23700 glycerate CoA-transferase from Klebsiella michiganensis M5al
27% identity, 100% coverage of query (71.2 bits)
Q9L3F7 propionate CoA-transferase (EC 2.8.3.1) from Anaerotignum propionicum (see paper)
25% identity, 98% coverage of query (68.2 bits)
CARA_ACEWO / F1CYZ5 Caffeate CoA-transferase; Hydrocaffeyl-CoA:caffeate CoA transferase; EC 2.8.3.23 from Acetobacterium woodii (see 2 papers)
F1CYZ5 caffeate CoA-transferase (EC 2.8.3.23) from Acetobacterium woodii (see 2 papers)
24% identity, 99% coverage of query (62.8 bits)
IPDA_RHOJR / Q0S7P9 Cholesterol ring-cleaving hydrolase IpdA subunit; (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA hydrolase alpha subunit; COCHEA-CoA hydrolase alpha subunit; EC 4.1.99.- from Rhodococcus jostii (strain RHA1) (see 2 papers)
29% identity, 90% coverage of query (56.2 bits)
6co9A / Q0S7P9 Crystal structure of rhodococcus jostii rha1 ipdab cochea-coa complex (see paper)
29% identity, 90% coverage of query (56.2 bits)
ipdA / P9WPW1 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA ligase α subunit from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 6 papers)
IPDA_MYCTU / P9WPW1 Cholesterol ring-cleaving hydrolase IpdA subunit; (3E)-2-(2-carboxylatoethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA hydrolase alpha subunit; COCHEA-CoA hydrolase alpha subunit; EC 4.1.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
26% identity, 90% coverage of query (48.1 bits)
pct / G0VND6 propanoyl-CoA transferase monomer (EC 2.8.3.1) from Megasphaera elsdenii DSM 20460 (see 3 papers)
A0A140JTF0 propionate CoA-transferase (EC 2.8.3.1) from Megasphaera elsdenii (see paper)
22% identity, 98% coverage of query (45.1 bits)
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Lawrence Berkeley National Laboratory