Searching for up to 100 curated homologs for 16506 FitnessBrowser__Keio:16506 (277 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 97
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
3odgA / Q66D48 Crystal structure of xanthosine phosphorylase bound with xanthine from yersinia pseudotuberculosis
70% identity, 99% coverage of query (397 bits)
P46354 Purine nucleoside phosphorylase 1; PNP 1; Inosine phosphorylase; Inosine-guanosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; Pu-NPase I; EC 2.4.2.1 from Bacillus subtilis (strain 168)
47% identity, 91% coverage of query (245 bits)
A0A3G5E8S8 purine-nucleoside phosphorylase (EC 2.4.2.1) from Aneurinibacillus migulanus (see paper)
46% identity, 92% coverage of query (244 bits)
PUNA_GEOSE / P77834 Purine nucleoside phosphorylase 1; PNP 1; Inosine phosphorylase; Inosine-guanosine phosphorylase; Purine nucleoside phosphorylase I; PNP I; Pu-NPase I; EC 2.4.2.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
P77834 purine-nucleoside phosphorylase (EC 2.4.2.1) from Geobacillus stearothermophilus (see paper)
47% identity, 91% coverage of query (244 bits)
8swuA / A0A0H2YR30 Structure of clostridium perfringens pnp bound to transition state analog immucillin h and sulfate (see paper)
44% identity, 92% coverage of query (232 bits)
4m1eB / D5SMY7 Crystal structure of purine nucleoside phosphorylase i from planctomyces limnophilus dsm 3776, nysgrc target 029364.
43% identity, 91% coverage of query (212 bits)
PNPH_ANOGA / A4Q998 Purine nucleoside phosphorylase; AgPNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Anopheles gambiae (African malaria mosquito) (see paper)
44% identity, 86% coverage of query (210 bits)
2p4sA / A4Q998 Structure of purine nucleoside phosphorylase from anopheles gambiae in complex with dadme-immh (see paper)
46% identity, 81% coverage of query (209 bits)
3d1vA / P00491 Crystal structure of human pnp complexed with 2-mercapto(3h) quinazolinone (see paper)
44% identity, 91% coverage of query (203 bits)
3lbaA / Q8DTU4 The crystal structure of smu.1229 from streptococcus mutans ua159 bound to hypoxanthine
43% identity, 91% coverage of query (203 bits)
3phbE Crystal structure of human purine nucleoside phosphorylase in complex with dadme-immg
44% identity, 91% coverage of query (203 bits)
3inyA Crystal structure of human purine nucleoside phosphorylase in complex with 7-deazaguanine
44% identity, 91% coverage of query (203 bits)
1yryE Crystal structure of human pnp complexed with mesg
44% identity, 91% coverage of query (203 bits)
1v45E Crystal structure of human pnp complexed with 3-deoxyguanosine
44% identity, 91% coverage of query (203 bits)
1v41E Crystal structure of human pnp complexed with 8-azaguanine
44% identity, 91% coverage of query (203 bits)
1v3qE Structure of human pnp complexed with ddi
44% identity, 91% coverage of query (203 bits)
1v2hE Crystal structure of human pnp complexed with guanine
44% identity, 91% coverage of query (203 bits)
1rfgE Crystal structure of human purine nucleoside phosphorylase complexed with guanosine
44% identity, 91% coverage of query (203 bits)
1rctE Crystal structure of human purine nucleoside phosphorylase complexed with inosine
44% identity, 91% coverage of query (203 bits)
1pwyE Crystal structure of human pnp complexed with acyclovir
44% identity, 91% coverage of query (203 bits)
1pf7E Crystal structure of human pnp complexed with immucillin h
44% identity, 91% coverage of query (203 bits)
3k8qA Crystal structure of human purine nucleoside phosphorylase in complex with serme-immucillin h
44% identity, 91% coverage of query (203 bits)
1rszA Structure of human purine nucleoside phosphorylase in complex with dadme-immucillin-h and sulfate
44% identity, 91% coverage of query (203 bits)
3k8oE Crystal structure of human purine nucleoside phosphorylase in complex with datme-immh
44% identity, 91% coverage of query (203 bits)
PNP / P00491 purine nucleoside phosphorylase subunit (EC 2.4.2.1; EC 2.4.2.15) from Homo sapiens (see 9 papers)
PNPH_HUMAN / P00491 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Homo sapiens (Human) (see 6 papers)
P00491 purine-nucleoside phosphorylase (EC 2.4.2.1) from Homo sapiens (see 29 papers)
44% identity, 91% coverage of query (202 bits)
PNPH_MOUSE / P23492 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Mus musculus (Mouse) (see 2 papers)
43% identity, 92% coverage of query (202 bits)
7zspA Human purine nucleoside phosphorylase in complex with js-555
44% identity, 91% coverage of query (202 bits)
7zsoA Human purine nucleoside phosphorylase in complex with js-554
44% identity, 91% coverage of query (202 bits)
7zsnA Human purine nucleoside phosphorylase in complex with js-379
44% identity, 91% coverage of query (202 bits)
7zsmA Human purine nucleoside phosphorylase in complex with js-375
44% identity, 91% coverage of query (202 bits)
1a9sA Bovine purine nucleoside phosphorylase complexed with inosine and sulfate
44% identity, 88% coverage of query (201 bits)
1a9qA Bovine purine nucleoside phosphorylase complexed with inosine
44% identity, 88% coverage of query (201 bits)
1a9oA / P55859 Bovine purine nucleoside phosphorylase complexed with phosphate (see paper)
44% identity, 88% coverage of query (200 bits)
1a9tA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate
44% identity, 88% coverage of query (200 bits)
1a9pA Bovine purine nucleoside phosphorylase complexed with 9-deazainosine and phosphate
44% identity, 88% coverage of query (200 bits)
1b8oA Purine nucleoside phosphorylase
44% identity, 88% coverage of query (200 bits)
1b8nA Purine nucleoside phosphorylase
44% identity, 88% coverage of query (200 bits)
P55859 purine-nucleoside phosphorylase (EC 2.4.2.1) from Bos taurus (see 13 papers)
44% identity, 88% coverage of query (199 bits)
8swtA / Q5LAA3 Structure of bacteroides fragilis pnp bound to transition state analog immucillin h and sulfate (see paper)
39% identity, 91% coverage of query (199 bits)
P55859 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Bos taurus (Bovine)
44% identity, 88% coverage of query (199 bits)
3gb9A Human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoroadenine
43% identity, 91% coverage of query (199 bits)
3ggsA Human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2'-deoxyadenosine
43% identity, 91% coverage of query (199 bits)
4earA Crystal structure of purine nucleoside phosphorylase (w16y, w94y, w178y, h257w) mutant from human complexed with dadme-immg and phosphate
44% identity, 91% coverage of query (199 bits)
1fxuA Purine nucleoside phosphorylase from calf spleen in complex with n(7)- acycloguanosine inhibitor and a phosphate ion
44% identity, 88% coverage of query (199 bits)
3e0qC / Q9BMI9 Crystal structure of schistosoma mansoni purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor (see paper)
44% identity, 89% coverage of query (198 bits)
Q9BMI9 purine-nucleoside phosphorylase (EC 2.4.2.1) from Schistosoma mansoni (see 2 papers)
44% identity, 89% coverage of query (198 bits)
Q72L69 purine-nucleoside phosphorylase (EC 2.4.2.1) from Thermus thermophilus (see paper)
41% identity, 92% coverage of query (198 bits)
1lv8A Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit
48% identity, 77% coverage of query (196 bits)
P85973 purine-nucleoside phosphorylase (EC 2.4.2.1) from Rattus norvegicus (see paper)
42% identity, 91% coverage of query (195 bits)
3fb1A Crystal structure of purine nucleoside phosphorylase in complex with ribose-1-phosphate
43% identity, 89% coverage of query (190 bits)
3fazA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in complex with inosine
43% identity, 89% coverage of query (190 bits)
1tcuA Crystal structure of the purine nucleoside phosphorylase from schistosoma mansoni in complex with phosphate and acetate
43% identity, 89% coverage of query (190 bits)
3fnqA Crystal structure of schistosoma purine nucleoside phosphorylase in complex with hypoxanthine
43% identity, 89% coverage of query (190 bits)
3f8wA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in complex with adenosine
43% identity, 89% coverage of query (190 bits)
3e9zA Crystal structure of purine nucleoside phosphorylase from schistosoma mansoni in complex with 6-chloroguanine
43% identity, 89% coverage of query (190 bits)
3djfA Crystal structure of schistosoma mansoni purine nucleoside phosphorylase in a complex with bcx-34
43% identity, 89% coverage of query (190 bits)
4nsnA / B2RKN6 Crystal structure of purine nucleoside phosphorylase from porphyromonas gingivalis atcc 33277, nysgrc target 030972, orthorhombic symmetry
44% identity, 88% coverage of query (188 bits)
2ai3A Purine nucleoside phosphorylase from calf spleen
43% identity, 88% coverage of query (187 bits)
2qplA Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue
46% identity, 77% coverage of query (186 bits)
1tcvA Crystal structure of the purine nucleoside phosphorylase from schistosoma mansoni in complex with non-detergent sulfobetaine 195 and acetate
44% identity, 89% coverage of query (186 bits)
7zslA Human purine nucleoside phosphorylase in complex with js-196
42% identity, 88% coverage of query (184 bits)
2ai2A Purine nucleoside phosphorylase from calf spleen
42% identity, 88% coverage of query (184 bits)
2ai1A Purine nucleoside phosphorylase from calf spleen
42% identity, 88% coverage of query (184 bits)
6bj6A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 2-{[(s)- benzenesulfinyl]methyl}benzoic acid
43% identity, 91% coverage of query (184 bits)
6bifA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 1-(4-amino-2-hydroxyphenyl)ethan- 1-one
43% identity, 91% coverage of query (184 bits)
6bi9A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 1,2,5-trimethyl-1h-pyrrole-3- carboxylic acid
43% identity, 91% coverage of query (184 bits)
6bi1A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with (2r)-2-amino-3-(benzyloxy)propan- 1-ol
43% identity, 91% coverage of query (184 bits)
6bhbA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 2-aminopyrimidin-5-ol
43% identity, 91% coverage of query (184 bits)
6bfvA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 5-fluoro-1,2-dihydropyrimidin-2- one
43% identity, 91% coverage of query (184 bits)
6bb7A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 3-methyl-1,2-dihydropyridin-2-one
43% identity, 91% coverage of query (184 bits)
6b71A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with3-(4-chlorophenyl)-5h,6h- imidazo[2,1-b][1,3]thiazole
43% identity, 91% coverage of query (184 bits)
6b56A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 5-butylpyridine-2-carboxylic acid
43% identity, 91% coverage of query (184 bits)
6b4tA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 4-methylpyridin-2-ol
43% identity, 91% coverage of query (184 bits)
6b4qA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with pyridin-4-ol
43% identity, 91% coverage of query (184 bits)
6b3lA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 2,3-dihydro-1h-inden-2-amine
43% identity, 91% coverage of query (184 bits)
6b37A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 1,3-benzothiazol-2-ol
43% identity, 91% coverage of query (184 bits)
6b2lA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with piperidin-2-imine
43% identity, 91% coverage of query (184 bits)
6axaA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with (3s)-5-fluoro-3-hydroxy-1,3- dihydroindol-2-one
43% identity, 91% coverage of query (184 bits)
6aweA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 2-fluoro-6-(2-pyridin-2- ylethylamino)benzonitrile
43% identity, 91% coverage of query (184 bits)
6bj7A Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 4-chloro-6-methylpyrimidin-2- amine
43% identity, 91% coverage of query (184 bits)
6b7iA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with (2s)-2-(3,5-difluorophenyl)-2- hydroxyacetic acid
43% identity, 91% coverage of query (184 bits)
6b6kA Crystal structure of purine nucleoside phosphorylase isoform 2 from schistosoma mansoni in complex with 6-methyl-2,3-dihydropyridazin-3- one
43% identity, 91% coverage of query (184 bits)
5tbsA Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed with adenine
43% identity, 91% coverage of query (184 bits)
5tbvA Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed with tubercidin
43% identity, 91% coverage of query (184 bits)
5tbuA Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed with hypoxanthine
43% identity, 91% coverage of query (184 bits)
5tbtA Crystal structure of isoform 2 of purine nucleoside phosphorylase complexed with cytidine
43% identity, 91% coverage of query (184 bits)
5ko6A / A0A0U3AGT1 Crystal structure of isoform 2 of purine nucleoside phosphorylase from schistosoma mansoni in complex with cytosine and ribose-1-phosphate (see paper)
43% identity, 91% coverage of query (183 bits)
3fucC Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'- phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
42% identity, 88% coverage of query (182 bits)
3fucA Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'- phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit
42% identity, 88% coverage of query (182 bits)
4uc0A / B9JYS2 Crystal structure of a purine nucleoside phosphorylase (psi-nysgrc- 029736) from agrobacterium vitis
42% identity, 88% coverage of query (181 bits)
Q6CSZ6 purine-nucleoside phosphorylase (EC 2.4.2.1) from Kluyveromyces lactis (see paper)
43% identity, 79% coverage of query (180 bits)
8swqA / Q6CSZ6 Structure of k. Lactis pnp bound to transition state analog dadme- immucillin h and sulfate (see paper)
43% identity, 79% coverage of query (180 bits)
1v48A Calf spleen purine nucleoside phosphorylase (pnp) binary complex with 9-(5,5-difluoro-5-phosphonopenthyl)guanine
45% identity, 77% coverage of query (180 bits)
3e9rB Crystal structure of purine nucleoside phosphorylase from schistosoma mansoni in complex with adenine
45% identity, 79% coverage of query (180 bits)
3iexA Schistosoma purine nucleoside phosphorylase in complex with guanosine
43% identity, 89% coverage of query (179 bits)
PNPH_YEAST / Q05788 Purine nucleoside phosphorylase; PNP; Inosine phosphorylase; Inosine-guanosine phosphorylase; EC 2.4.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
40% identity, 90% coverage of query (177 bits)
4ns1A Crystal structure of purine nucleoside phosphorylase from porphyromonas gingivalis atcc 33277, nysgrc target 30972
42% identity, 88% coverage of query (177 bits)
Build an alignment for 16506 and 97 homologs with ≥ 30% identity
Or download the sequences
Or start over
Lawrence Berkeley National Laboratory