Searching for up to 100 curated homologs for 16521 FitnessBrowser__Keio:16521 (365 a.a.)

Found high-coverage hits (≥70%) to 20 curated proteins.

Removed hits that are identical to the query, leaving 19

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
    53% identity, 72% coverage of query (276 bits)

YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    44% identity, 78% coverage of query (244 bits)

TC 3.A.1.20.2 / Q9KLQ5 Fe(3+) ions import ATP-binding protein FbpC, component of Hexose-phosphate transporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    39% identity, 87% coverage of query (238 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    46% identity, 70% coverage of query (238 bits)

TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
    44% identity, 77% coverage of query (230 bits)

Ac3H11_2066 glucose ABC transporter, ATPase component from Acidovorax sp. GW101-3H11
    42% identity, 76% coverage of query (229 bits)

Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
    40% identity, 77% coverage of query (223 bits)

TC 3.A.1.1.38 / Q9WYQ2 Glycerol-3-phosphate-transporting ATPase, component of Inositol phosphate porter (Rodionova et al. 2013). Binds inositol phosphate with low Kd and inositol with a lower affinity from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    39% identity, 95% coverage of query (222 bits)

TC 3.A.1.11.6 / Q1M7Q1 Putative ABC transporter component, component of The γ-aminobutyrate (GABA) uptake system, GtsABCD from Rhizobium leguminosarum bv. viciae (strain 3841) (see paper)
    40% identity, 81% coverage of query (217 bits)

PS417_22130 glucose/xylose ABC transporter, ATPase component from Pseudomonas simiae WCS417
    36% identity, 97% coverage of query (214 bits)

1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
    42% identity, 76% coverage of query (214 bits)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    32% identity, 94% coverage of query (190 bits)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus
    32% identity, 94% coverage of query (190 bits)

GLCV_SACS2 / Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
TC 3.A.1.1.13 / Q97UY8 GlcV, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see 3 papers)
1oxuA / Q97UY8 Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
    32% identity, 94% coverage of query (190 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    37% identity, 85% coverage of query (183 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    35% identity, 79% coverage of query (175 bits)

Build an alignment

Build an alignment for 16521 and 16 homologs with ≥ 30% identity

Or download the sequences

Additional hits (identity < 30%)

ABCG5_MOUSE / Q99PE8 ATP-binding cassette sub-family G member 5; Sterolin-1; EC 7.6.2.- from Mus musculus (Mouse) (see 15 papers)
    26% identity, 79% coverage of query (96.3 bits)

ABCG5_HUMAN / Q9H222 ATP-binding cassette sub-family G member 5; Sterolin-1; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
TC 3.A.1.204.5 / Q9H222 ABCG5 aka ATP-binding cassette sub-family G member 5, component of The ABCG5 (sterolin-1)/ABCG8 (sterolin-2) heterodimeric neutral sterol (cholesterol and plant sterols) (e.g., sitosterol) (phosphoryl donors ATP > CTP > GTP > UTP) exporter; present in the apical membranes of enterocytes and hepatocytes. Cholesteryl oleate, phosphatidyl choline and enantiomeric cholesterol are poorly transported (mutation of either ABCG5 or ABCG8 cause sitosterolemia and coronary atherosclerosis) (Zhang et al., 2006; Wang et al., 2006; 2011) from Homo sapiens (Human) (see 5 papers)
ABCG5 / GI|11692800 ATP-binding cassette sub-family G member 5 from Homo sapiens (see paper)
    25% identity, 82% coverage of query (94.4 bits)

8cubC / Q9H222 Crystal structure of abcg5/g8 in complex with cholesterol (see paper)
    25% identity, 82% coverage of query (94.4 bits)

Or start over