Searching for up to 100 curated homologs for 16650 FitnessBrowser__Keio:16650 (417 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 99
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1eqbA X-ray crystal structure at 2.7 angstroms resolution of ternary complex between the y65f mutant of e-coli serine hydroxymethyltransferase, glycine and 5-formyl tetrahydrofolate
100% identity, 100% coverage of query (857 bits)
GLYA_SALTY / P0A2E1 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P0A2E1 glycine hydroxymethyltransferase (EC 2.1.2.1) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Salmonella enterica subsp. enterica serovar Typhimurium (see 3 papers)
93% identity, 100% coverage of query (793 bits)
R9YJZ9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Shewanella algae (see paper)
84% identity, 100% coverage of query (750 bits)
A1SUU0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Psychromonas ingrahamii (see 2 papers)
75% identity, 100% coverage of query (652 bits)
PfGW456L13_2685 Glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas fluorescens GW456-L13
72% identity, 100% coverage of query (628 bits)
L7Y8B0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Pseudomonas plecoglossicida (see paper)
71% identity, 100% coverage of query (607 bits)
A0A069BAT4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia pseudomallei (see paper)
64% identity, 99% coverage of query (563 bits)
4n0wA / B4ECY9 X-ray crystal structure of a serine hydroxymethyltransferase from burkholderia cenocepacia with covalently attached pyridoxal phosphate
64% identity, 99% coverage of query (548 bits)
4ot8A X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and serine
64% identity, 99% coverage of query (548 bits)
B4ECY9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Burkholderia cenocepacia (see paper)
64% identity, 99% coverage of query (547 bits)
4otlA X-ray crystal structure of serine hydroxymethyl transferase from burkholderia cenocepacia bound to plp and glycine
65% identity, 98% coverage of query (546 bits)
GLYA_HYDTT / D3DKC4 Serine hydroxymethyltransferase; SHMT; Serine methylase; L-threonine/L-allo-threonine aldolase; EC 2.1.2.1; EC 4.1.2.48 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see paper)
62% identity, 98% coverage of query (533 bits)
7x5oB / I3U4H4 Crystal structure of e. Faecium shmt in complex with me-thf and plp- gly (see paper)
62% identity, 97% coverage of query (508 bits)
7x5nA Crystal structure of e. Faecium shmt in complex with (+)-shin-1 and plp-ser
62% identity, 97% coverage of query (507 bits)
7v3dA Complex structure of serine hydroxymethyltransferase from enterococcus faecium and its inhibitor
62% identity, 97% coverage of query (507 bits)
GLYA_METBF / Q46A52 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Methanosarcina barkeri (strain Fusaro / DSM 804) (see paper)
Q46A52 glycine hydroxymethyltransferase (EC 2.1.2.1) from Methanosarcina barkeri (see 2 papers)
58% identity, 98% coverage of query (506 bits)
1kkjA / Q7SIB6 Crystal structure of serine hydroxymethyltransferase from b.Stearothermophilus (see paper)
61% identity, 95% coverage of query (505 bits)
1kl2A Crystal structure of serine hydroxymethyltransferase complexed with glycine and 5-formyl tetrahydrofolate
61% identity, 95% coverage of query (505 bits)
1kl1A Crystal structure of serine hydroxymethyltransferase complexed with glycine
61% identity, 95% coverage of query (505 bits)
1kkpA Crystal structure of serine hydroxymethyltransferase complexed with serine
61% identity, 95% coverage of query (505 bits)
2vmyA Crystal structure of f351gbsshmt in complex with gly and fthf
61% identity, 95% coverage of query (501 bits)
2vmxA Crystal structure of f351gbsshmt in complex with l-allo-thr
61% identity, 95% coverage of query (501 bits)
I7H6W6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Aphanothece halophytica (see paper)
59% identity, 97% coverage of query (500 bits)
6ymdA / I7H6W6 Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the covalent complex with malonate (see paper)
59% identity, 97% coverage of query (499 bits)
6ymfA Crystal structure of serine hydroxymethyltransferase from aphanothece halophytica in the plp-serine external aldimine state
59% identity, 97% coverage of query (499 bits)
GLYA_STAAC / Q5HE87 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Staphylococcus aureus (strain COL)
Q5HE87 glycine hydroxymethyltransferase (EC 2.1.2.1) from Staphylococcus aureus (see paper)
60% identity, 98% coverage of query (498 bits)
Q5M0B4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Streptococcus thermophilus (see paper)
61% identity, 97% coverage of query (497 bits)
4wxgA Crystal structure of l-serine hydroxymethyltransferase in complex with a mixture of l-threonine and glycine
61% identity, 97% coverage of query (497 bits)
4wxfA Crystal structure of l-serine hydroxymethyltransferase in complex with glycine
61% identity, 97% coverage of query (497 bits)
6tghA / Q5M0B4 Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
61% identity, 97% coverage of query (494 bits)
6ti4A Shmt from streptococcus thermophilus tyr55ser variant in complex with plp/d-serine/lys230 gem diamine complex
61% identity, 97% coverage of query (494 bits)
6ti3A Apo-shmt from streptococcus thermophilus tyr55ser variant in complex with d-threonine
61% identity, 97% coverage of query (494 bits)
6tghC Shmt from streptococcus thermophilus tyr55thr variant in complex with d-serine both as external aldimine and as non-covalent complex
61% identity, 97% coverage of query (494 bits)
GLYA_BACSU / P39148 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Bacillus subtilis (strain 168) (see 2 papers)
59% identity, 97% coverage of query (492 bits)
GLYA_CAMJE / P24531 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
glyA serine hydroxymethyltransferase; EC 2.1.2.1 from Campylobacter jejuni (see 2 papers)
56% identity, 99% coverage of query (492 bits)
glyA / P77962 glycine hydroxymethyltransferase (EC 2.1.2.1) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
59% identity, 98% coverage of query (489 bits)
U5TRK6 glycine hydroxymethyltransferase (EC 2.1.2.1) from Glutamicibacter nicotianae (see paper)
58% identity, 98% coverage of query (489 bits)
GLYA_THET8 / Q5SI56 Serine hydroxymethyltransferase; SHMT; Serine methylase; EC 2.1.2.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SI56 glycine hydroxymethyltransferase (EC 2.1.2.1) from Thermus thermophilus (see paper)
61% identity, 94% coverage of query (475 bits)
2dkjA / Q5SI56 Crystal structure of t.Th.Hb8 serine hydroxymethyltransferase
61% identity, 94% coverage of query (474 bits)
8suiB Joint x-ray/neutron structure of thermus thermophilus serine hydroxymethyltransferase (tthshmt) in internal aldimine state with l- ser bound in a pre-michalis complex
61% identity, 94% coverage of query (474 bits)
8ssyA Room-temperature x-ray structure of thermus thermophilus serine hydroxymethyltransferase (shmt) bound with d-ser in a pseudo- michaelis complex
61% identity, 94% coverage of query (474 bits)
3pgyB / Q5HE87 Serine hydroxymethyltransferase from staphylococcus aureus, s95p mutant.
58% identity, 98% coverage of query (473 bits)
A8GTI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Rickettsia rickettsii (see paper)
55% identity, 98% coverage of query (470 bits)
GLYA2_BURP1 / Q3JGP5 Serine hydroxymethyltransferase 2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Burkholderia pseudomallei (strain 1710b)
56% identity, 98% coverage of query (463 bits)
glyA / P34895 serine hydroxymethyltransferase subunit (EC 2.1.2.1) from Hyphomicrobium methylovorum (see paper)
58% identity, 99% coverage of query (456 bits)
P56089 glycine hydroxymethyltransferase (EC 2.1.2.1) from Helicobacter pylori (see paper)
54% identity, 97% coverage of query (453 bits)
GLYA2_MYCTU / P9WGI7 Serine hydroxymethyltransferase 2; SHM2; SHMT 2; Serine methylase 2; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WGI7 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see paper)
54% identity, 98% coverage of query (451 bits)
GLYA1_MYCTU / P9WGI9 Serine hydroxymethyltransferase 1; SHM1; SHMT 1; Serine methylase 1; EC 2.1.2.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WGI9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Mycobacterium tuberculosis (see 2 papers)
53% identity, 98% coverage of query (432 bits)
6uldA Crystal structure of serine hydroxymethyltransferase from mycobacterium tuberculosis with bound plp forming a schiff base with substrate serine in one monomer and plp forming a schiff base with product glycine in the other monomer
53% identity, 98% coverage of query (431 bits)
MSHMT_PARSX / B2DEU7 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Paracoccus sp.
50% identity, 99% coverage of query (413 bits)
MSHMT_AMISX / B2DEU8 2-methylserine hydroxymethyltransferase; MSHMT; AHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EC 2.1.2.7 from Aminobacter sp. (see paper)
B2DEU8 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Aminobacter sp. AJ110403 (see paper)
51% identity, 98% coverage of query (412 bits)
MSHMT_ENSSX / B2DEV1 2-methylserine hydroxymethyltransferase; MSHMT; Alpha-methylserine hydroxymethyltransferase; D-alanine 2-hydroxymethyltransferase; EHMT; EC 2.1.2.7 from Ensifer sp. (see paper)
B2DEV1 D-alanine 2-hydroxymethyltransferase (EC 2.1.2.7) from Ensifer sp. AJ110404 (see paper)
49% identity, 99% coverage of query (404 bits)
8t4pA Serine hydroxymethyltransferase, mitochondrial
49% identity, 91% coverage of query (377 bits)
GLYM_SCHPO / Q10104 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
47% identity, 97% coverage of query (376 bits)
8aqlA High-resolution crystal structure of human shmt2
49% identity, 91% coverage of query (376 bits)
6qvlA Human shmt2 in complex with pemetrexed
49% identity, 91% coverage of query (376 bits)
6qvgA Human shmt2 in complex with lometrexol
49% identity, 91% coverage of query (376 bits)
7e13A Caprylic acid targets a serine hydroxymethyltransferase to kill horseweed
50% identity, 90% coverage of query (374 bits)
GLYC_SHEEP / P35623 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Ovis aries (Sheep) (see paper)
48% identity, 91% coverage of query (372 bits)
8t4oA Serine hydroxymethyltransferase, mitochondrial
49% identity, 91% coverage of query (372 bits)
6m5oA Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with pyridoxal 5'-phosphate (plp) and glycodeoxycholic acid
49% identity, 91% coverage of query (372 bits)
5v7iA Crystal structure of homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (shmt2), in complex with glycine, plp and folate- competitive pyrazolopyran inhibitor: 6-amino-4-isopropyl-3-methyl-4- (3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2, 3-c]pyrazole-5-carbonitrile
49% identity, 91% coverage of query (372 bits)
SHMT2 / P34897 serine hydroxymethyltransferase (EC 2.1.2.1) from Homo sapiens (see 4 papers)
GLYM_HUMAN / P34897 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Homo sapiens (Human) (see 9 papers)
P34897 glycine hydroxymethyltransferase (EC 2.1.2.1) from Homo sapiens (see 6 papers)
49% identity, 91% coverage of query (371 bits)
GLYP3_ARATH / Q94JQ3 Serine hydroxymethyltransferase 3, chloroplastic; AtSHM3; AtSHMT3; Glycine hydroxymethyltransferase 3; Serine methylase 3; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q94JQ3 glycine hydroxymethyltransferase (EC 2.1.2.1) from Arabidopsis thaliana (see paper)
50% identity, 92% coverage of query (371 bits)
8fjtA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf362 inhibitor
48% identity, 91% coverage of query (371 bits)
SHM1 / P37292 serine hydroxymethyltransferase, mitochondrial (EC 2.1.2.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see paper)
GLYM_YEAST / P37292 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
47% identity, 91% coverage of query (370 bits)
8tlcA Serine hydroxymethyltransferase, mitochondrial
49% identity, 91% coverage of query (370 bits)
8fjuA Human mitochondrial serine hydroxymethyltransferase (shmt2) in complex with plp, glycine and agf347 inhibitor
48% identity, 91% coverage of query (370 bits)
Q7SXN1 glycine hydroxymethyltransferase (EC 2.1.2.1) from Danio rerio (see paper)
46% identity, 95% coverage of query (369 bits)
GLYM_EREGS / Q758F0 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Eremothecium gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Ashbya gossypii) (see paper)
47% identity, 92% coverage of query (369 bits)
7byiA / P34897 Structure of shmt2 in complex with cbx
49% identity, 91% coverage of query (369 bits)
GLYM_MOUSE / Q9CZN7 Serine hydroxymethyltransferase, mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Mus musculus (Mouse) (see 2 papers)
48% identity, 91% coverage of query (363 bits)
SHM1 / Q9SZJ5 serine hydroxymethyltransferase (EC 2.1.2.1) from Arabidopsis thaliana (see 7 papers)
GLYM1_ARATH / Q9SZJ5 Serine hydroxymethyltransferase 1, mitochondrial; AtSHMT1; Glycine hydroxymethyltransferase 1; Serine Transhydroxymethyltransferase; STM; Serine methylase 1; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
48% identity, 91% coverage of query (362 bits)
6cd1A / G7ILW0 Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates (see paper)
50% identity, 91% coverage of query (362 bits)
GLYM2_ARATH / Q94C74 Serine hydroxymethyltransferase 2, mitochondrial; AtSHMT2; Glycine hydroxymethyltransferase 2; Serine methylase 2; EC 2.1.2.1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
48% identity, 91% coverage of query (362 bits)
6cczA Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3) soaked with selenourea
50% identity, 91% coverage of query (362 bits)
6cd1E Crystal structure of medicago truncatula serine hydroxymethyltransferase 3 (mtshmt3), complexes with reaction intermediates
50% identity, 91% coverage of query (362 bits)
SHMT / Q8W4V3 serine hydroxymethyltransferase (EC 2.1.2.1) from Chlamydomonas reinhardtii (see paper)
46% identity, 98% coverage of query (361 bits)
G7ILW0 glycine hydroxymethyltransferase (EC 2.1.2.1) from Medicago truncatula (see paper)
50% identity, 91% coverage of query (361 bits)
6smnD / Q94C74 A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with methotrexate (see paper)
48% identity, 91% coverage of query (360 bits)
6smwC A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
48% identity, 91% coverage of query (360 bits)
6smwB A. Thaliana serine hydroxymethyltransferase isoform 2 (atshmt2) in complex with pemetrexed
48% identity, 91% coverage of query (360 bits)
GLYC_CANAL / O13426 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; SHMII; Serine methylase; EC 2.1.2.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
SHM2 serine hydroxymethyltransferase; EC 2.1.2.1 from Candida albicans (see paper)
47% identity, 92% coverage of query (357 bits)
A9LDD9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Danio rerio (see paper)
46% identity, 91% coverage of query (356 bits)
F2QZA4 glycine hydroxymethyltransferase (EC 2.1.2.1) from Komagataella pastoris (see paper)
47% identity, 92% coverage of query (353 bits)
P50432 Serine hydroxymethyltransferase; SHMT; Glycine hydroxymethyltransferase; Glycosylation-related protein 1; Maternal effect lethal protein 32; Serine methylase; EC 2.1.2.1 from Caenorhabditis elegans
47% identity, 91% coverage of query (353 bits)
GLYC_BOMMO / Q2F5L3 Serine hydroxymethyltransferase; SHMT; Glycine hydroxymethyltransferase; Serine methylase; bmSHMT; EC 2.1.2.1 from Bombyx mori (Silk moth) (see paper)
47% identity, 91% coverage of query (349 bits)
1rvyA E75q mutant of rabbit cytosolic serine hydroxymethyltransferase, complex with glycine
50% identity, 91% coverage of query (349 bits)
1ls3A Crystal structure of the complex between rabbit cytosolic serine hydroxymethyltransferase and triglu-5-formyl-tetrahydrofolate
50% identity, 91% coverage of query (349 bits)
1ls3C Crystal structure of the complex between rabbit cytosolic serine hydroxymethyltransferase and triglu-5-formyl-tetrahydrofolate
50% identity, 91% coverage of query (348 bits)
GLYC_RABIT / P07511 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
49% identity, 91% coverage of query (347 bits)
1rv3B / P07511 E75l mutant of rabbit cytosolic serine hydroxymethyltransferase, complex with glycine (see paper)
49% identity, 91% coverage of query (345 bits)
Q86LS9 glycine hydroxymethyltransferase (EC 2.1.2.1) from Leishmania donovani (see paper)
48% identity, 91% coverage of query (345 bits)
1ejiA / P50431 Recombinant serine hydroxymethyltransferase (mouse) (see paper)
49% identity, 91% coverage of query (344 bits)
SHMT1 / P34896 serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) from Homo sapiens (see 7 papers)
GLYC_HUMAN / P34896 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Homo sapiens (Human) (see 5 papers)
49% identity, 91% coverage of query (344 bits)
8a11B Cryo-em structure of the human shmt1-RNA complex
49% identity, 91% coverage of query (344 bits)
6m5wA Co-crystal structure of human serine hydroxymethyltransferase 1 in complex with pyridoxal 5'-phosphate (plp) and glycodeoxycholic acid
49% identity, 91% coverage of query (344 bits)
1bj4A Recombinant serine hydroxymethyltransferase (human)
49% identity, 91% coverage of query (344 bits)
GLYC_MOUSE / P50431 Serine hydroxymethyltransferase, cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine methylase; EC 2.1.2.1 from Mus musculus (Mouse) (see paper)
49% identity, 91% coverage of query (343 bits)
Build an alignment for 16650 and 99 homologs with ≥ 30% identity
Or download the sequences
Or start over
Lawrence Berkeley National Laboratory