Searching for up to 100 curated homologs for 17013 FitnessBrowser__Keio:17013 (147 a.a.)
Found high-coverage hits (≥70%) to 20 curated proteins.
Removed hits that are identical to the query, leaving 19
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
UlaC L-ascorbate specific PTS enzyme IIA component (EC 2.7.1.194) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
UlaC / P69820 L-ascorbate specific PTS enzyme IIA component (EC 2.7.1.194) from Escherichia coli (strain K12) (see 2 papers)
ULAC_ECOLI / P69820 Ascorbate-specific PTS system EIIA component; Ascorbate-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12) (see 3 papers)
TC 4.A.7.1.1 / P69820 SgaA aka B4195, component of The L-ascorbate transporting and phosphorylating group translocator, SgaTBA or UlaCBA (SgaT = UlaA = YjfS; SgaB = UlaB = YjfT; SgaA = UlaC = PtxA = YjfU) (Hvorup et al., 2003; Zhang et al., 2003). Two conformations of the 3-d structure have been determined at 1.65 and 2.35 Å resolution, respectively (Luo et al., 2015). UlaA (SgaT) forms a homodimer with a novel fold. Each UlaA protomer consists of 11 TMSs arranged into a 'V-motif' domain and a 'core' domain. The V motifs form the interface between the two protomers, and the core-domain residues coordinate vitamin C. Alternating access of the substrate to the two sides of the cell membrane may be achieved through rigid-body rotation of the core relative to the V motif (Luo et al., 2015; Zhang et al., 2003). This structure does not resemble the ChbC structure (TC# 4.A.3.2.8) from Escherichia coli (see 6 papers)
ulaC / RF|NP_418616 PTS system ascorbate-specific EIIA component; EC 2.7.1.- from Escherichia coli K12 (see 6 papers)
37% identity, 99% coverage of query (103 bits)
YjhL / b4302 putative PTS enzyme IIA component SgcA from Escherichia coli K-12 substr. MG1655 (see paper)
sgcA / P39363 putative PTS enzyme IIA component SgcA from Escherichia coli (strain K12) (see paper)
TC 4.A.5.1.3 / P39363 Putative phosphotransferase IIA component sgcA, component of Paralogous system of the E. coli galactitol PTS permease system, SgcABC (SgcC is annotated as a KpLE2 phage-like element) from Escherichia coli (strain K12) (see 3 papers)
38% identity, 88% coverage of query (94.7 bits)
SgaR2 / VIMSS7471841 SgaR2 regulator of Ascorbate utilization, effector SgaB2, ascorbate-specific PTS system, EIIB component; HPr, phosphocarrier protein from Streptococcus dysgalactiae subsp. equisimilis GGS_124
40% identity, 88% coverage of query (91.7 bits)
SgaR2 / VIMSS3591184 SgaR2 regulator of Ascorbate utilization, effector SgaB2, ascorbate-specific PTS system, EIIB component; HPr, phosphocarrier protein from Streptococcus suis 05ZYH33
38% identity, 84% coverage of query (85.1 bits)
SgaR2 / VIMSS10161800 SgaR2 regulator of Ascorbate utilization, effector SgaB2, ascorbate-specific PTS system, EIIB component; HPr, phosphocarrier protein from Streptococcus mitis B6
35% identity, 86% coverage of query (84.7 bits)
SgaR2 / VIMSS5937003 SgaR2 regulator of Ascorbate utilization, effector SgaB2, ascorbate-specific PTS system, EIIB component; HPr, phosphocarrier protein from Streptococcus uberis 0140J
32% identity, 98% coverage of query (82.4 bits)
SgaR2 / VIMSS5803672 SgaR2 regulator of Ascorbate utilization, effector SgaB2, ascorbate-specific PTS system, EIIB component; HPr, phosphocarrier protein from Streptococcus equi subsp. zooepidemicus MGCS10565
34% identity, 85% coverage of query (77.4 bits)
Build an alignment for 17013 and 7 homologs with ≥ 30% identity
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PTMA_STACT / P17876 Mannitol-specific phosphotransferase enzyme IIA component; EIIA; EIII; PTS system mannitol-specific EIIA component from Staphylococcus carnosus (strain TM300) (see paper)
25% identity, 94% coverage of query (57.4 bits)
TC 4.A.2.1.4 / P71012 The fructose porter, FruA (fructose-1-P forming IIABC) (Delobbe et al. 1975) FruA is 39% identical to 4.A.2.1.1). fructose can be metabolized to Fru-1-P via this system as well as Fru-6-P by another PTS system from Bacillus subtilis (see paper)
29% identity, 99% coverage of query (53.9 bits)
1j6tA / P00550 Complex of enzyme iiamtl and the histidine-containing phosphocarrier protein hpr from escherichia coli nmr, restrained regularized mean structure (see paper)
29% identity, 88% coverage of query (53.5 bits)
MtlC / b3599 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
mtlA / P00550 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli (strain K12) (see 24 papers)
PTM3C_ECOLI / P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12) (see 6 papers)
P00550 protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197) from Escherichia coli (see 7 papers)
TC 4.A.2.1.2 / P00550 Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex from Escherichia coli (see 9 papers)
mtlA / GB|AAC76623.1 PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12 (see 9 papers)
28% identity, 97% coverage of query (52.0 bits)
TC 4.A.2.1.5 / C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component, component of The mannitol porter (MtlA) (mannitol-1-P forming), MtlAF from Bacillus subtilis (strain 168)
25% identity, 93% coverage of query (50.1 bits)
C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component; EIIA; EIII; PTS system mannitol-specific EIIA component from Bacillus subtilis (strain 168)
25% identity, 93% coverage of query (50.1 bits)
TC 4.A.2.1.12 / Q9KKQ7 The mannitol/glucitol transporter, MtlA (IICBAMtl) from Vibrio cholerae (see paper)
29% identity, 88% coverage of query (47.0 bits)
AO353_05485 Fructose-specific PTS system, I, HPr, and IIA components from Pseudomonas fluorescens FW300-N2E3
28% identity, 90% coverage of query (47.0 bits)
AO356_07335 fructose-specific PTS system (fructose 1-phosphate forming), EI, Hpr, and EII-A components from Pseudomonas fluorescens FW300-N2C3
27% identity, 90% coverage of query (44.3 bits)
PTFAH_HAEIN / P44715 Multiphosphoryl transfer protein; MTP; Diphosphoryl transfer protein; DTP; Phosphotransferase FPr protein; Pseudo-HPr from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
24% identity, 93% coverage of query (43.9 bits)
PS417_03965 fructose-specific PTS system (fructose 1-phosphate forming), EI, Hpr, and EII-A components from Pseudomonas simiae WCS417
27% identity, 90% coverage of query (43.5 bits)
Pf1N1B4_1146 fructose-specific PTS system (fructose 1-phosphate forming), EI, Hpr, and EII-A components from Pseudomonas fluorescens FW300-N1B4
27% identity, 90% coverage of query (43.1 bits)
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