Searching for up to 100 curated homologs for 17164 FitnessBrowser__Keio:17164 (414 a.a.)
Found high-coverage hits (≥70%) to 26 curated proteins.
Removed hits that are identical to the query, leaving 25
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 9 papers)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii (see 2 papers)
27% identity, 96% coverage of query (121 bits)
Sama_1319 symporter for L-glutamate, L-glutamine, and L-aspartate from Shewanella amazonensis SB2B
29% identity, 93% coverage of query (120 bits)
6x15A / O59010 Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
27% identity, 96% coverage of query (114 bits)
2nwwA Crystal structure of gltph in complex with tboa
27% identity, 93% coverage of query (112 bits)
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa
27% identity, 95% coverage of query (111 bits)
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine
27% identity, 93% coverage of query (111 bits)
6bauA Crystal structure of gltph r397c in complex with l-cysteine
27% identity, 93% coverage of query (111 bits)
5e9sA / Q5JID0 Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
27% identity, 96% coverage of query (108 bits)
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor
27% identity, 96% coverage of query (108 bits)
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound
27% identity, 95% coverage of query (107 bits)
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis)
27% identity, 93% coverage of query (106 bits)
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate
27% identity, 93% coverage of query (105 bits)
6bmiA Crystal structure of gltph r397c in complex with l-serine
29% identity, 73% coverage of query (100 bits)
Psest_4075 symporter for L-glutamate, L-glutamine, and L-proline from Pseudomonas stutzeri RCH2
27% identity, 93% coverage of query (92.8 bits)
AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
23% identity, 83% coverage of query (85.9 bits)
DctA / b3528 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
dctA / P0A830 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli (strain K12) (see 23 papers)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12) (see 6 papers)
dctA / GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli (see 5 papers)
24% identity, 81% coverage of query (83.6 bits)
TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
24% identity, 83% coverage of query (81.6 bits)
GltP / b4077 glutamate/aspartate : H+ symporter GltP from Escherichia coli K-12 substr. MG1655 (see paper)
gltP / P21345 glutamate/aspartate : H+ symporter GltP from Escherichia coli (strain K12) (see 5 papers)
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli (see 6 papers)
24% identity, 94% coverage of query (77.8 bits)
GLTT_BACSU / O07605 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus subtilis (strain 168) (see 2 papers)
24% identity, 97% coverage of query (77.4 bits)
DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
23% identity, 82% coverage of query (77.4 bits)
TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
25% identity, 82% coverage of query (73.9 bits)
EAA1_AMBTI / O57321 Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST from Ambystoma tigrinum (Eastern tiger salamander) (see 2 papers)
23% identity, 78% coverage of query (73.6 bits)
AAAT_MOUSE / P51912 Neutral amino acid transporter B(0); ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Mus musculus (Mouse) (see 4 papers)
TC 2.A.23.3.2 / P51912 Insulin-activated, Na+-dependet amino acid (serine, alanine, glutamate, glutamine and other neutral amino acids):amino acid antiporter (Ndaru et al. 2019). Also transports homocysteine from Mus musculus (Mouse) (see 2 papers)
Slc1a5 neutral amino acid transporter B(0) from Mus musculus (see paper)
28% identity, 73% coverage of query (73.6 bits)
TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis (see 2 papers)
23% identity, 81% coverage of query (71.6 bits)
TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
23% identity, 82% coverage of query (69.3 bits)
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Lawrence Berkeley National Laboratory