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Searching for up to 100 curated homologs for 17168 FitnessBrowser__Keio:17168 (472 a.a.)

Found high-coverage hits (≥70%) to 26 curated proteins.

Removed hits that are identical to the query, leaving 24

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HSERO_RS23010 D-galacturonate transporter ExuT from Herbaspirillum seropedicae SmR1
    58% identity, 83% coverage of query (477 bits)

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Build an alignment for 17168 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Pf1N1B4_5129 D-galacturonate transporter ExuT from Pseudomonas fluorescens FW300-N1B4
    28% identity, 76% coverage of query (160 bits)

CA265_RS19855 D-galacturonate transporter ExuT from Pedobacter sp. GW460-11-11-14-LB5
    28% identity, 89% coverage of query (154 bits)

BT4105 D-galacturonate transporter ExuT from Bacteroides thetaiotaomicron VPI-5482
    29% identity, 80% coverage of query (151 bits)

YidT / b3691 D-galactonate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 9 papers)
dgoT / P0AA76 D-galactonate:H+ symporter from Escherichia coli (strain K12) (see 11 papers)
DGOT_ECOLI / P0AA76 D-galactonate transporter; D-galactonate/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.14.7 / P0AA76 Galactonate transporter from Escherichia coli (see 4 papers)
    27% identity, 85% coverage of query (148 bits)

6e9nA / J7QAK3 E. Coli d-galactonate:proton symporter in the inward open form (see paper)
    27% identity, 85% coverage of query (145 bits)

6e9oA E. Coli d-galactonate:proton symporter mutant e133q in the outward substrate-bound form
    27% identity, 85% coverage of query (134 bits)

SAUU_CUPNH / Q0K843 Probable sulfoacetate transporter SauU from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
    27% identity, 82% coverage of query (131 bits)

GarP / b3127 galactarate/D-glucarate transporter GarP from Escherichia coli K-12 substr. MG1655 (see 6 papers)
garP / P0AA80 galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 5 papers)
GARP_ECOLI / P0AA80 Probable galactarate/D-glucarate transporter GarP from Escherichia coli (strain K12) (see 2 papers)
    26% identity, 82% coverage of query (128 bits)

TC 2.A.1.14.14 / Q8FDB7 Probable D-galactarate (glucarate?):H+ symporter, GarP or YhaU from Escherichia coli O6 (see paper)
    26% identity, 82% coverage of query (128 bits)

PS417_04205 D-galacturonate transporter (MFS superfamily) from Pseudomonas simiae WCS417
    26% identity, 81% coverage of query (122 bits)

GUDP_BACSU / P42237 Probable galactarate/D-glucarate transporter GudP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.14.1 / P42237 Glucarate porter from Bacillus subtilis (see 3 papers)
    24% identity, 90% coverage of query (117 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    24% identity, 78% coverage of query (109 bits)

AO356_28540 D-mannose transporter from Pseudomonas fluorescens FW300-N2C3
    24% identity, 90% coverage of query (95.9 bits)

ANTR2_ARATH / Q8GX78 Ascorbate transporter, chloroplastic; Phosphate transporter PHT4;4; AtPHT4;4; Probable anion transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
    24% identity, 85% coverage of query (95.1 bits)

YfaV / b2246 putative transporter YfaV from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TC 2.A.1.14.35 / P76470 Inner membrane transport protein RhmT from Escherichia coli (strain K12) (see 4 papers)
    23% identity, 88% coverage of query (86.3 bits)

S17A5_HUMAN / Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 10 papers)
TC 2.A.1.14.10 / Q9NRA2 Lysosomal sialate transporter (Salla disease and infantile sialate storage disease protein (Morin et al., 2004)). Also transports glucuronic acid and aspartate. Structure-function studies have identify crucial residues and substrate-induced conformational changes (Courville et al., 2010). Also called SLC17A5. The substrate binding pocket has been identified based on modeling studies (see 8 papers)
    23% identity, 75% coverage of query (84.3 bits)

ANTR1_ARATH / O82390 Sodium-dependent phosphate transport protein 1, chloroplastic; Anion transporter 1; Na(+)/PI cotransporter 1; Phosphate transporter PHT4;1; Sodium/phosphate cotransporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
O82390 ABC-type phosphate transporter (EC 7.3.2.1) from Arabidopsis thaliana (see 2 papers)
TC 2.A.1.14.22 / O82390 The chloroplast thylakoid Na+:phosphate symporter, ANTR1 (512aas) (Pavón et al., 2008). Residues essential for function have been identified from Arabidopsis thaliana (see 7 papers)
    23% identity, 87% coverage of query (73.6 bits)

BWI76_RS23725 2-deoxy-D-ribonate transporter 2 from Klebsiella michiganensis M5al
    22% identity, 90% coverage of query (71.6 bits)

NPT1_HUMAN / Q14916 Sodium-dependent phosphate transport protein 1; Na(+)/PI cotransporter 1; Na/Pi-4; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.1.14.27 / Q14916 Voltage-driven Na+:phosphate cotransporter; solute carrier family 17, member 1 from Homo sapiens (see 7 papers)
    24% identity, 82% coverage of query (70.1 bits)

TC 2.A.1.4.2 / P12681 P-glycerate:Pi antiporter, Pgt from Salmonella typhimurium (see 2 papers)
    22% identity, 89% coverage of query (69.7 bits)

Q9HTV5 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Pseudomonas aeruginosa (see paper)
    23% identity, 89% coverage of query (65.9 bits)

BWI76_RS23715 2-deoxy-D-ribonate transporter 1 from Klebsiella michiganensis M5al
    21% identity, 82% coverage of query (64.7 bits)

TC 2.A.1.8.11 / Q93PW1 NarK, component of The 24 TMS, 2 domain, NarK1-NarK2 porter (NarK1 = a NO3-/H+ symporter; NarK2 = a NO3-/NO2- antiporter) from Paracoccus pantotrophus (Thiosphaera pantotropha) (see paper)
    25% identity, 84% coverage of query (63.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory