Searching for up to 100 curated homologs for 17199 b3126 alpha-dehydro-beta-deoxy-D-glucarate aldolase (NCBI) (256 a.a.)
Found high-coverage hits (≥70%) to 30 curated proteins.
Removed hits that are identical to the query, leaving 27
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
HPCH_ECOLX / Q47098 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; HHED aldolase; 4-hydroxy-2-ketoheptane-1,7-dioate aldolase; HKHD aldolase; EC 4.1.2.52 from Escherichia coli (see 3 papers)
B1IS70 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52) from Escherichia coli (see paper)
Q47098 4-hydroxy-2-oxoheptanedioate aldolase (EC 4.1.2.52); 4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39) from Escherichia coli (see 3 papers)
50% identity, 91% coverage of query (229 bits)
2v5kA / Q47098 Class ii aldolase hpch - magnesium - oxamate complex (see paper)
50% identity, 91% coverage of query (229 bits)
4b5vA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with 4-hydroxyl-2-ketoheptane-1,7-dioate
50% identity, 91% coverage of query (229 bits)
4b5tA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with ketobutyrate
50% identity, 91% coverage of query (229 bits)
4b5sA Crystal structures of divalent metal dependent pyruvate aldolase, hpai, in complex with pyruvate
50% identity, 91% coverage of query (229 bits)
7et9A / A0A8I1ZEE8 Crystal structure of abhpai-zn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii (see paper)
45% identity, 97% coverage of query (226 bits)
7etiA Crystal structure of abhpai-zn-pyruvate-4-hydroxybenzaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7etfA Crystal structure of abhpai-mn-pyruvate-succinic semialdehyde complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7eteA Crystal structure of abhpai-mg-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7etdA Crystal structure of abhpai-zn-(4s)-kdglu complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7etcA Crystal structure of abhpai-zn-(4r)-kdgal complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7etbA Crystal structure of abhpai-mn-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7etaA Crystal structure of abhpai-co-pyruvate complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
7ethA Crystal structure of abhpai-zn-pyruvate-propionaldehyde complex, class ii aldolase, hpai from acinetobacter baumannii
45% identity, 97% coverage of query (226 bits)
2vwtA / P76469 Crystal structure of yfau, a metal ion dependent class ii aldolase from escherichia coli k12 - mg-pyruvate product complex (see paper)
44% identity, 99% coverage of query (217 bits)
YfaU / b2245 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yfaU / P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli (strain K12) (see 4 papers)
RHMA_ECOLI / P76469 2-keto-3-deoxy-L-rhamnonate aldolase; KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; EC 4.1.2.53 from Escherichia coli (strain K12) (see 2 papers)
P76469 2-keto-3-deoxy-L-rhamnonate aldolase (EC 4.1.2.53) from Escherichia coli (see 3 papers)
44% identity, 99% coverage of query (217 bits)
BPHF_RHOJR / O05151 4-hydroxy-2-oxovalerate aldolase; HOA; EC 4.1.3.39 from Rhodococcus jostii (strain RHA1) (see paper)
44% identity, 97% coverage of query (211 bits)
KDSGA_PSEPU / P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase; 2-keto-3,6-dideoxy-6-sulfogluconate aldolase; KDSG aldolase; EC 4.1.2.58 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
P0DOV8 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase (EC 4.1.2.58) from Pseudomonas putida (see paper)
39% identity, 95% coverage of query (197 bits)
7nr1A Crystal structure of holo-s116a mutant of hydroxy ketone aldolase (swhka) from sphingomonas wittichii rw1 (see paper)
32% identity, 95% coverage of query (139 bits)
8adqA / A0A9J9HGY6 Crystal structure of holo-swhpa-mg (hydroxy ketone aldolase) from sphingomonas wittichii rw1 in complex with hydroxypyruvate and d- glyceraldehyde (see paper)
32% identity, 95% coverage of query (138 bits)
7o5rA Crystal structure of holo-swhpa-mn (hydroxyketoacid aldolase) from sphingomonas wittichii rw1
32% identity, 95% coverage of query (138 bits)
A0A0H3K9Z0 citrate synthase (unknown stereospecificity) (EC 2.3.3.16) from Staphylococcus aureus (see paper)
30% identity, 92% coverage of query (112 bits)
Build an alignment for 17199 and 22 homologs with ≥ 30% identity
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4tv5A / A0A0H3K9Z0 Crystal structure of citrate synthase sbng (see paper)
29% identity, 92% coverage of query (110 bits)
4tv6A Crystal structure of citrate synthase variant sbng e151q
28% identity, 92% coverage of query (99.4 bits)
TASA_HAPIR / A0A0F7GG11 4-hydroxy-4-methyl-2-oxoglutarate aldolase tasA; Tetramic acid Sch210971/2 biosynthesis cluster protein A; EC 4.1.3.17 from Hapsidospora irregularis (see paper)
29% identity, 89% coverage of query (83.2 bits)
CGHB_CHAGB / Q2HBN5 4-hydroxy-4-methyl-2-oxoglutarate aldolase cghB; Sch210972 biosynthesis cluster protein B; EC 4.1.3.17 from Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus) (see paper)
27% identity, 88% coverage of query (81.6 bits)
1izcA / Q9UVD4 Crystal structure analysis of macrophomate synthase (see paper)
30% identity, 81% coverage of query (72.4 bits)
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Lawrence Berkeley National Laboratory