Searching for up to 100 curated homologs for 17213 FitnessBrowser__Keio:17213 (263 a.a.)
Found high-coverage hits (≥70%) to 26 curated proteins.
Removed hits that are identical to the query, leaving 25
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 4.A.6.1.4 / Q9KIQ2 AgaE, component of N-acetyl galactosamine (GalNAc or Aga) porter (used the same IIA protein (AgaF) as does 4.A.6.1.5) from Escherichia coli (see paper)
42% identity, 97% coverage of query (206 bits)
TC 4.A.6.1.14 / Q8DR74 Phosphotransferase system sugar-specific EII component, component of Probable PTS uptake porter (IIA - IID) of disaccharides of gluconate and N-acetyglucosamine derived from degradation of hyaluronate and chondroitin by hyaluronidase (Marion et al. 2012). The cytoplasmic disaccharide may be hydrolyzed by the enzyme Ugl from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
37% identity, 99% coverage of query (176 bits)
ManZ / b1819 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ManZ / P69805 mannose-specific PTS enzyme IID component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli (strain K12) (see 5 papers)
PTND_ECOLI / P69805 PTS system mannose-specific EIID component; EII-M-Man; EIID-Man; Mannose permease IID component from Escherichia coli (strain K12) (see 9 papers)
35% identity, 99% coverage of query (163 bits)
TC 4.A.6.1.1 / P69805 PTND aka MANZ aka PTSM aka GPTB aka B1819, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli (see 7 papers)
35% identity, 99% coverage of query (163 bits)
7dyrZ / P69805 Cryoem structure of mannose transporter manyz and microcin e492 (mcea) complex (see paper)
35% identity, 99% coverage of query (163 bits)
7xnoZ / Q38YH5 Cryo-em structure of the bacteriocin-receptor-immunity ternary complex from lactobacillus sakei (see paper)
33% identity, 96% coverage of query (161 bits)
7vlxZ / A0A1E8EBU8 Cryo-em structures of listeria monocytogenes man-pts (see paper)
34% identity, 99% coverage of query (159 bits)
TC 4.A.6.1.25 / CAQ67971.1 CAQ67971.1 Putative phosphotransferase system enzyme II, component of D-ribitol (D-aldonitol) (a pentitol) PTS Enzyme II complex RtlABCD from Lactobacillus casei BL23
39% identity, 93% coverage of query (158 bits)
TC 4.A.6.1.15 / E1UCI2 PTS system, mannose/fructose/sorbose family, IID component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
33% identity, 99% coverage of query (157 bits)
TC 4.A.6.1.9 / Q97N94 PTS system, IID component, component of The fucose PTS uptake transporter, IIA/IIB/IIC/IIDFuc (FcsABCD) (Manzoor et al. 2015). Expression in response to fucose is under the control of the FcsR transcriptional activator, and its DNA binding site has been identified from Streptococcus pneumoniae (see paper)
37% identity, 100% coverage of query (155 bits)
gfrD / A0A0F6BB80 fructoselysine/glucoselysine PTS enzyme IID component from Salmonella typhimurium (strain 14028s / SGSC 2262) (see paper)
TC 4.A.6.1.19 / V7RGM6 PTS mannose transporter subunit IID, component of PTS uptake system for glucoselysine and fructoselysine, GfrABCD from Salmonella enterica subsp. enterica serovar Give var. 15 str. CFSAN004343
33% identity, 98% coverage of query (153 bits)
TC 4.A.6.1.16 / Q8Y8W1 Lmo0781 protein, component of Constitutively synthesized sensor, MpoABCD, controlling man operon (see TC# 4.A.6.1.15) expression by interacting with and phosphorylating ManR, the transcriptional regulator of the man operon from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
34% identity, 99% coverage of query (152 bits)
TC 4.A.6.1.6 / Q2QKM2 ManN aka EIID, component of Glucose porter, ManLMN from Lactobacillus casei (see paper)
32% identity, 93% coverage of query (150 bits)
PTRD_LACCA / Q9RGG2 PTS system sorbose-specific EIID component; EIID-Sor; Sorbose permease IID component from Lacticaseibacillus casei (Lactobacillus casei) (see paper)
Q9RGG2 protein-Npi-phosphohistidine-L-sorbose phosphotransferase (subunit 1/4) (EC 2.7.1.206) from Lacticaseibacillus casei (see paper)
37% identity, 99% coverage of query (148 bits)
TC 4.A.6.1.2 / P26382 PTFD aka LEVG, component of Fructose group translocator, LevDEFG from Bacillus subtilis (see 3 papers)
36% identity, 99% coverage of query (147 bits)
Q5IRC0 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Streptococcus suis (see paper)
31% identity, 99% coverage of query (145 bits)
TC 4.A.6.1.7 / Q5M5W8 ManN, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
30% identity, 99% coverage of query (143 bits)
TC 4.A.6.1.13 / B3WB11 PTS system, IID component, component of Fucosyl-α-1,3-N-acetylglucosamine PTS uptake porter, AlfEFG (next to an operon encoding a fucosidase (AlfB) and a transcriptional regulator of the GntR family, AlfR) from Lactobacillus casei (strain BL23)
35% identity, 99% coverage of query (142 bits)
PTRD_KLEPN / P37083 PTS system sorbose-specific EIID component; EIID-Sor; Sorbose permease IID component from Klebsiella pneumoniae (see 2 papers)
TC 4.A.6.1.3 / P37083 PTRD aka SORM, component of Sorbose porter from Klebsiella pneumoniae (see 2 papers)
36% identity, 99% coverage of query (140 bits)
TC 4.A.6.1.11 / D2BKY9 Mannose-specific PTS system, IID component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147) (see 2 papers)
32% identity, 96% coverage of query (139 bits)
TC 4.A.6.1.10 / Q04GJ9 PTS system IID component, Man family, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1) (see paper)
36% identity, 73% coverage of query (138 bits)
8hfsZ / D2BKY9 The structure of lcna, lcia, and the man-pts of lactococcus lactis (see paper)
32% identity, 96% coverage of query (138 bits)
dgaD / A0A0F6B8S5 D-glucosaminate PTS permease components EIID (EC 2.7.1.203) from Salmonella typhimurium (strain 14028s / SGSC 2262) (see paper)
TC 4.A.6.1.17 / D0ZLR4 Putative phosphotransferase system enzyme II, component of D-glucosaminate group translocating uptake porter, DgaABCD (IIA-141 aas, IIB-161 aas, IIC-249 aas, and IID-285 aas, respectively) from Salmonella typhimurium (strain 14028s / SGSC 2262)
32% identity, 98% coverage of query (132 bits)
TC 4.A.6.1.18 / B3W756 Phosphotransferase system sugar-specific EIID component, component of Uptake porter/group translocator of galacto N-biose (Gal-β-1,3-GalNAc: galactose linked β-1,3 to N-acetylgalactosamine), lacto N-biose (Gal-β-1,3-GlcNAc: galactose linked β-1,3 to N-acetylglucosamine), and D-N-acetylgalactosamine (Bidart et al. 2014). The system is designated the GnbABCD system where GnbA = IIA, GnbB = IIB, GnbC = IIC, and GnbD = IID of the mannose-type PTS Enzyme II complex from Lactobacillus casei (strain BL23)
31% identity, 99% coverage of query (129 bits)
TC 4.A.6.1.8 / Q82ZC6 PTS system, IID component, component of The gluconate PTS uptake system. IIAGnt and IIBGnt form a high affinity 2:2 heterotetrameric complex from Enterococcus faecalis (see paper)
32% identity, 97% coverage of query (103 bits)
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Lawrence Berkeley National Laboratory