Searching for up to 100 curated homologs for 17275 FitnessBrowser__Keio:17275 (163 a.a.)
Found high-coverage hits (≥70%) to 14 curated proteins.
Removed hits that are identical to the query, leaving 13
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 4.A.2.1.7 / Q1LZ59 The fructose inducible fructose/xylitol porter, FruI from Streptococcus mutans UA159 (see paper)
26% identity, 96% coverage of query (70.5 bits)
MngA 2-O-α-mannosyl-D-glycerate specific PTS enzyme II (EC 2.7.1.195) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
MngA / P54745 2-O-α-mannosyl-D-glycerate specific PTS enzyme II (EC 2.7.1.195) from Escherichia coli (strain K12) (see 5 papers)
MNGA_ECOLI / P54745 PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component; 2-O-alpha-mannosyl-D-glycerate-specific phosphotransferase enzyme MngA; Protein-Npi-phosphohistidine--2-O-alpha-mannosyl-D-glycerate phosphotransferase; EC 2.7.1.195 from Escherichia coli (strain K12) (see 2 papers)
P54745 protein-Npi-phosphohistidine-2-O-alpha-mannosyl-D-glycerate phosphotransferase (EC 2.7.1.195) from Escherichia coli (see paper)
TC 4.A.2.1.3 / P54745 The 2-O-α-mannosyl D-glycerate porter (2-O-α-mannosyl D-glycerate-6-P forming), MngA (HrsA) from Escherichia coli (see 5 papers)
28% identity, 96% coverage of query (69.7 bits)
TC 4.A.2.1.20 / Q3K0G6 Chromosomal fructose Enzyme IIABC (Fru1) of 654 aas; in an operon with fructose-1-P kinase from Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
28% identity, 87% coverage of query (69.3 bits)
PTN3B_BACSU / O31645 PTS system mannose-specific EIIBCA component; EIIBCA-Man; EII-Man; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see 2 papers)
O31645 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Bacillus subtilis (see paper)
TC 4.A.2.1.6 / O31645 The mannose porter (ManP) (37% identical to 4.A.2.1.1). It is encoded in an operon with 3 genes: from Bacillus subtilis (see 5 papers)
31% identity, 77% coverage of query (67.8 bits)
TC 4.A.2.1.4 / P71012 The fructose porter, FruA (fructose-1-P forming IIABC) (Delobbe et al. 1975) FruA is 39% identical to 4.A.2.1.1). fructose can be metabolized to Fru-1-P via this system as well as Fru-6-P by another PTS system from Bacillus subtilis (see paper)
27% identity, 94% coverage of query (67.4 bits)
PTFA_HALVD / D4GYE4 PTS system fructose-specific EIIA component; EIIA-Fru; Fructose-specific phosphotransferase enzyme IIA component from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
TC 4.A.2.1.15 / D4GYE4 Sugar phosphotransferase system IIA component, component of Fructose-specific PTS, PtfABC from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see paper)
32% identity, 79% coverage of query (66.6 bits)
Q8DWE6 protein-Npi-phosphohistidine-D-fructose phosphotransferase (subunit 1/2) (EC 2.7.1.202) from Streptococcus mutans serotype c (see paper)
TC 4.A.2.1.8 / Q1LZ68 Constitutive fructose permease aka FruD, component of The constitutive fructose porter FruC/FruD from Streptococcus mutans UA159 (see paper)
27% identity, 80% coverage of query (60.5 bits)
TC 4.A.2.1.22 / Q3JZE3 PTS system, fructose-specific, IIA component, component of D-allose/D-ribose transporting Enzyme II complex (Fru2; IIA/IIB/IIC) (Patron et al. 2017). This system is similar to Frz of E. coli (TC#4.A.2.1.9) which is involved in environmental sensing, host adaptation and virulence from Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
27% identity, 88% coverage of query (59.3 bits)
TC 4.A.2.1.9 / Q1R4S9 Putative phosphotransferase system (PTS), fructose-specific, component of The FrzABC PTS putative transporter (promotes bacterial fitness under stress conditions and promotes fimbrial (fim) gene expression indirectly (Rouquet et al., 2009). Might transport D-tagatose, D-psicose and/or D-sorbose, or a disaccharide of these (Rouquet et al. 2009); involved in environmental sensing, host adaptation and virulence from Escherichia coli (strain UTI89 / UPEC) (see paper)
30% identity, 90% coverage of query (52.8 bits)
UlaC L-ascorbate specific PTS enzyme IIA component (EC 2.7.1.194) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
UlaC / P69820 L-ascorbate specific PTS enzyme IIA component (EC 2.7.1.194) from Escherichia coli (strain K12) (see 2 papers)
ULAC_ECOLI / P69820 Ascorbate-specific PTS system EIIA component; Ascorbate-specific phosphotransferase enzyme IIA component from Escherichia coli (strain K12) (see 3 papers)
TC 4.A.7.1.1 / P69820 SgaA aka B4195, component of The L-ascorbate transporting and phosphorylating group translocator, SgaTBA or UlaCBA (SgaT = UlaA = YjfS; SgaB = UlaB = YjfT; SgaA = UlaC = PtxA = YjfU) (Hvorup et al., 2003; Zhang et al., 2003). Two conformations of the 3-d structure have been determined at 1.65 and 2.35 Å resolution, respectively (Luo et al., 2015). UlaA (SgaT) forms a homodimer with a novel fold. Each UlaA protomer consists of 11 TMSs arranged into a 'V-motif' domain and a 'core' domain. The V motifs form the interface between the two protomers, and the core-domain residues coordinate vitamin C. Alternating access of the substrate to the two sides of the cell membrane may be achieved through rigid-body rotation of the core relative to the V motif (Luo et al., 2015; Zhang et al., 2003). This structure does not resemble the ChbC structure (TC# 4.A.3.2.8) from Escherichia coli (see 6 papers)
ulaC / RF|NP_418616 PTS system ascorbate-specific EIIA component; EC 2.7.1.- from Escherichia coli K12 (see 6 papers)
26% identity, 90% coverage of query (49.3 bits)
MtlC / b3599 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
mtlA / P00550 mannitol-specific PTS enzyme IICBA component (EC 2.7.1.197; EC 2.7.1.198) from Escherichia coli (strain K12) (see 24 papers)
PTM3C_ECOLI / P00550 PTS system mannitol-specific EIICBA component; EIICBA-Mtl; EII-Mtl; EC 2.7.1.197 from Escherichia coli (strain K12) (see 6 papers)
P00550 protein-Npi-phosphohistidine-D-mannitol phosphotransferase (EC 2.7.1.197) from Escherichia coli (see 7 papers)
TC 4.A.2.1.2 / P00550 Mannitol porter (MtlA) (mannitol-1-P forming), the mannitol IICBA complex from Escherichia coli (see 9 papers)
mtlA / GB|AAC76623.1 PTS system mannitol-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Escherichia coli K12 (see 9 papers)
26% identity, 78% coverage of query (48.9 bits)
1j6tA / P00550 Complex of enzyme iiamtl and the histidine-containing phosphocarrier protein hpr from escherichia coli nmr, restrained regularized mean structure (see paper)
26% identity, 78% coverage of query (45.4 bits)
PTFAH_SALTY / P17127 Multiphosphoryl transfer protein; MTP; Diphosphoryl transfer protein; DTP; Phosphotransferase FPr protein; Pseudo-HPr from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
27% identity, 80% coverage of query (44.7 bits)
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Lawrence Berkeley National Laboratory