Searching for up to 100 curated homologs for 17326 FitnessBrowser__Keio:17326 (449 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
Removed hits that are identical to the query, leaving 83
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
1dv2A / P24182 The structure of biotin carboxylase, mutant e288k, complexed with atp (see paper)
100% identity, 100% coverage of query (918 bits)
2vr1A Crystal structure of biotin carboxylase from e. Coli in complex with atp analog, adpcf2p.
100% identity, 99% coverage of query (907 bits)
1dv1A Structure of biotin carboxylase (apo)
97% identity, 99% coverage of query (879 bits)
2j9gA Crystal structure of biotin carboxylase from e. Coli in complex with amppnp and adp
100% identity, 99% coverage of query (877 bits)
2j9gB Crystal structure of biotin carboxylase from e. Coli in complex with amppnp and adp
98% identity, 99% coverage of query (870 bits)
1dv1B / P24182 Structure of biotin carboxylase (apo) (see paper)
96% identity, 100% coverage of query (865 bits)
4mv4A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and mg2
82% identity, 99% coverage of query (766 bits)
6oi8A Crystal structure of haemophilus influenzae biotin carboxylase complexed with 7-((1r,5s,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)- 6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine
81% identity, 99% coverage of query (761 bits)
4mv3A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with amppcp and bicarbonate
81% identity, 99% coverage of query (759 bits)
P43873 biotin carboxylase (EC 6.3.4.14) from Haemophilus influenzae (see paper)
82% identity, 100% coverage of query (751 bits)
P43873 Biotin carboxylase; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
82% identity, 100% coverage of query (751 bits)
6ojhA / P43873 Crystal structure of haemophilus influenzae biotin carboxylase complexed with (r)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl) pyrido[2,3-d]pyrimidin-2-amine
82% identity, 99% coverage of query (748 bits)
4mv1A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with adp and phosphate
80% identity, 99% coverage of query (735 bits)
4rzqA / P43873 Structural analysis of substrate, reaction intermediate and product binding in haemophilus influenzae biotin carboxylase (see paper)
78% identity, 99% coverage of query (713 bits)
3jzfA / P24182 Crystal structure of biotin carboxylase from e. Coli in complex with benzimidazoles series (see paper)
80% identity, 100% coverage of query (698 bits)
4mv7A Crystal structure of biotin carboxylase form haemophilus influenzae in complex with phosphonoformate
77% identity, 99% coverage of query (697 bits)
4mv6A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with phosphonoacetamide
77% identity, 99% coverage of query (694 bits)
4mv9A Crystal structure of biotin carboxylase from haemophilus influenzae in complex with bicarbonate
76% identity, 99% coverage of query (690 bits)
2vqdA / P37798 Crystal structure of biotin carboxylase from pseudomonas aeruginosa complexed with ampcp (see paper)
72% identity, 99% coverage of query (672 bits)
C1DLJ7 biotin carboxylase (EC 6.3.4.14) from Azotobacter vinelandii (see paper)
71% identity, 100% coverage of query (654 bits)
A4SVB6 biotin carboxylase (EC 6.3.4.14) from Polynucleobacter asymbioticus QLW-P1DMWA-1 (see paper)
69% identity, 100% coverage of query (619 bits)
Q12EJ0 biotin carboxylase (EC 6.3.4.14) from Polaromonas sp. (see paper)
66% identity, 100% coverage of query (605 bits)
Q3A2P1 biotin carboxylase (EC 6.3.4.14) from Syntrophotalea carbinolica (see paper)
60% identity, 98% coverage of query (537 bits)
PYCA_METJA / Q58626 Pyruvate carboxylase subunit A; Pyruvic carboxylase A; EC 6.4.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
58% identity, 100% coverage of query (515 bits)
Q54755 biotin carboxylase (EC 6.3.4.14) from Synechococcus sp. (see paper)
56% identity, 99% coverage of query (509 bits)
Q10YA8 biotin carboxylase (EC 6.3.4.14) from Trichodesmium erythraeum (see paper)
57% identity, 100% coverage of query (502 bits)
pycA / O27939 pyruvate carboxylase subunit A (EC 6.4.1.1) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
55% identity, 98% coverage of query (502 bits)
F2WMV4 biotin carboxylase (EC 6.3.4.14) from Jatropha curcas (see paper)
55% identity, 98% coverage of query (490 bits)
CAC2 / O04983 biotin carboxylase (EC 6.3.4.14) from Arabidopsis thaliana (see paper)
ACCC_ARATH / O04983 Biotin carboxylase, chloroplastic; Acetyl-coenzyme A carboxylase biotin carboxylase subunit A; EC 6.3.4.14 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
54% identity, 98% coverage of query (486 bits)
pycA / Q6M0D0 pyruvate carboxylase subunit A (EC 6.4.1.1) from Methanococcus maripaludis (strain S2 / LL) (see paper)
53% identity, 99% coverage of query (483 bits)
2vpqB / A0A0H3JRR2 Crystal structure of biotin carboxylase from s. Aureus complexed with amppnp (see paper)
54% identity, 98% coverage of query (472 bits)
A4APF1 biotin carboxylase (EC 6.3.4.14) from Maribacter sp. HTCC2170 (see paper)
54% identity, 98% coverage of query (466 bits)
8hz4A / A9W9X0 The tetrameric structure of biotin carboxylase from chloroflexus aurantiacus in complex with bicarbonate
53% identity, 98% coverage of query (452 bits)
7kctA / D3DJ42 Crystal structure of the hydrogenobacter thermophilus 2-oxoglutarate carboxylase (ogc) biotin carboxylase (bc) domain dimer in complex with adenosine 5'-diphosphate magnesium salt (mgadp), adenosine 5'- diphosphate (adp, and bicarbonate anion (hydrogen carbonate/hco3-) (see paper)
53% identity, 98% coverage of query (446 bits)
2OCS_HYDTT / D3DJ42 2-oxoglutarate carboxylase small subunit; 2-oxoglutarate carboxylase beta subunit; EC 6.4.1.7 from Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6) (see 2 papers)
53% identity, 98% coverage of query (446 bits)
atuF / Q9HZV6 cis-geranyl-CoA carboxylase α-subunit (EC 6.4.1.5) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
51% identity, 99% coverage of query (445 bits)
3ouuA / Q0P8W7 Crystal structure of biotin carboxylase-beta-gamma-atp complex from campylobacter jejuni
53% identity, 98% coverage of query (439 bits)
3ouzA Crystal structure of biotin carboxylase-adp complex from campylobacter jejuni
53% identity, 98% coverage of query (439 bits)
accC / A9W9X0 biotin carboxylase (EC 6.3.4.14) from Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) (see paper)
A9W9X0 biotin carboxylase (EC 6.3.4.14) from Chloroflexus aurantiacus (see paper)
53% identity, 98% coverage of query (437 bits)
Dsui_0516 Propionyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.3) from Dechlorosoma suillum PS
50% identity, 99% coverage of query (431 bits)
MCCA_MOUSE / Q99MR8 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Mus musculus (Mouse) (see paper)
49% identity, 98% coverage of query (431 bits)
MCCC1 / Q96RQ3 3-methylcrotonyl-CoA carboxylase α subunit (EC 6.4.1.4) from Homo sapiens (see 4 papers)
MCCA_HUMAN / Q96RQ3 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Homo sapiens (Human) (see 15 papers)
48% identity, 100% coverage of query (427 bits)
A0A1U7EYC1 biotin carboxylase (EC 6.3.4.14) from Natronomonas pharaonis (see paper)
48% identity, 99% coverage of query (426 bits)
PCCA_PIG / P0DTA4 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Sus scrofa (Pig) (see paper)
50% identity, 98% coverage of query (426 bits)
xccC / Q5P8S2 4-hydroxyacetophenone carboxylase biotin carboxylase subunit from Aromatoleum aromaticum (strain EbN1) (see paper)
48% identity, 97% coverage of query (424 bits)
MCCA_ORYSJ / Q2QMG2 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Oryza sativa subsp. japonica (Rice) (see paper)
48% identity, 98% coverage of query (424 bits)
PCCA_HALMT / I3R7G3 Propionyl-CoA carboxylase, biotin carboxylase and biotin-carboxyl carrier subunit; PCC; EC 6.4.1.3; EC 6.3.4.14 from Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) (see paper)
I3R7G3 propionyl-CoA carboxylase (subunit 3/3) (EC 6.4.1.3) from Haloferax mediterranei (see paper)
48% identity, 99% coverage of query (423 bits)
AO356_01595 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2C3
52% identity, 96% coverage of query (422 bits)
Sama_1359 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Shewanella amazonensis SB2B
51% identity, 98% coverage of query (421 bits)
Pf6N2E2_2194 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N2E2
52% identity, 96% coverage of query (421 bits)
7ybuA / P05165 Human propionyl-coenzyme a carboxylase
49% identity, 98% coverage of query (418 bits)
Pf1N1B4_3984 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Pseudomonas fluorescens FW300-N1B4
51% identity, 96% coverage of query (418 bits)
Q9FAF5 biotin carboxylase (EC 6.3.4.14) from Myxococcus xanthus (see paper)
48% identity, 100% coverage of query (417 bits)
PCCA / P05165 propionyl-CoA carboxylase α chain, mitochondrial (EC 6.4.1.3) from Homo sapiens (see 4 papers)
PCCA_HUMAN / P05165 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Homo sapiens (Human) (see 11 papers)
P05165 propionyl-CoA carboxylase (subunit 1/2) (EC 6.4.1.3) from Homo sapiens (see paper)
49% identity, 98% coverage of query (417 bits)
PYC_BACSU / Q9KWU4 Pyruvate carboxylase; Pyruvic carboxylase; PYC; EC 6.4.1.1 from Bacillus subtilis (strain 168) (see 2 papers)
47% identity, 98% coverage of query (417 bits)
SM_b21124 3-methylcrotonyl-CoA carboxylase, alpha (biotin-containing) subunit (EC 6.4.1.4) from Sinorhizobium meliloti 1021
50% identity, 99% coverage of query (416 bits)
MCCA_ARATH / Q42523 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; MCCase subunit alpha; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q42523 methylcrotonoyl-CoA carboxylase (EC 6.4.1.4) from Arabidopsis thaliana (see 2 papers)
48% identity, 98% coverage of query (416 bits)
8sgxX / A0A640KC69 Leishmania tarentolae propionyl-coa carboxylase (alpha-4-beta-6) (see paper)
48% identity, 98% coverage of query (416 bits)
PCCA_MOUSE / Q91ZA3 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Mus musculus (Mouse) (see paper)
49% identity, 98% coverage of query (416 bits)
ACCA1_MYCTU / P9WPQ3 Biotin-dependent 3-methylcrotonyl-coenzyme A carboxylase alpha1 subunit; EC 6.3.4.14 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CAA79609.1 biotin carboxyl carrier protein from Mycobacterium tuberculosis (see paper)
47% identity, 99% coverage of query (415 bits)
Pcca / P14882 propionyl-CoA carboxylase α subunit (EC 6.4.1.3) from Rattus norvegicus (see paper)
49% identity, 98% coverage of query (414 bits)
PCCA_CAEEL / Q19842 Propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha; EC 6.4.1.3 from Caenorhabditis elegans (see paper)
Q19842 propionyl-CoA carboxylase (subunit 2/2) (EC 6.4.1.3) from Caenorhabditis elegans (see paper)
48% identity, 98% coverage of query (413 bits)
Msed_0147 / A4YD22 acyl CoA carboxylase biotin carboxyl carrier protein subunit from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
Q8J2Z4 biotin carboxylase (EC 6.3.4.14); acetyl-CoA carboxylase (EC 6.4.1.2) from Metallosphaera sedula (see 2 papers)
47% identity, 99% coverage of query (409 bits)
5vyzA Crystal structure of lactococcus lactis pyruvate carboxylase in complex with cyclic-di-amp (see paper)
46% identity, 99% coverage of query (403 bits)
7zz3A Cryo-em structure of "bc react" conformation of lactococcus lactis pyruvate carboxylase with acetyl-coa
46% identity, 99% coverage of query (403 bits)
7zyyA Cryo-em structure of lactococcus lactis pyruvate carboxylase with acetyl-coa
46% identity, 99% coverage of query (402 bits)
liuD / Q9I299 methylcrotonyl-CoA carboxylase α-subunit (EC 6.4.1.4) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I299 methylcrotonoyl-CoA carboxylase (subunit 2/2) (EC 6.4.1.4) from Pseudomonas aeruginosa (see 3 papers)
52% identity, 96% coverage of query (398 bits)
Q9HPP8 biotin carboxylase (EC 6.3.4.14) from Halobacterium salinarum (see paper)
47% identity, 99% coverage of query (398 bits)
accC / Q877I5 acyl CoA carboxylase biotin carboxylase subunit (EC 2.1.3.15; EC 6.4.1.3; EC 6.3.4.14) from Acidianus brierleyi (see 2 papers)
Q877I5 biotin carboxylase (EC 6.3.4.14); acetyl-CoA carboxylase (subunit 2/3) (EC 6.4.1.2); propionyl-CoA carboxylase (subunit 1/3) (EC 6.4.1.3) from Acidianus brierleyi (see 2 papers)
accC / BAC55867.1 biotin carboxylase subunit of acetyl-CoA carboxylase from Acidianus brierleyi (see paper)
46% identity, 98% coverage of query (395 bits)
Dshi_0723 Propionyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.3) from Dinoroseobacter shibae DFL-12
45% identity, 99% coverage of query (395 bits)
PCCA_RUEPO / Q5LUF3 Propionyl-CoA carboxylase alpha chain; EC 6.4.1.3 from Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi) (see paper)
Q5LUF3 propionyl-CoA carboxylase (EC 6.4.1.3) from Ruegeria pomeroyi (see paper)
45% identity, 99% coverage of query (394 bits)
PYC_STAAM / A0A0H3JRU9 Pyruvate carboxylase; EC 6.4.1.1 from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 3 papers)
A0A0H3JRU9 pyruvate carboxylase (EC 6.4.1.1) from Staphylococcus aureus (see 4 papers)
43% identity, 98% coverage of query (391 bits)
3n6rG / Q5LUF3 Crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc) (see paper)
45% identity, 98% coverage of query (388 bits)
PYC_MOUSE / Q05920 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Mus musculus (Mouse) (see paper)
44% identity, 98% coverage of query (375 bits)
3tw6B / Q2K340 Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a (see paper)
44% identity, 98% coverage of query (375 bits)
7wtbB / P11498 Cryo-em structure of human pyruvate carboxylase with acetyl-coa (see paper)
44% identity, 98% coverage of query (372 bits)
7wtdC Cryo-em structure of human pyruvate carboxylase with acetyl-coa in the intermediate state 1
44% identity, 98% coverage of query (372 bits)
PC / P11498 pyruvate carboxylase, mitochondrial (EC 6.4.1.1) from Homo sapiens (see 5 papers)
PYC_HUMAN / P11498 Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase; PCB; EC 6.4.1.1 from Homo sapiens (Human) (see 5 papers)
P11498 pyruvate carboxylase (EC 6.4.1.1) from Homo sapiens (see 5 papers)
44% identity, 98% coverage of query (371 bits)
3bg5A / A0A0H3JRU9 Crystal structure of staphylococcus aureus pyruvate carboxylase (see paper)
42% identity, 98% coverage of query (370 bits)
3hb9A Crystal structure of s. Aureus pyruvate carboxylase a610t mutant
42% identity, 98% coverage of query (360 bits)
3tw6C Structure of rhizobium etli pyruvate carboxylase t882a with the allosteric activator, acetyl coenzyme-a
42% identity, 98% coverage of query (353 bits)
8gk8A R21a staphylococcus aureus pyruvate carboxylase
41% identity, 98% coverage of query (340 bits)
PYC1_YEAST / P11154 Pyruvate carboxylase 1; Pyruvic carboxylase 1; PCB 1; EC 6.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P11154 pyruvate carboxylase (EC 6.4.1.1) from Saccharomyces cerevisiae (see 2 papers)
46% identity, 96% coverage of query (332 bits)
Build an alignment for 17326 and 83 homologs with ≥ 30% identity
Or download the sequences
Or start over
Lawrence Berkeley National Laboratory