Searching for up to 100 curated homologs for 17584 b3523 predicted transporter (NCBI) (440 a.a.)
Found high-coverage hits (≥70%) to 28 curated proteins.
Removed hits that are identical to the query, leaving 27
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ABAF_ACIBT / P0DPR5 Fosfomycin resistance protein AbaF; Acinetobacter baumannii fosfomycin efflux from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see paper)
38% identity, 95% coverage of query (280 bits)
YeeM / b1981 shikimate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
shiA / P76350 shikimate:H+ symporter from Escherichia coli (strain K12) (see 3 papers)
SHIA_ECOLI / P76350 Shikimate transporter; Shikimate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.1.6.6 / P76350 Shikimate:H+ symporter from Escherichia coli (see 5 papers)
36% identity, 99% coverage of query (259 bits)
TC 2.A.1.6.5 / Q45082 4-Methyl-o-phthalate:H+ symporter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
35% identity, 99% coverage of query (237 bits)
ProP proline/betaine MFS transporter / b4111 osmolyte:H+ symporter ProP from Escherichia coli K-12 substr. MG1655 (see 64 papers)
proP / P0C0L7 osmolyte:H+ symporter ProP from Escherichia coli (strain K12) (see 66 papers)
PROP_ECOLI / P0C0L7 Proline/betaine transporter; Proline porter II; PPII from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.6.4 / P0C0L7 (Proline/glycine-betaine):(H+/Na+) symporter, ProP (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1-carboxymethyl-pyridinium) (subject to osmotic activation). Transmembrane helix I and periplasmic loop 1 are involved in osmosensing and osmoprotectant transport from Escherichia coli (see 6 papers)
proP / RF|NP_418535 proline porter II from Escherichia coli K12 (see 22 papers)
proP / AAB00919.1 a proline/betaine transporter from Escherichia coli (see paper)
33% identity, 98% coverage of query (236 bits)
OUSA_DICD3 / Q47421 Glycine betaine/proline/ectoine/pipecolic acid transporter OusA; Osmoprotectant uptake system A from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see 3 papers)
33% identity, 95% coverage of query (223 bits)
SHIA_CORGB / A4QH18 Shikimate transporter; Shikimate permease from Corynebacterium glutamicum (strain R) (see paper)
36% identity, 85% coverage of query (209 bits)
AO353_03810 Alpha-ketoglutarate permease, MFS superfamily from Pseudomonas fluorescens FW300-N2E3
33% identity, 96% coverage of query (202 bits)
AO356_17790 alpha-ketoglutarate permease (MHS family) from Pseudomonas fluorescens FW300-N2C3
33% identity, 96% coverage of query (201 bits)
TC 2.A.1.6.13 / M1Q159 Acetate/monochloroacetate permease, Deh4p, of 468 aas and 12 TMSs from Dehalococcoides mccartyi DCMB5
33% identity, 95% coverage of query (195 bits)
TC 2.A.1.6.8 / Q7X4L6 The acetate/monochloroacetate (haloacid) permease, Deh4p (Km = 5.5 mμM for acetate; 9 mμM for monochloroacetate) from Burkholderia cepacia (see 2 papers)
35% identity, 82% coverage of query (191 bits)
YdfJ / b1543 putative transporter YdfJ from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YDFJ_ECOLI / P77228 Putative transporter YdfJ from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.9 / P77228 YdfJ. Can function as an inward rectifying K+ channel when expressed in animal cells as measured by whole cell patch clamping. Blocked by barium and protopine from Escherichia coli (strain K12) (see 4 papers)
30% identity, 92% coverage of query (187 bits)
WitA / b2587 α-ketoglutarate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
kgtP / P0AEX3 α-ketoglutarate:H+ symporter from Escherichia coli (strain K12) (see 6 papers)
KGTP_ECOLI / P0AEX3 Alpha-ketoglutarate permease from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.2 / P0AEX3 α-Ketoglutarate (oxoglutarate):H+ symporter from Escherichia coli (see 9 papers)
31% identity, 98% coverage of query (186 bits)
TC 2.A.1.6.11 / F8SVK1 Acetate/haloacid transporter, Dehp2, with a possible atypical topology from Burkholderia sp. MBA4
34% identity, 78% coverage of query (181 bits)
HSERO_RS16820 2-oxoglutarate:H+ symporter from Herbaspirillum seropedicae SmR1
32% identity, 96% coverage of query (174 bits)
TC 2.A.1.6.3 / Q52000 Dicarboxylate:H+ symporter from Pseudomonas putida
34% identity, 89% coverage of query (173 bits)
TC 2.A.1.6.1 / P16482 Citrate:H+ symporter from Klebsiella pneumoniae (see paper)
31% identity, 85% coverage of query (164 bits)
TC 3.A.7.9.1 / Q5ZYB5 TphA aka ProP, component of The Icm/Dot or Dot/Icm multicomponent protein secretion system. IcmS and IcmW form a complex that interacts with and may translocate substrate proteins (Ninio et al., 2005; De Buck et al., 2007; Cambronne and Roy, 2007). The crystal structure of the IcmR-IcmQ complex has been solved (Raychaudhury et al., 2009). Legionella pneumophila survives and replicates inside host cells by secreting ~300 effectors through the defective in organelle trafficking (Dot)/intracellular multiplication (Icm) type IVB secretion system (T4BSS). Ghosal et al. 2019, using electron cryotomography mapped the location of the core and accessory components of the Legionella core transmembrane subcomplex, revealing a well-ordered central channel that opens into a large, windowed secretion chamber with an unusual 13-fold symmetry. Immunofluorescence microscopy deciphered an early-stage assembly process that begins with the targeting of Dot/Icm components to the bacterial poles. Polar targeting of this T4BSS is mediated by two Dot/Icm proteins, DotU and IcmF, that are homologues of the T6SS membrane complex components TssL and TssM, suggesting that the Dot/Icm T4BSS is a hybrid system. Thus, the Dot/Icm complex assembles in an 'axial-to-peripheral' pattern from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) (see paper)
32% identity, 88% coverage of query (163 bits)
citA / GB|AAA88472.1 citrate transporter from Escherichia coli (see paper)
30% identity, 92% coverage of query (162 bits)
Build an alignment for 17584 and 18 homologs with ≥ 30% identity
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tcuC / P0A2G3 propane-1,2,3-tricarboxylate-proton symporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
CITA_SALTY / P0A2G3 Citrate-proton symporter; Citrate carrier protein; Citrate transporter; Citrate utilization determinant; Citrate utilization protein A from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 2.A.1.6.7 / P0A2G3 The citrate/tricarballylate:H+ symporter (CitA or TcuC); probably orthologous to 2.A.1.6.1 from Salmonella typhimurium (see 2 papers)
29% identity, 96% coverage of query (159 bits)
PROP_CORGL / Q79VC4 Ectoine/proline transporter ProP from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
29% identity, 99% coverage of query (150 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
27% identity, 96% coverage of query (99.0 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
28% identity, 95% coverage of query (92.0 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
25% identity, 97% coverage of query (87.8 bits)
P36035 Carboxylic acid transporter protein homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
26% identity, 83% coverage of query (59.3 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
23% identity, 74% coverage of query (50.8 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
23% identity, 74% coverage of query (48.9 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
23% identity, 74% coverage of query (48.9 bits)
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Lawrence Berkeley National Laboratory