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Searching for up to 100 curated homologs for 17782 FitnessBrowser__Keio:17782 (625 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

Removed hits that are identical to the query, leaving 16

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

abgF / AAC05713.1 PTS-dependent enzyme II from Clostridium longisporum (see paper)
    44% identity, 100% coverage of query (519 bits)

TC 4.A.1.2.14 / ART98499 PTS beta-glucoside transporter, EIIBCA of 672 aas and 12 predicted TMSs from Lactobacillus gasseri
    39% identity, 99% coverage of query (510 bits)

TC 4.A.1.2.6 / Q9KJ80 β-glucoside (Aesculin/arbutin) porter, BglP from Streptococcus mutans (see paper)
    39% identity, 100% coverage of query (419 bits)

bglP / CAA84286.1 beta-glucoside permease from Bacillus subtilis (see paper)
    39% identity, 99% coverage of query (412 bits)

TC 4.A.1.2.11 / P40739 Aryl β-glucoside porter, IIBCA (BglP; SytA) (35% identical to 4.A.1.2.2) from Bacillus subtilis (see 5 papers)
    39% identity, 99% coverage of query (412 bits)

TC 4.A.1.2.5 / Q8GGK3 β-glucoside (methyl-β-glucoside, salicin, arbutin) porter, BglF [a V317A or V317M mutation allows it to transport cellobiose as well] from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
bglF / AAO15901.1 PTS enzyme II BCA protein from Corynebacterium glutamicum (see paper)
    41% identity, 97% coverage of query (395 bits)

TC 4.A.1.2.15 / ART98417 PTS beta-glucoside transporter, EIIBCA of 624 aas and 10 predicted TMSs from Lactobacillus gasseri
    34% identity, 97% coverage of query (358 bits)

TC 4.A.1.2.16 / ART98386 PTS beta-glucoside transporter, EIIBCA of 647 aas and 10 predicted TMSs from Lactobacillus gasseri
    31% identity, 100% coverage of query (314 bits)

PTS3B_STRMU / P12655 PTS system sucrose-specific EIIBCA component; EIIBCA-Scr; EII-Scr; EC 2.7.1.211 from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 2 papers)
P12655 protein-Npi-phosphohistidine-sucrose phosphotransferase (EC 2.7.1.211) from Streptococcus mutans serotype c (see 3 papers)
scrA / GB|AAN59464.1 PTS system, sucrose-specific, EIIBCA component; EC 2.7.1.69 from Streptococcus mutans (see paper)
    33% identity, 100% coverage of query (290 bits)

TC 4.A.1.2.12 / Q8NMD6 The sucrose porter, PtsS (regulated by SugR which also regulates other enzymes II) from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
    31% identity, 100% coverage of query (286 bits)

Build an alignment

Build an alignment for 17782 and 10 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q46072 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191); protein-Npi-phosphohistidine-D-glucose phosphotransferase (EC 2.7.1.199) from Corynebacterium glutamicum (see 2 papers)
ptsM / AAA53546.1 phosphoenolpyruvate sugar phosphotransferase from Corynebacterium glutamicum (see 2 papers)
    29% identity, 97% coverage of query (246 bits)

PS417_23050 trehalose PTS system, EII-BC components TreB from Pseudomonas simiae WCS417
    30% identity, 71% coverage of query (207 bits)

PTSBC_SALTM / P08470 PTS system sucrose-specific EIIBC component; EIIBC-Scr; EII-Scr; EC 2.7.1.211 from Salmonella typhimurium (see paper)
TC 4.A.1.2.1 / P08470 Sucrose porter (ScrA) from Salmonella typhimurium (see 4 papers)
    31% identity, 71% coverage of query (206 bits)

Sac / b2715 β-glucoside specific PTS enzyme IIBC component (EC 2.7.1.199) from Escherichia coli K-12 substr. MG1655 (see paper)
ascF / P24241 β-glucoside specific PTS enzyme IIBC component (EC 2.7.1.199) from Escherichia coli (strain K12) (see 7 papers)
PTIBC_ECOLI / P24241 PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component; EIIBC-Asc; EII-Asc; EC 2.7.1.- from Escherichia coli (strain K12) (see paper)
TC 4.A.1.2.3 / P24241 β-Glucoside [arbutin-salicin-cellobiose] (ASC) group translocator, AscF (see 5 papers)
    31% identity, 72% coverage of query (202 bits)

AO353_15980 trehalose PTS system, EII-BC components TreB from Pseudomonas fluorescens FW300-N2E3
    30% identity, 71% coverage of query (200 bits)

SACX_BACSU / P15400 Probable PTS system sucrose-specific EIIBC component; Negative regulator of SacY activity; EC 2.7.1.- from Bacillus subtilis (strain 168) (see 2 papers)
TC 4.A.1.2.10 / P15400 Sucrose porter and regulatory sensor, IIBC (SacX) (43% identical to 4.A.1.2.1) (Tortosa and Le Coq 1995). The IIA domains of PtsA, GamP, PtsG and GmuA can all phosphorylate the IIB domain in the SacX sensor from Bacillus subtilis (see 5 papers)
    31% identity, 72% coverage of query (198 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory