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Searching for up to 100 curated homologs for 18312 FitnessBrowser__Keio:18312 (318 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

Removed hits that are identical to the query, leaving 24

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.14.8 / Q8GRB1 PvuD, component of The iron-vibrioferrin uptake porter from Vibrio parahaemolyticus (see paper)
    47% identity, 87% coverage of query (230 bits)

FPUB_BACAN / Q81L64 Petrobactin import system permease protein FpuB from Bacillus anthracis (see paper)
    41% identity, 85% coverage of query (196 bits)

YFHA_BACSU / O31569 Probable siderophore transport system permease protein YfhA from Bacillus subtilis (strain 168) (see 2 papers)
    39% identity, 91% coverage of query (196 bits)

fhuG / GI|2832797 ferrichrome transport system permease protein FhuG from Bacillus subtilis (see paper)
    38% identity, 94% coverage of query (193 bits)

FEUC_BACSU / P40411 Iron-uptake system permease protein FeuC from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.14.15 / P40411 Iron-uptake system permease protein feuC, component of Uptake transporter for the catecholic trilactone (2, 3-dihydroxybenzoate-glycine-threonine)3 siderophore bacillibactin (for ferric iron scavenging), FeuABC from Bacillus subtilis (see 5 papers)
    32% identity, 100% coverage of query (180 bits)

TC 3.A.1.14.18 / Q32AY2 Putative permease of iron compound ABC transport system, component of The heme uptake porter, ShuTUV (Burkhard and Wilks, 2008). Transports a single heme per reaction cycle (Mattle et al., 2010). (3-d structure of ShuT is known (2RG7) from Shigella dysenteriae serotype 1 (strain Sd197) (see paper)
    38% identity, 93% coverage of query (180 bits)

hmuU / CAC34394.1 HmuU protein from Rhizobium leguminosarum (see paper)
    38% identity, 86% coverage of query (179 bits)

TC 3.A.1.14.5 / Q56992 HmuU aka YPO0280 aka Y0540, component of Heme (hemin) uptake porter. The receptor, HmuT, binds two parallel stacked heme molecules, and two are transported per reaction cycle from Yersinia pestis (see 4 papers)
    40% identity, 94% coverage of query (177 bits)

TC 3.A.1.14.16 / A8GDS7 HemU, component of The heme-specific uptake porter, HemTUV from Serratia proteamaculans (strain 568)
    40% identity, 93% coverage of query (170 bits)

TC 3.A.1.14.7 / Q9X664 FhuB, component of Iron (Fe3+)-hydroxamate porter (transports Fe3+-ferrichrome and Fe3+-ferrioxamine B with FhuD1, and these compounds plus aerobactin and coprogen with FhuD2) from Staphylococcus aureus (see 2 papers)
    33% identity, 88% coverage of query (162 bits)

feuC / GI|1256154 iron-uptake system permease protein FeuC from Bacillus subtilis (see 5 papers)
    32% identity, 93% coverage of query (158 bits)

FHUB_BACSU / P49936 Iron(3+)-hydroxamate import system permease protein FhuB; Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein FhuB; Iron(III)-hydroxamate import system permease protein FhuB from Bacillus subtilis (strain 168) (see paper)
fhuB / GI|2832796 ferrichrome transport system permease protein FhuB from Bacillus subtilis (see paper)
    35% identity, 95% coverage of query (158 bits)

BTUCA_HALSA / Q9HQ19 Cobalamin import system permease protein BtuC from Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) (see paper)
TC 3.A.1.14.9 / Q9HQ19 Iron (III) ABC transporter permease, component of The Corrinoid porter, BtuCDE from Halobacterium salinarium (Halobacterium halobium) (see paper)
    35% identity, 98% coverage of query (157 bits)

TC 3.A.1.14.8 / Q8GRB2 PvuC, component of The iron-vibrioferrin uptake porter from Vibrio parahaemolyticus (see paper)
    38% identity, 97% coverage of query (156 bits)

YFIZ_BACSU / O31568 Probable siderophore transport system permease protein YfiZ from Bacillus subtilis (strain 168) (see 2 papers)
    38% identity, 97% coverage of query (155 bits)

TC 3.A.1.14.12 / Q9L179 DesB, component of Desferrioxamine B uptake porter, DesABC from Streptomyces coelicolor (see paper)
    37% identity, 89% coverage of query (151 bits)

FEUB_BACSU / P40410 Iron-uptake system permease protein FeuB from Bacillus subtilis (strain 168) (see 4 papers)
TC 3.A.1.14.15 / P40410 Iron-uptake system permease protein feuB, component of Uptake transporter for the catecholic trilactone (2, 3-dihydroxybenzoate-glycine-threonine)3 siderophore bacillibactin (for ferric iron scavenging), FeuABC from Bacillus subtilis (see 4 papers)
feuB / GB|BAA19495.1 iron-uptake system permease protein feuB from Bacillus subtilis (see 4 papers)
    33% identity, 89% coverage of query (150 bits)

TC 3.A.1.14.10 / Q99YA3 Ferrichrome transport system permease protein, component of The heme porter, Shp/SiaABC (HtsABC). Shp is a cell surface heme binding protein that transfers the heme directly to HstA (Nygaard et al., 2006). The crystal structure of the heme binding domain of Shp has been solved (Aranda et al., 2007). HtsABC is required for the uptake of staphyloferrin A (Beasley et al. 2009). The Shp cell surface heme receptor feeds iron-heme to the transporter in preparation for uptake from Streptococcus pyogenes serotype M1 (see 2 papers)
    33% identity, 94% coverage of query (145 bits)

ISDF_STAAW / Q8NX64 Probable heme-iron transport system permease protein IsdF; Iron-regulated surface determinant protein F; Staphylococcal iron-regulated protein G from Staphylococcus aureus (strain MW2) (see paper)
    35% identity, 95% coverage of query (145 bits)

TC 3.A.1.14.17 / Q7A651 IsdF, component of Heme acquisition ABC uptake transporter, IsdDEF from Staphylococcus aureus (strain N315) (see paper)
    35% identity, 95% coverage of query (145 bits)

TC 3.A.1.14.4 / Q47085 CbrB, component of Iron-chrysobactine porter from Erwinia chrysanthemi (see paper)
    38% identity, 87% coverage of query (144 bits)

FecC / b4289 ferric citrate ABC transporter membrane subunit FecC (EC 7.2.2.18) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
FecC / P15030 ferric citrate ABC transporter membrane subunit FecC (EC 7.2.2.18) from Escherichia coli (strain K12) (see paper)
FECC_ECOLI / P15030 Fe(3+) dicitrate transport system permease protein FecC; Iron(III) dicitrate transport system permease protein FecC from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.14.1 / P15030 FecC aka B4289, component of Iron (Fe3+) or ferric-dicitrate porter from Escherichia coli (see 5 papers)
    38% identity, 85% coverage of query (134 bits)

FhuB / b0153 iron(III) hydroxamate ABC transporter membrane subunit (EC 7.2.2.16) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
FhuB / P06972 iron(III) hydroxamate ABC transporter membrane subunit (EC 7.2.2.16) from Escherichia coli (strain K12) (see 2 papers)
FHUB_ECOLI / P06972 Iron(3+)-hydroxamate import system permease protein FhuB; Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein FhuB; Ferrichrome uptake protein FhuB; Iron(III)-hydroxamate import system permease protein FhuB from Escherichia coli (strain K12) (see 7 papers)
TC 3.A.1.14.3 / P06972 FhuB aka B0153, component of Iron (Fe3+)-hydroxamate (ferrichrome, coprogen, aerobactin, ferrioxamine B, schizakinen, rhodotorulic acid) porter, albomycin porter from Escherichia coli (see 7 papers)
    37% identity, 85% coverage of query (124 bits)

5b57A / B4EKB4 Inward-facing conformation of abc heme importer bhuuv from burkholderia cenocepacia (see paper)
    35% identity, 95% coverage of query (95.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory