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Searching for up to 100 curated homologs for 18402 FitnessBrowser__Keio:18402 (259 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

Removed hits that are identical to the query, leaving 26

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1jcjA / P0A6L0 Observation of covalent intermediates in an enzyme mechanism at atomic resolution (see paper)
    100% identity, 97% coverage of query (508 bits)

6z9iB Escherichia coli d-2-deoxyribose-5-phosphate aldolase - n21k mutant complex with reaction products
    100% identity, 96% coverage of query (501 bits)

5el1A Crystal structure of deoxyribose-phosphate aldolase from escherichia coli (k58e-y96w mutant) after acetaldehyde treatment
    99% identity, 96% coverage of query (501 bits)

5ekyA Crystal structure of deoxyribose-phosphate aldolase from escherichia coli (k58e-y96w mutant)
    99% identity, 96% coverage of query (501 bits)

DEOC_SALTY / Q8ZJV8 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    97% identity, 100% coverage of query (467 bits)

Q7WT44 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Klebsiella pneumoniae (see paper)
    95% identity, 100% coverage of query (457 bits)

7p76A Re-engineered 2-deoxy-d-ribose-5-phosphate aldolase catalysing asymmetric michael addition reactions, schiff base complex with cinnamaldehyde
    95% identity, 95% coverage of query (451 bits)

8forA Crystal structure of kemp eliminase ke70-core with bound transition state analogue
    92% identity, 90% coverage of query (405 bits)

3q2dA Optimization of the in silico designed kemp eliminase ke70 by computational design and directed evolution
    91% identity, 91% coverage of query (402 bits)

DEOC_HUMAN / Q9Y315 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Homo sapiens (Human) (see paper)
Q9Y315 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Homo sapiens (see paper)
    38% identity, 93% coverage of query (166 bits)

A0A125YLW2 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Toxoplasma gondii (see paper)
    36% identity, 90% coverage of query (138 bits)

C7E719 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Paenibacillus sp. (see paper)
    38% identity, 87% coverage of query (102 bits)

D5AHU8 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Streptococcus suis (see paper)
    33% identity, 94% coverage of query (101 bits)

3ngjD / C4M5C6 Crystal structure of a putative deoxyribose-phosphate aldolase from entamoeba histolytica
    33% identity, 79% coverage of query (92.8 bits)

DEOC_THEKO / Q877I0 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
Q877I0 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Thermococcus kodakarensis (see paper)
    36% identity, 77% coverage of query (92.0 bits)

DEOC_BACSU / P39121 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Bacillus subtilis (strain 168) (see paper)
    35% identity, 82% coverage of query (91.7 bits)

Q9AIP7 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Streptococcus mutans (see paper)
    36% identity, 80% coverage of query (90.1 bits)

DEOC_ACIB4 / B5IEU6 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Aciduliprofundum boonei (strain DSM 19572 / T469)
    37% identity, 77% coverage of query (89.0 bits)

DEOC_THEMA / Q9X1P5 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    32% identity, 87% coverage of query (85.1 bits)

DEOC_RHOE4 / C0ZUQ6 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Rhodococcus erythropolis (strain PR4 / NBRC 100887) (see paper)
C0ZUQ6 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Rhodococcus erythropolis (see paper)
    33% identity, 79% coverage of query (83.2 bits)

DEOC_STRP6 / Q5XA31 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
    32% identity, 70% coverage of query (77.4 bits)

Build an alignment

Build an alignment for 18402 and 21 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3qyqA / B9PVB4 1.8 angstrom resolution crystal structure of a putative deoxyribose- phosphate aldolase from toxoplasma gondii me49 (see paper)
    29% identity, 75% coverage of query (73.9 bits)

deoC / C0LSK9 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Yersinia sp. EA015 (see paper)
C0LSK9 deoxyribose-phosphate aldolase (EC 4.1.2.4) from Yersinia sp. EA015 (see paper)
    31% identity, 78% coverage of query (73.9 bits)

DEOC_PSEU2 / Q4ZMV1 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Pseudomonas syringae pv. syringae (strain B728a) (see paper)
    30% identity, 98% coverage of query (69.3 bits)

DEOC_PYRAE / Q8ZXK7 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) (see paper)
    31% identity, 85% coverage of query (65.9 bits)

DEOC_AERPE / Q9Y948 Deoxyribose-phosphate aldolase; DERA; 2-deoxy-D-ribose 5-phosphate aldolase; Phosphodeoxyriboaldolase; Deoxyriboaldolase; EC 4.1.2.4 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) (see paper)
    29% identity, 76% coverage of query (57.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory