Searching for up to 100 curated homologs for 199958 FitnessBrowser__MR1:199958 (239 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
54% identity, 99% coverage of query (244 bits)
Build an alignment for 199958 and 1 homologs with ≥ 30% identity
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fabG / P51831 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Bacillus subtilis (strain 168) (see 3 papers)
27% identity, 96% coverage of query (76.3 bits)
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
27% identity, 99% coverage of query (75.1 bits)
gra-orf6 / BAD51477.1 ketoreductase from Streptomyces violaceoruber (see 3 papers)
24% identity, 99% coverage of query (74.7 bits)
pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
27% identity, 98% coverage of query (73.2 bits)
6j7uA / D6NKF4 Crystal structure of blue fluorescent protein from metagenomic library in complex with NADPH (see paper)
31% identity, 96% coverage of query (73.2 bits)
FABG_SALTY / P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
27% identity, 97% coverage of query (72.8 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
30% identity, 91% coverage of query (71.6 bits)
FabG / b1093 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
fabG / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC 1.1.1.100) from Escherichia coli (strain K12) (see 22 papers)
FABG_ECOLI / P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 9 papers)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Escherichia coli (see 2 papers)
27% identity, 97% coverage of query (70.9 bits)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+
27% identity, 97% coverage of query (70.9 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
27% identity, 97% coverage of query (69.7 bits)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment
27% identity, 97% coverage of query (69.7 bits)
6t77A / W9B6I8 Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
27% identity, 97% coverage of query (68.2 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
27% identity, 97% coverage of query (66.2 bits)
4b79A / Q9HWT0 The aeropath project and pseudomonas aeruginosa high-throughput crystallographic studies for assessment of potential targets in early stage drug discovery. (see paper)
29% identity, 97% coverage of query (65.1 bits)
6rxcA Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
24% identity, 99% coverage of query (65.1 bits)
TPRL3_ERYCB / H9BFQ2 Tropinone reductase-like 3; EC 1.1.1.- from Erythroxylum coca (Coca plant) (see paper)
24% identity, 98% coverage of query (64.3 bits)
swb2 / D2KTX1 3-hydroxykynurenate reductase/dehydratase from Streptomyces sp. SNA15896 (see paper)
27% identity, 97% coverage of query (64.3 bits)
Q2FZ53 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Staphylococcus aureus (see paper)
25% identity, 100% coverage of query (63.9 bits)
FABG_STAAM / P0A0H9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Staphylococcus aureus (strain Mu50 / ATCC 700699)
3osuA / P0A0H9 Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
25% identity, 100% coverage of query (63.9 bits)
5gwrA 4-hydroxyisoleucine dehydrogenase complexed with nadh (see paper)
24% identity, 97% coverage of query (63.9 bits)
5l42A Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
24% identity, 99% coverage of query (63.5 bits)
4bo9A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9a resolution
26% identity, 97% coverage of query (63.5 bits)
4bo0A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4a resolution
26% identity, 97% coverage of query (63.5 bits)
KDUD_BACSU / P50842 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase; EC 1.1.1.127 from Bacillus subtilis (strain 168) (see paper)
29% identity, 96% coverage of query (63.2 bits)
FABG_RICPR / P50941 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Rickettsia prowazekii (strain Madrid E)
P50941 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Rickettsia prowazekii (see paper)
27% identity, 96% coverage of query (63.2 bits)
Q4UN54 acetoacetyl-CoA reductase (EC 1.1.1.36) from Rickettsia felis (see paper)
25% identity, 100% coverage of query (63.2 bits)
4bo8A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7a resolution
26% identity, 97% coverage of query (63.2 bits)
4bo2A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9a resolution
26% identity, 97% coverage of query (63.2 bits)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH
25% identity, 97% coverage of query (62.8 bits)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH
24% identity, 99% coverage of query (62.4 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
24% identity, 99% coverage of query (62.4 bits)
2qhxA Structure of pteridine reductase from leishmania major complexed with a ligand
24% identity, 99% coverage of query (62.4 bits)
1mxfA Crystal structure of inhibitor complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi
26% identity, 96% coverage of query (62.4 bits)
NR_NARAP / A0A1C9II22 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus aff. pseudonarcissus MK-2014 (Daffodil) (see paper)
NR_NARPS / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see 2 papers)
5ff9B / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
23% identity, 97% coverage of query (62.0 bits)
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal
23% identity, 97% coverage of query (62.0 bits)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution
26% identity, 97% coverage of query (62.0 bits)
O54438 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas aeruginosa (see paper)
26% identity, 97% coverage of query (61.6 bits)
G0HY85 acetoacetyl-CoA reductase (EC 1.1.1.36) from Haloarcula hispanica (see paper)
26% identity, 74% coverage of query (61.2 bits)
ptmO8 / D8L2W5 ent-kauranol 7β-dehydrogenase from Streptomyces platensis (see paper)
30% identity, 96% coverage of query (61.2 bits)
6t62A / V5VHN7 Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
23% identity, 97% coverage of query (61.2 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
24% identity, 97% coverage of query (61.2 bits)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii
23% identity, 97% coverage of query (61.2 bits)
DDGLD_PSEA6 / Q15SS0 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; 2,5-diketo-3-deoxy-L-galactonate 5-reductase; EC 1.1.1.127 from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)
26% identity, 98% coverage of query (60.8 bits)
1p33B / P42556 Pteridine reductase from leishmania tarentolae complex with NADPH and mtx (see paper)
24% identity, 99% coverage of query (60.8 bits)
4bo5A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-chlorophenyl)-4- pyrrol-1-yl-1,3,5-triazin-2-amine at 2.6a resolution
26% identity, 97% coverage of query (60.8 bits)
8of2A Trypanosoma brucei pteridine reductase 1 (tbptr1) in complex with 2,4, 6 triamminopyrimidine (tap)
26% identity, 97% coverage of query (60.8 bits)
6tbxA Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
26% identity, 97% coverage of query (60.8 bits)
6hnrA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 1 (f217)
26% identity, 97% coverage of query (60.8 bits)
6hncA Trypanosoma brucei ptr1 in complex with cycloguanil
26% identity, 97% coverage of query (60.8 bits)
5jdiA Trypanosoma brucei ptr1 in complex with cofactor and inhibitor nmt- h024 (compound 2)
26% identity, 97% coverage of query (60.8 bits)
6tbxC Trypanosoma brucei ptr1 (tbptr1) in complex with a tricyclic-based inhibitor
26% identity, 97% coverage of query (60.5 bits)
2bfaC Leishmania major pteridine reductase 1 in complex with NADP and cb3717
24% identity, 97% coverage of query (60.5 bits)
5l4nA Leishmania major pteridine reductase 1 (ptr1) in complex with compound 1
24% identity, 99% coverage of query (60.1 bits)
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution
26% identity, 97% coverage of query (60.1 bits)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
24% identity, 97% coverage of query (60.1 bits)
4bo7A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2,3-dihydro-1h-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6a resolution
26% identity, 97% coverage of query (60.1 bits)
1w0cD Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex.
24% identity, 99% coverage of query (59.7 bits)
1e92D Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
24% identity, 99% coverage of query (59.7 bits)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
25% identity, 97% coverage of query (59.3 bits)
2bfmA Leishmania major pteridine reductase 1 in complex with NADP and trimethoprim
24% identity, 97% coverage of query (59.3 bits)
4bo6A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8a resolution
26% identity, 97% coverage of query (59.3 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
26% identity, 97% coverage of query (58.9 bits)
Q5SLC4 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermus thermophilus (see paper)
24% identity, 97% coverage of query (58.9 bits)
SDRA_ARATH / Q9S9W2 Short-chain dehydrogenase/reductase SDRA; Protein INDOLE-3-BUTYRIC ACID RESPONSE 1; Short-chain dehydrogenase/reductase A; EC 1.1.-.- from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
24% identity, 98% coverage of query (58.9 bits)
2bfpA Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin
24% identity, 97% coverage of query (58.9 bits)
1e7wA One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
23% identity, 99% coverage of query (58.9 bits)
7pxxC The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
24% identity, 97% coverage of query (58.9 bits)
5ha5D Crystal structure of an NAD-bound oxidoreductase from brucella ovis
26% identity, 97% coverage of query (58.5 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
24% identity, 99% coverage of query (58.5 bits)
O09352 pteridine reductase (EC 1.5.1.33) from Leishmania amazonensis (see paper)
24% identity, 100% coverage of query (58.2 bits)
1mxhA / Q8I814 Crystal structure of substrate complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi (see paper)
26% identity, 96% coverage of query (58.2 bits)
3h4vA Selective screening and design to identify inhibitors of leishmania major pteridine reductase 1
24% identity, 99% coverage of query (58.2 bits)
1e92A Pteridine reductase 1 from leishmania major complexed with NADP+ and dihydrobiopterin
24% identity, 97% coverage of query (58.2 bits)
5wuwA / A0A192ICX3 Serratia marcescens short-chain dehydrogenase/reductase f98l/f202l mutant (see paper)
28% identity, 96% coverage of query (57.8 bits)
4bnxA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 6-(4-(2-chloroanilino)- 1h-quinazolin-2-ylidene)cyclohexa-2, 4-dien-1-one at 2.3a resolution
26% identity, 97% coverage of query (57.8 bits)
5gwsB 4-hydroxyisoleucine dehydrogenase complexed with nadh and succinate (see paper)
24% identity, 97% coverage of query (57.4 bits)
4bo4C / O54438 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
26% identity, 97% coverage of query (57.4 bits)
4bnyA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8a resolution
26% identity, 97% coverage of query (57.4 bits)
Q86RB1 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Plasmodium falciparum (see paper)
23% identity, 96% coverage of query (57.0 bits)
phaB / BAC45231.1 3-keto-acyl-CoA reductase from Bacillus sp. INT005 (see paper)
28% identity, 97% coverage of query (57.0 bits)
5l42C Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
24% identity, 99% coverage of query (57.0 bits)
novJ / Q9L9F8 NovJ from Streptomyces niveus (see paper)
NOVJ_STRNV / Q9L9F8 Short-chain reductase protein NovJ; Novobiocin biosynthesis protein J; EC 1.1.1.- from Streptomyces niveus (Streptomyces spheroides) (see paper)
26% identity, 97% coverage of query (56.6 bits)
7emgB / A0A0G8B235 Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
24% identity, 98% coverage of query (56.6 bits)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
26% identity, 96% coverage of query (56.2 bits)
S5U393 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Comamonas testosteroni (see paper)
27% identity, 96% coverage of query (55.8 bits)
2bfpD / Q01782 Leishmania major pteridine reductase 1 in complex with NADP and tetrahydrobiopterin (see paper)
23% identity, 99% coverage of query (55.8 bits)
PTR1 / Q01782 pteridine reductase 1 monomer (EC 1.5.1.33; EC 1.5.1.3) from Leishmania major (see 4 papers)
PTR1_LEIMA / Q01782 Pteridine reductase 1; H region methotrexate resistance protein; EC 1.5.1.33 from Leishmania major (see 4 papers)
23% identity, 100% coverage of query (55.8 bits)
4bo3A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-(3-(trifluoromethyl) anilino)pyridine-3-sulfonamide at 2.5a resolution
26% identity, 97% coverage of query (55.8 bits)
1yxmB / Q9BY49 Crystal structure of peroxisomal trans 2-enoyl coa reductase
28% identity, 97% coverage of query (55.5 bits)
Q4AE87 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas sp. (see paper)
fabG / BAE19680.1 3-oxoacyl-(acyl-carrier-protein) reductase from Pseudomonas sp. 61-3 (see paper)
23% identity, 97% coverage of query (55.1 bits)
4nbtA / A9NFJ2 Crystal structure of fabg from acholeplasma laidlawii (see paper)
25% identity, 97% coverage of query (55.1 bits)
CBR4 / Q8N4T8 carbonyl reductase family member 4 (EC 1.1.1.100) from Homo sapiens (see 2 papers)
CBR4_HUMAN / Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; Carbonyl reductase family member 4; CBR4; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1; EC 1.1.1.100; EC 1.6.5.10 from Homo sapiens (Human) (see 3 papers)
25% identity, 100% coverage of query (55.1 bits)
A4I067 pteridine reductase (EC 1.5.1.33) from Leishmania infantum (see paper)
23% identity, 99% coverage of query (54.7 bits)
4cqmF / Q8N4T8 Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP (see paper)
25% identity, 100% coverage of query (54.7 bits)
4k6fB / B4EAU4 X-ray crystal structure of a putative acetoacetyl-coa reductase from burkholderia cenocepacia bound to the co-factor NADP
25% identity, 97% coverage of query (53.9 bits)
MTDH_AGABI / O93868 NADP-dependent mannitol dehydrogenase; MtDH; Mannitol 2-dehydrogenase [NADP(+)]; EC 1.1.1.138 from Agaricus bisporus (White button mushroom) (see paper)
26% identity, 97% coverage of query (53.5 bits)
6y4dA Crystal structure of a short-chain dehydrogenase/reductase (sdr) from zephyranthes treatiae in complex with NADP+ (see paper)
23% identity, 97% coverage of query (53.5 bits)
1w0cA / Q01782 Inhibition of leishmania major pteridine reductase (ptr1) by 2,4,6- triaminoquinazoline; structure of the NADP ternary complex. (see paper)
23% identity, 97% coverage of query (53.5 bits)
3i3oA 2.06 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD-acetone
23% identity, 97% coverage of query (53.5 bits)
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