Searching for up to 100 curated homologs for 201027 FitnessBrowser__MR1:201027 (302 a.a.)
Found high-coverage hits (≥70%) to 57 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
LNRL_BACSU / P94440 Linearmycin resistance ATP-binding protein LnrL; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 2 papers)
32% identity, 93% coverage of query (156 bits)
TC 3.A.1.132.2 / Q52900 NosF, component of The NosDFY Copper ABC transporter from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
nosF / AAC44025.1 NosF protein from Sinorhizobium meliloti (see paper)
35% identity, 83% coverage of query (144 bits)
TC 3.A.1.124.3 / Q75V15 NukF, component of The lantibiotic Nukacin ISK-1 (TC# 1.C.21.1.5)/NukH (BAD01013; 92aas) exporter, NukEFG from Staphylococcus warneri (see paper)
33% identity, 79% coverage of query (129 bits)
DRRA_STRPE / P32010 Daunorubicin/doxorubicin resistance ATP-binding protein DrrA; EC 7.6.2.- from Streptomyces peucetius (see 2 papers)
P32010 ABC-type xenobiotic transporter (EC 7.6.2.2) from Streptomyces peucetius (see paper)
TC 3.A.1.105.1 / P32010 DrrA, component of Daunorubicin, doxorubicin etc. (multidrug resistance) exporter, DrrAB from Streptomyces peucetius (see 2 papers)
32% identity, 77% coverage of query (127 bits)
TC 3.A.1.124.5 / Q09II0 SboF, component of The salivaricin exporter, SboEFG from Streptococcus salivarius (see paper)
32% identity, 79% coverage of query (125 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
33% identity, 76% coverage of query (122 bits)
7tbwA / O95477 The structure of atp-bound abca1 (see paper)
32% identity, 92% coverage of query (122 bits)
TC 3.A.1.142.1 / Q8DNB9 Putative uncharacterized protein ABC-NBD, component of Glycolipid translocase (flippase) Spr1816/Spr1817 (R.Hakenbeck, personal communication) from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
35% identity, 75% coverage of query (122 bits)
ABCA7_MOUSE / Q91V24 ATP-binding cassette sub-family A member 7 from Mus musculus (Mouse) (see 10 papers)
34% identity, 75% coverage of query (121 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
31% identity, 92% coverage of query (120 bits)
ABCA7_RAT / Q7TNJ2 ATP-binding cassette sub-family A member 7 from Rattus norvegicus (Rat) (see paper)
33% identity, 75% coverage of query (120 bits)
7roqA / O95477 Alternative structure of human abca1
33% identity, 71% coverage of query (120 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
33% identity, 76% coverage of query (120 bits)
TC 3.A.1.211.1 / P41233 The cholesterol/phospholipid flippase, ABC1 (called ABCA1 in humans; Tangier disease proteins; 2261 aas; sp: O95477). An amphipathic helical region of the N-terminal barrel of the phospholipid transfer protein (PLTP) is critical for ABCA1-dependent cholesterol efflux (Oram et al., 2008). PLTP helix 144-163 removes lipid domains formed by ABCA1, stabilizing ABCA1, interacting with phospholipids, and promoting phospholipid transfer by direct interactions with ABCA1. May transport sphingosine-1-phosphate (Kobayashi et al., 2009). May protect from cardiovascular disease and diabetes from Mus musculus (Mouse) (see 7 papers)
Abca1 ATP-binding cassette sub-family A member 1 from Mus musculus (see paper)
33% identity, 76% coverage of query (120 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
30% identity, 81% coverage of query (119 bits)
BCRA_ENTFL / Q5WNX0 Bacitracin transport ATP-binding protein BcrA from Enterococcus faecalis (Streptococcus faecalis) (see 2 papers)
33% identity, 71% coverage of query (119 bits)
YdcT / b1441 putative ABC transporter ATP-binding protein YdcT from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ydcT / P77795 putative ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see 3 papers)
YDCT_ECOLI / P77795 Uncharacterized ABC transporter ATP-binding protein YdcT from Escherichia coli (strain K12) (see paper)
33% identity, 71% coverage of query (119 bits)
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
31% identity, 79% coverage of query (118 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
31% identity, 79% coverage of query (117 bits)
ABCA9_HUMAN / Q8IUA7 ATP-binding cassette sub-family A member 9; EC 7.6.2.- from Homo sapiens (Human) (see paper)
TC 3.A.1.211.16 / Q8IUA7 ATP-binding cassette sub-family A member 9, ABCA9 of 1624 aas. May play a role in monocyte differentiation and lipid homeostasis. Expressed in fetal tissues with highest expression in fetal heart and kidney. Up-regulated during monocyte differentiation into macrophages. Down-regulated by cholesterol loading of macrophages from Homo sapiens
31% identity, 75% coverage of query (117 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
30% identity, 79% coverage of query (117 bits)
7tbyA / O95477 The structure of human abca1 in nanodisc (see paper)
32% identity, 84% coverage of query (117 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
30% identity, 75% coverage of query (110 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
30% identity, 75% coverage of query (109 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
30% identity, 71% coverage of query (108 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
30% identity, 72% coverage of query (108 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
30% identity, 71% coverage of query (108 bits)
7m1qA / P78363 Human abca4 structure in complex with n-ret-pe (see paper)
31% identity, 76% coverage of query (108 bits)
Build an alignment for 201027 and 28 homologs with ≥ 30% identity
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7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
29% identity, 72% coverage of query (107 bits)
7lkzA Structure of atp-bound human abca4
30% identity, 71% coverage of query (107 bits)
7lkpA Structure of atp-free human abca4
30% identity, 71% coverage of query (107 bits)
7mdyC Lolcde nucleotide-bound
34% identity, 71% coverage of query (106 bits)
LolD / b1117 lipoprotein release complex - ATP binding subunit from Escherichia coli K-12 substr. MG1655 (see 2 papers)
LolD / P75957 lipoprotein release complex - ATP binding subunit from Escherichia coli (strain K12) (see paper)
LOLD_ECOLI / P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
TC 3.A.1.125.1 / P75957 LolD aka B1117, component of Lipoprotein translocation system (translocates lipoproteins from the inner membrane to periplasmic chaperone, LolA, which transfers the lipoproteins to an outer membrane receptor, LolB, which anchors the lipoprotein to the outer membrane of the Gram-negative bacterial cell envelope) (see 1.B.46; Narita et al., 2003; Ito et al., 2006; Watanabe et al., 2007). The structure of ligand-bound LolCDE has been solved (Ito et al., 2006). LolC and LolE each have 4 TMSs (1+3). Unlike most ATP binding cassette transporters mediating the transmembrane flux of substrates, the LolCDE complex catalyzes the extrusion of lipoproteins anchored to the outer leaflet of the inner membrane. The LolCDE complex is unusual in that it can be purified as a liganded form, which is an intermediate of the lipoprotein release reaction (Taniguchi and Tokuda, 2008). LolCDE has been reconstituted from separated subunits from Escherichia coli (see 5 papers)
lolD / GB|BAA35937.2 lipoprotein releasing system, ATP-binding protein; EC 3.6.3.- from Escherichia coli K12 (see 5 papers)
33% identity, 71% coverage of query (105 bits)
7v8iD / P75957 Lolcd(e171q)e with bound amppnp in nanodiscs (see paper)
33% identity, 71% coverage of query (103 bits)
6z4wA / Q8DQH4 Ftse structure from streptococcus pneumoniae in complex with adp (space group p 1) (see paper)
29% identity, 71% coverage of query (103 bits)
6z67B Ftse structure of streptococcus pneumoniae in complex with amppnp at 2.4 a resolution
29% identity, 70% coverage of query (102 bits)
6xjiC / X5EJW5 Pmtcd abc exporter at c1 symmetry (see paper)
25% identity, 99% coverage of query (101 bits)
6xjhC Pmtcd abc exporter without the basket domain at c2 symmetry
29% identity, 70% coverage of query (98.6 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
29% identity, 79% coverage of query (96.3 bits)
ECSA_BACSU / P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.143.1 / P55339 ABC-type transporter ATP-binding protein EcsA, component of The exoprotein (including α-amylase) secretion system, EcsAB(C) (Leskelä et al., 1999). Also may play roles in sporulation, competence (Leskelä et al., 1996) and transformation using purified DNA (Takeno et al., 2011). An involvement of EcsC in transport is not established, but it is homologous to the C-terminus of the P-type ATPase, 3.A.3.31.2 from Bacillus subtilis (strain 168) (see 3 papers)
27% identity, 78% coverage of query (93.2 bits)
FtsE / b3463 cell division protein FtsE from Escherichia coli K-12 substr. MG1655 (see 9 papers)
FTSE_ECOLI / P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see 4 papers)
ftsE cell division ATP-binding protein ftsE from Escherichia coli K12 (see 3 papers)
29% identity, 70% coverage of query (91.7 bits)
5eg1B / Q9X2W0 Antibacterial peptide abc transporter mcjd with a resolved lipid (see paper)
29% identity, 70% coverage of query (81.6 bits)
5ofrA Structure of the antibacterial peptide abc transporter mcjd in a high energy outward occluded intermediate state
29% identity, 70% coverage of query (81.3 bits)
2pclA / O66646 Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
28% identity, 70% coverage of query (79.7 bits)
7ahhC Opua inhibited inward-facing, sbd docked
24% identity, 76% coverage of query (79.7 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
24% identity, 76% coverage of query (79.7 bits)
7ahdC Opua (e190q) occluded
25% identity, 71% coverage of query (78.2 bits)
ECFA1_STRT2 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA1; ECF transporter A component EcfA1; EC 7.-.-.- from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
TC 3.A.1.25.6 / Q5M243 Energy-coupling factor transporter ATP-binding protein EcfA 2, component of Riboflavin ECF transport system, EcfAA'T/RibU from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)
26% identity, 70% coverage of query (77.8 bits)
7r89B / Q9H221 The structure of human abcg5/abcg8 purified from yeast (see paper)
28% identity, 70% coverage of query (77.4 bits)
8dncA Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen and adp
23% identity, 76% coverage of query (75.5 bits)
8dkuA / O67181 Cryoem structure of the a. Aeolicus wzmwzt transporter bound to the native o antigen (see paper)
23% identity, 76% coverage of query (75.5 bits)
8g4cB / O34697 Bceabs atpgs high res tm (see paper)
22% identity, 82% coverage of query (75.1 bits)
P0A9U3 Probable ATP-binding protein YbiT from Escherichia coli (strain K12)
28% identity, 74% coverage of query (73.9 bits)
YbiT / b0820 putative ATP-binding protein YbiT from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YBIT_ECOL6 / P0A9U4 Probable ATP-binding protein YbiT from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) (see paper)
ybiT / MB|P0A9U3 uncharacterized ABC transporter ATP-binding protein ybiT from Escherichia coli K12 (see 2 papers)
28% identity, 74% coverage of query (73.9 bits)
7tchB Bceab e169q variant atp-bound conformation
22% identity, 82% coverage of query (73.2 bits)
7p7q0 7p7q0 (see paper)
25% identity, 77% coverage of query (72.4 bits)
4f4cA / P34712 The crystal structure of the multi-drug transporter (see paper)
28% identity, 75% coverage of query (63.5 bits)
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Lawrence Berkeley National Laboratory