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Searching for up to 100 curated homologs for 201857 FitnessBrowser__MR1:201857 (234 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3occF / B1JL34 Crystal structure of pnp with dadmeimmh from yersinia pseudotuberculosis
    55% identity, 99% coverage of query (273 bits)

Pup / b4384 purine nucleoside phosphorylase (EC 2.4.2.15; EC 2.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
deoD / P0ABP8 purine nucleoside phosphorylase (EC 2.4.2.15; EC 2.4.2.1) from Escherichia coli (strain K12) (see 30 papers)
DEOD_ECOLI / P0ABP8 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Escherichia coli (strain K12) (see 5 papers)
deoD / RF|NP_418801 purine nucleoside phosphorylase deoD-type; EC 2.4.2.1 from Escherichia coli K12 (see 13 papers)
    55% identity, 99% coverage of query (270 bits)

5iu6A Crystal structure of e.Coli purine nucleoside phosphorylase with 7- deazahypoxanthine
    55% identity, 99% coverage of query (270 bits)

5i3cA Crystal structure of e.Coli purine nucleoside phosphorylase with acycloguanosine
    55% identity, 99% coverage of query (270 bits)

3ut6A Crystal structure of e. Coli pnp complexed with po4 and formycin a
    55% identity, 99% coverage of query (270 bits)

1pw7A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 9-beta-d-arabinofuranosyladenine and sulfate/phosphate
    55% identity, 99% coverage of query (270 bits)

1pr0A Escherichia coli purine nucleoside phosphorylase complexed with inosine and phosphate/sulfate
    55% identity, 99% coverage of query (270 bits)

1pkeA Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine and sulfate/phosphate
    55% identity, 99% coverage of query (270 bits)

1pk9A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with 2-fluoroadenosine and sulfate/phosphate
    55% identity, 99% coverage of query (270 bits)

1pk7A Crystal structure of e. Coli purine nucleoside phosphorylase complexed with adenosine and sulfate/phosphate
    55% identity, 99% coverage of query (270 bits)

1otyA Native pnp +allo
    55% identity, 99% coverage of query (270 bits)

1k9sD Purine nucleoside phosphorylase from e. Coli in complex with formycin a derivative and phosphate
    55% identity, 99% coverage of query (270 bits)

1k9sA Purine nucleoside phosphorylase from e. Coli in complex with formycin a derivative and phosphate
    55% identity, 99% coverage of query (270 bits)

1a69A Purine nucleoside phosphorylase in complex with formycin b and sulphate (phosphate)
    55% identity, 99% coverage of query (270 bits)

P0ABP9 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Escherichia coli O157:H7
    55% identity, 99% coverage of query (270 bits)

1ovgA M64v pnp +mepdr
    55% identity, 99% coverage of query (268 bits)

1ov6A M64v pnp + allo
    55% identity, 99% coverage of query (268 bits)

1oumA M64v pnp +talo
    55% identity, 99% coverage of query (268 bits)

DEOD_SALTY / Q8ZJV7 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    53% identity, 99% coverage of query (263 bits)

1vhwA Crystal structure of purine nucleoside phosphorylase with adenosine
    53% identity, 99% coverage of query (263 bits)

1pr6A Escherichia coli purine nucleoside phosphorylase complexed with 9- beta-d-xylofuranosyladenine and phosphate/sulfate
    54% identity, 99% coverage of query (263 bits)

3of3A / Q9KPM0 Crystal structure of pnp with an inhibitor dadme_immh from vibrio cholerae
    53% identity, 99% coverage of query (262 bits)

C8CPR9 purine-nucleoside phosphorylase (EC 2.4.2.1) from Pseudoalteromonas sp. (see paper)
    55% identity, 98% coverage of query (261 bits)

1pr4A Escherichia coli purine nucleoside phosphorylase complexed with 9- beta-d-ribofuranosyl-6-methylthiopurine and phosphate/sulfate
    54% identity, 99% coverage of query (261 bits)

1pr5A Escherichia coli purine nucleoside phosphorylase complexed with 7- deazaadenosine and phosphate/sulfate
    54% identity, 99% coverage of query (259 bits)

deoD purine nucleoside phosphorylase; EC 2.4.2.1 from Bacillus anthracis (see paper)
    51% identity, 100% coverage of query (253 bits)

3uawA / Q5EEL8 Crystal structure of adenosine phosphorylase from bacillus cereus complexed with adenosine (see paper)
    51% identity, 99% coverage of query (251 bits)

P77835 purine-nucleoside phosphorylase (EC 2.4.2.1) from Geobacillus stearothermophilus (see paper)
punB / BAA13510.1 purine nucleoside phosphorylase from Geobacillus stearothermophilus (see paper)
    50% identity, 100% coverage of query (236 bits)

3uaxA Crystal structure of adenosine phosphorylase from bacillus cereus complexed with inosine
    48% identity, 99% coverage of query (234 bits)

O34925 purine-nucleoside phosphorylase (EC 2.4.2.1) from Bacillus subtilis (see paper)
    50% identity, 99% coverage of query (231 bits)

4daeA / O34925 Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 6-chloroguanosine (see paper)
    49% identity, 99% coverage of query (230 bits)

4darA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with tubercidin
    49% identity, 98% coverage of query (228 bits)

4dabA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with hypoxanthine
    49% identity, 98% coverage of query (228 bits)

4da8A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 8-bromoguanosine
    49% identity, 98% coverage of query (228 bits)

4da7A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with aciclovir
    49% identity, 98% coverage of query (228 bits)

4da6A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with ganciclovir
    49% identity, 98% coverage of query (228 bits)

4d9hA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with adenosine
    49% identity, 98% coverage of query (228 bits)

4d8vA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis at ph 4.2
    49% identity, 98% coverage of query (228 bits)

4da0A Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 2'-deoxyguanosine
    49% identity, 98% coverage of query (228 bits)

4danA Crystal structure of the hexameric purine nucleoside phosphorylase from bacillus subtilis in complex with 2-fluoroadenosine
    49% identity, 98% coverage of query (228 bits)

P56463 purine-nucleoside phosphorylase (EC 2.4.2.1) from Helicobacter pylori (see paper)
6f4wA / P56463 Crystal structure of h. Pylori purine nucleoside phosphorylase in complex with formycin a (see paper)
    46% identity, 98% coverage of query (214 bits)

7op9A Purine nucleoside phosphorylase(deod-type) from h. Pylori with 2,6- dichloropurine
    46% identity, 98% coverage of query (214 bits)

7oozB Purine nucleoside phosphorylase(deod-type) from h. Pylori with 6- benzyloxo-2-chloropurine
    46% identity, 98% coverage of query (214 bits)

7ooyB Purine nucleoside phosphorylase(deod-type) from h. Pylori with 6- benzylthio-2-chloropurine
    46% identity, 98% coverage of query (214 bits)

5lu0A Crystal structure of h. Pylori referent strain in complex with po4
    46% identity, 98% coverage of query (214 bits)

5mx4C Crystal structure of h. Pylori purine nucleoside phosphorylase from clinical isolate hppnp-1
    46% identity, 98% coverage of query (213 bits)

A0A518Y5Z2 purine-nucleoside phosphorylase (EC 2.4.2.1) from Helicobacter pylori (see paper)
    46% identity, 98% coverage of query (212 bits)

2iscD / A2E7Y6 Crystal structure of purine nucleoside phosphorylase from trichomonas vaginalis with dadme-imm-a (see paper)
    47% identity, 100% coverage of query (212 bits)

1z39A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with 2'-deoxyinosine
    45% identity, 100% coverage of query (198 bits)

1z38A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with inosine
    45% identity, 100% coverage of query (198 bits)

1z37A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with adenosine
    45% identity, 100% coverage of query (198 bits)

1z36A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with formycin a
    45% identity, 100% coverage of query (198 bits)

1z35A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoroadenosine
    45% identity, 100% coverage of query (198 bits)

1z34A Crystal structure of trichomonas vaginalis purine nucleoside phosphorylase complexed with 2-fluoro-2'-deoxyadenosine
    45% identity, 100% coverage of query (198 bits)

2i4tA Crystal structure of purine nucleoside phosphorylase from trichomonas vaginalis with imm-a
    45% identity, 100% coverage of query (196 bits)

3u40D / C4LXG4 Crystal structure of a purine nucleoside phosphorylase from entamoeba histolytica bound to adenosine (see paper)
    44% identity, 99% coverage of query (195 bits)

DEOD_MYCGE / P47295 Purine nucleoside phosphorylase DeoD-type; PNP; EC 2.4.2.1 from Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium) (see paper)
    40% identity, 98% coverage of query (159 bits)

Q72IR2 purine-nucleoside phosphorylase (EC 2.4.2.1) from Thermus thermophilus (see 2 papers)
    32% identity, 99% coverage of query (127 bits)

1odiA / Q5SID9 Purine nucleoside phosphorylase from thermus thermophilus (see paper)
    32% identity, 99% coverage of query (127 bits)

1odjA Purine nucleoside phosphorylase from thermus thermophilus
    32% identity, 99% coverage of query (127 bits)

1jdvC / P50389 Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with adenosine and sulfate ion (see paper)
    30% identity, 88% coverage of query (97.1 bits)

PNPH_SACS2 / P50389 Purine nucleoside phosphorylase; PNP; 5'-methylthioadenosine phosphorylase I; MTA phosphorylase I; MTAPI; EC 2.4.2.1; EC 2.4.2.28 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see 3 papers)
P50389 S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) from Saccharolobus solfataricus (see 4 papers)
    30% identity, 88% coverage of query (96.7 bits)

1jdtA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with mta and sulfate ion
    31% identity, 89% coverage of query (96.7 bits)

1jdvA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase complexed with adenosine and sulfate ion
    30% identity, 86% coverage of query (95.9 bits)

1je1A 5'-deoxy-5'-methylthioadenosine phosphorylase complex with guanosine and sulfate
    30% identity, 89% coverage of query (95.9 bits)

1jdsA 5'-deoxy-5'-methylthioadenosine phosphorylase complex with phosphate (space group p21)
    30% identity, 86% coverage of query (95.9 bits)

1jdzA Crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase with formycin b and sulfate ion
    30% identity, 86% coverage of query (95.9 bits)

4mchA / Q5E046 Crystal structure of uridine phosphorylase from vibrio fischeri es114 complexed with 6-hydroxy-1-naphthoic acid, nysgrc target 029520.
    31% identity, 85% coverage of query (84.7 bits)

Build an alignment

Build an alignment for 201857 and 68 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

B9LS20 guanosine phosphorylase (EC 2.4.2.15) from Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) (see paper)
    27% identity, 99% coverage of query (83.2 bits)

Q9YDC0 purine-nucleoside phosphorylase (EC 2.4.2.1) from Aeropyrum pernix (see 2 papers)
    27% identity, 87% coverage of query (82.0 bits)

Q9YA34 uridine phosphorylase (EC 2.4.2.3) from Aeropyrum pernix (see 2 papers)
    28% identity, 88% coverage of query (77.0 bits)

TK1479 / Q5JJC1 uridine phosphorylase (EC 2.4.2.2) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
UDP_THEKO / Q5JJC1 Uridine phosphorylase; UPase; UrdPase; EC 2.4.2.3 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    29% identity, 94% coverage of query (74.7 bits)

3qpbC / Q5XA29 Crystal structure of streptococcus pyogenes uridine phosphorylase reveals a subclass of the np-i superfamily (see paper)
    28% identity, 82% coverage of query (72.4 bits)

Q5XA29 pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) from Streptococcus pyogenes (see paper)
    28% identity, 82% coverage of query (72.4 bits)

Q2HXR2 purine-nucleoside phosphorylase (EC 2.4.2.1) from Toxoplasma gondii (see 3 papers)
PNP purine nucleoside phosphorylase; EC 2.4.2.1 from Toxoplasma gondii (see paper)
    28% identity, 99% coverage of query (65.9 bits)

Shewana3_3680 Uridine phosphorylase (EC 2.4.2.3) from Shewanella sp. ANA-3
    29% identity, 81% coverage of query (65.1 bits)

3mb8A / Q2HXR2 Crystal structure of purine nucleoside phosphorylase from toxoplasma gondii in complex with immucillin-h (see paper)
    27% identity, 99% coverage of query (65.1 bits)

SO4133 Uridine phosphorylase (EC 2.4.2.3) from Shewanella oneidensis MR-1
C7EWM3 uridine phosphorylase (EC 2.4.2.3) from Shewanella oneidensis (see 4 papers)
    29% identity, 81% coverage of query (65.1 bits)

4r2wD / Q8E9X9 X-ray structure of uridine phosphorylase from shewanella oneidensis mr-1 in complex with uridine at 1.6 a resolution (see paper)
    29% identity, 81% coverage of query (64.7 bits)

4yjkA Crystal structure of c212s mutant of shewanella oneidensis mr-1 uridine phosphorylase
    29% identity, 82% coverage of query (64.7 bits)

4r2wF X-ray structure of uridine phosphorylase from shewanella oneidensis mr-1 in complex with uridine at 1.6 a resolution
    29% identity, 81% coverage of query (64.7 bits)

Sama_0412 Uridine phosphorylase (EC 2.4.2.3) from Shewanella amazonensis SB2B
    26% identity, 82% coverage of query (63.5 bits)

PNPH_PLAVS / A5K9M4 Purine nucleoside phosphorylase; PvPNP; EC 2.4.2.1 from Plasmodium vivax (strain Salvador I) (see paper)
    26% identity, 99% coverage of query (57.4 bits)

Q9K4U1 uridine phosphorylase (EC 2.4.2.3) from Vibrio cholerae (see 2 papers)
5efoB / Q9K4U1 X-ray structure uridine phosphorylase from vibrio cholerae in complex with cytidine and cytosine at 1.63a.
udp / CAB94933.1 uridine phosphorylase from Vibrio cholerae (see paper)
    28% identity, 79% coverage of query (57.0 bits)

4u2kB X-ray structure uridine phosphorylase from vibrio cholerae in complex with anticancer compound at 2.13 a resolution
    28% identity, 82% coverage of query (57.0 bits)

4k6oA X-ray structure uridine phosphorylase from vibrio cholerae in complex with 6-methyluracil at 1.17 a resolution
    28% identity, 79% coverage of query (57.0 bits)

3pnsB Crystal structure of uridine phosphorylase complexed with uracil from vibrio cholerae o1 biovar el tor
    28% identity, 82% coverage of query (57.0 bits)

6rcaA X-ray structure uridine phosphorylase from vibrio cholerae in complex with 2.2'-anhydrouridine at 1.34 a
    28% identity, 79% coverage of query (57.0 bits)

5efoE X-ray structure uridine phosphorylase from vibrio cholerae in complex with cytidine and cytosine at 1.63a.
    28% identity, 79% coverage of query (57.0 bits)

5c80A X-ray structure uridine phosphorylase from vibrio cholerae in complex with uridine at 2.24 a resolution
    28% identity, 79% coverage of query (57.0 bits)

4oglA X-ray structure uridine phosphorylase from vibrio cholerae in complex with thymine at 1.25 a resolution
    28% identity, 79% coverage of query (56.6 bits)

4u2kD X-ray structure uridine phosphorylase from vibrio cholerae in complex with anticancer compound at 2.13 a resolution
    28% identity, 82% coverage of query (56.6 bits)

udp / CAB94934.1 uridine phosphorylase from Yersinia pseudotuberculosis (see paper)
    26% identity, 79% coverage of query (55.5 bits)

2bsxA Crystal structure of the plasmodium falciparum purine nucleoside phosphorylase complexed with inosine
    25% identity, 97% coverage of query (53.1 bits)

P0A1F6 uridine phosphorylase (EC 2.4.2.3) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
2hn9A / P0A1F6 Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with thymine and phosphate ion at 2.12a resolution
    25% identity, 79% coverage of query (52.4 bits)

2hwuA Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with uridine and phosphate ion at 2.91a resolution
    25% identity, 79% coverage of query (52.4 bits)

1zl2B Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with 2,2'-anhydrouridine and phosphate ion at 1.85a resolution
    25% identity, 79% coverage of query (52.4 bits)

1y1rB Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with inhibitor and phosphate ion at 2.11a resolution
    25% identity, 79% coverage of query (52.4 bits)

1y1qC Crystal structure of the uridine phosphorylase from salmonella typhimurium in complex with uridine-5p-monophosphate and sulfate ion at 2.35a resolution
    25% identity, 79% coverage of query (52.0 bits)

PNP / Q8T9Z7 purine nucleoside phosphorylase monomer (EC 2.4.2.44; EC 2.4.2.1) from Plasmodium falciparum (see 3 papers)
PNPH_PLAF7 / Q8I3X4 Purine nucleoside phosphorylase; PfPNP; S-methyl-5'-thioinosine phosphorylase; EC 2.4.2.1; EC 2.4.2.44 from Plasmodium falciparum (isolate 3D7) (see 6 papers)
PNPH_PLAFA / Q8T9Z7 Purine nucleoside phosphorylase; S-methyl-5'-thioinosine phosphorylase; EC 2.4.2.1; EC 2.4.2.44 from Plasmodium falciparum (see 2 papers)
Q8I3X4 purine-nucleoside phosphorylase (EC 2.4.2.1); uridine phosphorylase (EC 2.4.2.3) from Plasmodium falciparum (see 3 papers)
Q8T9Z7 purine-nucleoside phosphorylase (EC 2.4.2.1) from Plasmodium falciparum (see 5 papers)
    25% identity, 97% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory