Searching for up to 100 curated homologs for 202237 FitnessBrowser__MR1:202237 (408 a.a.)
Found high-coverage hits (≥70%) to 34 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YgjU / b3089 serine/threonine:Na+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
sstT / P0AGE4 serine/threonine:Na+ symporter from Escherichia coli (strain K12) (see 7 papers)
SSTT_ECOLI / P0AGE4 Serine/threonine transporter SstT; Na(+)/serine-threonine symporter from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.23.4.1 / P0AGE4 Serine/threonine:Na+ symporter, SstT from Escherichia coli (see 5 papers)
65% identity, 99% coverage of query (516 bits)
Build an alignment for 202237 and 1 homologs with ≥ 30% identity
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Sama_1319 symporter for L-glutamate, L-glutamine, and L-aspartate from Shewanella amazonensis SB2B
27% identity, 96% coverage of query (111 bits)
GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 9 papers)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii (see 2 papers)
26% identity, 93% coverage of query (109 bits)
2nwwA Crystal structure of gltph in complex with tboa
27% identity, 93% coverage of query (108 bits)
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine
26% identity, 93% coverage of query (107 bits)
6bauA Crystal structure of gltph r397c in complex with l-cysteine
26% identity, 93% coverage of query (107 bits)
6x15A / O59010 Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
27% identity, 96% coverage of query (105 bits)
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa
27% identity, 96% coverage of query (105 bits)
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate
27% identity, 95% coverage of query (99.0 bits)
6bmiA Crystal structure of gltph r397c in complex with l-serine
28% identity, 74% coverage of query (97.4 bits)
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound
27% identity, 95% coverage of query (95.9 bits)
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis)
27% identity, 95% coverage of query (95.5 bits)
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor
27% identity, 95% coverage of query (95.5 bits)
5e9sA / Q5JID0 Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
27% identity, 95% coverage of query (95.1 bits)
TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
26% identity, 94% coverage of query (90.1 bits)
DctA / b3528 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 13 papers)
dctA / P0A830 C4 dicarboxylate/orotate:H+ symporter from Escherichia coli (strain K12) (see 23 papers)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12) (see 6 papers)
dctA / GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli (see 5 papers)
25% identity, 84% coverage of query (88.6 bits)
GLTT_BACSU / O07605 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus subtilis (strain 168) (see 2 papers)
24% identity, 96% coverage of query (87.8 bits)
TC 2.A.23.2.12 / B0W0K5 Dicarboxylic acid over dicarboxylic amino acid from Culex quinquefasciatus
25% identity, 89% coverage of query (87.0 bits)
Psest_4075 symporter for L-glutamate, L-glutamine, and L-proline from Pseudomonas stutzeri RCH2
26% identity, 92% coverage of query (87.0 bits)
GltP / b4077 glutamate/aspartate : H+ symporter GltP from Escherichia coli K-12 substr. MG1655 (see paper)
gltP / P21345 glutamate/aspartate : H+ symporter GltP from Escherichia coli (strain K12) (see 5 papers)
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12) (see 5 papers)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli (see 6 papers)
24% identity, 91% coverage of query (85.9 bits)
TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis (see 2 papers)
24% identity, 82% coverage of query (84.3 bits)
DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
27% identity, 84% coverage of query (84.0 bits)
TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
27% identity, 84% coverage of query (80.1 bits)
TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
25% identity, 84% coverage of query (74.7 bits)
AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
24% identity, 84% coverage of query (73.6 bits)
TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
25% identity, 90% coverage of query (69.3 bits)
AAAT_BOVIN / Q95JC7 Neutral amino acid transporter B(0); ATB(0); Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 from Bos taurus (Bovine) (see paper)
28% identity, 71% coverage of query (66.6 bits)
7awmA / P43003,Q15758 Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
24% identity, 90% coverage of query (65.5 bits)
7nsgA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with hip-b
23% identity, 71% coverage of query (65.5 bits)
6s3qA Structure of human excitatory amino acid transporter 3 (eaat3) in complex with tfb-tboa
23% identity, 71% coverage of query (65.5 bits)
SATT_HUMAN / P43007 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Homo sapiens (Human) (see 7 papers)
TC 2.A.23.3.1 / P43007 Neutral amino acid (alanine, serine, cysteine, threonine):Na+ symporter. Also transports homocysteine (Jiang et al., 2007). AscT1 is the Syncytin-1 (Q9UQF0) receptor. Syncytin-1, of 538 aas with 4-7 TMSs, is a viral fusion protein and is involved in the development of multiple sclerosis (Antony et al. 2007). Mutation causes nuerological problems including global developmental delay, severe progressive microcephaly, seizures, spasticity and thin corpus callosum (CC) from Homo sapiens (Human) (see 9 papers)
SLC1A4 / RF|NP_003029.2 neutral amino acid transporter A from Homo sapiens (see paper)
25% identity, 71% coverage of query (64.3 bits)
8ctcA Human excitatory amino acid transporter 3 (eaat3) with bound glutamate in an intermediate outward facing state
23% identity, 71% coverage of query (63.2 bits)
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101
24% identity, 90% coverage of query (62.4 bits)
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse)
25% identity, 72% coverage of query (61.6 bits)
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Lawrence Berkeley National Laboratory