Searching for up to 100 curated homologs for 202654 FitnessBrowser__MR1:202654 (588 a.a.)
Found high-coverage hits (≥70%) to 62 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 2.A.53.3.9 / A1JRS3 SulP homologue. The low resolution structure is available from Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081) (see paper)
59% identity, 95% coverage of query (605 bits)
DauA / b1206 aerobic C4-dicarboxylate transporter DauA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
DauA / P0AFR2 aerobic C4-dicarboxylate transporter DauA from Escherichia coli (strain K12) (see 9 papers)
DAUA_ECOLI / P0AFR2 C4-dicarboxylic acid transporter DauA; Dicarboxylic acid uptake system A from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.53.3.11 / P0AFR2 Bicarbonate transporter, DauA (YchM). Also transports dicarboxylic acids including fumarate, aspartate and succinate, and is therefore designated the dicarboxylic acid uptake system A (DauA) (Karinou et al. 2013) It is the only succinate uptake porter at acidic pHs. The STAS domain forms a complex with the acyl carrier protein, ACP and malonyl-ACP, and the complex has been determined by x-ray crystallography (PDB# 3NY7) from Escherichia coli (strain K12)
56% identity, 96% coverage of query (587 bits)
Build an alignment for 202654 and 2 homologs with ≥ 30% identity
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TC 2.A.53.3.13 / Q1J2S8 Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs from Deinococcus geothermalis (strain DSM 11300)
26% identity, 88% coverage of query (168 bits)
BICA_SYNY3 / Q55415 Bicarbonate transporter BicA from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
27% identity, 94% coverage of query (165 bits)
BICA_SYNP2 / Q14SY0 Bicarbonate transporter BicA from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) (see 2 papers)
TC 2.A.53.3.3 / Q14SY0 12 TMS Na+:bicarbonate symporter, BicA (Price et al., 2004; Shelden et al., 2010) (low affinity but high efficiency) from Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (see paper)
25% identity, 95% coverage of query (164 bits)
5da0A / Q1J2S8 Structure of the the slc26 transporter slc26dg in complex with a nanobody (see paper)
25% identity, 88% coverage of query (164 bits)
TC 2.A.53.3.1 / O07488 Sulfate permease from Yersinia enterocolitica (see paper)
25% identity, 84% coverage of query (149 bits)
TC 2.A.53.3.8 / Q8F8H7 SulP homologue with fused C-terminal carbonic anhydrase domain, probable bicarbonate uptake transporter from Leptospira interrogans (see paper)
27% identity, 72% coverage of query (149 bits)
6ki1B / Q55415 The transmembrane domain of a cyanobacterium bicarbonate transporter bica (see paper)
29% identity, 70% coverage of query (139 bits)
SUT41_ARATH / Q9FY46 Sulfate transporter 4.1, chloroplastic; AST82 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 93% coverage of query (138 bits)
7lhvA / Q9FY46 Structure of arabidopsis thaliana sulfate transporter atsultr4;1 (see paper)
24% identity, 93% coverage of query (138 bits)
P96878 carbonic anhydrase (EC 4.2.1.1) from Mycobacterium tuberculosis (see paper)
TC 2.A.53.3.12 / P96878 A bicarbonate transporter fused to a carbonic anhydrase, Rv3273 from Mycobacterium tuberculosis
26% identity, 84% coverage of query (134 bits)
S2611_CAVPO / G3C7W6 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Cavia porcellus (Guinea pig) (see paper)
TC 2.A.53.1.9 / G3C7W6 Slc26a11 Cl-/oxalate or sulfate (but not bicarbonate) exchanger from Cavia porcellus (see paper)
25% identity, 93% coverage of query (130 bits)
TC 2.A.53.3.2 / Q7U617 Bicarbonate:Na+ symporter, BicA (see paper)
26% identity, 86% coverage of query (128 bits)
S2611_HUMAN / Q86WA9 Sodium-independent sulfate anion transporter; Solute carrier family 26 member 11 from Homo sapiens (Human) (see 3 papers)
26% identity, 92% coverage of query (125 bits)
SUT21_ARATH / O04722 Sulfate transporter 2.1; AST68 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
23% identity, 93% coverage of query (125 bits)
SUT22_ARATH / P92946 Sulfate transporter 2.2; AST56; AtH14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
24% identity, 93% coverage of query (125 bits)
7v75A Thermostabilized human prestin in complex with salicylate (see paper)
25% identity, 84% coverage of query (123 bits)
7v74A Thermostabilized human prestin in complex with sulfate
25% identity, 84% coverage of query (123 bits)
7xulA Human slc26a3 in complex with tenidap
26% identity, 77% coverage of query (120 bits)
7xujA Human slc26a3 in complex with uk5099
26% identity, 77% coverage of query (119 bits)
7xuhA / P40879 Down-regulated in adenoma in complex with tqr1122
25% identity, 77% coverage of query (116 bits)
SULT2_CHLRE / A8J6J0 Proton/sulfate cotransporter 2 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see 2 papers)
TC 2.A.53.1.8 / A8J6J0 The proton:sulfate symporter, SulP from Chlamydomonas reinhardtii (see paper)
22% identity, 94% coverage of query (114 bits)
S26A3_HUMAN / P40879 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Homo sapiens (Human) (see 16 papers)
TC 2.A.53.2.18 / P40879 Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3) from Homo sapiens (see 12 papers)
26% identity, 77% coverage of query (113 bits)
TC 2.A.53.1.12 / Q0P7I2 Symbiotic sulfate transporter-1, SST1 of 645 aas from Lotus japonicus
23% identity, 93% coverage of query (110 bits)
TC 2.A.53.4.1 / P72770 Sulfate transporter (see paper)
25% identity, 80% coverage of query (110 bits)
TC 2.A.53.1.4 / P53393 Low-affinity sulfate:H+ symporter, Sut3 from Stylosanthes hamata (see paper)
25% identity, 93% coverage of query (108 bits)
bst3.1 / CAE46442.1 sulphate transporter from Brassica napus (see paper)
22% identity, 89% coverage of query (104 bits)
SUT33_ARATH / Q9SXS2 Probable sulfate transporter 3.3; AST91 from Arabidopsis thaliana (Mouse-ear cress)
22% identity, 90% coverage of query (103 bits)
SUT11_ARATH / Q9SAY1 Sulfate transporter 1.1; AST101; High-affinity sulfate transporter 1; Hst1At from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.7 / Q9SAY1 High affinity sulfate transporter, Sultr1.1 regulated differently from Sultr1.2 (2.A.53.1.6) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
21% identity, 87% coverage of query (103 bits)
ST1 / CAA65291.1 high affinity sulphate transporter from Hordeum vulgare (see paper)
22% identity, 94% coverage of query (102 bits)
Y1739_MYCTU / P9WGF7 Probable sulfate transporter Rv1739c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 2.A.53.4.2 / P71997 Sulfate transporter, Rv1739c from Mycobacterium tuberculosis
27% identity, 78% coverage of query (101 bits)
sB sulfate permease from Emericella nidulans (see 3 papers)
25% identity, 71% coverage of query (99.4 bits)
SULX_YEAST / P53394 Putative sulfate transporter YPR003C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
24% identity, 72% coverage of query (99.0 bits)
sutA / AAF14540.1 SutA from Penicillium chrysogenum (see paper)
25% identity, 71% coverage of query (97.4 bits)
SUT12_ARATH / Q9MAX3 Sulfate transporter 1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
TC 2.A.53.1.6 / Q9MAX3 The sulfate transporter, Sultr1.2 with C-terminal STAS domain that is required both for activity and biogenesis/stability (Shibagaki and Grossman, 2006). It physically interacts with 0-acetylserine (thiol)lyase (cysteine synthetase) via its STAS domain. This interaction stimulates the activity of from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
SULTR1;2 / RF|NP_849899.1 sulfate transporter 1.2 from Arabidopsis thaliana (see paper)
23% identity, 94% coverage of query (95.1 bits)
TC 2.A.53.2.5 / Q99NH7 Prestin, the outer hair cell voltage-sensitive motor protein (voltage sensitivity depends on intracellular Cl- and HCO3- which may bind to prestin). Prestin transports anions including formate and oxalate; transport and voltage-sensing capabilities are independent functions of the same protein (Bai et al., 2009). Prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility from Mus musculus (Mouse) (see paper)
Slc26a5 / GB|AAG59999.2 prestin from Mus musculus
22% identity, 78% coverage of query (94.7 bits)
S26A7_HUMAN / Q8TE54 Anion exchange transporter; Solute carrier family 26 member 7 from Homo sapiens (Human) (see 11 papers)
TC 2.A.53.2.6 / Q8TE54 Basolateral kidney cortical collecting duct and parietal cell chloride/sulfate/oxalate permease or channel, SLC26A7 [substrate preference: NO3- >> Cl- = Br- = I- > SO42- = Glucarate-] (minimal OH- and HCO3- transport; regulated by cytoplasmic pH) (see 7 papers)
SLC26A7 / RF|NP_439897.1 anion exchange transporter from Homo sapiens (see paper)
23% identity, 82% coverage of query (93.6 bits)
S26A5_RAT / Q9EPH0 Prestin; Solute carrier family 26 member 5 from Rattus norvegicus (Rat) (see 11 papers)
22% identity, 78% coverage of query (92.8 bits)
SUT13_ARATH / Q9FEP7 Sulfate transporter 1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 94% coverage of query (92.0 bits)
S26A5_MERUN / Q9JKQ2 Prestin; Solute carrier family 26 member 5 from Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus) (see 4 papers)
21% identity, 78% coverage of query (90.9 bits)
S26A5_MOUSE / Q99NH7 Prestin; Solute carrier family 26 member 5 from Mus musculus (Mouse) (see 5 papers)
21% identity, 78% coverage of query (90.5 bits)
S26A7_MOUSE / Q8R2Z3 Anion exchange transporter; Solute carrier family 26 member 7 from Mus musculus (Mouse) (see 9 papers)
22% identity, 82% coverage of query (88.2 bits)
TC 2.A.53.1.1 / P38359 High-affinity sulfate permease from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
SUL1 / RF|NP_009853.1 sulfate permease 1 from Saccharomyces cerevisiae
23% identity, 72% coverage of query (87.8 bits)
7lguA / P58743 Structure of human prestin in the presence of nacl (see paper)
20% identity, 78% coverage of query (86.7 bits)
S26A5_HUMAN / P58743 Prestin; Solute carrier family 26 member 5 from Homo sapiens (Human) (see 2 papers)
TC 2.A.53.2.19 / P58743 Prestin (Solute carrier family 26 member 5) from Homo sapiens (see 3 papers)
21% identity, 78% coverage of query (86.3 bits)
S26A1_RAT / P45380 Sulfate anion transporter 1; SAT-1; Canalicular sulfate transporter; Solute carrier family 26 member 1; Sulfate/carbonate antiporter from Rattus norvegicus (Rat) (see 7 papers)
TC 2.A.53.2.2 / P45380 Canicular sulfate:HCO3- antiporter (Slc26a1) from Rattus norvegicus (Rat) (see paper)
24% identity, 80% coverage of query (84.7 bits)
S26A5_TURTR / D7PC76 Prestin; Solute carrier family 26 member 5 from Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) (see paper)
21% identity, 78% coverage of query (84.0 bits)
S26A1_MOUSE / P58735 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Mus musculus (Mouse) (see 4 papers)
24% identity, 80% coverage of query (82.4 bits)
TC 2.A.53.2.11 / G3C7W5 Guinea pig Slc26a3 electroneutral Cl-/HCO3- exchanger (does not transport oxalate or sulfate). from Cavia porcellus (see paper)
23% identity, 77% coverage of query (80.1 bits)
S26A4_RAT / Q9R154 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Rattus norvegicus (Rat) (see 4 papers)
24% identity, 85% coverage of query (80.1 bits)
7ch1A / Q7LBE3 The overall structure of slc26a9 (see paper)
22% identity, 83% coverage of query (79.3 bits)
8sgwC / A0A8D0Z6H8 Pendrin in complex with chloride
22% identity, 88% coverage of query (79.0 bits)
8sieC Pendrin in complex with bicarbonate
22% identity, 88% coverage of query (79.0 bits)
8shcC Pendrin in complex with niflumic acid
22% identity, 88% coverage of query (79.0 bits)
S26A4_MOUSE / Q9R155 Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 from Mus musculus (Mouse) (see 5 papers)
TC 2.A.53.2.4 / Q9R155 Pendrin (Pendred) syndrome (hereditary deafness) anion transporter (Na+-independent). Anions transported: iodide (thyroid gland; apical membrane of follicular epithelium); bicarbonate (kidney; apical membrane of intercalated cells of the cortical collecting duct), chloride, formate, etc. Pendrin probably catalyzes uniport and anion/anion antiport (SLC26A4). It also regulates Na+ absorption by the epithelial Na+ channel (Wall and Pech, 2008). CFTR controls the rate of liquid secretion while pendrin mediates transcellular HCO3- from Mus musculus (Mouse) (see paper)
24% identity, 86% coverage of query (78.6 bits)
S26A5_DANRE / Q7T2C4 Prestin; Solute carrier family 26 member 5 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
21% identity, 78% coverage of query (75.1 bits)
S26A9_MOUSE / Q8BU91 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.53.2.10 / Q8BU91 The anion exchanger, channel and Na+-transporter, SLC26a9 from Mus musculus (see 3 papers)
22% identity, 80% coverage of query (74.7 bits)
S26A3_MOUSE / Q9WVC8 Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.53.2.3 / Q9WVC8 Intestinal down-regulated in adenoma (DRA) protein; HCO3-/Cl- antiporter, SLC26a3 (responsible for congenital chloride-losing diarrhea in humans) (Schweinfest et al., 2006). DRA has 12 putative TMSs and a C-terminal STAS domain required for function and activation of CFTR by DRA (Dorwart et al., 2008). Catalyzes 2Cl-/1HCO3- antiport, Cl-/OH- exchange and sulfate transport (Shcheynikov et al., 2006; Moseley et al., 1999). Loss in mice impairs mucosal HCO3- from Mus musculus (Mouse) (see 2 papers)
Slc26a3 / RF|NP_067328.1 chloride anion exchanger from Mus musculus (see paper)
23% identity, 77% coverage of query (73.2 bits)
S26A9_HUMAN / Q7LBE3 Solute carrier family 26 member 9; Anion transporter/exchanger protein 9 from Homo sapiens (Human) (see 5 papers)
TC 2.A.53.2.15 / Q7LBE3 Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9) from Homo sapiens (see 4 papers)
21% identity, 80% coverage of query (72.8 bits)
TC 2.A.53.3.7 / Q09764 SulP homologue with fused C-terminal STAS-CAP-ED domain (function unknown) from Schizosaccharomyces pombe (Fission yeast) (see paper)
RF|NP_592941.1 uncharacterized protein C24H6.11c from Schizosaccharomyces pombe
22% identity, 80% coverage of query (72.0 bits)
S26A1_HUMAN / Q9H2B4 Sulfate anion transporter 1; SAT-1; Solute carrier family 26 member 1 from Homo sapiens (Human) (see 3 papers)
TC 2.A.53.2.16 / Q9H2B4 Sulfate anion transporter 1 (SAT-1 or SAT1) (Solute carrier family 26 member 1); anion exchanger. Transports chloride, sulfate, bicarbonate and oxalate (Regeer et al. 2003; Lee et al. 2003). The mouse and rat orthologues have the same specificities and functions. Loss in mice is associated with hyperoxalurea and calcium oxalate kidney stones, and specific mutations when heterozygous in humans cause urolithiasis (Dawson et al. 2013). When homozygous, they can cause severe nephrocalcinosis from Homo sapiens (see 5 papers)
24% identity, 83% coverage of query (71.6 bits)
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Lawrence Berkeley National Laboratory