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Searching for up to 100 curated homologs for 203771 FitnessBrowser__MR1:203771 (451 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5u1oB / Q87TK1 2.3 angstrom resolution crystal structure of glutathione reductase from vibrio parahaemolyticus in complex with fad.
    75% identity, 100% coverage of query (691 bits)

5vdnA / Q8CZL0 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
    71% identity, 100% coverage of query (647 bits)

GorA / b3500 glutathione reductase (NADPH) (EC 1.8.1.7) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
gor / P06715 glutathione reductase (NADPH) (EC 1.8.1.7) from Escherichia coli (strain K12) (see 31 papers)
gor / GB|AAC76525.1 glutathione reductase; EC 1.8.1.7 from Escherichia coli K12 (see 6 papers)
    69% identity, 100% coverage of query (632 bits)

P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12)
    69% identity, 100% coverage of query (632 bits)

1gerB / P06715 The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
    69% identity, 100% coverage of query (630 bits)

1getA Anatomy of an engineered NAD-binding site
    69% identity, 100% coverage of query (630 bits)

1geuA Anatomy of an engineered NAD-binding site
    67% identity, 100% coverage of query (611 bits)

5v36A / Q8DUR5 1.88 angstrom resolution crystal structure of glutathione reductase from streptococcus mutans ua159 in complex with fad
    66% identity, 100% coverage of query (597 bits)

6n7fA / Q9A0E2 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
    62% identity, 100% coverage of query (571 bits)

6b4oA / Q82Z09 1.73 angstrom resolution crystal structure of glutathione reductase from enterococcus faecalis in complex with fad
    58% identity, 99% coverage of query (522 bits)

6du7A / A0A0U0ARX4 Glutathione reductase from streptococcus pneumoniae (see paper)
    55% identity, 96% coverage of query (489 bits)

2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD
    51% identity, 100% coverage of query (455 bits)

Q9NL96 glutathione-disulfide reductase (EC 1.8.1.7) from Physarum polycephalum (see paper)
    53% identity, 100% coverage of query (453 bits)

GASHR_MARGR / D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
    51% identity, 100% coverage of query (452 bits)

2r9zB / D0VWY5 Glutathione amide reductase from chromatium gracile (see paper)
    51% identity, 100% coverage of query (447 bits)

GSHR_DICDI / Q8T137 Glutathione reductase; GR; GRase; GSR; EC 1.8.1.7 from Dictyostelium discoideum (Social amoeba) (see paper)
    51% identity, 99% coverage of query (446 bits)

5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex
    51% identity, 99% coverage of query (446 bits)

4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme
    51% identity, 99% coverage of query (446 bits)

3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex
    51% identity, 99% coverage of query (446 bits)

2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex
    51% identity, 99% coverage of query (446 bits)

4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase
    51% identity, 99% coverage of query (438 bits)

3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity
    51% identity, 99% coverage of query (438 bits)

2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5
    51% identity, 99% coverage of query (438 bits)

2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi
    51% identity, 99% coverage of query (438 bits)

1xanA Human glutathione reductase in complex with a xanthene inhibitor
    51% identity, 99% coverage of query (438 bits)

1grbA Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 angstroms resolution
    51% identity, 99% coverage of query (438 bits)

1dncA Human glutathione reductase modified by diglutathione-dinitroso-iron
    51% identity, 99% coverage of query (438 bits)

1bwcA Structure of human glutathione reductase complexed with ajoene inhibitor and subversive substrate
    51% identity, 99% coverage of query (438 bits)

GSR / P00390 glutathione reductase subunit (EC 1.8.1.7) from Homo sapiens (see 6 papers)
GSHR_HUMAN / P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
    51% identity, 99% coverage of query (437 bits)

3djjA / P00390 Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
    51% identity, 99% coverage of query (437 bits)

2hqmA / P41921 Crystal structure of glutathione reductase glr1 from the yeast saccharomyces cerevisiae (see paper)
    50% identity, 100% coverage of query (428 bits)

GSHR_YEAST / P41921 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    50% identity, 100% coverage of query (426 bits)

GSHR_CAEEL / Q93379 Glutathione reductase, mitochondrial; GR; Glutathione disulfide reductase; EC 1.8.1.7 from Caenorhabditis elegans (see 2 papers)
Q93379 glutathione-disulfide reductase (EC 1.8.1.7) from Caenorhabditis elegans (see paper)
    54% identity, 100% coverage of query (421 bits)

F1LRE1 glutathione-disulfide reductase (EC 1.8.1.7) from Rattus norvegicus (see paper)
    50% identity, 91% coverage of query (410 bits)

GSHR_SCHPO / P78965 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
pgr1 / RF|NP_595589.1 glutathione reductase from Schizosaccharomyces pombe (see 2 papers)
    49% identity, 100% coverage of query (409 bits)

Q59NQ5 glutathione-disulfide reductase (EC 1.8.1.7) from Candida albicans (see paper)
GLR1 glutathione oxidoreductase from Candida albicans (see paper)
    46% identity, 99% coverage of query (397 bits)

glrA hypothetical glutathione reductase (Eurofung) from Emericella nidulans (see paper)
    47% identity, 100% coverage of query (371 bits)

P42770 glutathione-disulfide reductase (EC 1.8.1.7) from Arabidopsis thaliana (see 2 papers)
    40% identity, 99% coverage of query (332 bits)

GSHRP_PEA / P27456 Glutathione reductase, chloroplastic/mitochondrial; GR; GRase; GOR1; EC 1.8.1.7 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
    40% identity, 99% coverage of query (332 bits)

1onfA / Q94655 Crystal structure of plasmodium falciparum glutathione reductase (see paper)
    42% identity, 99% coverage of query (330 bits)

GSHR_PLAF7 / O15770 Glutathione reductase; GRase; PfGR; EC 1.8.1.7 from Plasmodium falciparum (isolate 3D7) (see 2 papers)
    39% identity, 99% coverage of query (322 bits)

GSHR_PLAFK / Q94655 Glutathione reductase; GRase; PfGR; EC 1.8.1.7 from Plasmodium falciparum (isolate K1 / Thailand) (see 3 papers)
    39% identity, 99% coverage of query (321 bits)

A8CCK2 glutathione-disulfide reductase (EC 1.8.1.7) from Hordeum vulgare (see paper)
    38% identity, 99% coverage of query (316 bits)

A0A068EUE1 glutathione-disulfide reductase (EC 1.8.1.7) from Cenchrus americanus (see paper)
    37% identity, 99% coverage of query (301 bits)

GSHRC_BRARP / O04955 Glutathione reductase, cytosolic; GR; GRase; EC 1.8.1.7 from Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis) (see paper)
    39% identity, 99% coverage of query (299 bits)

P48642 glutathione-disulfide reductase (EC 1.8.1.7) from Oryza sativa (see 2 papers)
    37% identity, 99% coverage of query (295 bits)

GB|AAC43334 glutathione reductase; EC 1.8.1.7 from Burkholderia cepacia (see paper)
    38% identity, 99% coverage of query (295 bits)

D5LPR3 glutathione-disulfide reductase (EC 1.8.1.7) from Hevea brasiliensis (see paper)
    37% identity, 99% coverage of query (291 bits)

A8CCK8 glutathione-disulfide reductase (EC 1.8.1.7) from Hordeum vulgare (see paper)
    37% identity, 99% coverage of query (289 bits)

TRXR1_EMIHU / B9A1H3 Thioredoxin reductase SEP1; EhSEP1; EC 1.8.1.9 from Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi) (see paper)
B9A1H3 thioredoxin-disulfide reductase (EC 1.8.1.9) from Emiliania huxleyi (see paper)
    38% identity, 99% coverage of query (281 bits)

8plwA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 33.
    36% identity, 99% coverage of query (277 bits)

8pluA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 31.
    36% identity, 99% coverage of query (277 bits)

8ploA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 25.
    36% identity, 99% coverage of query (277 bits)

8pliA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 19.
    36% identity, 99% coverage of query (277 bits)

8plhA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 18.
    36% identity, 99% coverage of query (277 bits)

8plgA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 17.
    36% identity, 99% coverage of query (277 bits)

Q7XEM9 glutathione-disulfide reductase (EC 1.8.1.7) from Oryza sativa (see paper)
    42% identity, 77% coverage of query (276 bits)

8pl1A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 2.
    36% identity, 99% coverage of query (276 bits)

TRXR_PLAF7 / P61076 Thioredoxin reductase; PfTrxR; EC 1.8.1.9 from Plasmodium falciparum (isolate 3D7) (see 6 papers)
    35% identity, 99% coverage of query (275 bits)

TRXR_PLAF5 / Q25861 Thioredoxin reductase; PfTrxR; EC 1.8.1.9 from Plasmodium falciparum (isolate FCH-5) (see paper)
    35% identity, 99% coverage of query (275 bits)

4j56A / P61076 Structure of plasmodium falciparum thioredoxin reductase-thioredoxin complex (see paper)
    35% identity, 99% coverage of query (275 bits)

8a1rA / Q962Y6 Cryo-em structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor (see paper)
    37% identity, 99% coverage of query (275 bits)

Q962Y6 glutathione-disulfide reductase (EC 1.8.1.7); thioredoxin-disulfide reductase (EC 1.8.1.9) from Schistosoma mansoni (see 2 papers)
    37% identity, 99% coverage of query (275 bits)

8plvA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 32.
    37% identity, 99% coverage of query (275 bits)

8pllA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 22.
    37% identity, 99% coverage of query (275 bits)

8plkA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 21.
    37% identity, 99% coverage of query (275 bits)

8plfA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 16.
    37% identity, 99% coverage of query (275 bits)

8plmA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 23.
    37% identity, 99% coverage of query (275 bits)

6zstA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 3-(3-methoxyquinoxalin-2-yl)propanoic acid
    37% identity, 99% coverage of query (275 bits)

6rtmA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 2 hour of soaking
    37% identity, 99% coverage of query (275 bits)

8plyB Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 35.
    37% identity, 99% coverage of query (275 bits)

8plxA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 34.
    37% identity, 99% coverage of query (275 bits)

8pltA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 30.
    37% identity, 99% coverage of query (275 bits)

8plsA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 29.
    37% identity, 99% coverage of query (275 bits)

8plrA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 28.
    37% identity, 99% coverage of query (275 bits)

8plqB Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 27.
    37% identity, 99% coverage of query (275 bits)

8plpA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 26.
    37% identity, 99% coverage of query (275 bits)

8plnA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 24.
    37% identity, 99% coverage of query (275 bits)

8pljA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 20.
    37% identity, 99% coverage of query (275 bits)

8pleA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 15.
    37% identity, 99% coverage of query (275 bits)

8pldA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 14.
    37% identity, 99% coverage of query (275 bits)

8plcA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 13.
    37% identity, 99% coverage of query (275 bits)

8plbA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 12.
    37% identity, 99% coverage of query (275 bits)

8plaA Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 11.
    37% identity, 99% coverage of query (275 bits)

8pl9A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 10.
    37% identity, 99% coverage of query (275 bits)

8pl8A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 9.
    37% identity, 99% coverage of query (275 bits)

8pl7A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 8.
    37% identity, 99% coverage of query (275 bits)

8pl6A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 7.
    37% identity, 99% coverage of query (275 bits)

8pl5A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 6.
    37% identity, 99% coverage of query (275 bits)

8pl4A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 5.
    37% identity, 99% coverage of query (275 bits)

8pl3A Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 4.
    37% identity, 99% coverage of query (275 bits)

8pl2B Thioredoxin glutathione reductase of schistosoma mansoni fragment screen hit 3.
    37% identity, 99% coverage of query (275 bits)

8pddA Thioredoxin glutathione reductase of schistosoma mansoni at 1.25a resolution.
    37% identity, 99% coverage of query (275 bits)

6zp3A Thioredoxin glutathione reductase from schistosoma mansoni in complex with 2-methylindole-3-acetic acid
    37% identity, 99% coverage of query (275 bits)

6zlpA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 4-aminopiazthiole
    37% identity, 99% coverage of query (275 bits)

6rtjA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 1 hour of soaking
    37% identity, 99% coverage of query (275 bits)

6fmzA Thioredoxin glutathione reductase from schistosoma mansoni in complex with 1,4-bis(2-hydroxyethyl)piperazine
    37% identity, 99% coverage of query (275 bits)

6fmuA Thioredoxin glutathione reductase from schistosome mansoni in complex with 2-[4-(4-amino-butyl)-piperazin-1-yl]-ethanol
    37% identity, 99% coverage of query (275 bits)

3h4kA Crystal structure of the wild type thioredoxin glutatione reductase from schistosoma mansoni in complex with auranofin
    37% identity, 99% coverage of query (275 bits)

2x8hA Thioredoxin glutathione reductase from schistosoma mansoni in complex with gsh
    37% identity, 99% coverage of query (275 bits)

Build an alignment

Build an alignment for 203771 and 100 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory