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Searching for up to 100 curated homologs for 206872 MicrobesOnline__882:206872 (551 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

celB / AAA21561.1 phosphoglucomutase from Komagataeibacter xylinus (see paper)
    59% identity, 99% coverage of query (690 bits)

A0A0H3NJ17 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
Q8ZQW9 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    60% identity, 99% coverage of query (675 bits)

2fuvA / Q8ZQW9 Phosphoglucomutase from salmonella typhimurium.
    60% identity, 99% coverage of query (672 bits)

Blu / b0688 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
pgm / P36938 phosphoglucomutase (EC 5.4.2.2) from Escherichia coli (strain K12) (see 11 papers)
PGM_ECOLI / P36938 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Escherichia coli (strain K12) (see 2 papers)
pgm / GB|ABB65241.1 phosphoglucomutase; EC 5.4.2.2 from Escherichia coli K12 (see 6 papers)
    59% identity, 99% coverage of query (660 bits)

pgmA / I6Y2G3 phosphoglucomutase (EC 5.4.2.2) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
I6Y2G3 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Mycobacterium tuberculosis (see paper)
    57% identity, 99% coverage of query (587 bits)

Build an alignment

Build an alignment for 206872 and 5 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

6y8yA / A0A6P3VN15 Structure of baltic herring (clupea harengus) phosphoglucomutase 5 (pgm5) with bound glucose-1-phosphate (see paper)
    26% identity, 76% coverage of query (106 bits)

PGM5_MOUSE / Q8BZF8 Phosphoglucomutase-like protein 5 from Mus musculus (Mouse) (see paper)
    26% identity, 75% coverage of query (101 bits)

PGM1 / P33401 phosphoglucomutase-1 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
PGM1_YEAST / P33401 Phosphoglucomutase 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
    27% identity, 76% coverage of query (101 bits)

PGM5_RAT / D3ZVR9 Phosphoglucomutase-like protein 5 from Rattus norvegicus (Rat) (see paper)
    26% identity, 71% coverage of query (100 bits)

7pjcB / A0A1D8PSA9 The structure of candida albicans phosphoglucomutase with isothiazolone modification on cys359
    25% identity, 87% coverage of query (99.8 bits)

6snoA / P36871 Crystal structures of human pgm1 isoform 2 (see paper)
    25% identity, 76% coverage of query (97.1 bits)

6snqA Crystal structures of human pgm1 isoform 2
    25% identity, 76% coverage of query (97.1 bits)

PGM_EMENI / Q9P931 Phosphoglucomutase; PGM; Glucose phosphomutase; EC 5.4.2.2 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
pgmB phosphoglucomutase; EC 5.4.2.2 from Emericella nidulans (see paper)
    27% identity, 78% coverage of query (92.8 bits)

PGM1 / P36871 phosphoglucomutase-1 (EC 5.4.2.2) from Homo sapiens (see 3 papers)
PGM1_HUMAN / P36871 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Homo sapiens (Human) (see 8 papers)
P36871 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Homo sapiens (see 4 papers)
    25% identity, 79% coverage of query (92.4 bits)

PGMMM_THEKO / Q68BJ6 Phosphoglucomutase/phosphomannomutase; PGM/PMM; EC 5.4.2.2; EC 5.4.2.8 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    24% identity, 87% coverage of query (91.3 bits)

PGM1_RABIT / P00949 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
    24% identity, 79% coverage of query (91.3 bits)

3pmgA Structure of rabbit muscle phosphoglucomutase at 2.4 angstroms resolution. Use of freezing point depressant and reduced temperature to enhance diffractivity
    24% identity, 79% coverage of query (91.3 bits)

1c4gA Phosphoglucomutase vanadate based transition state analog complex
    24% identity, 79% coverage of query (91.3 bits)

1c47A Binding driven structural changes in crystaline phosphoglucomutase associated with chemical reaction
    24% identity, 79% coverage of query (91.3 bits)

PGM2 / P37012 phosphoglucomutase-2 (EC 5.4.2.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
PGM2_YEAST / P37012 Phosphoglucomutase 2; PGM 2; D-glucose-1,6-diphosphate:D-glucose-1-phosphate phosphotransferase; Glucose phosphomutase 2; EC 5.4.2.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 10 papers)
    25% identity, 76% coverage of query (90.1 bits)

7p5oB / Q4WY53 Crystal structure of aspergillus fumigatus phosphoglucomutase in complex with the reaction intermediate
    25% identity, 84% coverage of query (89.7 bits)

5jn5A Crystal structure of the d263y missense variant of human pgm1
    24% identity, 79% coverage of query (89.0 bits)

AAV49510.1 phosphoglucomutase from Acidithiobacillus ferrooxidans (see paper)
    29% identity, 74% coverage of query (87.4 bits)

PGM1_RAT / P38652 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Rattus norvegicus (Rat) (see paper)
    25% identity, 76% coverage of query (87.0 bits)

7s0wB / P36871 Crystal structure of the t337m variant of human pgm-1 (see paper)
    25% identity, 76% coverage of query (87.0 bits)

pgcA / P18159 α-phosphoglucomutase (EC 5.4.2.2) from Bacillus subtilis (strain 168) (see paper)
PGCA_BACSU / P18159 Phosphoglucomutase; PGM; Alpha-phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Bacillus subtilis (strain 168) (see 2 papers)
    26% identity, 87% coverage of query (84.3 bits)

Q670S5 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Trypanosoma cruzi (see paper)
    25% identity, 87% coverage of query (84.0 bits)

PH0923 / O58651 phosphomannose mutase (EC 5.4.2.8) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
1wqaA / O58651 Crystal structure of pyrococcus horikoshii phosphomannomutase/phosphoglucomutase complexed with mg2+
    23% identity, 87% coverage of query (83.2 bits)

P93805 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
    27% identity, 74% coverage of query (82.8 bits)

Q980S1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2); phosphomannomutase (EC 5.4.2.8) from Saccharolobus solfataricus (see paper)
    22% identity, 87% coverage of query (82.0 bits)

Q4QCF1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Leishmania major (see paper)
    27% identity, 79% coverage of query (81.6 bits)

PGMC1_MAIZE / P93804 Phosphoglucomutase, cytoplasmic 1; PGM 1; Glucose phosphomutase 1; EC 5.4.2.2 from Zea mays (Maize) (see paper)
P93804 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Zea mays (see paper)
    26% identity, 70% coverage of query (81.6 bits)

A8N8Z1 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Coprinopsis cinerea (see paper)
    26% identity, 76% coverage of query (81.3 bits)

A0A2H5BEG8 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) (EC 5.4.2.2) from Ganoderma lucidum (see paper)
    26% identity, 71% coverage of query (80.5 bits)

P74027 glucose-1,6-bisphosphate synthase from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    24% identity, 88% coverage of query (80.1 bits)

pgmA / CAB96418.1 phosphoglucomutase from Streptococcus thermophilus (see paper)
    26% identity, 93% coverage of query (79.7 bits)

PGM_ENTH1 / O15820 Phosphoglucomutase; Glucose phosphomutase; EC 5.4.2.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
    25% identity, 74% coverage of query (79.3 bits)

4qg5A / Q4QCF1 Crystal structure of phosphoglucomutase from leishmania major at 3.5 angstrom resolution
    27% identity, 76% coverage of query (78.2 bits)

PGM1_PARTE / P47244 Phosphoglucomutase-1; PGM 1; Glucose phosphomutase 1; Parafusin; Pf; pp63; EC 5.4.2.2 from Paramecium tetraurelia (see paper)
    25% identity, 74% coverage of query (75.1 bits)

1kfqA / P47244 Crystal structure of exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutse) from paramecium. Open form (see paper)
    25% identity, 74% coverage of query (75.1 bits)

1kfiA Crystal structure of the exocytosis-sensitive phosphoprotein, pp63/parafusin (phosphoglucomutase) from paramecium
    25% identity, 74% coverage of query (75.1 bits)

ST0242 / Q976E4 hexose-6-phosphate mutase/isomerase (EC 5.3.1.8; EC 5.3.1.9; EC 5.4.2.10; EC 5.4.2.13) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (see paper)
PGMUT_SULTO / Q976E4 Phosphoglucosamine/phosphogalactosamine mutase; PGlcNM; EC 5.4.2.10; EC 5.4.2.13 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see paper)
Q976E4 phosphogalactosamine mutase (EC 5.4.2.13) from Sulfurisphaera tokodaii (see paper)
    22% identity, 87% coverage of query (72.4 bits)

4il8A / P26276 Crystal structure of an h329a mutant of p. Aeruginosa pmm/pgm (see paper)
    21% identity, 76% coverage of query (48.1 bits)

2h5aX Complex of the enzyme pmm/pgm with xylose 1-phosphate
    21% identity, 76% coverage of query (45.8 bits)

2h4lX Complex of pmm/pgm with ribose 1-phosphate
    21% identity, 76% coverage of query (45.8 bits)

2fkfA Phosphomannomutase/phosphoglucomutase from pseudomonas aeruginosa with alpha-d-glucose 1,6-bisphosphate bound
    21% identity, 76% coverage of query (45.8 bits)

1pcmX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    21% identity, 76% coverage of query (45.8 bits)

1p5gX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    21% identity, 76% coverage of query (45.8 bits)

1p5dX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    21% identity, 76% coverage of query (45.8 bits)

1pcjX Enzyme-ligand complex of p. Aeruginosa pmm/pgm
    21% identity, 76% coverage of query (45.8 bits)

algC / P26276 phosphomannomutase (EC 5.4.2.2; EC 5.4.2.8) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
ALGC_PSEAE / P26276 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 12 papers)
    21% identity, 76% coverage of query (45.8 bits)

Q02E40 Phosphomannomutase/phosphoglucomutase; PMM / PGM; EC 5.4.2.2; EC 5.4.2.8 from Pseudomonas aeruginosa (strain UCBPP-PA14)
    21% identity, 76% coverage of query (45.8 bits)

1k2yX Crystal structure of phosphomannomutase/phosphoglucomutase s108a mutant from p. Aeruginosa
    21% identity, 76% coverage of query (44.7 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory