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Searching for up to 100 curated homologs for 207136 MicrobesOnline__882:207136 (251 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4y96A / A0A0M3KL18 Crystal structure of triosephosphate isomerase from gemmata obscuriglobus (see paper)
    49% identity, 100% coverage of query (208 bits)

pgk / P36204 Pgk (EC 2.7.2.3; EC 5.3.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 4 papers)
PGKT_THEMA / P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 3 papers)
P36204 triose-phosphate isomerase (EC 5.3.1.1) from Thermotoga maritima (see 2 papers)
    44% identity, 99% coverage of query (205 bits)

6neeB Crystal structure of a reconstructed ancestor of triosephosphate isomerase from eukaryotes (see paper)
    44% identity, 100% coverage of query (197 bits)

TPIS_GEOSE / P00943 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 3 papers)
P00943 triose-phosphate isomerase (EC 5.3.1.1) from Geobacillus stearothermophilus (see paper)
    45% identity, 100% coverage of query (197 bits)

1btmA / P00943 Triosephosphate isomerase (tim) complexed with 2-phosphoglycolic acid (see paper)
    45% identity, 100% coverage of query (197 bits)

6ooiC / P48501 Crystal structure of triosephosphate isomerase from schistosoma mansoni in complex with 2pg (see paper)
    42% identity, 100% coverage of query (191 bits)

TPIS_CAEEL / Q10657 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Caenorhabditis elegans (see paper)
Q10657 triose-phosphate isomerase (EC 5.3.1.1) from Caenorhabditis elegans (see paper)
    45% identity, 100% coverage of query (190 bits)

TPIS_BARHE / Q8L1Z5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bartonella henselae (strain ATCC 49882 / DSM 28221 / CCUG 30454 / Houston 1) (Rochalimaea henselae)
Q8L1Z5 triose-phosphate isomerase (EC 5.3.1.1) from Bartonella henselae (see paper)
    42% identity, 99% coverage of query (189 bits)

TPIS_PROCL / F5A6E9 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Pro c 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Procambarus clarkii (Red swamp crayfish) (see paper)
    41% identity, 100% coverage of query (188 bits)

TPIS_THET8 / Q5SJR1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
    46% identity, 96% coverage of query (188 bits)

TPIS_RABIT / P00939 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Oryctolagus cuniculus (Rabbit) (see 3 papers)
P00939 triose-phosphate isomerase (EC 5.3.1.1) from Oryctolagus cuniculus (see 3 papers)
    44% identity, 100% coverage of query (187 bits)

5zfxB / A0A074Z863 Crystal structure of triosephosphate isomerase from opisthorchis viverrini (see paper)
    42% identity, 96% coverage of query (187 bits)

1r2rB Crystal structure of rabbit muscle triosephosphate isomerase
    44% identity, 100% coverage of query (187 bits)

4owgA Crystal structure of rabbit muscle triosephosphate isomerase-pep complex
    44% identity, 100% coverage of query (187 bits)

P35144 triose-phosphate isomerase (EC 5.3.1.1) from Priestia megaterium (see paper)
    42% identity, 100% coverage of query (186 bits)

TPI1 / P60174 Triosephosphate isomerase (EC 5.3.1.1) from Homo sapiens (see 9 papers)
TPIS_HUMAN / P60174 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Homo sapiens (Human) (see 6 papers)
P60174 triose-phosphate isomerase (EC 5.3.1.1) from Homo sapiens (see 2 papers)
    44% identity, 100% coverage of query (185 bits)

1htiB / P60174 Crystal structure of recombinant human triosephosphate isomerase at 2.8 angstroms resolution. Triosephosphate isomerase related human genetic disorders and comparison with the trypanosomal enzyme (see paper)
    44% identity, 100% coverage of query (185 bits)

4pocB Structure of triosephosphate isomerase wild type human enzyme.
    44% identity, 100% coverage of query (185 bits)

TPIS_SCYPA / A0A1L5YRA2 Triosephosphate isomerase; TIM; Allergen Scy p 8; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Scy p 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Scylla paramamosain (Mud crab) (see 2 papers)
    41% identity, 100% coverage of query (184 bits)

TPIS_CLOPE / Q8XKU1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Clostridium perfringens (strain 13 / Type A) (see paper)
    43% identity, 98% coverage of query (184 bits)

P17751 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Mus musculus (Mouse)
    44% identity, 100% coverage of query (184 bits)

P27876 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus subtilis (strain 168)
    41% identity, 99% coverage of query (184 bits)

TPIS_BACCE / Q4MQ55 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus cereus (see paper)
    42% identity, 97% coverage of query (181 bits)

TPIS_STAAR / Q6GIL6 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Staphylococcus aureus (strain MRSA252) (see 3 papers)
Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) from Staphylococcus aureus (see paper)
    39% identity, 98% coverage of query (181 bits)

3uwuA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-3-phosphate
    39% identity, 98% coverage of query (181 bits)

3uwvA / Q6GIL6 Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 2-phosphoglyceric acid (see paper)
    39% identity, 98% coverage of query (180 bits)

3uwzA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate
    39% identity, 98% coverage of query (180 bits)

3uwwA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 3-phosphoglyceric acid
    39% identity, 98% coverage of query (180 bits)

Q8MPF2 triose-phosphate isomerase (EC 5.3.1.1) from Tenebrio molitor (see 2 papers)
    42% identity, 100% coverage of query (178 bits)

A8B3A8 triose-phosphate isomerase (EC 5.3.1.1) from Rhipicephalus microplus (see paper)
    42% identity, 99% coverage of query (178 bits)

A2FT29 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 2 papers)
    41% identity, 95% coverage of query (178 bits)

TPIS_CANAL / Q9P940 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
TPI1 triosephosphate isomerase (TIM); EC 5.3.1.1 from Candida albicans (see 7 papers)
    44% identity, 90% coverage of query (177 bits)

Q0H294 triose-phosphate isomerase (EC 5.3.1.1) from Pteris vittata (see paper)
    42% identity, 99% coverage of query (177 bits)

Q5CSE7 triose-phosphate isomerase (EC 5.3.1.1) from Cryptosporidium parvum (see paper)
    42% identity, 99% coverage of query (177 bits)

A2EGX9 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis (see 3 papers)
    40% identity, 95% coverage of query (176 bits)

P00941 purine-nucleoside phosphorylase (EC 2.4.2.1) from Homo sapiens (see paper)
    42% identity, 96% coverage of query (176 bits)

6bveA / Q59994 Triosephosphate isomerase of synechocystis in complex with 2- phosphoglycolic acid (see paper)
    41% identity, 99% coverage of query (176 bits)

TPIS_CHICK / P00940 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Gallus gallus (Chicken) (see paper)
P00940 triose-phosphate isomerase (EC 5.3.1.1) from Gallus gallus (see 3 papers)
    44% identity, 100% coverage of query (176 bits)

5eywA / K0E682 Crystal structure of litopenaeus vannamei triosephosphate isomerase complexed with 2-phosphoglycolic acid (see paper)
    40% identity, 100% coverage of query (176 bits)

TPIS_DROME / P29613 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Drosophila melanogaster (Fruit fly) (see paper)
    42% identity, 96% coverage of query (175 bits)

1tpb1 Offset of a catalytic lesion by a bound water soluble
    44% identity, 100% coverage of query (174 bits)

6oogA / Q9GTX8 Crystal structure of triosephosphate isomerase from taenia solium in complex with 2pg (see paper)
    41% identity, 100% coverage of query (173 bits)

CTIMC / P48491 cytosolic triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see paper)
TPIS_ARATH / P48491 Triosephosphate isomerase, cytosolic; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
P48491 triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana (see 2 papers)
    42% identity, 96% coverage of query (173 bits)

4y90A / Q9RUP5 Crystal structure of triosephosphate isomerase from deinococcus radiodurans (see paper)
    47% identity, 96% coverage of query (172 bits)

tpiA / P50918 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactococcus lactis subsp. lactis (strain IL1403) (see paper)
    41% identity, 97% coverage of query (172 bits)

tpi / AAC43268.1 triosephosphate isomerase from Lactococcus lactis subsp. lactis (see paper)
    41% identity, 97% coverage of query (172 bits)

TPIS_YEAST / P00942 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
P00942 triose-phosphate isomerase (EC 5.3.1.1) from Saccharomyces cerevisiae (see 8 papers)
    41% identity, 95% coverage of query (171 bits)

TPIS_DEIRA / Q9RUP5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
    46% identity, 96% coverage of query (170 bits)

Q5S7Y5 triose-phosphate isomerase (EC 5.3.1.1) from Chlamydomonas reinhardtii (see paper)
    39% identity, 100% coverage of query (170 bits)

1ssgA / P00940 Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase (see paper)
    43% identity, 100% coverage of query (170 bits)

7rdeB Human triose phosphate isomerase q181p
    43% identity, 100% coverage of query (169 bits)

3uwzB Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate
    38% identity, 98% coverage of query (169 bits)

TPIS_STRCO / Q9Z520 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    45% identity, 98% coverage of query (168 bits)

TPIS_PARBA / Q96VN5 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) (see paper)
    41% identity, 100% coverage of query (168 bits)

3ypiA Electrophilic catalysis in triosephosphase isomerase: the role of histidine-95
    41% identity, 95% coverage of query (168 bits)

4ff7A / P00942 Structure of c126s mutant of saccharomyces cerevisiae triosephosphate isomerase (see paper)
    41% identity, 95% coverage of query (167 bits)

4ff7B Structure of c126s mutant of saccharomyces cerevisiae triosephosphate isomerase
    41% identity, 95% coverage of query (167 bits)

tpi1 triosephosphate isomerase; EC 5.3.1.1 from Schizosaccharomyces pombe (see 2 papers)
    41% identity, 99% coverage of query (166 bits)

P07669 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    41% identity, 99% coverage of query (166 bits)

tpiA / O32757 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
    40% identity, 96% coverage of query (164 bits)

TPIS_ENTH1 / O02611 Triosephosphate isomerase; EhTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see 2 papers)
O02611 triose-phosphate isomerase (EC 5.3.1.1) from Entamoeba histolytica (see 2 papers)
    37% identity, 99% coverage of query (163 bits)

TPI / GI|2143243 triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
    37% identity, 99% coverage of query (163 bits)

TIM / PDB|1M6J_A triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (see paper)
    37% identity, 99% coverage of query (163 bits)

A0A1D3TX75 triose-phosphate isomerase (EC 5.3.1.1) from Anaerobium acetethylicum (see paper)
    38% identity, 99% coverage of query (163 bits)

3taoA / P9WG43 Structure of mycobacterium tuberculosis triosephosphate isomerase bound to phosphoglycolohydroxamate (see paper)
    45% identity, 98% coverage of query (158 bits)

TPIS_MYCTU / P9WG43 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WG43 triose-phosphate isomerase (EC 5.3.1.1) from Mycobacterium tuberculosis (see 2 papers)
    45% identity, 98% coverage of query (158 bits)

2y63A Crystal structure of leishmanial e65q-tim complexed with bromohydroxyacetone phosphate
    40% identity, 99% coverage of query (158 bits)

2y61A Crystal structure of leishmanial e65q-tim complexed with s-glycidol phosphate
    40% identity, 99% coverage of query (158 bits)

2vxnA E65q-tim complexed with phosphoglycolohydroxamate at 0.82 a resolution
    40% identity, 99% coverage of query (158 bits)

1if2A X-ray structure of leishmania mexicana triosephosphate isomerase complexed with ipp
    40% identity, 99% coverage of query (158 bits)

1ci1B / P52270 Crystal structure of triosephosphate isomerase from trypanosoma cruzi in hexane (see paper)
    40% identity, 100% coverage of query (157 bits)

1amkA / P48499 Leishmania mexicana triose phosphate isomerase (see paper)
    40% identity, 99% coverage of query (156 bits)

4bi7A / P36186 Crystal structure of a mutant (c202a) of triosephosphate isomerase from giardia lamblia complexed with 2-phosphoglycolic acid (see paper)
    38% identity, 96% coverage of query (152 bits)

3pf3A Crystal structure of a mutant (c202a) of triosephosphate isomerase from giardia lamblia derivatized with mmts
    38% identity, 96% coverage of query (152 bits)

Tpi / b3919 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
tpiA / P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (strain K12) (see 32 papers)
TPIS_ECODH / B1XB85 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12 / DH10B) (see paper)
TPIS_ECOLI / P0A858 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12) (see 8 papers)
P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (see paper)
4mvaA 1.43 angstrom resolution crystal structure of triosephosphate isomerase (tpia) from escherichia coli in complex with acetyl phosphate. (see paper)
tpiA / RF|NP_418354 triose-phosphate isomerase from Escherichia coli K12 (see 4 papers)
    40% identity, 99% coverage of query (151 bits)

TPIS_PLAFA / Q07412 Triosephosphate isomerase; PfTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Plasmodium falciparum (see 7 papers)
Q07412 triose-phosphate isomerase (EC 5.3.1.1) from Plasmodium falciparum (see 13 papers)
tpi / AAA18799.1 triosephosphate isomerase from Plasmodium falciparum (see paper)
    36% identity, 99% coverage of query (150 bits)

6timB The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes
    41% identity, 96% coverage of query (149 bits)

4timB Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate
    41% identity, 96% coverage of query (149 bits)

1trdB The influence of crystal packing on crystallographic binding studies: a new crystal form of trypanosomal tim
    41% identity, 96% coverage of query (149 bits)

1iigB Structure of trypanosoma brucei brucei triosephosphate isomerase complexed with 3-phosphonopropionate
    41% identity, 96% coverage of query (149 bits)

1ag1T / P04789 Monohydrogen phosphate binding to trypanosomal triosephosphate isomerase (see paper)
    41% identity, 96% coverage of query (149 bits)

1o5xB Plasmodium falciparum tim complexed to 2-phosphoglycerate
    36% identity, 99% coverage of query (149 bits)

1o5xA Plasmodium falciparum tim complexed to 2-phosphoglycerate
    36% identity, 99% coverage of query (149 bits)

1m7pA Plasmodium falciparum triosephosphate isomerase (pftim) compled to substrate analog glycerol-3-phosphate (g3p).
    36% identity, 99% coverage of query (149 bits)

1tsiA Structure of the complex between trypanosomal triosephosphate isomerase and n-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop
    40% identity, 96% coverage of query (148 bits)

1kv5A Structure of trypanosoma brucei brucei tim with the salt-bridge- forming residue arg191 mutated to ser
    40% identity, 96% coverage of query (147 bits)

1wobA Structure of a loop6 hinge mutant of plasmodium falciparum triosephosphate isomerase, w168f, complexed to sulfate
    35% identity, 99% coverage of query (145 bits)

1woaA Structure of the loop6 hinge mutant of plasmodium falciparum triosephosphate isomerase, w168f, complexed with glycerol-2-phosphate
    35% identity, 99% coverage of query (145 bits)

5gzpA / Q07412 Y74cox mutant of plasmodium falciparum triosephosphate isomerase
    35% identity, 99% coverage of query (142 bits)

TPIS_HELPY / P56076 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) (see paper)
P56076 triose-phosphate isomerase (EC 5.3.1.1) from Helicobacter pylori (see 2 papers)
    37% identity, 99% coverage of query (141 bits)

1aw1A / P50921 Triosephosphate isomerase of vibrio marinus complexed with 2- phosphoglycolate (see paper)
    35% identity, 94% coverage of query (136 bits)

TPIS_MORMI / P50921 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (Vibrio marinus) (see paper)
P50921 triose-phosphate isomerase (EC 5.3.1.1) from Moritella marina (see 2 papers)
tpiA / PDB|1AW1_A triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (see paper)
    35% identity, 94% coverage of query (136 bits)

2jgqA / P56076 Kinetics and structural properties of triosephosphate isomerase from helicobacter pylori (see paper)
    37% identity, 98% coverage of query (134 bits)

1ttjA Three new crystal structures of point mutation variants of monotim: conformational flexibility of loop-1,loop-4 and loop-8
    38% identity, 96% coverage of query (133 bits)

2wsrA Monotim mutant rmm0-1, monomeric form.
    38% identity, 96% coverage of query (132 bits)

1ml1A Protein engineering with monomeric triosephosphate isomerase: the modelling and structure verification of a seven residue loop
    38% identity, 96% coverage of query (131 bits)

2x1rA Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase
    38% identity, 94% coverage of query (127 bits)

2vemA Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance of a single point mutation for generating an active site with suitable binding properties
    38% identity, 94% coverage of query (124 bits)

2x1tB Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase
    37% identity, 94% coverage of query (122 bits)

2vekB Structure-based enzyme engineering efforts with an inactive monomeric tim variant: the importance of a single point mutation for generating an active site with suitable binding properties
    37% identity, 94% coverage of query (122 bits)

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Build an alignment for 207136 and 100 homologs with ≥ 30% identity

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory