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Searching for up to 100 curated homologs for 207620 MicrobesOnline__882:207620 (307 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

GPI fructose-1,6-bisphosphate aldolase; EC 5.3.1.9 from Entamoeba histolytica HM-1:IMSS (see paper)
    51% identity, 99% coverage of query (316 bits)

Q9RHA2 fructose-bisphosphate aldolase (EC 4.1.2.13) from Thermus aquaticus (see paper)
1rv8B / Q9RHA2 Class ii fructose-1,6-bisphosphate aldolase from thermus aquaticus in complex with cobalt (see paper)
    52% identity, 94% coverage of query (294 bits)

ALF_GIAIC / A8B2U2 Fructose-bisphosphate aldolase; Glfba; glFBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia) (see 4 papers)
    51% identity, 97% coverage of query (292 bits)

3gayA / A8B2U2 Structure of giardia fructose-1,6-biphosphate aldolase in complex with tagatose-1,6-biphosphate (see paper)
    51% identity, 97% coverage of query (287 bits)

3gb6A Structure of giardia fructose-1,6-biphosphate aldolase d83a mutant in complex with fructose-1,6-bisphosphate
    51% identity, 97% coverage of query (286 bits)

ALF_THECA / Q703I2 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Thermus caldophilus (see paper)
    50% identity, 94% coverage of query (285 bits)

3ohiA Structure of giardia fructose-1,6-biphosphate aldolase in complex with 3-hydroxy-2-pyridone
    50% identity, 97% coverage of query (285 bits)

2isvB Structure of giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate
    50% identity, 97% coverage of query (275 bits)

P56109 fructose-bisphosphate aldolase (EC 4.1.2.13) from Helicobacter pylori (see 2 papers)
    44% identity, 99% coverage of query (268 bits)

3n9sA / D0IR47 Class ii fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with n-(4-hydroxybutyl)- glycolohydroxamic acid bis- phosphate, a competitive inhibitor (see paper)
    44% identity, 99% coverage of query (268 bits)

2isvA / A8B2U2 Structure of giardia fructose-1,6-biphosphate aldolase in complex with phosphoglycolohydroxamate (see paper)
    48% identity, 97% coverage of query (264 bits)

3n9rA Class ii fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with n-(4-hydroxybutyl)-phosphoglycolohydroxamic acid, a competitive inhibitor
    43% identity, 99% coverage of query (258 bits)

3c56A Class ii fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with n-(3-hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor
    43% identity, 99% coverage of query (258 bits)

3c52A Class ii fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with phosphoglycolohydroxamic acid, a competitive inhibitor
    43% identity, 99% coverage of query (258 bits)

Q5HE75 fructose-bisphosphate aldolase (EC 4.1.2.13) from Staphylococcus aureus (see paper)
    44% identity, 100% coverage of query (256 bits)

ALF_NOSS1 / Q8YNK2 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
    46% identity, 93% coverage of query (254 bits)

A0Q7I9 fructose-bisphosphate aldolase (EC 4.1.2.13) from Francisella tularensis subsp. novicida (see paper)
    46% identity, 95% coverage of query (253 bits)

5ucpA Class ii fructose-1,6-bisphosphate aldolase e142a variant of helicobacter pylori with fbp and cleavage products
    43% identity, 99% coverage of query (251 bits)

5uckA Class ii fructose-1,6-bisphosphate aldolase of helicobacter pylori with cleavage products
    43% identity, 99% coverage of query (251 bits)

5ud4A Class ii fructose-1,6-bisphosphate aldolase h180q variant of helicobacter pylori with tbp
    43% identity, 99% coverage of query (251 bits)

I3EBM6 fructose-bisphosphate aldolase (EC 4.1.2.13) from Bacillus methanolicus (see paper)
    43% identity, 100% coverage of query (249 bits)

fbaA / Q55664 class II fructose-bisphosphate aldolase/sedoheptulose-1,7-bisphosphate aldolase monomer (EC 4.1.2.13) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
Q55664 fructose-bisphosphate aldolase (EC 4.1.2.13) from Synechocystis sp. PCC 6803 (see paper)
    43% identity, 99% coverage of query (249 bits)

ALF_XANFL / Q56815 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Xanthobacter flavus (see paper)
    45% identity, 95% coverage of query (248 bits)

ALF_BACSU / P13243 Probable fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Bacillus subtilis (strain 168) (see 2 papers)
    43% identity, 100% coverage of query (241 bits)

Q602L6 fructose-bisphosphate aldolase (EC 4.1.2.13) from Methylococcus capsulatus (see paper)
    45% identity, 94% coverage of query (240 bits)

4to8A / W8TRN9 Methicillin-resistant staphylococcus aureus class iib fructose 1,6- bisphosphate aldolase (see paper)
    43% identity, 99% coverage of query (239 bits)

5ud0A / P56109 Class ii fructose-1,6-bisphosphate aldolase e149a variant of helicobacter pylori with cleavage products (see paper)
    41% identity, 99% coverage of query (232 bits)

GATY_KLEOX / Q8VS16 D-tagatose-1,6-bisphosphate aldolase subunit GatY; TBPA; TagBP aldolase; D-tagatose-bisphosphate aldolase class II; Tagatose-bisphosphate aldolase; EC 4.1.2.40 from Klebsiella oxytoca (see paper)
Q8VS16 tagatose-bisphosphate aldolase (EC 4.1.2.40) from Klebsiella oxytoca (see paper)
    40% identity, 100% coverage of query (229 bits)

3q94A / A0A6H3AA11 The crystal structure of fructose 1,6-bisphosphate aldolase from bacillus anthracis str. 'Ames ancestor'
    41% identity, 97% coverage of query (226 bits)

gatY / Q65EY6 D-tagatose-bisphosphate aldolase (EC 4.1.2.40) from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) (see paper)
    41% identity, 96% coverage of query (221 bits)

KBAY_ECOLX / Q9KIP8 D-tagatose-1,6-bisphosphate aldolase subunit KbaY; TBPA; TagBP aldolase; D-tagatose-bisphosphate aldolase class II; Ketose 1,6-bisphosphate aldolase class II; Tagatose-bisphosphate aldolase; EC 4.1.2.40 from Escherichia coli (see 2 papers)
    39% identity, 100% coverage of query (218 bits)

Kba / b3137 tagatose-1,6-bisphosphate aldolase 1 (EC 4.1.2.40) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
kbaY / P0AB76 D-tagatose-1,6-bisphosphate aldolase subunit KbaY (EC 4.1.2.40) from Escherichia coli O157:H7 (see 2 papers)
kbaY / P0AB74 tagatose-1,6-bisphosphate aldolase 1 (EC 4.1.2.40) from Escherichia coli (strain K12) (see 8 papers)
KBAY_ECOLI / P0AB74 D-tagatose-1,6-bisphosphate aldolase subunit KbaY; TBPA; TagBP aldolase; D-tagatose-bisphosphate aldolase class II; Ketose 1,6-bisphosphate aldolase class II; Tagatose-bisphosphate aldolase; EC 4.1.2.40 from Escherichia coli (strain K12) (see 3 papers)
kbaY / RF|NP_417606 tagatose-bisphosphate aldolase; EC 4.1.2.40 from Escherichia coli K12 (see 7 papers)
    39% identity, 100% coverage of query (218 bits)

Q8Y498 fructose-bisphosphate aldolase (EC 4.1.2.13) from Listeria monocytogenes EGD (see paper)
    40% identity, 97% coverage of query (213 bits)

1gvfB / P0AB74 Structure of tagatose-1,6-bisphosphate aldolase (see paper)
    38% identity, 99% coverage of query (207 bits)

iolJ / P42420 5-dehydro-2-deoxyphosphogluconate aldolase (EC 4.1.2.29) from Bacillus subtilis (strain 168) (see paper)
IOLJ_BACSU / P42420 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase; DKGP aldolase; EC 4.1.2.29 from Bacillus subtilis (strain 168) (see paper)
    39% identity, 97% coverage of query (204 bits)

YegF / b2096 tagatose-1,6-bisphosphate aldolase 2 (EC 4.1.2.40) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
gatY / P0C8J6 tagatose-1,6-bisphosphate aldolase 2 (EC 4.1.2.40) from Escherichia coli (strain K12) (see 14 papers)
GATY_ECOLI / P0C8J6 D-tagatose-1,6-bisphosphate aldolase subunit GatY; TBPA; TagBP aldolase; D-tagatose-bisphosphate aldolase class II; Tagatose-bisphosphate aldolase; EC 4.1.2.40 from Escherichia coli (strain K12) (see 3 papers)
    36% identity, 100% coverage of query (199 bits)

GATY_ECOLX / P0C8J7 D-tagatose-1,6-bisphosphate aldolase subunit GatY; TBPA; TagBP aldolase; D-tagatose-bisphosphate aldolase class II; Tagatose-bisphosphate aldolase; EC 4.1.2.40 from Escherichia coli (see paper)
    36% identity, 100% coverage of query (195 bits)

8q5aA / A0A2A2MA06 Crystal structure of metal-dependent class ii sulfofructosephosphate aldolase from hafnia paralvei hpsqia-zn in complex with dihydroxyacetone phosphate (dhap) (see paper)
    35% identity, 100% coverage of query (188 bits)

SQIA_ALKUR / A0A2P6MHY1 Sulfofructosephosphate aldolase; SFP aldolase; EC 4.1.2.57 from Alkalicoccus urumqiensis (Bacillus urumqiensis)
    35% identity, 100% coverage of query (186 bits)

8q59A / A0A0T9TPS2 Crystal structure of metal-dependent class ii sulfofructose phosphate aldolase from yersinia aldovae in complex with sulfofructose phosphate (yasqia-zn-sfp) (see paper)
    34% identity, 97% coverage of query (182 bits)

ALF_STRR6 / P0A4S2 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
    35% identity, 97% coverage of query (181 bits)

ALF_HALVD / D4GYE0 Fructose-bisphosphate aldolase class 2; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II; EC 4.1.2.13 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GYE0 fructose-bisphosphate aldolase (EC 4.1.2.13) from Haloferax volcanii (see paper)
    35% identity, 95% coverage of query (155 bits)

YdjI / b1773 L-glycero-L-galacto-octuluronate-1-phosphate aldolase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ydjI / P77704 L-glycero-L-galacto-octuluronate-1-phosphate aldolase from Escherichia coli (strain K12) (see 2 papers)
    33% identity, 93% coverage of query (145 bits)

6ofuB / P77704 X-ray crystal structure of the ydji aldolase from escherichia coli k12 (see paper)
    32% identity, 93% coverage of query (141 bits)

3pm6A / P0CJ44 Crystal structure of a putative fructose-1,6-biphosphate aldolase from coccidioides immitis solved by combined sad mr (see paper)
    34% identity, 85% coverage of query (124 bits)

PGA1_c07220 5-keto-2-deoxy-D-gluconate-6 phosphate aldolase (EC 4.1.2.29) from Phaeobacter inhibens BS107
    31% identity, 96% coverage of query (122 bits)

3pm6B / P0CJ44 Crystal structure of a putative fructose-1,6-biphosphate aldolase from coccidioides immitis solved by combined sad mr (see paper)
    31% identity, 85% coverage of query (103 bits)

Build an alignment

Build an alignment for 207620 and 47 homologs with ≥ 30% identity

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Change minimum %identity:

Additional hits (identity < 30%)

3qm3A / Q0PAS0 1.85 angstrom resolution crystal structure of fructose-bisphosphate aldolase (fba) from campylobacter jejuni
    28% identity, 98% coverage of query (85.9 bits)

ALF_CANAL / Q9URB4 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; 37 kDa major allergen; Fructose-1,6-bisphosphate aldolase; IgE-binding allergen; EC 4.1.2.13 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
Q9URB4 fructose-bisphosphate aldolase (EC 4.1.2.13) from Candida albicans (see paper)
FBA1 fructose-bisphosphate aldolase; EC 4.1.2.13 from Candida albicans (see 6 papers)
    27% identity, 93% coverage of query (84.7 bits)

D0ZEE4 fructose-bisphosphate aldolase (EC 4.1.2.13) from Vibrio anguillarum (see paper)
    26% identity, 91% coverage of query (84.7 bits)

fda / CAA10483.2 fructose 1,6-bisphosphate aldolase from Streptomyces galbus (see paper)
    27% identity, 100% coverage of query (83.6 bits)

ALF1_PARBA / Q96UH7 Fructose-bisphosphate aldolase 1; FBP aldolase 1; FBPA 1; Fructose-1,6-bisphosphate aldolase 1; EC 4.1.2.13 from Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis) (see 2 papers)
Q96UH7 fructose-bisphosphate aldolase (EC 4.1.2.13) from Paracoccidioides lutzii (see paper)
    26% identity, 97% coverage of query (82.8 bits)

A0KGD4 fructose-bisphosphate aldolase (EC 4.1.2.13) from Aeromonas hydrophila (see paper)
    25% identity, 91% coverage of query (78.2 bits)

fbaA putative fructose-bisphosphate aldolase from Emericella nidulans (see paper)
    24% identity, 93% coverage of query (77.4 bits)

4delA / P9WQA3 Active site loop dynamics of a class iia fructose 1,6-bisphosphate aldolase from m. Tuberculosis (see paper)
    25% identity, 99% coverage of query (72.8 bits)

1dosA / P0AB71 Structure of fructose-bisphosphate aldolase (see paper)
    24% identity, 92% coverage of query (72.0 bits)

P36580 Fructose-bisphosphate aldolase; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; EC 4.1.2.13 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    27% identity, 93% coverage of query (71.6 bits)

Fda / b2925 fructose-bisphosphate aldolase class II (EC 4.1.2.13) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
fbaA / P0AB71 fructose-bisphosphate aldolase class II (EC 4.1.2.13) from Escherichia coli (strain K12) (see 44 papers)
ALF_ECOLI / P0AB71 Fructose-bisphosphate aldolase class 2; FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II; Sedoheptulose bisphosphate aldolase; EC 4.1.2.13 from Escherichia coli (strain K12) (see 6 papers)
fbaA / RF|NP_417400 fructose-bisphosphate aldolase class II; EC 4.1.2.13 from Escherichia coli K12 (see 15 papers)
    24% identity, 92% coverage of query (71.6 bits)

7v6gB / Q9URB4 Structure of candida albicans fructose-1,6-bisphosphate aldolase mutation c157s with cn39
    25% identity, 93% coverage of query (69.7 bits)

7yvaB Crystal structure of candida albicans fructose-1,6-bisphosphate aldolase complexed with lipoic acid
    25% identity, 93% coverage of query (68.2 bits)

7v6fA Structure of candida albicans fructose-1,6-bisphosphate aldolase complexed with g3p
    25% identity, 93% coverage of query (68.2 bits)

7rgnA / A0A2H0ZD48 Crystal structure of putative fructose-1,6-bisphosphate aldolase from candida auris
    24% identity, 93% coverage of query (67.0 bits)

1b57A Class ii fructose-1,6-bisphosphate aldolase in complex with phosphoglycolohydroxamate
    23% identity, 92% coverage of query (65.1 bits)

3ekzA Structural characterization of tetrameric mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class iia bacterial aldolase
    24% identity, 99% coverage of query (64.7 bits)

3elfA Structural characterization of tetrameric mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class iia bacterial aldolase
    24% identity, 99% coverage of query (63.5 bits)

4a22A Structure of mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase bound to n-(4-hydroxybutyl)- glycolohydroxamic acid bis- phosphate
    24% identity, 99% coverage of query (63.5 bits)

4lv4A / P9WQA3 A noncompetitive inhibitor for m. Tuberculosis's class iia fructose 1, 6-bisphosphate aldolase (see paper)
    23% identity, 99% coverage of query (53.9 bits)

1gynA Class ii fructose 1,6-bisphosphate aldolase with cadmium (not zinc) in the active site
    22% identity, 92% coverage of query (53.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory