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Searching for up to 100 curated homologs for 207685 MicrobesOnline__882:207685 (385 a.a.)

Found high-coverage hits (≥70%) to 66 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

A7LGK0 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see paper)
    54% identity, 100% coverage of query (411 bits)

YqhD / b3011 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 35 papers)
yqhD / Q46856 NADPH-dependent aldehyde reductase YqhD (EC 1.1.1.21; EC 1.1.1.2) from Escherichia coli (strain K12) (see 38 papers)
YQHD_ECOLI / Q46856 Alcohol dehydrogenase YqhD; EC 1.1.1.2 from Escherichia coli (strain K12) (see paper)
Q46856 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Escherichia coli (see paper)
yqhD / RF|NP_417484 alcohol dehydrogenase yqhD; EC 1.1.1.- from Escherichia coli K12 (see 5 papers)
    53% identity, 100% coverage of query (396 bits)

1oj7A / Q46856 Structural genomics, unknown function crystal structure of e. Coli k-12 yqhd (see paper)
    53% identity, 99% coverage of query (393 bits)

1oj7B Structural genomics, unknown function crystal structure of e. Coli k-12 yqhd
    53% identity, 99% coverage of query (393 bits)

U6CL97 alcohol dehydrogenase (NADP+) (EC 1.1.1.2); alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Pectobacterium atrosepticum (see paper)
    52% identity, 100% coverage of query (390 bits)

ADH3_ENTH1 / Q24857 NADP-dependent alcohol dehydrogenase 3; ADH; EC 1.1.1.2 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see paper)
    41% identity, 92% coverage of query (274 bits)

bdhA / Q04944 BdhA from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 2 papers)
bdhA / GI|15026377 NADH-dependent butanol dehydrogenase A from Clostridium acetobutylicum ATCC 824 (see paper)
bdhA NADH-dependent butanol dehydrogenase A; EC 1.1.1.- from Clostridium acetobutylicum (see paper)
    37% identity, 100% coverage of query (254 bits)

7w9zA Crystal structure of bacillus subtilis yugj in complex with NADP and nitrate
    38% identity, 100% coverage of query (254 bits)

7w9yA Crystal structure of bacillus subtilis yugj in complex with NADP and nickel (see paper)
    38% identity, 100% coverage of query (253 bits)

ADH2_GEOTN / A4ISB9 Long-chain-alcohol dehydrogenase 2; Alcohol dehydrogenase 2; ADH2; Fatty alcohol oxidoreductase 2; EC 1.1.1.192 from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
A4ISB9 long-chain-alcohol dehydrogenase (EC 1.1.1.192); alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Geobacillus thermodenitrificans (see paper)
    39% identity, 100% coverage of query (250 bits)

bdhB / Q04945 BdhB from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) (see 5 papers)
    37% identity, 91% coverage of query (244 bits)

B0KB53 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermoanaerobacter pseudethanolicus (see paper)
    38% identity, 100% coverage of query (243 bits)

7fjgA / Q8R612 Crystal structure of butanol dehydrogenase a (yqdh) in complex with partial nadh from fusobacterium nucleatum
    34% identity, 90% coverage of query (215 bits)

8i29A Crystal structure of butanol dehydrogenase a (yqdh) in complex with nadh from fusobacterium nucleatum
    34% identity, 90% coverage of query (215 bits)

1vljB / Q9WZS7 Crystal structure of nadh-dependent butanol dehydrogenase a (tm0820) from thermotoga maritima at 1.78 a resolution
    35% identity, 100% coverage of query (197 bits)

Build an alignment

Build an alignment for 207685 and 15 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Q9X022 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Thermotoga maritima (see paper)
    28% identity, 78% coverage of query (109 bits)

ADH_THEBA / A0A0S1X9S7 Alcohol dehydrogenase; EC 1.1.1.1 from Thermococcus barophilus (see paper)
    30% identity, 92% coverage of query (109 bits)

1vhdA / Q9X022 Crystal structure of an iron containing alcohol dehydrogenase (see paper)
    28% identity, 78% coverage of query (109 bits)

1o2dA Crystal structure of alcohol dehydrogenase, iron-containing (tm0920) from thermotoga maritima at 1.30 a resolution
    28% identity, 78% coverage of query (109 bits)

A0A1D3TV27 alcohol dehydrogenase (EC 1.1.1.1) from Anaerobium acetethylicum (see paper)
    27% identity, 90% coverage of query (107 bits)

A0A0Q2QQL1 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Thermococcus thioreducens (see paper)
6c75A / A0A0Q2QQL1 Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form (see paper)
    30% identity, 93% coverage of query (104 bits)

6c75B Structure of iron containing alcohol dehydrogenase from thermococcus thioreducens in a monoclinic crystal form
    30% identity, 93% coverage of query (104 bits)

SQWF_CLOS9 / J1H1J3 Sulfoacetaldehyde reductase; EC 1.1.1.433 from Clostridium sp. (strain MSTE9)
    28% identity, 91% coverage of query (103 bits)

adh1 / P13604 NADPH-dependent butanol dehydrogenase (EC 1.1.1.2) from Clostridium saccharobutylicum (see 3 papers)
adh1 / GB|AAA83520.1 NADPH-dependent butanol dehydrogenase; EC 1.1.1.1 from Clostridium saccharobutylicum (see paper)
    24% identity, 93% coverage of query (100 bits)

4HBDH_CUPNE / Q59104 4-hydroxybutyrate dehydrogenase; 4HbD; Gamma-hydroxybutyrate dehydrogenase; GHBDH; EC 1.1.1.61 from Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha) (see 2 papers)
Q59104 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) from Cupriavidus necator (see paper)
gbd / PRF|2104199G 4-hydroxybutyrate dehydrogenase; EC 1.1.1.61 from Cupriavidus necator (see paper)
    29% identity, 85% coverage of query (97.4 bits)

O58517 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Pyrococcus horikoshii (see paper)
    27% identity, 93% coverage of query (97.1 bits)

6jkoA / A0A0A7I0A5 Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense (see paper)
    26% identity, 83% coverage of query (95.9 bits)

6jkpA Crystal structure of sulfoacetaldehyde reductase from bifidobacterium kashiwanohense in complex with NAD+
    26% identity, 83% coverage of query (95.9 bits)

hpfD / A0A374P995 3-hydroxypropane-1-sulfonate dehydrogenase from Hungatella hathewayi (see paper)
    26% identity, 96% coverage of query (95.5 bits)

3zdrA Structure of the alcohol dehydrogenase (adh) domain of a bifunctional adhe dehydrogenase from geobacillus thermoglucosidasius ncimb 11955 (see paper)
    24% identity, 92% coverage of query (91.7 bits)

Q59477 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 2 papers)
    26% identity, 90% coverage of query (90.1 bits)

Q7WRJ3 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see 3 papers)
    27% identity, 90% coverage of query (88.6 bits)

adh2 / GB|AAA81906.1 aldehyde-alcohol dehydrogenase 2; EC 1.1.1.1; EC 1.2.1.10 from Entamoeba histolytica (see paper)
AAA81906.1 alcohol dehydrogenase 2 from Entamoeba histolytica (see paper)
    27% identity, 77% coverage of query (87.8 bits)

ADH2_ENTH1 / Q24803 Aldehyde-alcohol dehydrogenase 2; EC 1.1.1.1; EC 1.2.1.10 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see 2 papers)
    27% identity, 77% coverage of query (87.8 bits)

3bfjA / Q7WRJ3 Crystal structure analysis of 1,3-propanediol oxidoreductase (see paper)
    26% identity, 90% coverage of query (87.0 bits)

ADHE_STRPN / A0A0H2URT2 Aldehyde-alcohol dehydrogenase; EC 1.1.1.1; EC 1.2.1.3 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
    26% identity, 74% coverage of query (86.7 bits)

ADHE_STRP2 / A0A0H2ZM56 Aldehyde-alcohol dehydrogenase; EC 1.1.1.1; EC 1.2.1.3 from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
    26% identity, 74% coverage of query (86.7 bits)

A0A0H3W5K4 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum (see paper)
I3VSF1 alcohol dehydrogenase (EC 1.1.1.1); L-lactate dehydrogenase (EC 1.1.1.27); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacterium saccharolyticum (see paper)
    25% identity, 78% coverage of query (86.3 bits)

A3RL85 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Klebsiella pneumoniae (see paper)
    26% identity, 90% coverage of query (85.9 bits)

EUTG_SALTY / P41795 Probable alcohol dehydrogenase EutG; Ethanolamine utilization protein EutG; EC 1.1.1.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 5 papers)
    30% identity, 74% coverage of query (85.5 bits)

B0KBJ9 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter pseudethanolicus (see paper)
    25% identity, 91% coverage of query (85.1 bits)

B0K4A2 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Thermoanaerobacter sp. X514 (see 2 papers)
    25% identity, 91% coverage of query (84.7 bits)

DHAT_CITFR / P45513 1,3-propanediol dehydrogenase; 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase; EC 1.1.1.202 from Citrobacter freundii (see paper)
P45513 1,3-propanediol dehydrogenase (EC 1.1.1.202) from Citrobacter freundii (see paper)
dhaT / GB|AAB48848.1 1,3-propanediol dehydrogenase; EC 1.1.1.202 from Citrobacter freundii (see paper)
dhaT / AAB48848.1 1,3-propanediol dehydrogenase from Citrobacter freundii (see 4 papers)
    25% identity, 90% coverage of query (84.3 bits)

A0A0H3W5V0 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Thermoanaerobacterium saccharolyticum (see paper)
    25% identity, 78% coverage of query (84.0 bits)

ADH4 / P10127 alcohol dehydrogenase IV (EC 1.1.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 11 papers)
ADH4_YEAST / P10127 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; ADHIV; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 11 papers)
    26% identity, 90% coverage of query (83.2 bits)

A0A1D3TRQ6 acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Anaerobium acetethylicum (see paper)
    25% identity, 75% coverage of query (82.8 bits)

Q0PH30 alcohol dehydrogenase (EC 1.1.1.1) from Thermoanaerobacter ethanolicus (see paper)
    25% identity, 91% coverage of query (82.0 bits)

ADH4_SCHPO / Q09669 Alcohol dehydrogenase 4; Alcohol dehydrogenase IV; EC 1.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 4 papers)
Q09669 alcohol dehydrogenase (EC 1.1.1.1) from Schizosaccharomyces pombe (see paper)
adh4 / RF|NP_592819.1 alcohol dehydrogenase Adh4; EC 1.1.1.1 from Schizosaccharomyces pombe (see 3 papers)
    23% identity, 91% coverage of query (81.6 bits)

ADH1_GEOTN / A4IP64 Long-chain-alcohol dehydrogenase 1; Alcohol dehydrogenase 1; ADH1; Fatty alcohol oxidoreductase 1; Glycerol dehydrogenase; EC 1.1.1.192; EC 1.1.1.6 from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
A4IP64 alcohol dehydrogenase (EC 1.1.1.1); long-chain-alcohol dehydrogenase (EC 1.1.1.192) from Geobacillus thermodenitrificans (see paper)
    24% identity, 98% coverage of query (81.6 bits)

5yvmA / A0A133UP32 Crystal structure of the archaeal halo-thermophilic red sea brine pool alcohol dehydrogenase adh/d1 bound to nzq (see paper)
    26% identity, 98% coverage of query (81.6 bits)

5yvrA Crystal structure of the h277a mutant of adh/d1, an archaeal halo- thermophilic red sea brine pool alcohol dehydrogenase
    25% identity, 98% coverage of query (77.8 bits)

6scgA Structure of adhe form 1
    26% identity, 91% coverage of query (76.6 bits)

7bvpA / P0A9Q7 Adhe spirosome in extended conformation (see paper)
    26% identity, 91% coverage of query (73.6 bits)

6tqmA Escherichia coli adhe structure in its compact conformation
    26% identity, 91% coverage of query (73.6 bits)

AdhE / b1241 fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (EC 1.1.1.1; EC 1.2.1.10) from Escherichia coli K-12 substr. MG1655 (see 62 papers)
adhE / P0A9Q7 fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (EC 1.1.1.1; EC 1.2.1.10) from Escherichia coli (strain K12) (see 64 papers)
ADHE_ECOLI / P0A9Q7 Bifunctional aldehyde-alcohol dehydrogenase AdhE; Alcohol dehydrogenase E; EC 1.2.1.10; EC 1.1.1.1 from Escherichia coli (strain K12) (see 13 papers)
ADHE_ECO57 / P0A9Q8 Bifunctional aldehyde-alcohol dehydrogenase AdhE; Alcohol dehydrogenase E; EC 1.2.1.10; EC 1.1.1.1 from Escherichia coli O157:H7 (see 2 papers)
P0A9Q7 alcohol dehydrogenase (EC 1.1.1.1); acetaldehyde dehydrogenase (acetylating) (EC 1.2.1.10) from Escherichia coli (see paper)
adhE / MB|P0A9Q7 aldehyde-alcohol dehydrogenase; EC 1.1.1.1; EC 1.2.1.10 from Escherichia coli K12 (see 12 papers)
    26% identity, 91% coverage of query (73.2 bits)

7qlqAAA Lactaldehyde reductase
    25% identity, 82% coverage of query (72.0 bits)

7qlgAAA Lactaldehyde reductase
    25% identity, 82% coverage of query (69.7 bits)

2bi4A Lactaldehyde:1,2-propanediol oxidoreductase of escherichia coli
    25% identity, 82% coverage of query (69.3 bits)

FucO / b2799 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli K-12 substr. MG1655 (see 22 papers)
fucO / P0A9S1 L-1,2-propanediol oxidoreductase (EC 1.1.1.77) from Escherichia coli (strain K12) (see 23 papers)
FUCO_ECOLI / P0A9S1 Lactaldehyde reductase; Propanediol oxidoreductase; EC 1.1.1.77 from Escherichia coli (strain K12) (see paper)
    25% identity, 82% coverage of query (69.3 bits)

1rrmA Crystal structure of lactaldehyde reductase
    23% identity, 82% coverage of query (69.3 bits)

5br4A / P0A9S1 E. Coli lactaldehyde reductase (fuco) m185c mutant (see paper)
    25% identity, 82% coverage of query (68.6 bits)

mdh / P31005 NAD-dependent methanol dehydrogenase monomer (EC 1.1.1.244) from Bacillus methanolicus (see paper)
MEDH_BACMT / P31005 NAD-dependent methanol dehydrogenase; MDH; MEDH; Type 3 alcohol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see 6 papers)
P31005 methanol dehydrogenase (EC 1.1.1.244) from Bacillus methanolicus (see paper)
mdh methanol dehydrogenase; EC 1.1.1.244 from Bacillus methanolicus (see paper)
    23% identity, 99% coverage of query (67.0 bits)

3ox4A Structures of iron-dependent alcohol dehydrogenase 2 from zymomonas mobilis zm4 complexed with NAD cofactor
    23% identity, 75% coverage of query (64.3 bits)

3owoA / P0DJA2 Structures of iron-dependent alcohol dehydrogenase 2 from zymomonas mobilis zm4 with and without NAD cofactor (see paper)
    23% identity, 75% coverage of query (64.3 bits)

adhB / P0DJA2 alcohol dehydrogenase II monomer (EC 1.1.1.1) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 8 papers)
ADH2_ZYMMO / P0DJA2 Alcohol dehydrogenase 2; Alcohol dehydrogenase II; ADH II; EC 1.1.1.1 from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 2 papers)
P0DJA2 alcohol dehydrogenase (EC 1.1.1.1) from Zymomonas mobilis subsp. mobilis (see paper)
    23% identity, 75% coverage of query (64.3 bits)

3jzdA / Q46TQ1 Crystal structure of putative alcohol dehedrogenase (yp_298327.1) from ralstonia eutropha jmp134 at 2.10 a resolution
    24% identity, 91% coverage of query (48.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory