Searching for up to 100 curated homologs for 207819 MicrobesOnline__882:207819 (265 a.a.)
Found high-coverage hits (≥70%) to 47 curated proteins.
Removed hits that are identical to the query, leaving 46
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
DvMF_3161 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Desulfovibrio vulgaris Miyazaki F
68% identity, 100% coverage of query (350 bits)
PROC1 / F2E7Q2 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Hordeum vulgare subsp. vulgare (see paper)
35% identity, 98% coverage of query (155 bits)
2rcyA / Q8IDC6 Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
31% identity, 98% coverage of query (144 bits)
ProC / b0386 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
proC / P0A9L8 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Escherichia coli (strain K12) (see 8 papers)
P5CR_ECOLI / P0A9L8 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Escherichia coli (strain K12) (see 2 papers)
proC / MB|P0A9L8 pyrroline-5-carboxylate reductase from Escherichia coli K12 (see paper)
34% identity, 100% coverage of query (142 bits)
Q4DH60 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Trypanosoma cruzi (see paper)
34% identity, 98% coverage of query (138 bits)
O87725 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Acetoanaerobium sticklandii (see paper)
33% identity, 99% coverage of query (138 bits)
5bseA / G7KRM5 Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
32% identity, 98% coverage of query (134 bits)
2ag8A / Q9K1N1 NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
35% identity, 97% coverage of query (134 bits)
G7KRM5 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Medicago truncatula (see paper)
32% identity, 98% coverage of query (134 bits)
5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline
32% identity, 98% coverage of query (134 bits)
5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+
32% identity, 98% coverage of query (134 bits)
5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+
32% identity, 98% coverage of query (134 bits)
Q97ZT3 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Saccharolobus solfataricus (see paper)
32% identity, 98% coverage of query (130 bits)
Build an alignment for 207819 and 13 homologs with ≥ 30% identity
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PRO3 / P32263 pyrroline-5-carboxylate reductase subunit (EC 1.5.1.2) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
P5CR_YEAST / P32263 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
29% identity, 99% coverage of query (128 bits)
P5CR_METAC / Q9HH99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) (see paper)
34% identity, 98% coverage of query (128 bits)
P5CR_PSEAE / P22008 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
34% identity, 97% coverage of query (127 bits)
P5CR_KLULA / Q6CR99 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; EC 1.5.1.2 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
31% identity, 98% coverage of query (126 bits)
P5CR3_HUMAN / Q53H96 Pyrroline-5-carboxylate reductase 3; P5C reductase 3; P5CR 3; Pyrroline-5-carboxylate reductase-like protein; EC 1.5.1.2 from Homo sapiens (Human) (see paper)
30% identity, 98% coverage of query (117 bits)
3triA / Q83A21 Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
31% identity, 99% coverage of query (115 bits)
proC / AAG27705.1 delta 1-pyrroline-5-carboxylate reductase from Bradyrhizobium japonicum (see paper)
37% identity, 100% coverage of query (110 bits)
BT3757 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Bacteroides thetaiotaomicron VPI-5482
29% identity, 95% coverage of query (108 bits)
P5CR1_MOUSE / Q922W5 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Mus musculus (Mouse) (see paper)
30% identity, 98% coverage of query (107 bits)
P5CR2_HUMAN / Q96C36 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
Q96C36 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 2 papers)
29% identity, 98% coverage of query (103 bits)
2ahrE / Q9A1S9 Crystal structures of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
30% identity, 94% coverage of query (103 bits)
6xp0A Structure of human pycr1 complexed with n-formyl l-proline
29% identity, 98% coverage of query (103 bits)
2amfA Crystal structure of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes
30% identity, 94% coverage of query (102 bits)
6xp1B / P32322 Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate (see paper)
29% identity, 98% coverage of query (101 bits)
PYCR1 / P32322 pyrroline-5-carboxylate reductase 1 subunit (EC 1.5.1.2) from Homo sapiens (see 2 papers)
P5CR1_HUMAN / P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 5 papers)
P32322 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Homo sapiens (see 7 papers)
29% identity, 98% coverage of query (101 bits)
Shew_1136 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Shewanella loihica PV-4
32% identity, 100% coverage of query (101 bits)
P5CR1_BACSU / P0CI77 Pyrroline-5-carboxylate reductase 1; P5C reductase 1; P5CR 1; PCA reductase 1; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
25% identity, 82% coverage of query (101 bits)
5uatC Structure of human pycr-1 complexed with NADPH
29% identity, 98% coverage of query (101 bits)
2izzA Crystal structure of human pyrroline-5-carboxylate reductase
29% identity, 98% coverage of query (101 bits)
5uauA Structure of human pycr-1 complexed with proline
29% identity, 98% coverage of query (101 bits)
6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid
29% identity, 98% coverage of query (101 bits)
5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid
29% identity, 98% coverage of query (101 bits)
2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP
29% identity, 98% coverage of query (101 bits)
2gr9A Crystal structure of p5cr complexed with nadh
29% identity, 98% coverage of query (101 bits)
P5CR2_BACSU / P54552 Pyrroline-5-carboxylate reductase 2; P5C reductase 2; P5CR 2; PCA reductase 2; EC 1.5.1.2 from Bacillus subtilis (strain 168) (see paper)
26% identity, 98% coverage of query (100 bits)
Q5NQR9 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Zymomonas mobilis subsp. mobilis (see paper)
30% identity, 78% coverage of query (99.8 bits)
6xp2A Structure of human pycr1 complexed with l-thiazolidine-4-carboxylate
30% identity, 86% coverage of query (97.8 bits)
P5CR_TREPA / P27771 Pyrroline-5-carboxylate reductase; P5C reductase; P5CR; PCA reductase; EC 1.5.1.2 from Treponema pallidum (strain Nichols) (see paper)
29% identity, 95% coverage of query (95.9 bits)
CA265_RS18505 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Pedobacter sp. GW460-11-11-14-LB5
28% identity, 97% coverage of query (94.7 bits)
F4K884 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Arabidopsis thaliana (see paper)
33% identity, 74% coverage of query (91.7 bits)
CCNA_00528 pyrroline-5-carboxylate reductase (EC 1.5.1.2) from Caulobacter crescentus NA1000
32% identity, 89% coverage of query (78.6 bits)
TR08_CURCL / A0A348AXY1 Pyrroline-5-carboxylate reductase-like protein TR08; KK-1 biosynthesis cluster protein TR08; EC 1.5.1.- from Curvularia clavata (see paper)
25% identity, 95% coverage of query (77.0 bits)
UCSG_ACRSP / A0A411KUQ8 Pyrroline-5-carboxylate reductase ucsG; UCS1025A pyrrolizidinone biosynthesis cluster protein G; EC 1.5.1.- from Acremonium sp. (see paper)
26% identity, 97% coverage of query (74.3 bits)
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Lawrence Berkeley National Laboratory