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Searching for up to 100 curated homologs for 209104 MicrobesOnline__882:209104 (393 a.a.)

Found high-coverage hits (≥70%) to 68 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

CBL_BACSU / Q08432 Cystathionine beta-lyase PatB; CBL; Beta-cystathionase PatB; Cysteine lyase PatB; Cysteine-S-conjugate beta-lyase PatB; EC 4.4.1.13 from Bacillus subtilis (strain 168) (see paper)
6qp3A / Q08432 Crystal structure of the plp-bound c-s lyase from bacillus subtilis (strain 168) (see paper)
    40% identity, 98% coverage of query (308 bits)

4dq6A / Q183G9 Crystal structure of plp-bound putative aminotransferase from clostridium difficile 630
    36% identity, 97% coverage of query (301 bits)

B9X1L2 L-cysteine desulfidase (EC 4.4.1.28) from Prevotella intermedia (see paper)
    37% identity, 97% coverage of query (286 bits)

hly hemolysin from Treponema denticola (see paper)
hly / AAA85439.1 hemolysin from Treponema denticola (see paper)
    34% identity, 97% coverage of query (266 bits)

1c7nA / Q56257 Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate cofactor (see paper)
    34% identity, 97% coverage of query (265 bits)

1c7oA Crystal structure of cystalysin from treponema denticola contains a pyridoxal 5'-phosphate-l-aminoethoxyvinylglycine complex
    34% identity, 97% coverage of query (265 bits)

lcd / Q8L0M8 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Streptococcus anginosus (see paper)
    35% identity, 97% coverage of query (256 bits)

3b1cA / A6BMJ3 Crystal structure of betac-s lyase from streptococcus anginosus: internal aldimine form (see paper)
    34% identity, 98% coverage of query (252 bits)

3b1eA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: alpha-aminoacrylate form
    34% identity, 98% coverage of query (252 bits)

3b1dA Crystal structure of betac-s lyase from streptococcus anginosus in complex with l-serine: external aldimine form
    34% identity, 98% coverage of query (252 bits)

3l8aB / Q8DST5 Crystal structure of metc from streptococcus mutans
    33% identity, 97% coverage of query (246 bits)

5z0qC / B2VJB8 Crystal structure of ovob (see paper)
    37% identity, 98% coverage of query (226 bits)

MalY / b1622 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 4.4.1.28; EC 5.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
malY / P23256 negative regulator of MalT activity/cystathionine β-lyase (EC 4.4.1.13; EC 4.4.1.1; EC 5.1.1.10) from Escherichia coli (strain K12) (see 18 papers)
MALY_ECOLI / P23256 Protein MalY; EC 4.4.1.13 from Escherichia coli (strain K12) (see 2 papers)
8bobA / P23256 Structural basis for negative regulation of the maltose system (see paper)
malY maltose regulon modulator MalY; EC 4.4.1.8 from Escherichia coli K12 (see 6 papers)
    33% identity, 97% coverage of query (226 bits)

A0A223K4L6 cysteine-S-conjugate beta-lyase (EC 4.4.1.13); amino-acid racemase (EC 5.1.1.10) from Latilactobacillus sakei (see paper)
    33% identity, 98% coverage of query (214 bits)

7qugA Crystal structure of carbon-sulfur lyase fnapatb1 from fusobacterium nucleatum subspecies animalis in complex with allyl-cysteine (see paper)
    30% identity, 97% coverage of query (207 bits)

A6YH85 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei (see paper)
    33% identity, 97% coverage of query (202 bits)

Build an alignment

Build an alignment for 209104 and 16 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

A0A0U5KG73 L-cysteine desulfidase (EC 4.4.1.28) from Lactobacillus delbrueckii subsp. bulgaricus (see paper)
    29% identity, 98% coverage of query (202 bits)

6qp2A Crystal structure of the plp-bound c-s lyase from staphylococcus hominis
    30% identity, 98% coverage of query (201 bits)

6qp1B Crystal structure of the plp-bound c-s lyase in the external aldimine form from staphylococcus hominis complexed with an inhibitor, l- cycloserine. (see paper)
    30% identity, 99% coverage of query (197 bits)

CBL_THET8 / Q5SHW0 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    36% identity, 94% coverage of query (185 bits)

CBL_CORGT / Q93QC6 Cystathionine beta-lyase; CBL; Beta-cystathionase; Cysteine lyase; Cysteine-S-conjugate beta-lyase; EC 4.4.1.13 from Corynebacterium glutamicum (Brevibacterium saccharolyticum) (see paper)
    28% identity, 97% coverage of query (163 bits)

Q46061 L-cysteine desulfidase (EC 4.4.1.28) from Corynebacterium glutamicum (see paper)
    28% identity, 84% coverage of query (142 bits)

metC / Q64HC5 cysteine-S-conjugate β-lyase (EC 4.4.1.13) from Corynebacterium striatum (see paper)
CBL_CORST / Q64HC5 Cysteine-S-conjugate beta-lyase; C-S lyase; Cystathionine beta-lyase; CBL; EC 4.4.1.13 from Corynebacterium striatum (see 2 papers)
    31% identity, 97% coverage of query (139 bits)

1gd9A / O59096 Crystall structure of pyrococcus protein-a1 (see paper)
    24% identity, 90% coverage of query (91.7 bits)

O59096 aromatic-amino-acid transaminase (EC 2.6.1.57) from Pyrococcus horikoshii (see paper)
    24% identity, 90% coverage of query (91.7 bits)

1gdeA Crystal structure of pyrococcus protein a-1 e-form
    24% identity, 90% coverage of query (91.7 bits)

aruH / Q9HUI9 L-arginine:pyruvate transaminase subunit (EC 2.6.1.84) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
ARUH_PSEAE / Q9HUI9 Arginine--pyruvate transaminase AruH; EC 2.6.1.84 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HUI9 arginine-pyruvate transaminase (EC 2.6.1.84) from Pseudomonas aeruginosa (see paper)
    29% identity, 95% coverage of query (87.4 bits)

ARAT2_THELN / H3ZPU1 Aromatic-amino-acid aminotransferase 2; ARAT-II; AROAT; EC 2.6.1.57 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
    23% identity, 89% coverage of query (86.3 bits)

KAT_AEDAE / Q17CS8 Kynurenine aminotransferase; AeKAT; EC 2.6.1.-; EC 2.6.1.63; EC 2.6.1.7 from Aedes aegypti (Yellowfever mosquito) (Culex aegypti) (see 5 papers)
    28% identity, 80% coverage of query (85.9 bits)

OsIDI4 / FAA00314.1 aminotransferase from Oryza sativa Japonica Group (see paper)
    27% identity, 88% coverage of query (83.2 bits)

AAT_MUSP7 / C6C2Z3 Aspartate aminotransferase; AAT; AspAT; EC 2.6.1.1 from Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya dadantii) (see paper)
    23% identity, 87% coverage of query (82.0 bits)

Q8YMS6 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    23% identity, 87% coverage of query (80.9 bits)

1o4sB / Q9X0Y2 Crystal structure of aspartate aminotransferase (tm1255) from thermotoga maritima at 1.90 a resolution (see paper)
    26% identity, 90% coverage of query (79.3 bits)

1gc4A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with aspartate
    27% identity, 89% coverage of query (79.3 bits)

1gc3A Thermus thermophilus aspartate aminotransferase tetra mutant 2 complexed with tryptophan
    27% identity, 89% coverage of query (79.3 bits)

Q9RAT0 aromatic-amino-acid transaminase (EC 2.6.1.57) from Lactococcus lactis (see paper)
    24% identity, 97% coverage of query (79.0 bits)

AAT_THEMA / Q9X0Y2 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    26% identity, 90% coverage of query (79.0 bits)

Q8YTF2 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    26% identity, 86% coverage of query (78.6 bits)

AAPAT_THET8 / Q56232 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.78 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see 5 papers)
Q56232 aspartate-prephenate aminotransferase (EC 2.6.1.78) from Thermus thermophilus (see paper)
aspC / RF|YP_143312.1 aspartate transaminase; EC 2.6.1.1 from Thermus thermophilus HB8 (see 2 papers)
    26% identity, 89% coverage of query (77.8 bits)

1bkgA Aspartate aminotransferase from thermus thermophilus with maleate
    26% identity, 89% coverage of query (77.8 bits)

1bjwA Aspartate aminotransferase from thermus thermophilus
    26% identity, 89% coverage of query (77.8 bits)

1b5oA / Q56232 Thermus thermophilus aspartate aminotransferase single mutant 1 (see paper)
    26% identity, 89% coverage of query (77.4 bits)

aspB-2 / P14909 aspartate aminotransferase subunit (EC 2.6.1.1) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (see paper)
P14909 aspartate transaminase (EC 2.6.1.1) from Saccharolobus solfataricus (see 5 papers)
    19% identity, 95% coverage of query (75.5 bits)

P14909 Aspartate aminotransferase; AspAT; Transaminase A; EC 2.6.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
    19% identity, 95% coverage of query (75.5 bits)

DAPC_MYCTU / P9WPZ5 Probable N-succinyldiaminopimelate aminotransferase DapC; DAP-AT; EC 2.6.1.17 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WPZ5 succinyldiaminopimelate transaminase (EC 2.6.1.17) from Mycobacterium tuberculosis (see paper)
    29% identity, 76% coverage of query (74.7 bits)

CAA67877.1 aspartate aminotransferase from Thermus aquaticus (see paper)
    25% identity, 90% coverage of query (74.7 bits)

2o0rA / P9WPZ5 The three-dimensional structure of n-succinyldiaminopimelate aminotransferase from mycobacterium tuberculosis (see paper)
    29% identity, 76% coverage of query (74.3 bits)

swb1 / D2KTX0 (2S,3R)-4-(2-aminophenyl)-2-amino-3-hydroxy-4-oxobutanoate aminotransferase from Streptomyces sp. SNA15896 (see paper)
    27% identity, 85% coverage of query (71.6 bits)

patA / P16524 N-acetyl-L,L-diaminopimelate aminotransferase from Bacillus subtilis (strain 168) (see 3 papers)
DAPX_BACSU / P16524 Probable N-acetyl-LL-diaminopimelate aminotransferase; Putative aminotransferase A; EC 2.6.1.- from Bacillus subtilis (strain 168) (see paper)
    21% identity, 90% coverage of query (71.6 bits)

Q8YUK5 aspartate transaminase (EC 2.6.1.1) from Nostoc sp. (see paper)
    25% identity, 87% coverage of query (71.2 bits)

DAPAT_SYNFM / A0LEA5 LL-diaminopimelate aminotransferase; DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase; EC 2.6.1.83 from Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) (see paper)
A0LEA5 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Syntrophobacter fumaroxidans (see paper)
    24% identity, 90% coverage of query (70.9 bits)

Q8TQ40 LL-diaminopimelate aminotransferase (EC 2.6.1.83) from Methanosarcina acetivorans (see paper)
    23% identity, 90% coverage of query (70.1 bits)

aspC / Q4FNY9 alanine—glyoxylate transaminase (EC 2.6.1.44) from Pelagibacter ubique (strain HTCC1062) (see 2 papers)
    21% identity, 89% coverage of query (69.3 bits)

1xi9C / Q9P9M8 Alanine aminotransferase from pyrococcus furiosus pfu-1397077-001
    23% identity, 88% coverage of query (67.8 bits)

6l1oB Product bound bacf structure from bacillus subtillis
    23% identity, 87% coverage of query (65.9 bits)

6l1lB / P39643 Apo-bacf structure from bacillus subtillis (see paper)
    23% identity, 87% coverage of query (65.5 bits)

6l1nA Substrate bound bacf structure from bacillus subtillis
    23% identity, 87% coverage of query (65.5 bits)

5yhvA / P96847 Crystal structure of an aminotransferase from mycobacterium tuberculosis
    26% identity, 87% coverage of query (63.2 bits)

AVTA_MYCTU / P96847 Valine--pyruvate aminotransferase; Alanine--valine transaminase; EC 2.6.1.66 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    26% identity, 87% coverage of query (63.2 bits)

5yhvB Crystal structure of an aminotransferase from mycobacterium tuberculosis
    26% identity, 87% coverage of query (63.2 bits)

3jtxB Crystal structure of aminotransferase (np_283882.1) from neisseria meningitidis z2491 at 1.91 a resolution
    22% identity, 89% coverage of query (62.4 bits)

AAPAT_RHIME / Q02635 Aspartate/prephenate aminotransferase; AspAT / PAT; Transaminase A; EC 2.6.1.1; EC 2.6.1.79 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see 4 papers)
Q02635 aspartate transaminase (EC 2.6.1.1); aspartate-prephenate aminotransferase (EC 2.6.1.78); glutamate-prephenate aminotransferase (EC 2.6.1.79) from Sinorhizobium meliloti (see 2 papers)
aatA / AAA26245.1 aspartate aminotransferase from Sinorhizobium meliloti (see paper)
    22% identity, 90% coverage of query (50.1 bits)

6f77A / Q02635 Crystal structure of the prephenate aminotransferase from rhizobium meliloti (see paper)
    22% identity, 90% coverage of query (50.1 bits)

3wx9A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, gla, 4ad, 2og, glu and kya
    23% identity, 89% coverage of query (48.5 bits)

3av7A Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with pmp, kyn as substrates and kya as products
    23% identity, 89% coverage of query (48.5 bits)

3aowC Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with akg
    23% identity, 89% coverage of query (48.5 bits)

3aovA / O57946 Crystal structure of pyrococcus horikoshii kynurenine aminotransferase in complex with plp
    23% identity, 89% coverage of query (48.5 bits)

1wstA / Q9V2W5 Crystal structure of multiple substrate aminotransferase (msat) from thermococcus profundus
    23% identity, 82% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory