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Searching for up to 100 curated homologs for 209225 MicrobesOnline__882:209225 (354 a.a.)

Found high-coverage hits (≥70%) to 22 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
    36% identity, 92% coverage of query (199 bits)

CysA / b2422 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
CysA / P16676 sulfate/thiosulfate ABC transporter ATP binding subunit (EC 7.3.2.3; EC 7.3.2.5) from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.6.1 / P16676 CysA aka B2422, component of Sulfate/thiosulfate porter from Escherichia coli (see 5 papers)
    38% identity, 92% coverage of query (194 bits)

TC 3.A.1.20.1 / O54370 BitD, component of The iron transporter, BitABCDEF from Treponema hyodysenteriae (Serpulina hyodysenteriae) (see paper)
    34% identity, 86% coverage of query (193 bits)

TC 3.A.1.20.3 / A3N296 Ferric ABC transporter ATP-binding protein, component of Iron (Fe3+) uptake porter, AfuABC (FbpABC) (Chin et al. 1996). AfuA has been characterized from Actinobacillus pleuropneumoniae serotype 5b (strain L20)
    36% identity, 92% coverage of query (192 bits)

YagC / b0262 CP4-6 prophage; ABC transporter ATP-binding protein AfuC from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    37% identity, 85% coverage of query (187 bits)

TC 3.A.1.6.3 / P0A4W2 Sulfate/thiosulfate import ATP-binding protein CysA aka RV2397C aka MT2468 aka MTCY253.24, component of Sulfate porter from Mycobacterium tuberculosis (see 3 papers)
    44% identity, 70% coverage of query (186 bits)

TC 3.A.1.10.3 / P44513 FbpC, component of Ferric iron (Fe3+) porter, FbpABC or HitABC (selective for trivalent cations, Fe3+, Ga3+ and Al3+) from Haemophilus influenzae (see 3 papers)
fbpC / OMNI|HI_0099 Fe(3+)-transporting ATPase; EC 3.6.3.30 from Haemophilus influenzae (see paper)
    32% identity, 88% coverage of query (182 bits)

PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
    38% identity, 79% coverage of query (181 bits)

TC 3.A.1.1.16 / Q8TZQ3 MalK aka PF1933, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    34% identity, 86% coverage of query (177 bits)

MALK_SALTY / P19566 Maltose/maltodextrin import ATP-binding protein MalK; EC 7.5.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    36% identity, 83% coverage of query (176 bits)

Pf1N1B4_5115 sucrose ABC transporter, ATPase component from Pseudomonas fluorescens FW300-N1B4
    36% identity, 87% coverage of query (176 bits)

sugC / P9WQI3 ABC-type trehalose transporter ATP-binding protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGC_MYCTU / P9WQI3 Trehalose import ATP-binding protein SugC; MtbSugC; Nucleotide-binding domain of SugABC transporter; NBD of SugABC transporter; SugABC transporter ATPase SugC; EC 7.5.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
TC 3.A.1.1.31 / O50454 PROBABLE SUGAR-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER SUGC, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    35% identity, 91% coverage of query (173 bits)

TC 3.A.1.11.4 / O50559 ChtG, component of Chrysopine porter from Agrobacterium sp
    37% identity, 79% coverage of query (171 bits)

8hprD Lpqy-sugabc in state 4
    37% identity, 74% coverage of query (162 bits)

8hplC / A0R2C0 Lpqy-sugabc in state 1 (see paper)
    37% identity, 74% coverage of query (162 bits)

8hprC Lpqy-sugabc in state 4
    37% identity, 74% coverage of query (162 bits)

3fvqB / Q5FA19 Crystal structure of the nucleotide binding domain fbpc complexed with atp (see paper)
    37% identity, 81% coverage of query (150 bits)

Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
    31% identity, 78% coverage of query (143 bits)

Build an alignment

Build an alignment for 209225 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

8cubC / Q9H222 Crystal structure of abcg5/g8 in complex with cholesterol (see paper)
    25% identity, 78% coverage of query (84.0 bits)

ABCG5_HUMAN / Q9H222 ATP-binding cassette sub-family G member 5; Sterolin-1; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
TC 3.A.1.204.5 / Q9H222 ABCG5 aka ATP-binding cassette sub-family G member 5, component of The ABCG5 (sterolin-1)/ABCG8 (sterolin-2) heterodimeric neutral sterol (cholesterol and plant sterols) (e.g., sitosterol) (phosphoryl donors ATP > CTP > GTP > UTP) exporter; present in the apical membranes of enterocytes and hepatocytes. Cholesteryl oleate, phosphatidyl choline and enantiomeric cholesterol are poorly transported (mutation of either ABCG5 or ABCG8 cause sitosterolemia and coronary atherosclerosis) (Zhang et al., 2006; Wang et al., 2006; 2011) from Homo sapiens (Human) (see 5 papers)
ABCG5 / GI|11692800 ATP-binding cassette sub-family G member 5 from Homo sapiens (see paper)
    25% identity, 77% coverage of query (83.2 bits)

3j5sD / P0A9W3 Etta binds to ribosome exit site and regulates translation by restricting ribosome and tRNA dynamics (see paper)
    27% identity, 70% coverage of query (69.3 bits)

YjjK / b4391 energy-dependent translational throttle protein EttA from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ETTA_ECOLI / P0A9W3 Energy-dependent translational throttle protein EttA; Translational regulatory factor EttA; EC 3.6.1.- from Escherichia coli (strain K12) (see 2 papers)
CH_004211 ABC transporter, ATP-binding protein YjiK from Escherichia coli K12 (see paper)
    27% identity, 70% coverage of query (69.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory