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Searching for up to 100 curated homologs for 209357 MicrobesOnline__882:209357 (290 a.a.)

Found high-coverage hits (≥70%) to 49 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SPEBH_THET2 / Q72JK8 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
    40% identity, 91% coverage of query (174 bits)

TTHA1129 / Q5SJ85 aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
SEPBH_THET8 / Q5SJ85 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q5SJ85 N1-aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (see paper)
    40% identity, 93% coverage of query (172 bits)

Q8YUM9 agmatinase (EC 3.5.3.11) from Anabaena sp. (see paper)
    35% identity, 92% coverage of query (146 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    34% identity, 89% coverage of query (139 bits)

TK0882 / Q5JI38 aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
SPEBH_THEKO / Q5JI38 N(1)-aminopropylagmatine ureohydrolase; Agmatinase; Protein SpeB homolog; EC 3.5.3.24; EC 3.5.3.11 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
Q5JI38 N1-aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermococcus kodakarensis (see paper)
    33% identity, 97% coverage of query (137 bits)

AGMT_PYRHO / O57839 Agmatinase; EC 3.5.3.11 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
    33% identity, 97% coverage of query (135 bits)

SPEB_METJA / Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q57757 agmatinase (EC 3.5.3.11) from Methanocaldococcus jannaschii (see paper)
    32% identity, 92% coverage of query (131 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    33% identity, 84% coverage of query (105 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    32% identity, 84% coverage of query (103 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    32% identity, 70% coverage of query (102 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    32% identity, 70% coverage of query (101 bits)

Build an alignment

Build an alignment for 209357 and 11 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

A0A146AXJ2 agmatinase (EC 3.5.3.11) from Apostichopus japonicus (see paper)
    28% identity, 88% coverage of query (98.2 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    33% identity, 82% coverage of query (98.2 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    33% identity, 84% coverage of query (98.2 bits)

gbuA / Q88EE2 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
    31% identity, 70% coverage of query (98.2 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    33% identity, 81% coverage of query (98.2 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    31% identity, 82% coverage of query (97.4 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    31% identity, 82% coverage of query (97.4 bits)

6vsuE / P46637 Arginase from arabidopsis thaliana in complex with ornithine (see paper)
    29% identity, 73% coverage of query (95.5 bits)

arginase / P46637 arginase (EC 3.5.3.1) from Arabidopsis thaliana (see paper)
ARGI1_ARATH / P46637 Arginase 1, mitochondrial; Agmatinase ARGAH1; Arginine amidohydrolase 1; AtARGAH1; EC 3.5.3.1; EC 3.5.3.11 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 73% coverage of query (95.5 bits)

7loxA The structure of agmatinase from e. Coli at 3.2 a displaying guanidine in the active site
    33% identity, 79% coverage of query (95.1 bits)

D4GWG4 agmatinase (EC 3.5.3.11) from Haloferax volcanii (see paper)
    32% identity, 89% coverage of query (90.9 bits)

3nipB / Q9I6K2 Crystal structure of pseudomonas aeruginosa guanidinopropionase complexed with 1,6-diaminohexane (see paper)
    36% identity, 71% coverage of query (90.9 bits)

GPUA_PSEAE / Q9I6K2 Guanidinopropionase; EC 3.5.3.17 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Q9I6K2 Guanidinopropionase (EC 3.5.3.17) from Pseudomonas aeruginosa (see paper)
    36% identity, 71% coverage of query (90.5 bits)

3niqA Crystal structure of pseudomonas aeruginosa guanidinopropionase
    36% identity, 71% coverage of query (90.5 bits)

ARGI1_ORYSI / B8AU84 Arginase 1, mitochondrial; Arginine amidohydrolase 1; EC 3.5.3.1 from Oryza sativa subsp. indica (Rice) (see paper)
    29% identity, 73% coverage of query (88.6 bits)

4dz4B / Q2T3W4 X-ray crystal structure of a hypothetical agmatinase from burkholderia thailandensis (see paper)
    31% identity, 81% coverage of query (86.3 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    27% identity, 89% coverage of query (85.9 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    27% identity, 89% coverage of query (85.5 bits)

ARG1 / Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
Q5UNS2 arginase (EC 3.5.3.1) from Solanum lycopersicum (see paper)
    27% identity, 73% coverage of query (84.3 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    31% identity, 88% coverage of query (82.8 bits)

Q1K7T0 agmatinase (EC 3.5.3.11) from Neurospora crassa (see paper)
    26% identity, 90% coverage of query (82.4 bits)

gbh / Q8KZT5 guanidinobutyrase subunit (EC 3.5.3.7) from Arthrobacter sp. (strain KUJ 8602) (see paper)
Q8KZT5 D-arginase (EC 3.5.3.10); guanidinobutyrase (EC 3.5.3.7) from Arthrobacter sp. (see paper)
    28% identity, 89% coverage of query (81.6 bits)

A0A145YEM9 arginase (EC 3.5.3.1) from Leishmania infantum (see paper)
    24% identity, 84% coverage of query (78.6 bits)

KlGBU1 / Q6CIB4 guanidinobutyrase (EC 3.5.3.7) from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (see paper)
GBU1_KLULA / Q6CIB4 Guanidinobutyrase; EC 3.5.3.7 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    28% identity, 90% coverage of query (78.2 bits)

Q6TUJ5 arginase (EC 3.5.3.1) from Leishmania mexicana (see 2 papers)
    25% identity, 84% coverage of query (77.4 bits)

O96394 arginase (EC 3.5.3.1) from Leishmania amazonensis (see 2 papers)
    25% identity, 84% coverage of query (77.0 bits)

6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    25% identity, 72% coverage of query (74.7 bits)

6dktA Crystal structure of arginase from bacillus subtilis
    25% identity, 72% coverage of query (74.3 bits)

CH_124010 agmatinase from Magnaporthe grisea 70-15 (see 3 papers)
    26% identity, 90% coverage of query (73.9 bits)

A0A060YSI8 arginase (EC 3.5.3.1) from Oncorhynchus mykiss (see paper)
    26% identity, 90% coverage of query (70.1 bits)

A0A1S3R1W2 arginase (EC 3.5.3.1) from Salmo salar (see paper)
    26% identity, 90% coverage of query (69.3 bits)

U6BQJ3 arginase (EC 3.5.3.1) from Heteropneustes fossilis (see 2 papers)
    27% identity, 96% coverage of query (65.5 bits)

W8R465 guanidinobutyrase (EC 3.5.3.7) from Aspergillus niger (see paper)
    27% identity, 89% coverage of query (65.1 bits)

ARGI_ENTH1 / C4LSS0 Arginase; EhArg; EC 3.5.3.1 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM) (see 3 papers)
C4LSS0 arginase (EC 3.5.3.1) from Entamoeba histolytica (see paper)
    23% identity, 71% coverage of query (63.9 bits)

5zeeB / C4LSS0 Crystal structure of entamoeba histolytica arginase in complex with n(omega)-hydroxy-l-arginine (noha) at 1.74 a (see paper)
    23% identity, 71% coverage of query (63.5 bits)

5zehA Crystal structure of entamoeba histolytica arginase in complex with l- ornithine at 2.35 a
    23% identity, 71% coverage of query (63.5 bits)

5zefA Crystal structure of entamoeba histolytica arginase in complex with l- norvaline at 2.01 a
    23% identity, 71% coverage of query (63.5 bits)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    25% identity, 92% coverage of query (52.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory