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Searching for up to 100 curated homologs for 349777 FitnessBrowser__Btheta:349777 (300 a.a.)

Found high-coverage hits (≥70%) to 8 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

3bulA / P13009 E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
    41% identity, 98% coverage of query (201 bits)

3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound
    41% identity, 98% coverage of query (201 bits)

1mskA Methionine synthase (activation domain)
    41% identity, 98% coverage of query (201 bits)

MetH / b4019 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli K-12 substr. MG1655 (see 60 papers)
metH / P13009 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Escherichia coli (strain K12) (see 58 papers)
METH_ECOLI / P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 4 papers)
metH methionine synthase; EC 2.1.1.13 from Escherichia coli K12 (see 15 papers)
    41% identity, 98% coverage of query (200 bits)

6bdyA Crystal structure of the meth reactivation domain bound to sinefungin
    41% identity, 98% coverage of query (200 bits)

MTR / Q99707 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Homo sapiens (see 5 papers)
METH_HUMAN / Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 7 papers)
Q99707 methionine synthase (EC 2.1.1.13) from Homo sapiens (see paper)
    37% identity, 97% coverage of query (179 bits)

METH_RAT / Q9Z2Q4 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Rattus norvegicus (Rat) (see 2 papers)
Q9Z2Q4 methionine synthase (EC 2.1.1.13) from Rattus norvegicus (see paper)
    36% identity, 97% coverage of query (176 bits)

Build an alignment

Build an alignment for 349777 and 7 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

8sseA / Q5SKM5 Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8
    24% identity, 88% coverage of query (77.0 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory