Searching for up to 100 curated homologs for 350037 FitnessBrowser__Btheta:350037 (576 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
TC 3.A.1.21.1 / Q9Z375 YbtQ, component of The Fe3+-Yersiniabactin uptake transporter, YbtPQ from Yersinia pestis (see 5 papers)
36% identity, 99% coverage of query (313 bits)
TC 3.A.1.21.1 / Q9R7V3 YbtP, component of The Fe3+-Yersiniabactin uptake transporter, YbtPQ from Yersinia pestis (see paper)
34% identity, 88% coverage of query (303 bits)
6p6jA / Q1RAG2 Structure of ybtpq importer with substrate ybt-fe bound (see paper)
34% identity, 88% coverage of query (301 bits)
YWJA_BACSU / P45861 Uncharacterized ABC transporter ATP-binding protein YwjA from Bacillus subtilis (strain 168) (see 2 papers)
35% identity, 89% coverage of query (299 bits)
Y1866_STAAM / Q99T13 Putative multidrug export ATP-binding/permease protein SAV1866; EC 7.6.2.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
Q99T13 ABC-type xenobiotic transporter (EC 7.6.2.2) from Staphylococcus aureus (see paper)
TC 3.A.1.106.2 / Q2G2M9 The homodimeric Sav1866 multidrug exporter (transports doxorubicin, verapamil, ethidium, tetraphenylphosphonium, vinblastine and the fluorescent dye, Hoechst 33342; 3-D structure known at 3 Å resolution; Dawson and Locher, 2006; Velamakanni et al., 2008) The empty site opens by rotation of the nucleotide-binding domain whereas the ATP-bound site remains occluded (Jones and George, 2011). Conformational changes induced by ATP-binding and hydrolysis have been proposed (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent (Becker et al. 2010; Oliveira et al., 2011). The alternating access mechanism and the flippase activity of this ABC exporter has been shown to be lipid-dependent from Staphylococcus aureus (strain NCTC 8325)
2hydA / Q99T13 Multidrug abc transporter sav1866 (see paper)
36% identity, 82% coverage of query (278 bits)
2onjA Structure of the multidrug abc transporter sav1866 from s. Aureus in complex with amp-pnp
36% identity, 82% coverage of query (278 bits)
TC 3.A.1.135.8 / Q837P4 ABC transporter, ATP-binding/permease protein, component of Multidrug efflux pump, EfrCD from Enterococcus faecalis (strain ATCC 700802 / V583)
34% identity, 82% coverage of query (277 bits)
IRTA_MYCT3 / G7CBF5 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
35% identity, 90% coverage of query (275 bits)
IRTA_MYCS2 / A0R6H8 Mycobactin import ATP-binding/permease protein IrtA; EC 7.2.2.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
35% identity, 90% coverage of query (275 bits)
msbA / Q2YJN8 lipid A-core oligosaccharide flippase (EC 7.5.2.6) from Brucella abortus (strain 2308) (see 2 papers)
36% identity, 81% coverage of query (267 bits)
TC 3.A.1.135.6 / E8MFM3 Putative ABC transporter permease component, component of Two component multidrug efflux pump with the 6 TMS membrane domain preceding the ATPase domain in both proteins from Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b)
32% identity, 88% coverage of query (265 bits)
TC 3.A.1.106.14 / P73239 Lipid A exporter homologue of 593 aas and 6 TMSs (N-terminal with a C-terminal ATPase domain from Synechocystis sp. (strain PCC 6803 / Kazusa)
31% identity, 98% coverage of query (263 bits)
MITOS_MOUSE / Q9CXJ4 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Mus musculus (Mouse) (see paper)
36% identity, 84% coverage of query (262 bits)
MITOS_RAT / Q5RKI8 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial sulfonylurea-receptor; MITOSUR from Rattus norvegicus (Rat) (see paper)
36% identity, 82% coverage of query (260 bits)
TAGA_DICDI / Q9GTN7 Serine protease/ABC transporter B family protein tagA; EC 3.4.21.- from Dictyostelium discoideum (Social amoeba) (see 3 papers)
31% identity, 99% coverage of query (260 bits)
TC 3.A.1.135.9 / Q832J9 ABC transporter, ATP-binding/permease protein, component of Multidrug exporter, EfrEF from Enterococcus faecalis (strain ATCC 700802 / V583)
32% identity, 83% coverage of query (259 bits)
5ochE / Q9NUT2 The crystal structure of human abcb8 in an outward-facing state
36% identity, 82% coverage of query (258 bits)
TC 3.A.1.135.2 / Q9A1K4 RscB, component of The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)] from Streptococcus pyogenes serotype M1 (see 2 papers)
31% identity, 82% coverage of query (258 bits)
TC 3.A.1.201.24 / Q00449 Multidrug exporter, MDR49 or Pgp of 1302 aas and 12 TMSs from Drosophila melanogaster
33% identity, 82% coverage of query (257 bits)
MITOS_HUMAN / Q9NUT2 Mitochondrial potassium channel ATP-binding subunit; ATP-binding cassette sub-family B member 8, mitochondrial; ABCB8; Mitochondrial ATP-binding cassette 1; M-ABC1; Mitochondrial sulfonylurea-receptor; MITOSUR from Homo sapiens (Human) (see 5 papers)
Q9NUT2 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
TC 3.A.1.201.22 / Q9NUT2 Mitochondrial ATP-binding cassette 1, ABCB8 from Homo sapiens
36% identity, 82% coverage of query (256 bits)
7wivA / P9WQJ9 Cryo-em structure of mycobacterium tuberculosis irtab in complex with an amp-pnp
36% identity, 80% coverage of query (254 bits)
IRTA_MYCTU / P9WQJ9 Mycobactin import ATP-binding/permease protein IrtA; Iron-regulated transporter A; EC 7.2.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
TC 3.A.1.21.2 / P63391 IrtA, component of The Fe3+-carboxymycobactin transporter, IrtAB (Rodriguez and Smith, 2006). IrtA contains an FAD-binding domain (see 2 papers)
36% identity, 80% coverage of query (254 bits)
IRTB_MYCTU / P9WQJ7 Mycobactin import ATP-binding/permease protein IrtB; Iron-regulated transporter B; EC 7.2.2.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
TC 3.A.1.21.2 / P63393 IrtB, component of The Fe3+-carboxymycobactin transporter, IrtAB (Rodriguez and Smith, 2006). IrtA contains an FAD-binding domain (see 2 papers)
35% identity, 76% coverage of query (254 bits)
7wixB / P9WQJ7 Cryo-em structure of mycobacterium tuberculosis irtab in complex with adp
35% identity, 76% coverage of query (254 bits)
7wixA Cryo-em structure of mycobacterium tuberculosis irtab in complex with adp
36% identity, 80% coverage of query (254 bits)
Q9HUG8 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6) from Pseudomonas aeruginosa (see paper)
31% identity, 95% coverage of query (253 bits)
7wiwA Cryo-em structure of mycobacterium tuberculosis irtab complexed with atp in an occluded conformation
36% identity, 80% coverage of query (253 bits)
CH_090868 putative lipid A export ATP-binding/permease protein MsbA from Haemophilus influenzae (see paper)
35% identity, 82% coverage of query (252 bits)
TC 3.A.1.201.16 / I0DHH7 MDR efflux pump, ABCB4a from Strongylocentrotus purpuratus
31% identity, 88% coverage of query (252 bits)
TC 3.A.1.135.3 / G9CHY9 SatB, component of Narrow spectrum fluoroquinolone (ciprofloxacin and norfloxacin) efflux pump, SatAB from Streptococcus suis
32% identity, 82% coverage of query (251 bits)
6qexA / P08183 Nanodisc reconstituted human abcb1 in complex with uic2 fab and taxol (see paper)
33% identity, 81% coverage of query (251 bits)
IRTB_MYCS2 / A0R6H7 Mycobactin import ATP-binding/permease protein IrtB; EC 7.2.2.- from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
36% identity, 76% coverage of query (251 bits)
7o9wA Encequidar-bound human p-glycoprotein in complex with uic2-fab
33% identity, 81% coverage of query (251 bits)
7a6fA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and zosuquidar
33% identity, 81% coverage of query (251 bits)
7a6eA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and tariquidar
33% identity, 81% coverage of query (251 bits)
7a6cA Nanodisc reconstituted human abcb1 in complex with mrk16 fab and elacridar
33% identity, 81% coverage of query (251 bits)
7a69A Nanodisc reconstituted human abcb1 in complex with mrk16 fab and vincristine
33% identity, 81% coverage of query (251 bits)
6fn1A Zosuquidar and uic2 fab complex of human-mouse chimeric abcb1 (abcb1hm)
33% identity, 81% coverage of query (250 bits)
AAA66477.1 SMDR2 from Schistosoma mansoni (see paper)
36% identity, 79% coverage of query (249 bits)
TC 3.A.1.135.4 / B8ZPD1 ABC transporter ATP-binding membrane protein, component of Multidrug resistance ABC exporter, PatAB (PatA, 564 aas; PatB, 588 aas) from Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)
32% identity, 87% coverage of query (249 bits)
Build an alignment for 350037 and 40 homologs with ≥ 30% identity
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TC 3.A.1.106.3 / Q8G7R7 Probable permease protein of ABC transporter system, component of The dimeric multidrug resistance exporter, ABC1/2 (exports the peptide antimicrobials, nisin and polymyxin; (Margolles et al., 2006) (both ABC1 and ABC2 also show striking similarity to family 3.A.1.117) from Bifidobacterium longum (see paper)
29% identity, 89% coverage of query (248 bits)
ABCB6_RAT / O70595 ATP-binding cassette sub-family B member 6; ABC-type heme transporter ABCB6; Ubiquitously-expressed mammalian ABC half transporter; EC 7.6.2.5 from Rattus norvegicus (Rat) (see 3 papers)
36% identity, 82% coverage of query (248 bits)
4q9iA P-glycoprotein cocrystallised with qz-ala
33% identity, 81% coverage of query (248 bits)
6qeeA Nanodisc reconstituted human-mouse chimeric abcb1 (abcb1hm)-eq mutant in complex with uic2 fab and zosuquidar.
33% identity, 81% coverage of query (248 bits)
MSBA_VIBCH / Q9KQW9 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; EC 7.5.2.6 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see paper)
Q9KQW9 ABC-type lipopolysaccharide transporter (EC 7.5.2.5) from Vibrio cholerae (see paper)
33% identity, 82% coverage of query (247 bits)
ABCB6_MESAU / A0A125QXJ1 ATP-binding cassette sub-family B member 6; ABC-type heme transporter ABCB6; Mitochondrial ABC transporter 3; Mt-ABC transporter 3; P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter; EC 7.6.2.5 from Mesocricetus auratus (Golden hamster) (see paper)
33% identity, 94% coverage of query (247 bits)
MDR_STABO / H6TB12 Sophorolipid transporter; EC 7.6.2.- from Starmerella bombicola (Yeast) (Candida bombicola) (see 2 papers)
32% identity, 96% coverage of query (247 bits)
7pslA / P40416 S. Cerevisiae atm1 in msp1d1 nanodiscs in nucleotide-free state (see paper)
36% identity, 81% coverage of query (246 bits)
ABCB1 / P08183 ATP-dependent translocase ABCB1 (EC 7.6.2.2) from Homo sapiens (see 39 papers)
MDR1_HUMAN / P08183 ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD243 antigen; EC 7.6.2.2; EC 7.6.2.1 from Homo sapiens (Human) (see 8 papers)
P08183 ABC-type xenobiotic transporter (EC 7.6.2.2); ABC-type glutathione-S-conjugate transporter (EC 7.6.2.3) from Homo sapiens (see 10 papers)
TC 3.A.1.201.1 / P08183 Broad specificity multidrug resistance (MDR1; MDR-1; Pgp; P-gp; ABCB1; P-glycoprotein) efflux pump. It exports organic cations and amphiphilic compounds of unrelated chemical structure from Homo sapiens (Human) (see 19 papers)
34% identity, 80% coverage of query (246 bits)
7psnA S. Cerevisiae atm1 in msp1e3d1 nanodiscs with bound amp-pnp and mg2+
36% identity, 81% coverage of query (246 bits)
7psmA S. Cerevisiae atm1 in msp1d1 nanodiscs with bound amp-pnp and mg2+
36% identity, 81% coverage of query (246 bits)
4myhB Structure of the glutathione bound mitochondrial abc transporter, atm1
36% identity, 81% coverage of query (246 bits)
6c0vA Molecular structure of human p-glycoprotein in the atp-bound, outward- facing conformation
33% identity, 81% coverage of query (246 bits)
ATM1_YEAST / P40416 Iron-sulfur clusters transporter ATM1, mitochondrial; EC 7.-.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
TC 3.A.1.210.1 / P40416 The mitochondrial iron transporter, ATM1 from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
ATM1 / RF|NP_014030.1 iron-sulfur clusters transporter ATM1, mitochondrial from Saccharomyces cerevisiae
36% identity, 81% coverage of query (246 bits)
7wiwB Cryo-em structure of mycobacterium tuberculosis irtab complexed with atp in an occluded conformation
35% identity, 74% coverage of query (246 bits)
ABCB7_ORYLA / H2LNR5 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial from Oryzias latipes (Japanese rice fish) (Japanese killifish) (see paper)
33% identity, 88% coverage of query (245 bits)
7zk4A The abcb1 l335c mutant (mabcb1) in the outward facing state
33% identity, 81% coverage of query (245 bits)
7zkaA Abcb1 v978c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 81% coverage of query (245 bits)
BMRA_BACSU / O06967 Multidrug resistance ABC transporter ATP-binding/permease protein BmrA; EC 7.6.2.- from Bacillus subtilis (strain 168) (see 7 papers)
TC 3.A.1.117.3 / O06967 Multidrug resistance homodimeric efflux pump, BmrA (YvcC) of 589 aas from Bacillus subtilis (strain 168)
33% identity, 86% coverage of query (244 bits)
7zk6A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to 2 molecules of aac
33% identity, 81% coverage of query (244 bits)
7zk5A Abcb1 l335c mutant (mabcb1) in the outward facing state bound to aac
33% identity, 81% coverage of query (244 bits)
6quzD / Q9WYC4 Structure of atpgs-bound outward-facing tm287/288 in complex with sybody sb_tm35 (see paper)
31% identity, 82% coverage of query (244 bits)
6qv0B Structure of atp-bound outward-facing tm287/288 in complex with sybody sb_tm35
31% identity, 82% coverage of query (243 bits)
7otgA Structure of abcb1/p-glycoprotein in the presence of the cftr potentiator ivacaftor
33% identity, 79% coverage of query (243 bits)
4xwkA P-glycoprotein co-crystallized with bde-100
33% identity, 81% coverage of query (243 bits)
4m1mA / P21447 Corrected structure of mouse p-glycoprotein (see paper)
33% identity, 79% coverage of query (243 bits)
6q81A Structure of p-glycoprotein(abcb1) in the post-hydrolytic state
33% identity, 79% coverage of query (243 bits)
3g61A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 79% coverage of query (243 bits)
3g60A Structure of p-glycoprotein reveals a molecular basis for poly- specific drug binding
33% identity, 79% coverage of query (243 bits)
7ow8A / O06967 Cryoem structure of the abc transporter bmra e504a mutant in complex with atp-mg (see paper)
33% identity, 86% coverage of query (242 bits)
ABCB7_HUMAN / O75027 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Homo sapiens (Human) (see 8 papers)
TC 3.A.1.210.4 / O75027 ABC7 or ABCB7 iron transporter (X-linked sideroblastis anemia protein, XLSA/A (Fujiwara and Harigae 2013)) from Homo sapiens (Human) (see 9 papers)
33% identity, 82% coverage of query (242 bits)
5koyA Mouse pgp 34 linker deleted bound with atp
33% identity, 79% coverage of query (242 bits)
MDR3_HUMAN / P21439 Phosphatidylcholine translocator ABCB4; ATP-binding cassette sub-family B member 4; Multidrug resistance protein 3; P-glycoprotein 3; EC 7.6.2.1 from Homo sapiens (Human) (see 28 papers)
TC 3.A.1.201.3 / P21439 Short chain fatty acid phosphatidylcholine translocase (phospholipid flippase), MDR3; AbcB4; Pgy3 from Homo sapiens (Human) (see 15 papers)
32% identity, 81% coverage of query (241 bits)
7metA / A0A0B9X4I2 A. Baumannii msba in complex with tbt1 decoupler (see paper)
35% identity, 73% coverage of query (240 bits)
8fpfD / O07549 Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to atp: bmrcd_if-atp (see paper)
32% identity, 82% coverage of query (239 bits)
8fmvD Heterodimeric abc transporter bmrcd in the inward-facing conformation bound to substrate and atp: bmrcd_if-2ht/atp
32% identity, 82% coverage of query (239 bits)
8t1pD Heterodimeric abc transporter bmrcd in the occluded conformation bound to adpvi: bmrcd_oc-adpvi
32% identity, 82% coverage of query (239 bits)
ABCB7_MOUSE / Q61102 Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein from Mus musculus (Mouse) (see 4 papers)
33% identity, 83% coverage of query (239 bits)
AB25B_ARATH / Q9LVM1 ABC transporter B family member 25, mitochondrial; ABC transporter ABCB.25; AtABCB25; ABC transporter of the mitochondrion 3; AtATM3; Iron-sulfur clusters transporter ATM3; Protein STARIK 1 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 3.A.1.210.8 / Q9LVM1 Mitochondrial ABC transporter, ATM3, involved in iron homeostasis (Chen et al. 2007) and heavy metal resistance (Kim et al. 2006). There are three isoforms: ATM1, ATM2 and ATM3 (Chen et al., 2007). ATM3 can replace the yeast iron/sulfur cluster exporter better than ATM1 or ATM2. Atm3 is most similar to the human and yeast homologues, TC# 3.A.1.210.4 and 3.A.1.210.1, 51% and 47% identical, respectively from Arabidopsis thaliana (Mouse-ear cress) (see 11 papers)
GB|AAN13224.1 putative ABC transporter protein from Arabidopsis thaliana (see paper)
33% identity, 82% coverage of query (238 bits)
7n5aA Structure of atatm3 in the closed conformation
34% identity, 81% coverage of query (238 bits)
7n59A / Q9LVM1 Structure of atatm3 in the inward-facing conformation with gssg bound (see paper)
34% identity, 81% coverage of query (238 bits)
6s7pA Nucleotide bound abcb4
32% identity, 80% coverage of query (238 bits)
ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
33% identity, 97% coverage of query (237 bits)
7bg4A Multidrug resistance transporter bmra mutant e504a bound with atp, mg, and rhodamine 6g solved by cryo-em
33% identity, 86% coverage of query (237 bits)
7niwA / P21439 Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (see paper)
32% identity, 80% coverage of query (236 bits)
ABCB9_HUMAN / Q9NP78 ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL; EC 7.4.2.6 from Homo sapiens (Human) (see 16 papers)
Q9NP78 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see 2 papers)
TC 3.A.1.209.2 / Q9NP78 Homodimeric transporter ABCB9 or TAPL. Transports a broad spectrum of peptides (low affinity) from the cytosol to the lysosomal lumen. It exists in two forms (812 aas and 1257 aas). The latter full length protein confers resistance to taxanes and anthracyclines (Kawanobe et al., 2012). Resistance and transport were demonstrated for paclitaxel and docetaxel. TapL transports a broad range of peptides of 6-60aas (23aas optimal). It has also been detected in the ER. It is stabilized by interaction with LAMP-1 and LAMP-2 (see 9.A.16) from Homo sapiens (see 18 papers)
30% identity, 89% coverage of query (235 bits)
7ph2A Nanodisc reconstituted msba in complex with nanobodies, spin-labeled at position a60c
31% identity, 81% coverage of query (234 bits)
MsbA / b0914 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli K-12 substr. MG1655 (see 54 papers)
msbA / P60752 ATP-binding lipopolysaccharide transport protein (EC 7.5.2.6) from Escherichia coli (strain K12) (see 57 papers)
MSBA_ECOLI / P60752 ATP-dependent lipid A-core flippase; Lipid A export ATP-binding/permease protein MsbA; Lipid flippase; EC 7.5.2.6 from Escherichia coli (strain K12) (see 17 papers)
P60752 ABC-type lipid A-core oligosaccharide transporter (EC 7.5.2.6); P-type phospholipid transporter (EC 7.6.2.1) from Escherichia coli (see 13 papers)
TC 3.A.1.106.1 / P60752 Phospholipid, LPS, lipid A and drug exporter, MsbA, which flips the substrate from the inner leaflet of the cytoplasmic membrane to the outer leaflet (Eckford and Sharom, 2010). MsbA also confers drug resistance to azidopine, daunomycin, vinblastine, Hoechst 33342 and ethidium (Reuter et al., 2003). Four x-ray structures, trapped in different conformations, two with and two without nucleotide, have been solved (Ward et al., 2007). They suggest an alternating accessibility mode of transport with major conformational changes from Escherichia coli (see 11 papers)
msbA / MB|P60752 lipid A export ATP-binding/permease protein msbA; EC 3.6.3.- from Escherichia coli K12 (see 24 papers)
31% identity, 81% coverage of query (234 bits)
7ph3A / P60752 Amp-pnp bound nanodisc reconstituted msba with nanobodies, spin- labeled at position a60c (see paper)
31% identity, 81% coverage of query (234 bits)
ABCBA_MOUSE / Q9JI39 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein from Mus musculus (Mouse) (see 9 papers)
32% identity, 97% coverage of query (234 bits)
7mewA E. Coli msba in complex with g247
31% identity, 81% coverage of query (233 bits)
8dmmA Structure of the vanadate-trapped msba bound to kdl
31% identity, 81% coverage of query (233 bits)
6tejB / A0A100XE85 Structure of apo irtab devoid sid in complex with sybody syb_nl5 (see paper)
31% identity, 97% coverage of query (233 bits)
6bppA E. Coli msba in complex with lps and inhibitor g092
31% identity, 81% coverage of query (233 bits)
6bplA E. Coli msba in complex with lps and inhibitor g907
31% identity, 81% coverage of query (233 bits)
7bcwA Structure of msba in salipro with adp vanadate
31% identity, 81% coverage of query (233 bits)
4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
32% identity, 95% coverage of query (233 bits)
7dv5U / O95342 Human bile salt exporter abcb11 in complex with taurocholate (see paper)
34% identity, 81% coverage of query (233 bits)
ABCBB_HUMAN / O95342 Bile salt export pump; ATP-binding cassette sub-family B member 11; EC 7.6.2.- from Homo sapiens (Human) (see 21 papers)
TC 3.A.1.201.2 / O95342 Bile salt export pump, BSEP, ABCB11 or SPGP in the canalicular membrane of liver cells, is associated with progressive familial intrahepatic cholestasis-2 and benign recurrent intrahepatic cholestasis (Kagawa et al., 2008; Stindt et al. 2013; Park et al. 2016). It exports unconjugaged bile salts and glycine conjugates > taurine conjugates as well as the statin, pravastatin (Nigam 2015). BSEP mediates biliary excretion of bile acids from hepatocytes. Compounds based on GW4064 (Q96RI1), a representative farnesoid X receptor (RXR) agonist, enhance E297G BSEP transport activity from Homo sapiens (Human) (see 11 papers)
34% identity, 81% coverage of query (233 bits)
7vgfA / O75027 Cryo-em structure of amp-pnp bound human abcb7
34% identity, 80% coverage of query (232 bits)
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