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Searching for up to 100 curated homologs for 350232 FitnessBrowser__Btheta:350232 (388 a.a.)

Found high-coverage hits (≥70%) to 51 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

purT / Q58881 phosphoribosylglycinamide formyltransferase monomer (EC 6.3.1.21) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see paper)
    55% identity, 98% coverage of query (371 bits)

PurT / b1849 phosphoribosylglycinamide formyltransferase 2 (EC 2.7.2.15; EC 2.7.2.1) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
purT / P33221 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21; EC 2.7.2.15) from Escherichia coli (strain K12) (see 8 papers)
PURT_ECOLI / P33221 Formate-dependent phosphoribosylglycinamide formyltransferase; 5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; GAR transformylase 2; GART 2; GAR transformylase T; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2; EC 6.3.1.21 from Escherichia coli (strain K12) (see 6 papers)
P33221 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Escherichia coli (see 5 papers)
    52% identity, 99% coverage of query (365 bits)

1eyzA / P33221 Structure of escherichia coli purt-encoded glycinamide ribonucleotide transformylase complexed with mg and amppnp (see paper)
    52% identity, 99% coverage of query (362 bits)

1kjiA Crystal structure of glycinamide ribonucleotide transformylase in complex with mg-amppcp
    52% identity, 99% coverage of query (362 bits)

1ez1A Structure of escherichia coli purt-encoded glycinamide ribonucleotide transformylase complexed with mg, amppnp, and gar
    52% identity, 99% coverage of query (362 bits)

1kjjA Crystal structure of glycniamide ribonucleotide transformylase in complex with mg-atp-gamma-s
    52% identity, 99% coverage of query (362 bits)

1kj8A Crystal structure of purt-encoded glycinamide ribonucleotide transformylase in complex with mg-atp and gar
    52% identity, 99% coverage of query (362 bits)

1kjqA Crystal structure of glycinamide ribonucleotide transformylase in complex with mg-adp
    51% identity, 99% coverage of query (354 bits)

E8X9F0 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    49% identity, 99% coverage of query (348 bits)

O58056 Formate-dependent phosphoribosylglycinamide formyltransferase; 5'-phosphoribosylglycinamide transformylase 2; Formate-dependent GAR transformylase; GAR transformylase 2; GART 2; Non-folate glycinamide ribonucleotide transformylase; Phosphoribosylglycinamide formyltransferase 2; EC 6.3.1.21 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    45% identity, 99% coverage of query (322 bits)

2dwcB / O58056 Crystal structure of probable phosphoribosylglycinamide formyl transferase from pyrococcus horikoshii ot3 complexed with adp
    44% identity, 99% coverage of query (298 bits)

P95197 phosphoribosylglycinamide formyltransferase 2 (EC 6.3.1.21) from Mycobacterium tuberculosis (see paper)
    32% identity, 100% coverage of query (200 bits)

Build an alignment

Build an alignment for 350232 and 12 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

3ax6A / Q9WYS8 Crystal structure of n5-carboxyaminoimidazole ribonucleotide synthetase from thermotoga maritima
    28% identity, 94% coverage of query (124 bits)

Q01930 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Ogataea methanolica (see paper)
    26% identity, 91% coverage of query (117 bits)

ADE2 / AAA96380.1 phosphoribosylaminoimidazole carboxylase from Schwanniomyces occidentalis (see paper)
    26% identity, 99% coverage of query (115 bits)

3r5hA Crystal structure of adp-air complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase (see paper)
    25% identity, 98% coverage of query (112 bits)

Q2QJL2 5-(carboxyamino)imidazole ribonucleotide mutase (EC 5.4.99.18) from Acetobacter aceti (see paper)
purK / AAZ04484.1 N5-carboxyaminoimidazole ribonucleotide synthetase from Acetobacter aceti (see paper)
    26% identity, 98% coverage of query (112 bits)

3q2oB Crystal structure of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    25% identity, 98% coverage of query (112 bits)

4dlkA Crystal structure of atp-ca++ complex of purk: n5- carboxyaminoimidazole ribonucleotide synthetase
    25% identity, 98% coverage of query (112 bits)

3v4sB Crystal structure of adp-atp complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    25% identity, 98% coverage of query (112 bits)

3v4sA Crystal structure of adp-atp complex of purk: n5-carboxyaminoimidazole ribonucleotide synthetase
    25% identity, 96% coverage of query (112 bits)

Q92210 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Candida albicans (see paper)
ADE2 phosphoribosylaminoimadazole carboxylase from Candida albicans (see 8 papers)
    25% identity, 92% coverage of query (110 bits)

P15567 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Schizosaccharomyces pombe (see paper)
ade6 / RF|NP_588141.1 phosphoribosylaminoimidazole carboxylase Ade6; EC 4.1.1.21 from Schizosaccharomyces pombe (see paper)
    27% identity, 92% coverage of query (110 bits)

3aw8A / Q5SKY0 Crystal structure of n5-carboxyaminoimidazole ribonucleotide synthetase from thermus thermophilus hb8
    31% identity, 92% coverage of query (105 bits)

Q9UVE6 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Zygosaccharomyces rouxii (see paper)
    27% identity, 77% coverage of query (105 bits)

3orqA / A0A0H3KFM7 Crystal structure of n5-carboxyaminoimidazole synthetase from staphylococcus aureus complexed with adp (see paper)
    25% identity, 90% coverage of query (103 bits)

A0A0H3KFM7 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Staphylococcus aureus (see paper)
    25% identity, 90% coverage of query (103 bits)

AN3626 phosphoribosyl-aminoimidazole carboxylase (AFU_orthologue; AFUA_4G12600) from Emericella nidulans (see paper)
    27% identity, 90% coverage of query (102 bits)

3k5hA / A1CII2 Crystal structure of carboxyaminoimidazole ribonucleotide synthase from asperigillus clavatus complexed with atp (see paper)
    27% identity, 78% coverage of query (98.2 bits)

3k5iA Crystal structure of n5-carboxyaminoimidazole synthase from aspergillus clavatus in complex with adp and 5-aminoimadazole ribonucleotide
    27% identity, 78% coverage of query (98.2 bits)

A1CII2 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Aspergillus clavatus (see paper)
    27% identity, 78% coverage of query (97.8 bits)

ADE2 / P21264 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
PUR6_YEAST / P21264 Phosphoribosylaminoimidazole carboxylase; AIR carboxylase; AIRC; EC 4.1.1.21 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P21264 phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) from Saccharomyces cerevisiae (see paper)
    24% identity, 91% coverage of query (94.7 bits)

PURK_MYCTU / P9WHL9 N5-carboxyaminoimidazole ribonucleotide synthase; N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase; EC 6.3.4.18 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    28% identity, 78% coverage of query (90.5 bits)

4mamA / Q5NGE8 The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with an adp analog, amp-cp
    24% identity, 77% coverage of query (87.8 bits)

5jqwA The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with adp
    24% identity, 77% coverage of query (87.8 bits)

4ma0A The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with partially hydrolysed atp
    24% identity, 77% coverage of query (87.8 bits)

4ma5A The crystal structure of phosphoribosylaminoimidazole carboxylase atpase subunit of francisella tularensis subsp. Tularensis schu s4 in complex with an atp analog, amp-pnp.
    24% identity, 77% coverage of query (87.4 bits)

PurK / b0522 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
purK / P09029 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) from Escherichia coli (strain K12) (see 9 papers)
PURK_ECOLI / P09029 N5-carboxyaminoimidazole ribonucleotide synthase; N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase; EC 6.3.4.18 from Escherichia coli (strain K12) (see 3 papers)
    25% identity, 84% coverage of query (72.8 bits)

3ethA Crystal structure of e. Coli purk in complex with mgatp
    25% identity, 84% coverage of query (72.0 bits)

1b6sB / P09029 Structure of n5-carboxyaminoimidazole ribonucleotide synthetase (see paper)
    25% identity, 84% coverage of query (71.6 bits)

CarB / b0033 carbamoyl phosphate synthetase subunit β (EC 6.3.5.5) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
carB / P00968 carbamoyl-phosphate synthetase large subunit (EC 6.3.5.5) from Escherichia coli (strain K12) (see 7 papers)
CARB_ECOLI / P00968 Carbamoyl phosphate synthase large chain; Carbamoyl phosphate synthetase ammonia chain; EC 6.3.4.16; EC 6.3.5.5 from Escherichia coli (strain K12) (see 5 papers)
P00968 carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Escherichia coli (see paper)
1bxrA / P00968 Structure of carbamoyl phosphate synthetase complexed with the atp analog amppnp (see paper)
carB carbamoyl phosphate synthase, large subunit; EC 6.3.5.5 from Escherichia coli (see 2 papers)
    25% identity, 71% coverage of query (70.1 bits)

1ce8A Carbamoyl phosphate synthetase from escherichis coli with complexed with the allosteric ligand imp
    25% identity, 71% coverage of query (70.1 bits)

1a9xA Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis
    25% identity, 71% coverage of query (70.1 bits)

1t36A Crystal structure of e. Coli carbamoyl phosphate synthetase small subunit mutant c248d complexed with uridine 5'-monophosphate
    25% identity, 71% coverage of query (70.1 bits)

1c3oA Crystal structure of the carbamoyl phosphate synthetase: small subunit mutant c269s with bound glutamine
    25% identity, 71% coverage of query (70.1 bits)

purK / CAA73603.1 purK from Saccharolobus solfataricus (see paper)
    24% identity, 90% coverage of query (68.9 bits)

1b6rA N5-carboxyaminoimidazole ribonucleotide synthetase from e. Coli
    24% identity, 84% coverage of query (68.9 bits)

carB / CAB56843.1 carbamoyl-phosphate synthase large subunit from Lactobacillus plantarum subsp. plantarum (see 3 papers)
    23% identity, 77% coverage of query (58.2 bits)

Q8RSS3 carbamoyl-phosphate synthase (glutamine-hydrolysing) (subunit 1/2) (EC 6.3.5.5) from Halomonas eurihalina (see paper)
    22% identity, 71% coverage of query (56.2 bits)

pyrAb1 / CAJ75872.1 PyrAb1 protein from Lactobacillus plantarum subsp. plantarum (see paper)
    24% identity, 77% coverage of query (51.2 bits)

B2G3Q3 carbamoyl-phosphate synthase (glutamine-hydrolysing) (EC 6.3.5.5) from Streptococcus thermophilus (see paper)
    24% identity, 71% coverage of query (49.3 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory