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Searching for up to 100 curated homologs for 350898 FitnessBrowser__Btheta:350898 (318 a.a.)

Found high-coverage hits (≥70%) to 56 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

E3PS87 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Acetoanaerobium sticklandii (see paper)
    61% identity, 99% coverage of query (409 bits)

7cgvA Full consensus l-threonine 3-dehydrogenase, fctdh-iiym (NAD+ bound form) (see paper)
    57% identity, 98% coverage of query (357 bits)

5z75A Artificial l-threonine 3-dehydrogenase designed by ancestral sequence reconstruction. (see paper)
    51% identity, 97% coverage of query (316 bits)

7eprB Partial consensus l-threonine 3-dehydrogenase (c-change) (see paper)
    48% identity, 98% coverage of query (298 bits)

7epsA Partial consensus l-threonine 3-dehydrogenase (e-change) (see paper)
    48% identity, 97% coverage of query (294 bits)

2yy7A / Q8KZM4 Crystal structure of thermolabile l-threonine dehydrogenase from flavobacterium frigidimaris kuc-1 (see paper)
    49% identity, 97% coverage of query (293 bits)

E5RQ20 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus necator (see paper)
    47% identity, 98% coverage of query (293 bits)

RR42_RS28300 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Cupriavidus basilensis FW507-4G11
    45% identity, 97% coverage of query (281 bits)

3a1nA / Q97BK3 Crystal structure of l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium (see paper)
    44% identity, 98% coverage of query (277 bits)

Q97BK3 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Thermoplasma volcanium (see paper)
    44% identity, 98% coverage of query (277 bits)

3a4vA Crystal structure of pyruvate bound l-threonine dehydrogenase from hyperthermophilic archaeon thermoplasma volcanium
    44% identity, 98% coverage of query (277 bits)

6jygD / D0N3N0 Crystal structure of l-threonine dehydrogenase from phytophthora infestans (see paper)
    44% identity, 99% coverage of query (276 bits)

3ajrA Crystal structure of l-3-hydroxynorvaline bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
    44% identity, 98% coverage of query (276 bits)

3a9wA Crystal structure of l-threonine bound l-threonine dehydrogenase (y137f) from hyperthermophilic archaeon thermoplasma volcanium
    44% identity, 98% coverage of query (275 bits)

3wmwB / Q0K312 Gale-like l-threonine dehydrogenase from cupriavidus necator (apo form) (see paper)
    46% identity, 97% coverage of query (269 bits)

TDH_MOUSE / Q8K3F7 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Mus musculus (Mouse) (see paper)
    44% identity, 91% coverage of query (267 bits)

D3ZN15 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Rattus norvegicus (see paper)
    43% identity, 91% coverage of query (264 bits)

4yr9A / Q8K3F7 Mouse tdh with NAD+ bound (see paper)
    44% identity, 91% coverage of query (262 bits)

TDH_PIG / Q8MIR0 L-threonine 3-dehydrogenase, mitochondrial; EC 1.1.1.103 from Sus scrofa (Pig) (see paper)
    43% identity, 91% coverage of query (258 bits)

D6PBM7 L-threonine 3-dehydrogenase (EC 1.1.1.103) from uncultured archaeon (see paper)
    40% identity, 97% coverage of query (246 bits)

5y1fA / D6PBM7 Monomeric l-threonine 3-dehydrogenase from metagenome database (NAD+ bound form) (see paper)
    40% identity, 97% coverage of query (246 bits)

5y1gA Monomeric l-threonine 3-dehydrogenase from metagenome database (akb and nadh bound form)
    40% identity, 97% coverage of query (246 bits)

5y1eA Monomeric l-threonine 3-dehydrogenase from metagenome database (l-ser and NAD+ bound form)
    40% identity, 97% coverage of query (246 bits)

5k4wC / Q7YW97 Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to nadh and l-threonine refined to 1.72 angstroms (see paper)
    41% identity, 98% coverage of query (243 bits)

5lc1A L-threonine dehydrogenase from trypanosoma brucei with NAD and the inhibitor pyruvate bound.
    41% identity, 98% coverage of query (243 bits)

5k4qA Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ refined to 2.3 angstroms
    41% identity, 98% coverage of query (243 bits)

Q7YW97 L-threonine 3-dehydrogenase (EC 1.1.1.103) from Trypanosoma brucei (see paper)
    41% identity, 97% coverage of query (242 bits)

5k50C Three-dimensional structure of l-threonine 3-dehydrogenase from trypanosoma brucei bound to NAD+ and l-allo-threonine refined to 2.23 angstroms
    41% identity, 97% coverage of query (242 bits)

4yrbC / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
    34% identity, 91% coverage of query (172 bits)

Build an alignment

Build an alignment for 350898 and 29 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

4yrbB / Q8K3F7 Mouse tdh mutant r180k with NAD+ bound (see paper)
    29% identity, 91% coverage of query (122 bits)

DEND_CUPNH / Q0KBD2 D-erythronate dehydrogenase; EC 1.1.1.410 from Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha) (see paper)
Q0KBD2 D-erythronate 2-dehydrogenase (EC 1.1.1.410) from Cupriavidus necator (see paper)
    26% identity, 73% coverage of query (77.8 bits)

Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
    25% identity, 98% coverage of query (75.5 bits)

denD / P44094 D-erythronate 2-dehydrogenase (EC 1.1.1.410) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
DEND_HAEIN / P44094 D-erythronate dehydrogenase; EC 1.1.1.410 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see paper)
    26% identity, 75% coverage of query (72.8 bits)

Q8W3J0 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Oryza sativa (see paper)
UXS-3 / BAB84334.1 UDP-glucuronic acid decarboxylase from Oryza sativa Japonica Group (see paper)
    25% identity, 99% coverage of query (59.7 bits)

wbpP / Q9RHD6 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Pseudomonas aeruginosa (see 8 papers)
    24% identity, 94% coverage of query (59.7 bits)

N0A8N8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    25% identity, 99% coverage of query (59.3 bits)

Q9ZV36 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    26% identity, 99% coverage of query (58.9 bits)

GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
    25% identity, 93% coverage of query (58.9 bits)

UDPGlcADCX1 / Q6IVK5 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Nicotiana tabacum (see paper)
    26% identity, 99% coverage of query (58.5 bits)

N0A422 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    26% identity, 99% coverage of query (58.2 bits)

Q8KN66 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Pseudomonas aeruginosa (see paper)
1sb8A / Q8KN66 Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
    25% identity, 74% coverage of query (58.2 bits)

1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose
    25% identity, 74% coverage of query (58.2 bits)

Q9SN95 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    26% identity, 99% coverage of query (57.0 bits)

UXS3 / Q9FIE8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see 2 papers)
UXS3_ARATH / Q9FIE8 UDP-glucuronic acid decarboxylase 3; UDP-XYL synthase 3; UDP-glucuronate decarboxylase 3; UGD; UXS-3; EC 4.1.1.35 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FIE8 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Arabidopsis thaliana (see paper)
    26% identity, 99% coverage of query (55.5 bits)

GAE5_ARATH / Q9STI6 UDP-glucuronate 4-epimerase 5; UDP-glucuronic acid epimerase 5; EC 5.1.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9STI6 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Arabidopsis thaliana (see 2 papers)
    23% identity, 94% coverage of query (55.1 bits)

N0A414 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Populus tomentosa (see paper)
    25% identity, 99% coverage of query (54.7 bits)

RMD_ANETH / Q6T1X6 GDP-6-deoxy-D-mannose reductase; EC 1.1.1.281 from Aneurinibacillus thermoaerophilus (see 2 papers)
2pk3A / Q6T1X6 Crystal structure of a gdp-4-keto-6-deoxy-d-mannose reductase (see paper)
    24% identity, 97% coverage of query (53.5 bits)

gla / P96481 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Streptococcus pneumoniae (see 2 papers)
    24% identity, 76% coverage of query (52.0 bits)

Q9AV98 UDP-glucuronate decarboxylase (EC 4.1.1.35) from Pisum sativum (see paper)
uxs1 / BAB40967.1 UDP-D-glucuronate carboxy-lyase from Pisum sativum (see paper)
    25% identity, 94% coverage of query (49.7 bits)

6vloA / Q5UR12 X-ray structure of the r141 sugar 4,6-dehydratase from acanthamoeba polyphaga minivirus (see paper)
    24% identity, 75% coverage of query (48.9 bits)

uxs1 / Q92WA4 UDP-xylose synthase 1 subunit (EC 4.1.1.35) from Rhizobium meliloti (strain 1021) (see paper)
    23% identity, 94% coverage of query (46.2 bits)

2b69A / Q8NBZ7 Crystal structure of human udp-glucoronic acid decarboxylase
    25% identity, 72% coverage of query (45.1 bits)

UXS1_HUMAN / Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 3 papers)
    25% identity, 72% coverage of query (45.1 bits)

7ystA / P9WN67 Crystal structure of udp-glucose 4-epimerase (rv3634c) in complex with both udp-glucose and udp-galactose in chain b from mycobacterium tuberculosis
    23% identity, 98% coverage of query (43.5 bits)

UXS1_DANRE / Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
    23% identity, 95% coverage of query (43.5 bits)

7ysmA Crystal structure of udp-glucose 4-epimerase (rv3634c) co-crystallized with udp-n-acetylglucosamine from mycobacterium tuberculosis
    23% identity, 98% coverage of query (43.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory