Sites on a Tree

 

Searching for up to 100 curated homologs for 351108 FitnessBrowser__Btheta:351108 (126 a.a.)

Found high-coverage hits (≥70%) to 12 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

P0A0T3 lactoylglutathione lyase (EC 4.4.1.5) from Neisseria meningitidis (see paper)
    33% identity, 95% coverage of query (61.2 bits)

Q9HY85 lactoylglutathione lyase (EC 4.4.1.5) from Pseudomonas aeruginosa (see paper)
    31% identity, 96% coverage of query (52.4 bits)

Q2PYM9 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania infantum (see paper)
    30% identity, 95% coverage of query (51.6 bits)

Q68RJ8 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania major (see 2 papers)
    30% identity, 95% coverage of query (51.6 bits)

2c21A / Q68RJ8 Specificity of the trypanothione-dependednt leishmania major glyoxalase i: structure and biochemical comparison with the human enzyme (see paper)
    30% identity, 95% coverage of query (51.2 bits)

Q5XQR1 lactoylglutathione lyase (EC 4.4.1.5) from Leishmania donovani (see paper)
    30% identity, 95% coverage of query (48.9 bits)

LGUL_SCHPO / Q09751 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
glo1 / RF|NP_596010.1 glyoxalase I; EC 4.4.1.5 from Schizosaccharomyces pombe (see 3 papers)
    31% identity, 95% coverage of query (47.4 bits)

GloA / b1651 glyoxalase I (EC 4.4.1.5) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
gloA / P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (strain K12) (see 19 papers)
LGUL_ECOLI / P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see 6 papers)
P0AC81 lactoylglutathione lyase (EC 4.4.1.5) from Escherichia coli (see 3 papers)
gloA / RF|NP_416168.1 lactoylglutathione lyase; EC 4.4.1.5 from Shigella flexneri (see 5 papers)
    33% identity, 95% coverage of query (44.7 bits)

Build an alignment

Build an alignment for 351108 and 8 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

4mttA / Q9I5L8 Ni- and zn-bound gloa2 at low resolution (see paper)
    24% identity, 94% coverage of query (44.3 bits)

1fa6A Crystal structure of the co(ii)-bound glyoxalase i of escherichia coli
    30% identity, 94% coverage of query (43.1 bits)

1fa5A / P0AC81 Crystal structure of the zn(ii)-bound glyoxalase i of escherichia coli (see paper)
    30% identity, 94% coverage of query (43.1 bits)

GLO1 / P50107 glyoxalase I (EC 4.4.1.5) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
LGUL_YEAST / P50107 Glyoxalase I; Glx I; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase; EC 4.4.1.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    26% identity, 97% coverage of query (40.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory