Sites on a Tree

 

Searching for up to 100 curated homologs for 351200 BT1672 phosphoglycerate kinase (NCBI ptt file) (419 a.a.)

Found high-coverage hits (≥70%) to 66 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PGKY3_ARATH / Q9SAJ4 Phosphoglycerate kinase 3, cytosolic; EC 2.7.2.3 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
    52% identity, 100% coverage of query (424 bits)

P50318 phosphoglycerate kinase (EC 2.7.2.3) from Arabidopsis thaliana (see paper)
    50% identity, 99% coverage of query (419 bits)

Q42961 phosphoglycerate kinase (EC 2.7.2.3) from Nicotiana benthamiana (see paper)
    51% identity, 98% coverage of query (416 bits)

E5LLE7 phosphoglycerate kinase (EC 2.7.2.3) from Nicotiana benthamiana (see paper)
    50% identity, 98% coverage of query (414 bits)

PGK_NOSS1 / Q8YPR1 Phosphoglycerate kinase; EC 2.7.2.3 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
    52% identity, 98% coverage of query (412 bits)

PGKH1_ARATH / Q9LD57 Phosphoglycerate kinase 1, chloroplastic; EC 2.7.2.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LD57 phosphoglycerate kinase (EC 2.7.2.3) from Arabidopsis thaliana (see paper)
    50% identity, 98% coverage of query (408 bits)

Q6H6C7 phosphoglycerate kinase (EC 2.7.2.3) from Oryza sativa (see paper)
    51% identity, 100% coverage of query (407 bits)

A8JC04 phosphoglycerate kinase (EC 2.7.2.3) from Chlamydomonas reinhardtii (see paper)
    49% identity, 99% coverage of query (399 bits)

PGK_GEOSE / P18912 Phosphoglycerate kinase; EC 2.7.2.3 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
1phpA / P18912 Structure of the adp complex of the 3-phosphoglycerate kinase from bacillus stearothermophilus at 1.65 angstroms (see paper)
    49% identity, 100% coverage of query (385 bits)

P40924 Phosphoglycerate kinase; EC 2.7.2.3 from Bacillus subtilis (strain 168)
    48% identity, 100% coverage of query (383 bits)

1vpeA / P36204 Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium thermotoga maritima (see paper)
    47% identity, 99% coverage of query (370 bits)

pgk / P36204 Pgk (EC 2.7.2.3; EC 5.3.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 4 papers)
PGKT_THEMA / P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see 3 papers)
P36204 triose-phosphate isomerase (EC 5.3.1.1) from Thermotoga maritima (see 2 papers)
    48% identity, 99% coverage of query (369 bits)

A0A1D3TPD1 phosphoglycerate kinase (EC 2.7.2.3) from Anaerobium acetethylicum (see paper)
    47% identity, 100% coverage of query (366 bits)

PGK_YEAST / P00560 Phosphoglycerate kinase; EC 2.7.2.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
    47% identity, 100% coverage of query (362 bits)

1qpgA 3-phosphoglycerate kinase, mutation r65q
    47% identity, 100% coverage of query (361 bits)

3pgkA / P00560 The structure of yeast phosphoglycerate kinase at 0.25 nm resolution (see paper)
    47% identity, 100% coverage of query (353 bits)

A0A0H5S3P5 phosphoglycerate kinase (EC 2.7.2.3) from Brugia malayi (see 2 papers)
A0A4E9EYJ5 phosphoglycerate kinase (EC 2.7.2.3) from Brugia malayi (see paper)
    47% identity, 99% coverage of query (352 bits)

PGK_DICDI / Q9GPM4 Phosphoglycerate kinase; EC 2.7.2.3 from Dictyostelium discoideum (Social amoeba) (see 3 papers)
    46% identity, 100% coverage of query (351 bits)

C1LT16 phosphoglycerate kinase (EC 2.7.2.3) from Schistosoma japonicum (see paper)
    46% identity, 100% coverage of query (350 bits)

PGK_SCHMA / P41759 Phosphoglycerate kinase; PGK; EC 2.7.2.3 from Schistosoma mansoni (Blood fluke) (see paper)
    46% identity, 100% coverage of query (348 bits)

pgkA / GI|168070 phosphoglycerate kinase; EC 2.7.2.3 from Emericella nidulans (see paper)
    47% identity, 100% coverage of query (347 bits)

Q27683 phosphoglycerate kinase (EC 2.7.2.3) from Leishmania major (see 2 papers)
    45% identity, 100% coverage of query (347 bits)

P50312 phosphoglycerate kinase (EC 2.7.2.3) from Leishmania major (see paper)
    45% identity, 100% coverage of query (346 bits)

PGK_PLAF7 / P27362 Phosphoglycerate kinase; EC 2.7.2.3 from Plasmodium falciparum (isolate 3D7) (see paper)
P27362 phosphoglycerate kinase (EC 2.7.2.3) from Plasmodium falciparum (see paper)
AAA29727.1 3-phosphoglycerate kinase from Plasmodium falciparum (see paper)
    48% identity, 97% coverage of query (345 bits)

1ltkC / P27362 Crystal structure of phosphoglycerate kinase from plasmodium falciparum, in the open conformation
    48% identity, 97% coverage of query (344 bits)

PGK1 / GI|799385 phosphoglycerate kinase; EC 2.7.2.3 from Candida albicans (see 11 papers)
    44% identity, 99% coverage of query (342 bits)

Q4D193 phosphoglycerate kinase (EC 2.7.2.3) from Trypanosoma cruzi (see paper)
    44% identity, 99% coverage of query (342 bits)

c1PGK / AAC37222.1 phosphoglycerate kinase from Trypanosoma congolense (see paper)
c2PGK / AAC37225.1 phosphoglycerate kinase from Trypanosoma congolense (see paper)
    43% identity, 100% coverage of query (340 bits)

P07377 phosphoglycerate kinase (EC 2.7.2.3) from Trypanosoma brucei brucei (see paper)
    43% identity, 100% coverage of query (339 bits)

6yjeA / A5K6T9 Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from peg3350 and ammonium acetate at ph 5.5
    47% identity, 97% coverage of query (338 bits)

A0A061J5A1 phosphoglycerate kinase (EC 2.7.2.3) from Trypanosoma rangeli (see 2 papers)
    43% identity, 100% coverage of query (338 bits)

N9V9W5 phosphoglycerate kinase (EC 2.7.2.3) from Entamoeba histolytica (see paper)
PGK phosphoglycerate kinase; EC 2.7.2.3 from Entamoeba histolytica HM-1:IMSS (see paper)
    43% identity, 100% coverage of query (338 bits)

PGK1 / P00558 phosphoglycerate kinase 1 (EC 2.7.2.3) from Homo sapiens (see 4 papers)
PGK1_HUMAN / P00558 Phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2; EC 2.7.2.3 from Homo sapiens (Human) (see 14 papers)
    44% identity, 99% coverage of query (337 bits)

1kf0A Crystal structure of pig muscle phosphoglycerate kinase ternary complex with amp-pcp and 3pg
    43% identity, 99% coverage of query (337 bits)

2y3iA The structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride
    44% identity, 99% coverage of query (337 bits)

2x15A The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp and 1,3- bisphosphoglycerate
    43% identity, 99% coverage of query (337 bits)

4o33A / P00558 Crystal structure of human pgk1 3pg and terazosin(tzn) ternary complex (see paper)
    44% identity, 99% coverage of query (336 bits)

PGK2_MOUSE / P09041 Phosphoglycerate kinase 2; Phosphoglycerate kinase, testis specific; EC 2.7.2.3 from Mus musculus (Mouse) (see 3 papers)
P09041 phosphoglycerate kinase (EC 2.7.2.3) from Mus musculus (see 2 papers)
    42% identity, 99% coverage of query (335 bits)

PGK2_PIG / Q6RI85 Phosphoglycerate kinase 2; Phosphoglycerate kinase, testis specific; EC 2.7.2.3 from Sus scrofa (Pig) (see paper)
Q6RI85 phosphoglycerate kinase (EC 2.7.2.3) from Sus scrofa (see paper)
    43% identity, 99% coverage of query (335 bits)

4axxA The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp 3-phosphoglycerate and beryllium trifluoride
    43% identity, 99% coverage of query (335 bits)

1vjcA Structure of pig muscle pgk complexed with mgatp
    43% identity, 99% coverage of query (335 bits)

P09403 phosphoglycerate kinase (EC 2.7.2.3) from Thermus thermophilus (see paper)
    43% identity, 100% coverage of query (334 bits)

5m1rA X-ray structure of human g166d pgk-1 mutant
    44% identity, 99% coverage of query (334 bits)

PGK1_MOUSE / P09411 Phosphoglycerate kinase 1; EC 2.7.2.3 from Mus musculus (Mouse) (see paper)
P09411 phosphoglycerate kinase (EC 2.7.2.3) from Mus musculus (see 2 papers)
    43% identity, 99% coverage of query (333 bits)

2wzcA The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp, 3pg and aluminium tetrafluoride
    43% identity, 99% coverage of query (333 bits)

2wzbA The catalytically active fully closed conformation of human phosphoglycerate kinase in complex with adp, 3pg and magnesium trifluoride
    43% identity, 99% coverage of query (333 bits)

PGKC_TRYBB / P07378 Phosphoglycerate kinase, glycosomal; Phosphoglycerate kinase C; EC 2.7.2.3 from Trypanosoma brucei brucei (see paper)
P07378 phosphoglycerate kinase (EC 2.7.2.3) from Trypanosoma brucei brucei (see paper)
    43% identity, 100% coverage of query (332 bits)

2paaA / P09041 Crystal structure of phosphoglycerate kinase-2 bound to atp and 3pg (see paper)
    42% identity, 99% coverage of query (332 bits)

13pkA / P07378 Ternary complex of phosphoglycerate kinase from trypanosoma brucei (see paper)
    43% identity, 100% coverage of query (332 bits)

16pkA Phosphoglycerate kinase from trypanosoma brucei bisubstrate analog
    43% identity, 100% coverage of query (332 bits)

PGK1_HORSE / P00559 Phosphoglycerate kinase 1; EC 2.7.2.3 from Equus caballus (Horse) (see paper)
    43% identity, 99% coverage of query (330 bits)

PGK1_PIG / Q7SIB7 Phosphoglycerate kinase 1; EC 2.7.2.3 from Sus scrofa (Pig) (see 2 papers)
    43% identity, 99% coverage of query (330 bits)

2wzdA The catalytically active fully closed conformation of human phosphoglycerate kinase k219a mutant in complex with adp, 3pg and aluminium trifluoride
    43% identity, 99% coverage of query (330 bits)

O60101 Phosphoglycerate kinase; EC 2.7.2.3 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    45% identity, 99% coverage of query (330 bits)

PGK2 / P07205 phosphoglycerate kinase 2 (EC 2.7.2.3) from Homo sapiens (see 4 papers)
PGK2_HUMAN / P07205 Phosphoglycerate kinase 2; Phosphoglycerate kinase, testis specific; EC 2.7.2.3 from Homo sapiens (Human) (see paper)
P07205 phosphoglycerate kinase (EC 2.7.2.3) from Homo sapiens (see paper)
    42% identity, 99% coverage of query (327 bits)

1hdiA Pig muscle 3-phosphoglycerate kinase complexed with 3-pg and mgadp.
    42% identity, 99% coverage of query (321 bits)

5np8A Pgk1 in complex with crt0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl- pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid)
    43% identity, 99% coverage of query (320 bits)

3c3bA Crystal structure of human phosphoglycerate kinase bound to d-cdp
    43% identity, 99% coverage of query (319 bits)

pgk / AAA62185.1 phosphoglycerate kinase from Xanthobacter flavus (see paper)
    43% identity, 99% coverage of query (318 bits)

3c3bB Crystal structure of human phosphoglycerate kinase bound to d-cdp
    43% identity, 99% coverage of query (314 bits)

PGK_STRR6 / Q8DQX8 Phosphoglycerate kinase; EC 2.7.2.3 from Streptococcus pneumoniae (strain ATCC BAA-255 / R6) (see paper)
3zlbA / Q04LZ5 Crystal structure of phosphoglycerate kinase from streptococcus pneumoniae (see paper)
    45% identity, 100% coverage of query (302 bits)

4feyA / Q5NF76 An x-ray structure of a putative phosphogylcerate kinase with bound adp from francisella tularensis subsp. Tularensis schu s4
    42% identity, 100% coverage of query (301 bits)

4ng4B / Q83AU6 Structure of phosphoglycerate kinase (cbu_1782) from coxiella burnetii (see paper)
    40% identity, 100% coverage of query (300 bits)

1zmrA / P0A799 Crystal structure of the e. Coli phosphoglycerate kinase (see paper)
    38% identity, 99% coverage of query (268 bits)

P0A799 Phosphoglycerate kinase; EC 2.7.2.3 from Escherichia coli (strain K12)
    38% identity, 99% coverage of query (268 bits)

O58965 Phosphoglycerate kinase; EC 2.7.2.3 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
    33% identity, 100% coverage of query (216 bits)

Build an alignment

Build an alignment for 351200 and 66 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory