Searching for up to 100 curated homologs for 351602 FitnessBrowser__Btheta:351602 (359 a.a.)
Found high-coverage hits (≥70%) to 62 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
ILVC_DESOH / A8ZTR0 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.382 from Desulfosudis oleivorans (strain DSM 6200 / JCM 39069 / Hxd3) (Desulfococcus oleovorans) (see paper)
65% identity, 96% coverage of query (471 bits)
ILV5 mitochondrial ketol-acid reductoisomerase from Candida albicans (see paper)
62% identity, 96% coverage of query (427 bits)
P78827 Probable ketol-acid reductoisomerase, mitochondrial; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.86 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
57% identity, 97% coverage of query (427 bits)
ILV5_YEAST / P06168 Ketol-acid reductoisomerase, mitochondrial; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Isoleucine-plus-valine requiring protein 5; EC 1.1.1.86 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
60% identity, 96% coverage of query (424 bits)
7tocA / A0A2H0ZMH9 Crystal structure of the mitochondrial ketol-acid reductoisomerase ilvc from candida auris
61% identity, 97% coverage of query (411 bits)
ilvC / AAL99358.2 ketol-acid reductoisomerase from Geobacillus stearothermophilus (see paper)
38% identity, 81% coverage of query (175 bits)
7q03A Ketol-acid reductoisomerase from methanothermococcus thermolithotrophicus in the close state with NADP and mg2+ (see paper)
41% identity, 70% coverage of query (171 bits)
ILVC_IGNAA / E0SRA9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1) (see 3 papers)
E0SRA9 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Ignisphaera aggregans (see paper)
35% identity, 89% coverage of query (167 bits)
5e4rA / E0SRA9 Crystal structure of domain-duplicated synthetic class ii ketol-acid reductoisomerase 2ia_kari-dd (see paper)
35% identity, 89% coverage of query (166 bits)
4xdzA Holo structure of ketol-acid reductoisomerase from ignisphaera aggregans
35% identity, 89% coverage of query (166 bits)
ILVC_HYDS0 / B4U6I9 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Hydrogenobaculum sp. (strain Y04AAS1) (see paper)
36% identity, 86% coverage of query (162 bits)
6bulB / Q2YUF3 Crystal structure of staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 2
36% identity, 89% coverage of query (161 bits)
A6UW80 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Methanococcus aeolicus (see paper)
39% identity, 70% coverage of query (160 bits)
6vo2A Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex with mg, NADPH and inhibitor.
36% identity, 89% coverage of query (160 bits)
6c5nA Crystal structure of staphylococcus aureus ketol-acid reductoisomerase with hydroxyoxamate inhibitor 1
36% identity, 89% coverage of query (160 bits)
6c55A Crystal structure of staphylococcus aureus ketol-acid reductosimerrase with hydroxyoxamate inhibitor 3
36% identity, 89% coverage of query (160 bits)
6aqjA Crystal structures of staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity.
36% identity, 89% coverage of query (160 bits)
5w3kA Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, mg2+ and cpd
36% identity, 89% coverage of query (160 bits)
3fr8B / Q65XK0 Rice ketolacid reductoisomerase in complex with mg2+-NADPH (see paper)
32% identity, 92% coverage of query (159 bits)
ILV5_ORYSJ / Q65XK0 Ketol-acid reductoisomerase, chloroplastic; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; Protein KARI; EC 1.1.1.86 from Oryza sativa subsp. japonica (Rice) (see paper)
Q65XK0 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Oryza sativa Japonica Group (see paper)
32% identity, 92% coverage of query (159 bits)
Q2FWK4 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Staphylococcus aureus (see 3 papers)
35% identity, 89% coverage of query (158 bits)
ILVC_UNCAG / Q64BR7 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Uncultured archaeon GZfos26G2 (see paper)
Q64BR7 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from uncultured archaeon GZfos26G2 (see paper)
37% identity, 76% coverage of query (157 bits)
4xdyA / Q64BR7 Structure of nadh-preferring ketol-acid reductoisomerase from an uncultured archean (see paper)
37% identity, 76% coverage of query (157 bits)
ILVC_LACLA / Q02138 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) (see paper)
Q02138 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Lactococcus lactis subsp. lactis (see paper)
37% identity, 88% coverage of query (156 bits)
6l2iA / Q04M32 Ilvc, a ketol-acid reductoisomerase, from streptococcus pneumoniae_wt
36% identity, 88% coverage of query (155 bits)
ILVC_METS5 / A4YI15 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
32% identity, 89% coverage of query (150 bits)
ILVC_THEPS / K4LVZ1 Ketol-acid reductoisomerase (NAD(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.382 from Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 26808 / PB) (see paper)
37% identity, 70% coverage of query (150 bits)
ILVC_SLAES / D0WGK0 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.86 from Slackia exigua (strain ATCC 700122 / DSM 15923 / CIP 105133 / JCM 11022 / KCTC 5966 / S-7) (see paper)
D0WGK0 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Slackia exigua (see paper)
31% identity, 88% coverage of query (149 bits)
8ep7C / Q81S27 Crystal structure of the ketol-acid reductoisomerase from bacillus anthracis in complex with NADP
34% identity, 86% coverage of query (149 bits)
4kqxB / D0WGK0 Mutant slackia exigua kari ddv in complex with NAD and an inhibitor (see paper)
31% identity, 88% coverage of query (149 bits)
4kqwA The structure of the slackia exigua kari in complex with NADP
31% identity, 88% coverage of query (149 bits)
7ke2A Crystal structure of staphylococcus aureus ketol-acid reductoisomerase in complex with mg2+ and nsc116565
35% identity, 89% coverage of query (149 bits)
7latA / Q9PHN5 Campylobacter jejuni keto-acid reductoisomerase in complex with mg2+
32% identity, 89% coverage of query (148 bits)
7rduA Crystal structure of campylobacter jejuni keto said reductoisomerase in complex with magnesium and oxidixized and reduced NADPH
32% identity, 89% coverage of query (148 bits)
5yeqB / Q4J8K9 The structure of sac-kari protein (see paper)
35% identity, 78% coverage of query (146 bits)
Q4J8K9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Sulfolobus acidocaldarius (see paper)
35% identity, 78% coverage of query (146 bits)
ilvC / O27491 acetohydroxy-acid isomeroreductase subunit (EC 1.1.1.383) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see 3 papers)
38% identity, 71% coverage of query (144 bits)
ILV5_SPIOL / Q01292 Ketol-acid reductoisomerase, chloroplastic; Acetohydroxy-acid reductoisomerase; Alpha-keto-beta-hydroxylacyl reductoisomerase; EC 1.1.1.86 from Spinacia oleracea (Spinach) (see 3 papers)
30% identity, 92% coverage of query (142 bits)
1qmgA / Q01292 Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and adp-ribose. (see paper)
30% identity, 92% coverage of query (142 bits)
1yveI Acetohydroxy acid isomeroreductase complexed with NADPH, magnesium and inhibitor ipoha (n-hydroxy-n-isopropyloxamate)
30% identity, 92% coverage of query (142 bits)
ILVC_ARCFU / O28294 Ketol-acid reductoisomerase (NAD(P)(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 1; Ketol-acid reductoisomerase type I; EC 1.1.1.383 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) (see paper)
O28294 ketol-acid reductoisomerase (NAD+) (EC 1.1.1.382) from Archaeoglobus fulgidus (see paper)
33% identity, 88% coverage of query (139 bits)
Q59818 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces avermitilis (see paper)
36% identity, 88% coverage of query (138 bits)
A0A0K2AZ61 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces ambofaciens (see paper)
35% identity, 86% coverage of query (135 bits)
D6EC76 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans (see paper)
35% identity, 86% coverage of query (134 bits)
D6ERQ9 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces lividans (see paper)
Q9Z565 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor (see paper)
35% identity, 86% coverage of query (133 bits)
Q9FBT8 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Streptomyces coelicolor (see paper)
35% identity, 86% coverage of query (133 bits)
8cy8A Apo form cryo-em structure of campylobacter jejune ketol-acid reductoisommerase crosslinked by glutaraldehyde
31% identity, 89% coverage of query (133 bits)
6jczC / Q97YJ9 Cryo-em structure of sulfolobus solfataricus ketol-acid reductoisomerase (sso-kari) in complex with mg2+, NADPH, and cpd at ph7.5 (see paper)
33% identity, 74% coverage of query (117 bits)
6jd1A Cryo-em structure of sulfolobus solfataricus ketol-acid reductoisomerase (sso-kari) in complex with mg2+, nadh, and cpd at ph7.5
33% identity, 74% coverage of query (117 bits)
7pciA / Q2T3G7 Burg (holo) in complex with hydroxypyruvate-enol (8): biosynthesis of cyclopropanol rings in bacterial toxins (see paper)
30% identity, 81% coverage of query (99.8 bits)
7pctA Burg e232q mutant (holo) in complex with enol-oxalacetate (15): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pcoA Burg e232q mutant (holo) in complex with 2r,3r-2,3-dihydroxy-6-methyl- heptanoate (12): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pceA Burg (apo): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pcnA Burg (holo) in complex with gonyenediol (14), trigonic acid (6) and dms: biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pcmA Burg (holo) in complex with (z)-2,3-dihydroxy-6-methyl-hept-2-enoate (13): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pclA Burg (holo) in complex with 2-hydroxy-2-(hydroxy(isopropyl)amino) acetate (11): biosynthesis of cyclopropanolrings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
7pcgA Burg (holo) in complex with cyclopropane-1,1-dicarboxylate (7): biosynthesis of cyclopropanol rings in bacterial toxins
30% identity, 81% coverage of query (99.8 bits)
Build an alignment for 351602 and 57 homologs with ≥ 30% identity
Or download the sequences
3ulkA / P05793 E. Coli ketol-acid reductoisomerase in complex with NADPH and mg2+ (see paper)
28% identity, 80% coverage of query (95.5 bits)
IlvC / b3774 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ilvC / P05793 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86; EC 1.1.1.169) from Escherichia coli (strain K12) (see 40 papers)
ILVC_ECOLI / P05793 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Escherichia coli (strain K12) (see 9 papers)
P05793 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383); ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Escherichia coli (see 3 papers)
ilvC ketol-acid reductoisomerase; EC 1.1.1.86 from Escherichia coli K12 (see 2 papers)
28% identity, 80% coverage of query (95.5 bits)
A0KS29 ketol-acid reductoisomerase [NAD(P)+] (EC 1.1.1.383) from Shewanella sp. (see paper)
26% identity, 76% coverage of query (94.7 bits)
A6TGG1 ketol-acid reductoisomerase (NADP+) (EC 1.1.1.86) from Klebsiella pneumoniae subsp. pneumoniae (see paper)
27% identity, 80% coverage of query (91.7 bits)
ILVC_SALTY / P05989 Ketol-acid reductoisomerase (NADP(+)); KARI; Acetohydroxy-acid isomeroreductase; AHIR; Alpha-keto-beta-hydroxylacyl reductoisomerase; Ketol-acid reductoisomerase type 2; Ketol-acid reductoisomerase type II; EC 1.1.1.86 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
27% identity, 80% coverage of query (91.7 bits)
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Lawrence Berkeley National Laboratory