Searching for up to 100 curated homologs for 351958 FitnessBrowser__Btheta:351958 (402 a.a.)
Found high-coverage hits (≥70%) to 71 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
3hm8A / P52790 Crystal structure of thE C-terminal hexokinase domain of human hk3
28% identity, 91% coverage of query (138 bits)
HK3 / P52790 hexokinase-3 (EC 2.7.1.1) from Homo sapiens (see 4 papers)
HXK3_HUMAN / P52790 Hexokinase-3; Hexokinase type III; HK III; Hexokinase-C; EC 2.7.1.1 from Homo sapiens (Human) (see paper)
P52790 hexokinase (EC 2.7.1.1) from Homo sapiens (see paper)
28% identity, 91% coverage of query (137 bits)
HXK3_RAT / P27926 Hexokinase-3; Hexokinase type III; HK III; Hexokinase-C; EC 2.7.1.1 from Rattus norvegicus (Rat) (see paper)
30% identity, 75% coverage of query (136 bits)
Q6X271 hexokinase (EC 2.7.1.1) from Physcomitrium patens (see paper)
28% identity, 94% coverage of query (126 bits)
5hfuB / P52789 Crystal structure of human hexokinase 2 with cmpd 27, a 2-amido-6- benzenesulfonamide glucosamine (see paper)
29% identity, 86% coverage of query (122 bits)
A9S9F8 hexokinase (EC 2.7.1.1) from Physcomitrium patens (see paper)
27% identity, 94% coverage of query (122 bits)
3vf6A Glucokinase in complex with glucose and activator
26% identity, 86% coverage of query (120 bits)
2nztB / P52789 Crystal structure of human hexokinase ii (see paper)
26% identity, 86% coverage of query (117 bits)
3fguA Catalytic complex of human glucokinase
25% identity, 86% coverage of query (117 bits)
6e0iA Crystal structure of glucokinase in complex with compound 72
25% identity, 86% coverage of query (116 bits)
3vevA Glucokinase in complex with an activator and glucose
26% identity, 86% coverage of query (115 bits)
4no7A Human glucokinase in complex with a nanomolar activator.
26% identity, 86% coverage of query (115 bits)
3imxA Crystal structure of human glucokinase in complex with a synthetic activator
25% identity, 86% coverage of query (115 bits)
3s41A Glucokinase in complex with activator and glucose
26% identity, 86% coverage of query (115 bits)
HXK2_RAT / P27881 Hexokinase-2; Hexokinase type II; HK II; Hexokinase-B; EC 2.7.1.1 from Rattus norvegicus (Rat) (see paper)
P27881 hexokinase (EC 2.7.1.1) from Rattus norvegicus (see 2 papers)
26% identity, 99% coverage of query (114 bits)
HXK2_MOUSE / O08528 Hexokinase-2; Hexokinase type II; HK II; EC 2.7.1.1 from Mus musculus (Mouse) (see 3 papers)
O08528 hexokinase (EC 2.7.1.1) from Mus musculus (see 2 papers)
26% identity, 99% coverage of query (114 bits)
HK2 / P52789 hexokinase-2 (EC 2.7.1.1) from Homo sapiens (see 4 papers)
HXK2_HUMAN / P52789 Hexokinase-2; Hexokinase type II; HK II; Hexokinase-B; Muscle form hexokinase; EC 2.7.1.1 from Homo sapiens (Human) (see 7 papers)
P52789 hexokinase (EC 2.7.1.1) from Homo sapiens (see 10 papers)
27% identity, 86% coverage of query (114 bits)
3idhA / P35557 Human pancreatic glucokinase in complex with glucose (see paper)
25% identity, 86% coverage of query (114 bits)
GCK / P35557 glucokinase (EC 2.7.1.1) from Homo sapiens (see 13 papers)
HXK4_HUMAN / P35557 Hexokinase-4; HK4; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-D; EC 2.7.1.1 from Homo sapiens (Human) (see 36 papers)
P35557 hexokinase (EC 2.7.1.1) from Homo sapiens (see 11 papers)
Q53Y25 hexokinase (EC 2.7.1.1) from Homo sapiens (see paper)
25% identity, 86% coverage of query (114 bits)
6e0eA Crystal structure of glucokinase in complex with compound 6
25% identity, 86% coverage of query (114 bits)
4rchA Discovery of 2-pyridyl ureas as glucokinase activators
25% identity, 86% coverage of query (114 bits)
4mlhA Human glucokinase in complex with a novel amino thiazole allosteric activator
25% identity, 86% coverage of query (114 bits)
4mleA Human glucokinase in complex with novel amino thiazole activator
25% identity, 86% coverage of query (114 bits)
3veyA Glucokinase in complex with glucose and atpgs
25% identity, 86% coverage of query (114 bits)
3goiA Human glucokinase in complex with a synthetic activator
25% identity, 86% coverage of query (114 bits)
3fr0A Human glucokinase in complex with 2-amino benzamide activator
25% identity, 86% coverage of query (114 bits)
3a0iX Human glucokinase in complex with a synthetic activator
25% identity, 86% coverage of query (114 bits)
1v4sA Crystal structure of human glucokinase
25% identity, 86% coverage of query (114 bits)
4l3qA Crystal structure of glucokinase-activator complex
25% identity, 86% coverage of query (114 bits)
3h1vX Human glucokinase in complex with a synthetic activator
25% identity, 86% coverage of query (114 bits)
HXK9_ORYSJ / Q2KNB7 Hexokinase-9; Hexokinase-5; EC 2.7.1.1 from Oryza sativa subsp. japonica (Rice) (see paper)
27% identity, 98% coverage of query (113 bits)
2nztA Crystal structure of human hexokinase ii
27% identity, 86% coverage of query (113 bits)
7t78A Crystal structure of glucokinase (hexokinase 4) complexed with ligand diethyl ({2-[3-(4-methanesulfonylpheno xy)-5-{[(2s)-1-methoxypropan- 2-yl]oxy}benzamido]-1,3-thiaz ol-4-yl}methyl)phosphonate
25% identity, 86% coverage of query (113 bits)
HXK4_RAT / P17712 Hexokinase-4; HK4; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-D; EC 2.7.1.1 from Rattus norvegicus (Rat) (see 6 papers)
P17712 hexokinase (EC 2.7.1.1) from Rattus norvegicus (see paper)
25% identity, 86% coverage of query (112 bits)
HXKB_CANAL / P83776 Hexokinase-2; Cytoplasmic antigenic protein 3; Hexokinase PII; Hexokinase-B; EC 2.7.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
32% identity, 72% coverage of query (112 bits)
HXK4_MOUSE / P52792 Hexokinase-4; HK4; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-D; EC 2.7.1.1 from Mus musculus (Mouse) (see 6 papers)
26% identity, 86% coverage of query (112 bits)
HXK2_ORYSJ / Q2KNB9 Hexokinase-2; Hexokinase-3; EC 2.7.1.1 from Oryza sativa subsp. japonica (Rice) (see paper)
Q2KNB9 hexokinase (EC 2.7.1.1) from Oryza sativa (see paper)
29% identity, 84% coverage of query (110 bits)
4ixcA Crystal structure of human glucokinase in complex with a small molecule activator.
25% identity, 86% coverage of query (110 bits)
4iwvA Crystals structure of human glucokinase in complex with small molecule activator
25% identity, 86% coverage of query (110 bits)
A0A0P0I1H5 hexokinase (EC 2.7.1.1) from Helicoverpa armigera (see paper)
27% identity, 93% coverage of query (109 bits)
A3EYB3 hexokinase (EC 2.7.1.1) from Felis catus (see paper)
25% identity, 86% coverage of query (108 bits)
1czaN Mutant monomer of recombinant human hexokinase type i complexed with glucose, glucose-6-phosphate, and adp
26% identity, 89% coverage of query (108 bits)
1dgkN Mutant monomer of recombinant human hexokinase type i with glucose and adp in the active site
26% identity, 89% coverage of query (108 bits)
HXK7_ORYSJ / Q1WM16 Hexokinase-7; Hexokinase-6; EC 2.7.1.1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
Q1WM16 hexokinase (EC 2.7.1.1) from Oryza sativa Japonica Group (see 2 papers)
28% identity, 83% coverage of query (107 bits)
4qs7A / Q42525 Arabidopsis hexokinase 1 (athxk1) structure in glucose-bound form (see paper)
29% identity, 88% coverage of query (107 bits)
7t79A Crystal structure of glucokinase (hexokinase 4) complexed with ligand aka diethyl {[3-(3-{[5-(azetidine-1-carbon yl)pyrazin-2-yl]oxy}-5- (propan-2-yloxy)benzamido)-1h- pyrazol-1-yl]methyl}phosphonate
25% identity, 86% coverage of query (107 bits)
HXK1 / Q42525 fructokinase (EC 2.7.1.4; EC 2.7.1.1) from Arabidopsis thaliana (see 2 papers)
HXK1_ARATH / Q42525 Hexokinase-1; Protein GLUCOSE INSENSITIVE 2; EC 2.7.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see 10 papers)
Q42525 hexokinase (EC 2.7.1.1) from Arabidopsis thaliana (see 4 papers)
28% identity, 88% coverage of query (106 bits)
1qhaA / P19367 Human hexokinase type i complexed with atp analogue amp-pnp (see paper)
25% identity, 89% coverage of query (105 bits)
B8K2W7 hexokinase (EC 2.7.1.1) from Helianthus annuus (see paper)
30% identity, 74% coverage of query (105 bits)
HXK1_SPIOL / Q9SEK3 Hexokinase-1; SoHxK1; EC 2.7.1.1 from Spinacia oleracea (Spinach) (see paper)
Q9SEK3 hexokinase (EC 2.7.1.1) from Spinacia oleracea (see paper)
29% identity, 86% coverage of query (105 bits)
4fpbA Crystal structure of recombinant human hexokinase type i with 1,5- anhydroglucitol 6-phosphate
25% identity, 89% coverage of query (105 bits)
4foeA Crystal structure of recombinant human hexokinase type i with mannose 6-phosphate
25% identity, 89% coverage of query (105 bits)
4f9oA Crystal structure of recombinant human hexokinase type i with 2-deoxy- glucose 6-phosphate
25% identity, 89% coverage of query (105 bits)
1hkbA Crystal structure of recombinant human brain hexokinase type i complexed with glucose and glucose-6-phosphate
25% identity, 89% coverage of query (105 bits)
HK1 / P19367 hexokinase-1 (EC 2.7.1.1) from Homo sapiens (see 7 papers)
HXK1_HUMAN / P19367 Hexokinase-1; Brain form hexokinase; Hexokinase type I; HK I; Hexokinase-A; EC 2.7.1.1 from Homo sapiens (Human) (see 17 papers)
25% identity, 89% coverage of query (104 bits)
HXK1_SCHPO / Q09756 Hexokinase-1; EC 2.7.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
Q09756 hexokinase (EC 2.7.1.1) from Schizosaccharomyces pombe (see paper)
hxk1 / RF|NP_592948.1 hexokinase 1; EC 2.7.1.1; EC 2.7.1.2; EC 2.7.1.4; EC 2.7.1.7 from Schizosaccharomyces pombe (see 2 papers)
32% identity, 73% coverage of query (103 bits)
Q5W5U3 hexokinase (EC 2.7.1.1) from Bos taurus (see paper)
26% identity, 89% coverage of query (101 bits)
hxkA hexokinase; EC 2.7.1.1 from Emericella nidulans (see paper)
29% identity, 100% coverage of query (101 bits)
Hxk1 hexokinase 1; EC 2.7.1.1 from Entamoeba histolytica (see paper)
HXK1 / GI|1070151 hexokinase 1; EC 2.7.1.1 from Entamoeba histolytica (see paper)
29% identity, 73% coverage of query (100 bits)
HXK1_MOUSE / P17710 Hexokinase-1; Hexokinase type I; HK I; Hexokinase, tumor isozyme; EC 2.7.1.1 from Mus musculus (Mouse) (see 5 papers)
P17710 hexokinase (EC 2.7.1.1) from Mus musculus (see paper)
25% identity, 89% coverage of query (99.8 bits)
5hg1A / P52789 Crystal structure of human hexokinase 2 with cmpd 1, a c-2-substituted glucosamine (see paper)
27% identity, 86% coverage of query (99.4 bits)
5hexA Crystal structure of human hexokinase 2 with cmpd 30, a 2-amino-6- benzenesulfonamide glucosamine
26% identity, 86% coverage of query (99.4 bits)
4isfA Human glucokinase in complex with novel activator (2s)-3-cyclohexyl-2- (6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2h)-yl)-n-(1,3-thiazol-2- yl)propanamide
24% identity, 86% coverage of query (99.4 bits)
4dchA / P35557 Insights into glucokinase activation mechanism: observation of multiple distinct protein conformations (see paper)
24% identity, 86% coverage of query (98.2 bits)
4iseA Human glucokinase in complex with novel activator (2s)-3-cyclohexyl-2- (6-fluoro-4-oxoquinazolin-3(4h)-yl)-n-(1,3-thiazol-2-yl)propanamide
24% identity, 86% coverage of query (95.1 bits)
HXK4_ARATH / Q56XE8 Hexokinase-4; EC 2.7.1.1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
28% identity, 73% coverage of query (92.8 bits)
5v4xA Human glucokinase in complex with novel pyrazole activator.
24% identity, 86% coverage of query (86.7 bits)
5v4wA Human glucokinase in complex with novel indazole activator.
23% identity, 86% coverage of query (86.3 bits)
4isgA Human glucokinase in complex with novel activator (2s)-3-cyclohexyl-2- [4-(methylsulfonyl)-2-oxopiperazin-1-yl]-n-(1,3-thiazol-2-yl) propanamide
24% identity, 82% coverage of query (84.7 bits)
Q02155 hexokinase (EC 2.7.1.1) from Plasmodium falciparum (see 2 papers)
24% identity, 82% coverage of query (83.6 bits)
6ksrA / U6KUE1 Crystal structure of hexokinase from eimeria tenella
24% identity, 92% coverage of query (70.9 bits)
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Lawrence Berkeley National Laboratory