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Searching for up to 100 curated homologs for 352326 FitnessBrowser__Btheta:352326 (329 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4k8pA / Q2KDX6 Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 2-ethylbenzyl alcohol
    38% identity, 93% coverage of query (191 bits)

4lbxA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with cytidine
    38% identity, 93% coverage of query (191 bits)

4k8kA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 1-(4-methoxyphenyl)-1-cyclopropane and 2- aminoperimidine
    38% identity, 93% coverage of query (191 bits)

4lc4A Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with guanosine
    38% identity, 93% coverage of query (191 bits)

4kbeA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with benzoguanamine
    38% identity, 93% coverage of query (191 bits)

4kanA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 2-(2,5-dimethyl-1,3-thiazol-4-yl)acetic acid
    38% identity, 93% coverage of query (191 bits)

4kalA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with quinoline-3-carboxylic acid
    38% identity, 93% coverage of query (191 bits)

4kahA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with 4-bromo-1h-pyrazole
    38% identity, 93% coverage of query (191 bits)

4kadA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n1-(2.3-dihydro-1h-inden-5-yl)acetam
    38% identity, 93% coverage of query (191 bits)

4k9iA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with norharmane
    38% identity, 93% coverage of query (191 bits)

4k9cA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n-(hydroxymethyl)benzamide and 4-methyl-3,4- dihydro-2h-1,4-benzoxazine-7-carboxylic acid
    38% identity, 93% coverage of query (191 bits)

4k93A Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with n-(hydroxymethyl)benzamide
    38% identity, 93% coverage of query (191 bits)

4k8tA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with ethyl 3,4-diaminobenzoate
    38% identity, 93% coverage of query (191 bits)

4k8cA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with adp
    38% identity, 93% coverage of query (191 bits)

4jkuA Crystal structure of probable sugar kinase protein from rhizobium etli cfn 42 complexed with quinaldic acid, nysgrc target 14306
    38% identity, 93% coverage of query (191 bits)

3uboA / Q92T17 The crystal structure of adenosine kinase from sinorhizobium meliloti
    35% identity, 93% coverage of query (185 bits)

Q9YG89 6-phosphofructokinase (EC 2.7.1.11) from Aeropyrum pernix (see 2 papers)
    31% identity, 78% coverage of query (114 bits)

Build an alignment

Build an alignment for 352326 and 17 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ADK_PHYPA / O49923 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens) (see paper)
    28% identity, 94% coverage of query (101 bits)

YdjH / b1772 L-glycero-L-galacto-octuluronate kinase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
ydjH / P77493 L-glycero-L-galacto-octuluronate kinase from Escherichia coli (strain K12) (see 2 papers)
    28% identity, 78% coverage of query (100 bits)

3in1A / P77493 Crystal structure of a putative ribokinase in complex with adp from e.Coli
    28% identity, 78% coverage of query (100 bits)

ADK2 / Q9LZG0 adenosine kinase 2 (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
ADK2_ARATH / Q9LZG0 Adenosine kinase 2; AK 2; Adenosine 5'-phosphotransferase 2; EC 2.7.1.20 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q9LZG0 adenosine kinase (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
    27% identity, 95% coverage of query (99.0 bits)

TK2029 / Q5JDG9 α-D-ribose-1-phosphate 5-kinase (ADP) (EC 2.7.1.212) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see paper)
R1PK_THEKO / Q5JDG9 ADP-dependent ribose-1-phosphate kinase; ADP-R1P kinase; ADP:alpha-D-ribose-1-phosphate 5-phosphotransferase; Alpha-D-ribose-1-phosphate 5-kinase (ADP); EC 2.7.1.212 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
    27% identity, 96% coverage of query (99.0 bits)

ADK1 / Q9SF85 adenosine kinase 1 (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
ADK1_ARATH / Q9SF85 Adenosine kinase 1; AK 1; Adenosine 5'-phosphotransferase 1; EC 2.7.1.20 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9SF85 adenosine kinase (EC 2.7.1.20) from Arabidopsis thaliana (see paper)
    28% identity, 95% coverage of query (98.6 bits)

Q5DKU8 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    28% identity, 95% coverage of query (96.7 bits)

Q5DKU6 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    28% identity, 95% coverage of query (96.7 bits)

8cqxA / A0A0B0SD75 Ribokinase from t.Sp mutant a92g
    28% identity, 86% coverage of query (96.3 bits)

ADK_MOUSE / P55264 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Mus musculus (Mouse) (see paper)
P55264 adenosine kinase (EC 2.7.1.20) from Mus musculus (see 3 papers)
    27% identity, 95% coverage of query (92.4 bits)

5kb5A Crystal structure of the adenosine kinase from mus musculus in complex with adenosine and adenosine-diphosphate
    27% identity, 95% coverage of query (92.4 bits)

Q5DKU9 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    26% identity, 95% coverage of query (90.1 bits)

ADK / AAC80288.1 adenosine kinase from Leishmania donovani (see paper)
    26% identity, 93% coverage of query (89.7 bits)

Q5DKV0 adenosine kinase (EC 2.7.1.20) from Nicotiana tabacum (see paper)
    26% identity, 95% coverage of query (89.4 bits)

2i6aA / P55263 Human adenosine kinase in complex with 5'-deoxy-5-iodotubercidin (see paper)
    26% identity, 95% coverage of query (87.4 bits)

ADK / P55263 adenosine kinase (EC 2.7.1.20) from Homo sapiens (see 2 papers)
ADK_HUMAN / P55263 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Homo sapiens (Human) (see 4 papers)
    26% identity, 95% coverage of query (87.4 bits)

1bx4A Structure of human adenosine kinase at 1.50 angstroms
    26% identity, 95% coverage of query (87.4 bits)

KDGK_THET8 / Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
    28% identity, 75% coverage of query (85.5 bits)

Q2F635 adenosine kinase (EC 2.7.1.20) from Bombyx mori (see 2 papers)
    23% identity, 96% coverage of query (85.1 bits)

1v1aA / Q53W83 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
    28% identity, 75% coverage of query (85.1 bits)

ADK_CRIGR / P55262 Adenosine kinase; AK; Adenosine 5'-phosphotransferase; EC 2.7.1.20 from Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (see paper)
    27% identity, 95% coverage of query (85.1 bits)

1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp
    28% identity, 75% coverage of query (85.1 bits)

5c41A / Q9H477 Crystal structure of human ribokinase in complex with amppcp in p21 spacegroup and with 4 protomers
    29% identity, 79% coverage of query (84.0 bits)

RBSK_HUMAN / Q9H477 Ribokinase; RK; EC 2.7.1.15 from Homo sapiens (Human) (see paper)
Q9H477 ribokinase (EC 2.7.1.15) from Homo sapiens (see paper)
    29% identity, 79% coverage of query (84.0 bits)

6wjzA Crystal structure of human ribokinase in complex with ampcp
    29% identity, 79% coverage of query (84.0 bits)

2fv7A Crystal structure of human ribokinase
    29% identity, 79% coverage of query (84.0 bits)

6wk0B Crystal structure of human ribokinase in complex with amppcp and ribose
    29% identity, 79% coverage of query (84.0 bits)

5byfA Crystal structure of human ribokinase in complex with amp
    29% identity, 79% coverage of query (84.0 bits)

5c3yA Structure of human ribokinase crystallized with amppnp
    29% identity, 79% coverage of query (84.0 bits)

6znxC / A0A0B0SD75 Ribokinase from thermus species
    28% identity, 74% coverage of query (83.2 bits)

3looB Crystal structure of anopheles gambiae adenosine kinase in complex with p1,p4-di(adenosine-5) tetraphosphate (see paper)
    24% identity, 95% coverage of query (83.2 bits)

KDGK_BACSU / P50845 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Bacillus subtilis (strain 168) (see paper)
    26% identity, 76% coverage of query (82.8 bits)

iolC / P42414 5-dehydro-2-deoxy-D-gluconate kinase (EC 2.7.1.92) from Bacillus subtilis (strain 168) (see 2 papers)
IOLC_BACSU / P42414 5-dehydro-2-deoxygluconokinase; 2-deoxy-5-keto-D-gluconate kinase; DKG kinase; EC 2.7.1.92 from Bacillus subtilis (strain 168) (see paper)
    28% identity, 75% coverage of query (82.0 bits)

1dgmA Crystal structure of adenosine kinase from toxoplasma gondii
    26% identity, 94% coverage of query (81.3 bits)

4o1lA Human adenosine kinase in complex with inhibitor
    24% identity, 91% coverage of query (81.3 bits)

1liiA Structure of t. Gondii adenosine kinase bound to adenosine 2 and amp- pcp
    25% identity, 94% coverage of query (80.9 bits)

1lijA Structure of t. Gondii adenosine kinase bound to prodrug 2 7- iodotubercidin and amp-pcp
    26% identity, 94% coverage of query (80.9 bits)

2i6bA Human adenosine kinase in complex with an acetylinic inhibitor
    26% identity, 89% coverage of query (80.1 bits)

ADK_YEAST / P47143 Adenosine kinase; EC 2.7.1.20 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    26% identity, 95% coverage of query (79.0 bits)

2a9yA / Q9TVW2 Crystal structure of t. Gondii adenosine kinase complexed with n6- dimethyladenosine (see paper)
    24% identity, 94% coverage of query (79.0 bits)

2aa0A Crystal structure of t. Gondii adenosine kinase complexed with 6- methylmercaptopurine riboside
    24% identity, 94% coverage of query (79.0 bits)

PFKB_THETC / D9TT10 ATP-dependent 6-phosphofructokinase; ATP-PFK; Phosphofructokinase; EC 2.7.1.11 from Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium thermosaccharolyticum) (see paper)
    25% identity, 80% coverage of query (78.6 bits)

RBSK / A1A6H3 ribokinase (EC 2.7.1.15) from Arabidopsis thaliana (see 2 papers)
RBSK_ARATH / A1A6H3 Ribokinase; AtRBSK; RK; EC 2.7.1.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
A1A6H3 ribokinase (EC 2.7.1.15) from Arabidopsis thaliana (see paper)
    28% identity, 81% coverage of query (78.6 bits)

STM4066 / Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
AIRSK_SALTY / Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
Q8ZKR2 aminoimidazole riboside kinase (EC 2.7.1.223) from Salmonella enterica subsp. enterica serovar Typhimurium (see 2 papers)
    28% identity, 76% coverage of query (78.6 bits)

6ilsB / A1A6H3 Structure of arabidopsis thaliana ribokinase complexed with ribose and atp (see paper)
    28% identity, 81% coverage of query (78.2 bits)

Q584S0 adenosine kinase (EC 2.7.1.20) from Trypanosoma brucei brucei (see paper)
4n09A / Q584S0 Structure of trypanosoma brucei brucei adenosine kinase in complex with adenosine and amppnp (see paper)
    24% identity, 93% coverage of query (77.4 bits)

Q0K080 dehydrogluconokinase (EC 2.7.1.13); 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) from Cupriavidus necator (see paper)
    25% identity, 78% coverage of query (76.3 bits)

3otxA Crystal structure of trypanosoma brucei rhodesiense adenosine kinase complexed with inhibitor ap5a
    24% identity, 90% coverage of query (75.9 bits)

2xtbA Crystal structure of trypanosoma brucei rhodesiense adenosine kinase complexed with activator
    24% identity, 90% coverage of query (75.9 bits)

BT2803 ribokinase (EC 2.7.1.15) from Bacteroides thetaiotaomicron VPI-5482
    29% identity, 73% coverage of query (75.5 bits)

RBSKI_FRUSL / P83534 Bifunctional ribokinase/ribose-5-phosphate isomerase A; EC 2.7.1.15; EC 5.3.1.6 from Fructilactobacillus sanfranciscensis (strain ATCC 27651 / DSM 20451 / JCM 5668 / CCUG 30143 / KCTC 3205 / NCIMB 702811 / NRRL B-3934 / L-12) (Lactobacillus sanfranciscensis) (see paper)
    28% identity, 78% coverage of query (74.3 bits)

A0A0H3AER7 fructokinase (EC 2.7.1.4) from Vibrio cholerae (see paper)
    27% identity, 72% coverage of query (73.9 bits)

5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
    27% identity, 72% coverage of query (73.9 bits)

2hw1A Crystal structure of human ketohexokinase complexed to different sugar molecules
    24% identity, 82% coverage of query (73.2 bits)

8omeA / P50053 Crystal structure of hkhk-a in complex with compound-4 (see paper)
    24% identity, 82% coverage of query (72.8 bits)

G4N8F5 adenosine kinase (EC 2.7.1.20) from Pyricularia oryzae (see paper)
    28% identity, 91% coverage of query (72.4 bits)

Q9C524 fructokinase (EC 2.7.1.4) from Arabidopsis thaliana (see 2 papers)
    30% identity, 71% coverage of query (72.4 bits)

BPHYT_RS25805 deoxyribose kinase (EC 2.7.1.15) from Burkholderia phytofirmans PsJN
    24% identity, 87% coverage of query (72.0 bits)

2c49A / Q57849 Crystal structure of methanocaldococcus jannaschii nucleoside kinase - an archaeal member of the ribokinase family (see paper)
    26% identity, 85% coverage of query (72.0 bits)

NK_METJA / Q57849 Nucleoside kinase; NK; ATP-dependent nucleoside monophosphokinase; Cytidine kinase; Guanosine-inosine kinase; EC 2.7.1.213; EC 2.7.1.73 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
    26% identity, 85% coverage of query (72.0 bits)

P97328 ketohexokinase (EC 2.7.1.3) from Mus musculus (see 2 papers)
    25% identity, 79% coverage of query (71.6 bits)

6ul7A Structure of human ketohexokinasE-C in complex with fructose, no3, and osthole
    23% identity, 81% coverage of query (71.6 bits)

KHK / P50053 Ketohexokinase (EC 2.7.1.3) from Homo sapiens (see 8 papers)
KHK_HUMAN / P50053 Ketohexokinase; Hepatic fructokinase; EC 2.7.1.3 from Homo sapiens (Human) (see 4 papers)
P50053 ketohexokinase (EC 2.7.1.3) from Homo sapiens (see 6 papers)
    23% identity, 81% coverage of query (71.2 bits)

8omdA / P97328 Crystal structure of mkhk in complex with compound-4 (see paper)
    25% identity, 79% coverage of query (71.2 bits)

8ug1B / P50053 Crystal structure of khk-c and compound 13 (see paper)
    23% identity, 81% coverage of query (71.2 bits)

6p2dA Structure of mouse ketohexokinasE-C in complex with fructose and adp
    25% identity, 79% coverage of query (71.2 bits)

8ug3A Crystal structure of khk-c and compound 23
    23% identity, 81% coverage of query (71.2 bits)

8omkA Hkhk-c in complex with adp & fructose 1-phosphate
    23% identity, 81% coverage of query (71.2 bits)

8omfA Crystal structure of hkhk-c in complex with compound-4
    23% identity, 81% coverage of query (71.2 bits)

6w0zA Structure of khk in complex with compound 8 (2-[(1~{s},5~{r})-3-[2- [(2~{s})-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3- azabicyclo[3.1.0]hexan-6-yl]ethanoic acid)
    23% identity, 81% coverage of query (71.2 bits)

6w0yA Structure of khk in complex with compound 6 (2-[(1~{r},5~{s})-3-[5- cyano-6-[(2~{s},3~{r})-2-methyl-3-oxidanyl-azetidin-1-yl]-4- (trifluoromethyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid)
    23% identity, 81% coverage of query (71.2 bits)

6w0xA Structure of khk in complex with compound 4 (6-[(1~{s},5~{r})-6- (hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-[(2~{s},3~{r})-2- methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3- carbonitrile)
    23% identity, 81% coverage of query (71.2 bits)

6w0wA Structure of khk in complex with compound 3
    23% identity, 81% coverage of query (71.2 bits)

6w0nA Structure of khk in complex with compound 2
    23% identity, 81% coverage of query (71.2 bits)

5wbzA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

5wbrA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

5wbqA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

5wbpA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

5wboA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

5wbmA Structure of human ketohexokinase complexed with hits from fragment screening
    23% identity, 81% coverage of query (71.2 bits)

3ro4A X-ray structure of ketohexokinase in complex with an indazole compound derivative
    23% identity, 81% coverage of query (71.2 bits)

3qaiA X-ray structure of ketohexokinase in complex with a pyrimidopyrimidine analog 3
    23% identity, 81% coverage of query (71.2 bits)

3q92A X-ray structure of ketohexokinase in complex with a pyrimidopyrimidine analog 1
    23% identity, 81% coverage of query (71.2 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory